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Alessio Crippa

Alessio Crippa

Senior Research Specialist
Telephone: +46852482264
Visiting address: Nobels väg 12a, 17165 Solna
Postal address: C8 Medicinsk epidemiologi och biostatistik, C8 MEB Eklund, 171 77 Stockholm
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About me

  • I am a postdoctoral researcher in Epidemiology and Biostatistics at the Department of Medical Epidemiology and Biostatistics (MEB) at ̽»¨¾«Ñ¡ (KI). I did all my undergraduate studies in Biostatistics at the University of Milan-Bicocca, a part from a six-semester stint at the Stockholm University where I studied Mathematical Statistics, and a six-semester stint at KI where I wrote my master thesis. I also did my Phd at ̽»¨¾«Ñ¡ focusing on the development of novel methods for dose-response meta-analysis, with several applications to lifestyle factors and cancer. During my PhD, I spent three months in Boston at the Harvard T.H. Chan School of Public Health under the supervision of Prof. Donna Spiegelman. Since 2018, I work at MEB as postdoctoral researcher, where my research focuses on the design and analysis of modern trials to reduce the prostate cancer mortality by using genetics biomarkers to individualized treatment decision.

    EDUCATION
    PhD Medical Science, ̽»¨¾«Ñ¡, 2018
    MSc Biostatistics and Experimental Statistics, University of Milan-Bicocca 2013
    BSc Statistics and Information Management, University of Milan-Bicocca 2011

Research

  • My research focuses on the development of methodologies within modern platform trials, with the aim of improving a personalized treatment decision for prostate cancer patients. I am the responsible for the statistical analysis plan, as well as the unblinded statistician, in the ProBio platform trial.

    ProBio

    Approximately 30% of men diagnosed with prostate cancer develop lethal metastatic castration-resistant prostate cancer (mCRPC). Although recently approved new drugs are beneficial for many mCRPC patients they carry three serious disadvantages. First, these drugs are all very expensive. Second, the response rates to these drugs are low, ranging between 20-40%. This leads to suboptimal treatment and unnecessary side-effects. Third, there are no predictive treatment markers available in clinical care today, which leads to ineffective trial-and-error in treatment decisions. Our hypothesis is that treatment decisions based on molecular profiling will significantly increase progression free survival compared to current clinical care. The vast majority of CRPC metastasize to the bone, with low success rate in obtaining sufficient material. Therefore, we will sequence circulating tumor DNA (ctDNA) consisting of DNA debris from apoptotic cancer being present at high levels in plasma. This hypothesis will be tested in the ProBio trial starting in the end of 2018, a large, nationwide, multicentre randomized study in men with CRPC. ProBio uses an outcome-adaptive randomization trial design, with the goal to learn as rapidly as possible which treatments are effective for which ctDNA biomarker profiles.

Teaching

  • I have been teaching courses in Biostatistics (Basic Statistics and Advanced Statistics in Epidemiology) in the Master program in Public Health at Karolinska Insitutet. I've also been teaching assistant in different courses in Epidemiology and Biostatistics (Introduction to Stata, Biostatistics II) in the Doctoral Program in Epidemiology, as well hold different workshops to introduce the statistical software R to public health researchers at ̽»¨¾«Ñ¡ and ̽»¨¾«Ñ¡ doctors at Uppsala Hospital. I regularly have seminars teaching statistical concepts survival analysis for students in the Master of Biostatistics and Experimental Statistics at the University of Milan-Bicocca.

