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Alejandra Machado

Alejandra Machado

Research Specialist
Visiting address: Avd försäkringsmedicin, ̽»¨¾«Ñ¡, 17177 Stockholm
Postal address: K8 Klinisk neurovetenskap, K8 Fm Friberg, 171 77 Stockholm

About me

  • My previous research work focused on cognitive changes in the context of normal aging and neurodegenerative disorders such as Alzheimer’s Disease (AD), with a focus on a multidimensional and integrative approach, combining demographic variables, cognitive assessments, biomarkers, and neuroimaging data. 

    Since 2020, I have extended my research into the field of insurance medicine, with a particular focus on neurological disorders. My work has primarily focused on identifying risk factors for, and the consequences of, sickness absence in individuals with multiple sclerosis (MS). My current line of research addresses individuals with mild cognitive impairment and early-onset dementia when still of working age, exploring how these conditions affect individuals during their final working years, often leading to premature exit from the labour market. My goal is to better understand the how  cognitive decline contributes to reduced work capacity, increased sickness absence or disability pension, and early retirement, as well as how these outcomes are shaped by the influence of demographic, socioeconomic, clinical and cognitive factors.

Articles

  • Article: MULTIPLE SCLEROSIS JOURNAL - EXPERIMENTAL, TRANSLATIONAL AND CLINICAL. 2025;11(1):20552173241304324
    Teni FS; Machado A; Dervish J; Fink K; Gyllensten H; Friberg E
  • Article: BMJ OPEN. 2024;14(12):e087563
    Machado A; Wredendal E; Fink K; Friberg E
  • Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2024;34:ckae144.1301
    Machado A; Teni FS; Friberg E
  • Article: MULTIPLE SCLEROSIS JOURNAL - EXPERIMENTAL, TRANSLATIONAL AND CLINICAL. 2024;10(4):20552173241305982
    Machado A; Pettersson E; Alexanderson K; Hillert J; Friberg E
  • Journal article: OCCUPATIONAL MEDICINE-OXFORD. 2024;74(Supplement_1):0
    Machado A; Friberg E
  • Journal article: OCCUPATIONAL MEDICINE-OXFORD. 2024;74(Supplement_1):0
    Saddal S; Van der Hiele K; Machado A; De Perez BD; Friberg E; Nair RD; Benedict R; Radford K; Daams J; Hulst H; De Groot V; Schaafsma F
  • Article: JOURNAL OF OCCUPATIONAL REHABILITATION. 2024;34(2):461-471
    Machado A; Murley C; Dervish J; Teni FS; Friberg E
  • Article: BMC PUBLIC HEALTH. 2024;24(1):1389
    Murley C; Dervish J; Machado A; Svard V; Wennman-Larsen A; Hillert J; Friberg E
  • Article: MULTIPLE SCLEROSIS JOURNAL - EXPERIMENTAL, TRANSLATIONAL AND CLINICAL. 2024;10(2):20552173241248293
    Murley C; Pettersson E; Hillert J; Machado A; Friberg E
  • Article: MULTIPLE SCLEROSIS JOURNAL. 2024;30(3):419-431
    Teni FS; Machado A; Fink K; Gyllensten H; Hillert J; Friberg E
  • Article: FRONTIERS IN PUBLIC HEALTH. 2024;12:1331746
