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Mechanisms of protein aggregation and inhibition – Axel Abelein group

Protein misfolding and formation of cross-β structured amyloid fibrils are linked to many neurodegenerative disorders but are also the building blocks of novel biomaterials. Our research aims to understand the underlying mechanisms of amyloid formation to both find treatment strategies against dementia diseases, in particular Alzheimer’s and Parkinson’s disease, and to develop new protein-based materials.

Part of the:

För detaljerad information om vÃ¥r forskning, se vÃ¥r engelska sida.

Publications

Selected publications

  • Article: PROTEIN SCIENCE. 2024;33(8):e5091
    Adam L; Kumar R; Arroyo-Garcia LE; Molenkamp WH; Nowak JS; Klute H; Farzadfard A; Alkenayeh R; Nielsen J; Biverstal H; Otzen DE; Johansson J; Abelein A
  • Journal article: NATURE COMMUNICATIONS. 2024;15(1):965
    Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstål H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
  • Review: ACCOUNTS OF CHEMICAL RESEARCH. 2023;56(19):2653-2663
    Abelein A
  • Review: RSC MEDICINAL CHEMISTRY. 2023;14(5):848-857
    Abelein A; Johansson J
  • Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511
    Kumar R; Arroyo-Garcia LE; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
  • Article: JACS AU. 2022;2(11):2571-2584
    Abelein A; Ciofi-Baffoni S; Morman C; Kumar R; Giachetti A; Piccioli M; Biverstal H
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(21):7224-7234
    Wallin C; Jarvet J; Biverstal H; Warmlander S; Danielsson J; Graslund A; Abelein A
  • Article: NATURE COMMUNICATIONS. 2017;8(1):2081
    Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstal H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J

Funding

Grants

  • Swedish Research Council
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
Keywords:
Biophysics Biophysics Neurosciences Neurosciences Structural Biology
Content reviewer:
Axel Abelein
Karin Vikström
14-04-2025