Articles

  • Article: EUROPEAN UROLOGY ONCOLOGY. 2025;:S2588-9311(25)00037-9
    Crippa A; Laere BD; Discacciati A; Larsson B; Persson M; Johansson S; D'hondt S; Hjälm-Eriksson M; Pettersson L; Enblad G; Ullén A; Lumen N; Karlsson CT; Sandzén J; Jänes E; Ghysel C; Olsson M; Sautois B; Schatteman P; Roock WD; Bruwaene SV; Verbiene I; Darras J; Everaert E; Maeseneer DD; Anden M; Strijbos M; Luyten D; Mortezavi A; Oldenburg J; Ost P; Lindberg J; Grönberg H; Eklund M; ProBio Investigators
  • Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2025;117(4):629-636
    Hammarstrom M; Gabrielson M; Bergqvist J; Lundholm C; Crippa A; Backlund M; Wengstrom Y; Borgquist S; Eliasson E; Eriksson M; Tapia J; Czene K; Hall P
  • Article: RADIOLOGY. 2025;314(3):e242566
    Dembrower KE; Crippa A; Eklund M; Strand F
  • Article: NATURE MEDICINE. 2024;30(11):3291-3302
    De Laere B; Crippa A; Discacciati A; Larsson B; Persson M; Johansson S; D'hondt S; Bergstrom R; Chellappa V; Mayrhofer M; Banijamali M; Kotsalaynen A; Schelstraete C; Vanwelkenhuyzen JP; Hjalm-Eriksson M; Pettersson L; Ullen A; Lumen N; Enblad G; Thellenberg Karlsson C; Janes E; Sandzen J; Schatteman P; Vigmostad M; Olsson M; Ghysel C; Sautois B; De Roock W; Van Bruwaene S; Anden M; Verbiene I; De Maeseneer D; Everaert E; Darras J; Aksnessether BY; Luyten D; Strijbos M; Mortezavi A; Oldenburg J; Ost P; Eklund M; Gronberg H; Lindberg J
  • Journal article: ANNALS OF ONCOLOGY. 2024;35:s991-s992
    Broer L; Oldenburg J; Mortezavi A; Lindberg J; Discacciati A; Karlsson CT; Ullen A; Janes E; Enblad G; Pettersson L; Vigmostad MN; Hjalm-Eriksson ME; Olsson M; Schatteman P; Ghysel C; De Laere B; Gronberg H; Ost P; Eklund M; Crippa A
  • Journal article: ANNALS OF ONCOLOGY. 2024;35:s978
    Kristiansen A; Sautois B; Crippa A; Mortezavi A; Discacciati A; Karlsson CT; Ullen A; Janes E; Enblad G; Oldenburg J; Sandzen J; Vigmostad MN; Hjalm-Eriksson ME; De Laere B; Strijbos MH; Ghysel C; Lindberg J; Eklund M; Ost P; Gronberg H
  • Journal article: ANNALS OF ONCOLOGY. 2024;35:s987
    Bultijnck R; Strijbos MH; Mortezavi A; Lindberg J; Discacciati A; Karlsson CT; Ullen A; Janes E; Enblad G; Oldenburg J; Sautois B; Hjalm-Eriksson ME; Haugnes HS; Schatteman P; Ghysel C; De Laere B; Eklund M; Gronberg H; Ost P; Crippa A
  • Journal article: ANNALS OF ONCOLOGY. 2024;35:s980
    Crippa A; Mortezavi A; Discacciati A; Karlsson CT; Strijbos MH; Janes E; Enblad G; Sautois B; Ullen A; Stenner-Liewen F; Hjalm-Eriksson ME; De Maeseneer DJ; Schatteman P; Ghysel C; Oldenburg J; Lindberg J; Ost P; Eklund M; Gronberg H; De Laere B
  • Journal article: ISEE CONFERENCE ABSTRACTS. 2024;2024(1)
    Schullehner J; Donat C; Crippa A; Chambers T; Sigsgaard T; Villanueva CM
  • Article: JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY. 2024;92(5):296-309
    Klein T; Breilmann J; Schneider C; Girlanda F; Fiedler I; Dawson S; Crippa A; Priebe S; Barbui C; Becker T; Koesters M
  • Article: JAMA NETWORK OPEN. 2024;7(5):e2412616
    Sabe M; Hyde J; Cramer C; Eberhard A; Crippa A; Brunoni AR; Aleman A; Kaiser S; Baldwin DS; Garner M; Sentissi O; Fiedorowicz JG; Brandt V; Cortese S; Solmi M
  • Article: BIOSTATISTICS. 2023;25(1):220-236
    Sachs MC; Gabriel EE; Crippa A; Daniels MJ
  • Article: BJU INTERNATIONAL. 2023;132(6):696-704
    Lehner F; Crippa A; Sigg S; Eberli D; Mortezavi A
  • Journal article: ANNALS OF ONCOLOGY. 2023;34:s1327
    Gronberg H; Lindberg J; De laere B; Crippa A; Discacciati A; Karlsson CT; Ullen A; Janes E; Mortezavi A; Ost P; Enblad G; Oldenburg J; Sandzen J; Pettersson L; Vigmostad MN; Hjalm-Eriksson ME; Olsson M; Schatteman P; Ghysel C; Eklund M
  • Article: LANCET DIGITAL HEALTH. 2023;5(10):e703-e711
    Dembrower K; Crippa A; Colon E; Eklund M
  • Article: BRITISH JOURNAL OF CANCER. 2023;129(1):61-71
    Hammarstroem M; Gabrielson M; Crippa A; Discacciati A; Eklund M; Lundholm C; Baecklund M; Wengstroem Y; Borgquist S; Bergqvist J; Eriksson M; Tapia J; Czene K; Hall P
  • Journal article: CRITICAL CARE EXPLORATIONS. 2023;5(6):e0930
    Yang P; Dickert NW; Haczku A; Spainhour C; Auld SC
  • Article: ECLINICALMEDICINE. 2023;58:101889
    I-SPY COVID Consortium
  • Journal article: INVESTIGATIVE UROLOGY. 2023;209(Supplement 4):e997
    Micoli C; Crippa A; Discacciati A; Palsdottir T; Vigneswaran H; Aly M; Adolfsson J; Lindberg J; Wiklund P; Thompson J; Brandberg Y; Clements M; Egevad L; Grönberg H; Nordström T; Eklund M
  • Article: JOURNAL OF CLINICAL PSYCHIATRY. 2023;84(2):22r14490
    Sabe M; Pallis K; Solmi M; Crippa A; Sentissi O; Kaiser S
  • Show more

