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Myelodysplastic syndromes – Eva Hellström Lindberg group

Our research program aims at understanding disease mechanisms in MDS and to improve outcome of MDS patients. We are closely linked to the MDS Clinic at the Department of Hematology, Karolinska University Hospital. The MDS research group consists of three independent team leaders, clinical scientists, cell and molecular biologists, technicians and a research nurse. Research students encompass both junior hematologists and young preclinical scientists.

Part of the:
Group photo in an archipelago setting.

VÃ¥r forskning

VÃ¥r forskning fokuserar pÃ¥ blodmaligniteten myelodysplastiskt syndrom (MDS). Vi är en translationell forskargrupp som studerar genetiska, epigenetiska och cellulära orsaker till sjukdomsuppkomst, samt progress till akut leukemi. Vi studerar funktionen av stam och progenitorceller vid olika typer av MDS genom avancerade odlingsmodeller, single-cell omics, och proteomics, och med speciellt fokus pÃ¥ splice factor mutationer och  erytroid benmärgssvikt.

Mer information om gruppen finns på den engelska sidan.

Publications

Selected publications

  • Letter: ANNALS OF INTERNAL MEDICINE. 2025;178(2):300-304
    Creignou M; Sirenko M; Moura PL; Mortera-Blanco T; Dimitriou M; Sander B; Domenico D; Ossa JEA; Tesi B; Beck DB; Woll P; Jacobsen S-EW; Papaemmanuil E; Bernard E; Hellstrom-Lindberg E
  • Article: LANCET HAEMATOLOGY. 2025;12(2):e128-e137
    Garelius HKG; Bagguley T; Taylor A; Fenaux P; Bowen D; Symeonidis A; Mittelmann M; Stauder R; Cermak J; Sanz G; Langemeijer S; Malcovati L; Germing U; Sanhes L; d'Aveni M; Culligan D; Kotsianidis I; Koinig KA; van Marrewijk C; Crouch S; Dewitte T; Smith A; Hellstroem-Lindberg E
  • Article: BLOOD. 2024;144(15):1617-1632
    Bernard E; Hasserjian RP; Greenberg PL; Ossa JEA; Creignou M; Tuechler H; Gutierrez-Abril J; Domenico D; Medina-Martinez JS; Levine M; Liosis K; Farnoud N; Sirenko M; Jaedersten M; Germing U; Sanz G; van de Loosdrecht AA; Nannya Y; Kosmider O; Follo MY; Thol F; Zamora L; Pinheiro RF; Pellagatti A; Elias HK; Haase D; Ganster C; Ades L; Tobiasson M; Palomo L; Porta MGD; Fenaux P; Belickova M; Savona MR; Klimek VM; Santos FPS; Boultwood J; Kotsianidis I; Santini V; Sole F; Platzbecker U; Heuser M; Valent P; Finelli C; Voso MT; Shih L-Y; Fontenay M; Jansen JH; Cervera J; Gattermann N; Ebert BL; Bejar R; Malcovati L; Ogawa S; Cazzola M; Hellstrom-Lindberg E; Papaemmanuil E
  • Article: BLOOD. 2024;144(11):1221-1229
    Sirenko M; Bernard E; Creignou M; Domenico D; Farina A; Ossa JEA; Kosmider O; Hasserjian R; Jadersten M; Germing U; Sanz G; van de Loosdrecht AA; Gurnari C; Follo MY; Thol F; Zamora L; Pinheiro RF; Pellagatti A; Elias HK; Haase D; Sander B; Orna E; Zoldan K; Eder LN; Sperr WR; Thalhammer R; Ganster C; Ades L; Tobiasson M; Palomo L; Della Porta MG; Huberman K; Fenaux P; Belickova M; Savona MR; Klimek VM; Santos FPS; Boultwood J; Kotsianidis I; Santini V; Sole F; Platzbecker U; Heuser M; Valent P; Finelli C; Voso MT; Shih L-Y; Ogawa S; Fontenay M; Jansen JH; Cervera J; Ebert BL; Bejar R; Greenberg PL; Gattermann N; Malcovati L; Cazzola M; Beck DB; Hellstrom-Lindberg E; Papaemmanuil E