    Dervish J; Arfuch VM; Murley C; Mckay KA; Machado A; Wennman-Larsen A; Friberg E
  • Article: EUROPEAN JOURNAL OF HEALTH ECONOMICS. 2023;24(8):1357-1371
    Murley C; Tinghog P; Teni FS; Machado A; Alexanderson K; Hillert J; Karampampa K; Friberg E
  • Article: PLOS ONE. 2023;18(8):e0288998
    Machado A; Azad A; Pettersson E; Hillert JV; Alexanderson KV; Friberg EV
  • Article: NEUROLOGY. 2023;101(3):e277-e288
    Dittrich A; Ashton NJJ; Zetterberg H; Blennow K; Zettergren A; Simren J; Skillback T; Shams S; Machado A; Westman E; Scholl M; Skoog I; Kern S
  • Article: EUROPEAN JOURNAL OF NEUROLOGY. 2023;30(7):1843-1853
    Teni FS; Machado A; Murley C; Fink K; Gyllensten H; Dervish J; Hillert J; Friberg E
  • Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S2)
    Dittrich A; Ashton NJ; Zetterberg H; Blennow K; Zettergren A; Simrén J; Shams S; Machado A; Westman E; Schöll M; Skoog I; Kern S
  • Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2023;69:104456
    Teni FS; Machado A; Murley C; He A; Fink K; Gyllensten H; Glaser A; Alexanderson K; Hillert J; Friberg E
  • Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2022;32(Supplement_3):ckac129.097
    Murley C; Tinghög P; Teni FS; Machado A; Alexanderson K; Hillert J; Karampampa K; Friberg E
  • Article: NEUROLOGY. 2022;99(15):e1619-e1629
    Cedres N; Ferreira D; Nemy M; Machado A; Pereira JB; Shams S; Wahlund L-O; Zettergren A; Stepankova O; Vyslouzilova L; Eriksdotter M; Teipel S; Grothe MJ; Blennow K; Zetterberg H; Scholl M; Kern S; Skoog I; Westman E
  • Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2022;32
    Murley C; Tinghog P; Teni FSS; Machado A; Alexanderson K; Hillert J; Karampampa K; Friberg E
  • Article: ACTA NEUROLOGICA SCANDINAVICA. 2022;146(3):283-294
    Machado A; Murley C; Hillert J; Alexanderson K; Friberg E
  • Article: MULTIPLE SCLEROSIS JOURNAL. 2022;28(9):1402-1413
    Bosma AR; Murley C; Aspling J; Hillert J; Schaafsma FG; Anema JR; Boot CRL; Alexanderson K; Machado A; Friberg E
  • Article: JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY. 2022;28(2):188-202
    van den Hurk W; Bergman I; Machado A; Bjermo J; Gustavsson A
  • Article: ALZHEIMER'S AND DEMENTIA: DIAGNOSIS, ASSESSMENT AND DISEASE MONITORING. 2022;14(1):e12295
    Dittrich A; Ashton NJ; Zetterberg H; Blennow K; Simren J; Geiger F; Zettergren A; Shams S; Machado A; Westman E; Scholl M; Skoog I; Kern S
  • Journal article: ALZHEIMERS & DEMENTIA. 2021;17(S5)
    Cedres N; Ferreira D; Nemy M; Machado A; Pereira JB; Wahlund L; Zettergren A; Teipel SJ; Grothe MJ; Eriksdotter M; Stepankova O; Vyslouzilova L; Blennow K; Zetterberg H; Kern S; Skoog I; Westman E
  • Article: NEUROBIOLOGY OF AGING. 2021;101:1-12
    Lindberg O; Kern S; Skoog J; Machado A; Pereira JB; Sacuiu SF; Wahlund L-O; Blennow K; Zetterberg H; Zettergren A; Westman E; Skoog I