  • Article: JOURNAL OF INTERNAL MEDICINE. 2024;296(1):53-67
    Creignou M; Bernard E; Gasparini A; Tranberg A; Todisco G; Moura PL; Ejerblad E; Nilsson L; Garelius H; Antunovic P; Lorenz F; Rasmussen B; Walldin G; Mortera-Blanco T; Jansson M; Tobiasson M; Elena C; Ferrari J; Galli A; Pozzi S; Malcovati L; Edgren G; Crowther MJ; Jaedersten M; Papaemmanuil E; Hellstroem-Lindberg E
  • Article: BLOOD NEOPLASIA. 2024;1(2):100011
    Moura PL; Nannya Y; Aliouat A; Hofman IJ; Mortera-Blanco T; Yoshizato T; Saiki R; Nakagawa MM; Creignou M; Björklund A-C; Walldin G; Barbosa I; Jansson M; Grasso F; Elvarsdottir EM; Woll PS; Jacobsen SEW; Ogawa S; Hellström-Lindberg E
  • Article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(12):1378-1390
    Tobiasson M; Pandzic T; Illman J; Nilsson L; Westrom S; Ejerblad E; Olesen G; Bjorklund A; Olsnes Kittang A; Werlenius O; Lorentz F; Rasmussen B; Cammenga J; Weber D; Lindholm C; Wiggh J; Dimitriou M; Moen AE; Lundstrom LY; von Bahr L; Baltzer-Sollander K; Jadersten M; Kytola S; Walldin G; Ljungman P; Groenbaek K; Mielke S; Jacobsen SEW; Ebeling F; Cavelier L; Smidstrup Friis L; Dybedal I; Hellstrom-Lindberg E
  • Article: BLOOD. 2024;143(11):953-966
    Dimitriou M; Mortera-Blanco T; Tobiasson M; Mazzi S; Lehander M; Hoegstrand K; Karimi M; Walldin G; Jansson M; Vonlanthen S; Ljungman P; Langemeijer S; Yoshizato T; Hellstroem-Lindberg E; Woll PS; Jacobsen SEW
  • Article: CANCER RESEARCH. 2024;84(2):211-225
    Moura PL; Mortera-Blanco T; Hofman IJ; Todisco G; Kretzschmar WW; Bjoerklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Cabrerizo Granados D; Barbosa I; Walldin G; Jansson M; Ashley N; Mead AJ; Lundin V; Dimitriou M; Yoshizato T; Woll PS; Ogawa S; Sandberg R; Jacobsen SEW; Hellstrom-Lindberg E
  • Journal article: BLOOD. 2023;142(26):2268-2281
    Hellstrom-Lindberg ES; Kroger N
  • Article: CLINICAL CANCER RESEARCH. 2023;29(20):4256-4267
    Todisco G; Creignou M; Bernard E; Bjorklund A-C; Moura PL; Tesi B; Mortera-Blanco T; Sander B; Jansson M; Walldin G; Barbosa I; Reinsbach SE; Hofman IJ; Nilsson C; Yoshizato T; Dimitriou M; Chang D; Olafsdottir S; Larsson SV; Tobiasson M; Malcovati L; Woll P; Jacobsen SEW; Papaemmanuil E; Hellstroem-Lindberg E
  • Letter: BLOOD ADVANCES. 2022;6(16):4705-4709
    Hofman IJF; Mortera-Blanco T; Moura PL; Vestlund J; Larsson SV; Elvarsdottir EM; Walldin G; Tobiasson M; Sander B; Dimitriou M; Jacobsen S-EW; Woll PS; Jadersten M; Hellstrom-Lindberg E
  • Article: NEJM EVID. 2022;1(7):evidoa2200008
    Bernard E; Tuechler H; Greenberg PL; Hasserjian RP; Arango Ossa JE; Nannya Y; Devlin SM; Creignou M; Pinel P; Monnier L; Gundem G; Medina-Martinez JS; Domenico D; Jadersten M; Germing U; Sanz G; van de Loosdrecht AA; Kosmider O; Follo MY; Thol F; Zamora L; Pinheiro RF; Pellagatti A; Elias HK; Haase D; Ganster C; Ades L; Tobiasson M; Palomo L; Della Porta MG; Takaori-Kondo A; Ishikawa T; Chiba S; Kasahara S; Miyazaki Y; Viale A; Huberman K; Fenaux P; Belickova M; Savona MR; Klimek VM; Santos FPS; Boultwood J; Kotsianidis I; Santini V; Sole F; Platzbecker U; Heuser M; Valent P; Ohyashiki K; Finelli C; Voso MT; Shih L-Y; Fontenay M; Jansen JH; Cervera J; Gattermann N; Ebert BL; Bejar R; Malcovati L; Cazzola M; Ogawa S; Hellstrom-Lindberg E; Papaemmanuil E
  • Letter: LEUKEMIA. 2022;36(5):1436-1439
    Rasmussen B; Gohring G; Bernard E; Nilsson L; Tobiasson M; Jadersten M; Garelius H; Dybedal I; Gronbaek K; Ejerblad E; Lorenz F; Flogegard M; Marcher CW; oster Fernstrom A; Cavelier L; Papaemmanuil E; Ebeling F; Kittang AO; Norgaard JM; Saft L; Mollgard L; Hellstrom-Lindberg E
  • Preprint: RESEARCH SQUARE. 2021
    Ogawa S; Tobiasson M; Sato S; Bernard E; Ohtake S; Takeda J; Creignou M; Zhao L; Kusakabe M; Shibata Y; Nakamura N; Watanabe M; Hiramoto N; Shiozawa Y; Shiraishi Y; Tanaka H; Yoshida K; Kakiuchi N; Makishima H; Nakagawa M; Usuki K; Watanabe M; Imada K; Handa H; Taguchi M; Kiguchi T; Ohyashiki K; Ishikawa T; Takaori-Kondo A; Tsurumi H; Kasahara S; Chiba S; Naoe T; Miyano S; Papaemmanuil E; Miyazaki Y; Hellstrom-Lindberg E
  • Article: NATURE MEDICINE. 2020;26(10):1549-1556
    Bernard E; Nannya Y; Hasserjian RP; Devlin SM; Tuechler H; Medina-Martinez JS; Yoshizato T; Shiozawa Y; Saiki R; Malcovati L; Levine MF; Arango JE; Zhou Y; Sole F; Cargo CA; Haase D; Creignou M; Germing U; Zhang Y; Gundem G; Sarian A; van de Loosdrecht AA; Jadersten M; Tobiasson M; Kosmider O; Follo MY; Thol F; Pinheiro RF; Santini V; Kotsianidis I; Boultwood J; Santos FPS; Schanz J; Kasahara S; Ishikawa T; Tsurumi H; Takaori-Kondo A; Kiguchi T; Polprasert C; Bennett JM; Klimek VM; Savona MR; Belickova M; Ganster C; Palomo L; Sanz G; Ades L; Della Porta MG; Smith AG; Werner Y; Patel M; Viale A; Vanness K; Neuberg DS; Stevenson KE; Menghrajani K; Bolton KL; Fenaux P; Pellagatti A; Platzbecker U; Heuser M; Valent P; Chiba S; Miyazaki Y; Finelli C; Voso MT; Shih L-Y; Fontenay M; Jansen JH; Cervera J; Atsuta Y; Gattermann N; Ebert BL; Bejar R; Greenberg PL; Cazzola M; Hellstrom-Lindberg E; Ogawa S; Papaemmanuil E
  • Article: LEUKEMIA. 2020;34(1):271-282
    Elvarsdottir EM; Mortera-Blanco T; Dimitriou M; Bouderlique T; Jansson M; Hofman IJF; Conte S; Karimi M; Sander B; Douagi I; Woll PS; Hellstrom-Lindberg E
  • Article: BLOOD. 2017;130(7):881-890
    Mortera-Blanco T; Dimitriou M; Woll PS; Karimi M; Elvarsdottir E; Conte S; Tobiasson M; Jansson M; Douagi I; Moarii M; Saft L; Papaemmanuil E; Jacobsen SEW; Hellstrom-Lindberg E

Staff and contact

Group leader

All members of the group

Keywords:
Hematology Immunology in the Medical Area Medical Biotechnology (Focus on Cell Biology (incl. Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Medical Genetics and Genomics Myelodysplastic Syndromes
Content reviewer:
Eva Hellström Lindberg
Karin Vikström
04-09-2025