  • Article: ALZHEIMER'S AND DEMENTIA: DIAGNOSIS, ASSESSMENT AND DISEASE MONITORING. 2021;13(1):e12141
    Skillback T; Blennow K; Zetterberg H; Shams S; Machado A; Pereira J; Lindberg O; Mielke MM; Zettergren A; Ryden L; Westman E; Wahlund L-O; Skoog I; Kern S
  • Journal article: ALZHEIMERS & DEMENTIA. 2020;16(S4)
    Skillback T; Blennow K; Zetterberg H; Shams S; Machado A; Pereira JB; Lindberg O; Mielke MM; Zettergren A; Rydén L; Westman E; Wahlund L; Skoog I; Kern S
  • Article: ALZHEIMERS RESEARCH & THERAPY. 2020;12(1):51
    Machado A; Ferreira D; Grothe MJ; Eyjolfsdottir H; Almqvist PM; Cavallin L; Lind G; Linderoth B; Seiger A; Teipel S; Wahlberg LU; Wahlund L-O; Westman E; Eriksdotter M
  • Article: AGING-US. 2020;12(1):894-901
    Cedres N; Ferreira D; Machado A; Shams S; Sacuiu S; Waern M; Wahlund L-O; Zettergren A; Kern S; Skoog I; Westman E
  • Article: FRONTIERS IN PSYCHOLOGY. 2019;10:2327
    Bjorngrim S; van den Hurk W; Betancort M; Machado A; Lindau M
  • Article: JOURNAL OF ALZHEIMERS DISEASE. 2019;68(1):295-309
    Cedres N; Machado A; Molina Y; Diaz-Galvan P; Andres Hernandez-Cabrera J; Barroso J; Westman E; Ferreira D
  • Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2019;34(2):191-209
    Sterner TR; Ahlner F; Blennow K; Dahlin-Ivanoff S; Falk H; Johansson LH; Hoff M; Holm M; Horder H; Jacobsson T; Johansson B; Johansson L; Kern J; Kern S; Machado A; Fassberg MM; Nilsson J; Ribbe M; Rothenberg E; Ryden L; Sadeghi A; Sacuiu S; Samuelsson J; Sigstrom R; Skoog J; Thorvaldsson V; Waern M; Westman E; Wetterberg H; Zetterberg H; Zetterberg M; Zettergren A; Ostling S; Skoog I
  • Article: NEUROBIOLOGY OF AGING. 2018;71:179-188
    Machado A; Barroso J; Molina Y; Nieto A; Diaz-Flores L; Westman E; Ferreira D
  • Article: FRONTIERS IN AGING NEUROSCIENCE. 2017;9:188
    Ferreira D; Machado A; Molina Y; Nieto A; Correia R; Westman E; Barroso J
  • Article: HIPPOCAMPUS. 2017;27(6):653-667
    Ferreira D; Hansson O; Barroso J; Molina Y; Machado A; Andres Hernandez-Cabrera J; Muehlboeck J-S; Stomrud E; Nagga K; Lindberg O; Ames D; Kalpouzos G; Fratiglioni L; Backman L; Graff C; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Lovestone S; Ahlstrom H; Lind L; Larsson E-M; Wahlund L-O; Simmons A; Westman E
  • Article: BEHAVIOURAL BRAIN RESEARCH. 2016;311:375-383
    Ferreira D; Bartres-Faz D; Nygren L; Rundkvist LJ; Molina Y; Machado A; Junque C; Barroso J; Westman E
  • Article: PSICOTHEMA. 2015;27(3):216-222
    Ferreira D; Correia R; Nieto A; Machado A; Molina Y; Barroso J
  • Article: REVISTA DE NEUROLOGIA. 2014;58(9):389-395
    Nieto A; Hernandez-Rodriguez E; Hernandez-Torres A; Velasco Rodriguez-Solis P; Hess-Medler S; Machado-Fernandez A; Molina-Rodriguez Y; Barroso J
  • Article: NEUROBIOLOGY OF AGING. 2014;35(5):1086-1094
    Ferreira D; Molina Y; Machado A; Westman E; Wahlund L-O; Nieto A; Correia R; Junque C; Diaz-Flores L; Barroso J
  • Show more

All other publications

  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2024;30(3):1065
    Teni FS; Machado A; Friberg E
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:433-434
    Machado A; Alexanderson K; Hillert J; Friberg E
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:452-453
    Murley C; Pettersson E; Hillert J; Machado A; Friberg E
  • Conference publication: INTERNATIONAL JOURNAL OF STROKE. 2023;18(3):11
    Baker K; Rosenfeldt A; Clark C; Nagel S; Machado A
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):672-673
    Teni FS; Machado A; Murley C; He A; Fink K; Gyllensten H; Glaser A; Alexanderson K; Hillert J; Friberg E
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):207-208
    Murley C; Machado A; Hillert J; Friberg E
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):200-201
    Teni FS; Machado A; Murley C; Fink K; Gyllensten H; Dervish J; Hillert J; Friberg E
  • Conference publication: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2021;31:ckab164.725
    Bosma A; Murley C; Aspling J; Hillert J; Schaafsma F; Anema J; Boot CRL; Alexanderson K; Machado A; Friberg E
  • Conference publication: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2021;31:459
    Machado A; Murley C; Hillert J; Alexanderson K; Friberg E
  • Conference publication: INTERNATIONAL JOURNAL OF STROKE. 2021;16(2_SUPPL):12
    Conforto A; Machado A; Ribeiro N; Plow E; Liew S-L; Da Costa Leite C; Zavaliangos-Petropulu A; Menezes I; Dos Anjos S; Luccas R; Peckham P; Cohen L
  • Conference publication: EUROPEAN HEART JOURNAL. 2020;41:3298
    Ferreira V; Monteiro AV; Santos MP; Patricio L; Borges A; Machado A; Castelo A; Bras PG; Mano T; Cardoso I; Grazina A; Alves MJ; Ferreira RC
  • Preprint: MEDRXIV. 2020
    Machado A; Ferreira D; Grothe M; Eyjolfsdottir H; Almqvist P; Cavallin L; Lind G; Linderoth B; Seiger Å; Teipel S; Wahlberg L; Wahlund L-O; Westman E; Eriksdotter M; for the Alzheimer’s Disease Neuroimaging Initiativ
  • Letter: REVISTA DE NEUROLOGIA. 2014;59(10):480
    Nieto A; Hernandez-Rodriguez E; Hernandez-Torres A; Velasco Rodriguez-Sols P; Hess-Medler S; Machado-Fernandez A; Molina-Rodriguez Y; Barroso J

Grants

  • Swedish Research Council for Health Working Life and Welfare
    1 January 2025 - 1 January 2028
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2024 - 31 December 2026
    Research problem and specific questions: The labour market is currently undergoing a substantial transformation. The nature of work and the way it is conceptualized is evolving in unprecedented ways. Work is increasingly becoming more remote, complex, and inter-connected whilst employees are expected to be more autonomous and efficient at work, whilst learning and adapting to the new technologies at the same time. Multiple sclerosis (MS) is the most common neurological disease-causing disability in young adults. In the past 20 years, treatment strategies have become increasingly effective. However, most people with MS (PwMS) experience limitations in respect to their work capacity and many are forced to exit the labour market once the disease progresses and substantial disabilities appear. It is uncertain how the changing dynamics of the labour market are impacting the work of PwMS and whether these changes can differ depending on the labour market attachment and the timing of disease onset and progression. Therefore, this project aims to study the impact of the described labour market changes in relation to individuals with MS and disease progression in light of the recently developed highly effective treatments.  Data and method and Plan for project realisation: Different research strategies will be used: Microdata linked from several Swedish registers including all people of working age diagnosed with MS, about 14 000 individuals and matched population references, will be used to explore factors associated with entering the labour market, remaining in paid work long term, and exiting from the workforce. In the second part, survey information collected from over 4000 responders in 2021, linked to register information will be used. Here we will focus on strategies used in relation to work and further deepen the understanding of how MS has influenced their work life. In the third part, individual and focus group interviews including PwMS and employers will be used to contrast our findings with the experiences of the work-life challenges related to new ways of working in combination with experienced physical or cognitive limitations both from a patient and an employer perspective.  Societal relevance and utilisation: This interdisciplinary project will generate new, relevant, and updated knowledge of working outcomes of PwMS given the transformation of the modern labour market and treatment advances for MS.

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