All other publications

  • Preprint: ARXIV. 2024
    Micoli C; Crippa A; Connor JT; Consortium I-SC; Eklund M; Discacciati A
  • Corrigendum: NATURE MEDICINE. 2024;30(11):3381
    De Laere B; Crippa A; Discacciati A; Larsson B; Persson M; Johansson S; D'hondt S; Bergstrom R; Chellappa V; Mayrhofer M; Banijamali M; Kotsalaynen A; Schelstraete C; Vanwelkenhuyzen JP; Hjaelm-Eriksson M; Pettersson L; Ullen A; Lumen N; Enblad G; Karlsson CT; Jaenes E; Sandzen J; Schatteman P; Vigmostad MN; Olsson M; Ghysel C; Sautois B; De Roock W; Van Bruwaene S; Anden M; Verbiene I; De Maeseneer D; Everaert E; Darras J; Aksnessether BY; Luyten D; Strijbos M; Mortezavi A; Oldenburg J; Ost P; Eklund M; Gronberg H; Lindberg J
  • Review: JOURNAL OF PINEAL RESEARCH. 2024;76(5):e12985
    Cruz-Sanabria F; Bruno S; Crippa A; Frumento P; Scarselli M; Skene DJ; Faraguna U
  • Preprint: MEDRXIV. 2024
    Mayrhofer M; Bergström R; Chellappa V; Kotsalaynen A; Murugan S; Crippa A; De Laere B; Urtishak K; Sorensen KD; Garg K; Singh U; Eklund M; Grönberg H; Lindberg J
  • Review: BRITISH JOURNAL OF SPORTS MEDICINE. 2023;57(15):979-989
    Garcia L; Pearce M; Abbas A; Mok A; Strain T; Ali S; Crippa A; Dempsey PC; Golubic R; Kelly P; Laird Y; McNamara E; Moore S; de Sa TH; Smith AD; Wijndaele K; Woodcock J; Brage S
  • Conference publication: JOURNAL OF UROLOGY. 2023;209:E997-E998
    Micoli C; Crippa A; Discacciati A; Palsdottir T; Vigneswaran H; Aly M; Adolfsson J; Lindberg J; Wiklund P; Thompson J; Brandberg Y; Clements M; Egevad L; Gronberg H; Nordstrom T; Eklund M
  • Editorial comment: EUROPEAN UROLOGY FOCUS. 2022;8(6):1617-1621
    De laere B; Crippa A; Discacciati A; Larsson B; Oldenburg J; Mortezavi A; Ost P; Eklund M; Lindberg J; Gronberg H
  • Preprint: 2022
    Sachs MC; Gabriel EE; Crippa A; Daniels MJ
  • Preprint: MEDRXIV. 2022
    Files DC; Matthay MA; Calfee CS; Aggarwal N; Asare AL; Beitler JR; Berger PA; Burnham EL; Cimino G; Coleman MH; Crippa A; Discacciati A; Gandotra S; Gibbs KW; Henderson PT; Ittner CAG; Jauregui A; Khan KT; Koff JL; Lang J; LaRose M; Levitt J; Lu R; McKeehan JD; Meyer NJ; Russell DW; Thomas KW; Eklund M; Esserman LJ; Liu KD
  • Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;205:a5284
    Calfee CS; Eklund M; Albertson TE; Auld S; Beitler JR; Berger PA; Burnham EL; Cobb NK; Crippa A; Daniel BM; Discacciati A; Files DC; Friedman EB; Gandotra S; Gong MN; Khan KT; Koff JL; Kumar SI; Lang JE; Lu R; Martin TR; Matthay MA; Meyer NJ; Moskowitz A; Obermiller TF; Robinson PA; Russell D; Thomas KW; Wong S; Wurfel MM; Wunderink RG; Yen YF; Youssef FA; Esserman LJ; Liu KD
  • Preprint: MEDRXIV. 2022
    Garcia L; Pearce M; Abbas A; Mok A; Strain T; Ali S; Crippa A; Dempsey PC; Golubic R; Kelly P; Laird Y; McNamara E; Moore S; de TH; Smith AD; Wijndaele K; Woodcock J; Brage S
  • Review: PROSTATE CANCER AND PROSTATIC DISEASES. 2022;25(2):165-173
    Vigneswaran HT; Mittelstaedt L; Crippa A; Eklund M; Vidal A; Freedland SJ; Abern MR
  • Letter: NATURE MEDICINE. 2022;28(1):9-11
    Calfee CS; Liu KD; Asare AL; Beitler JR; Berger PAIII; Coleman MH; Crippa A; Discacciati A; Eklund M; Files DC; Gandotra S; Gibbs KW; Henderson P; Levitt JE; Lu R; Matthay MA; Meyer NJ; Russell DW; Thomas KW; Esserman LJ; Mittel AM; Dzierba AL; Madahar P; Serra AL; Rosen A; Garcia I; Muir J; Schicchi J; Darmanian A; Wahab R; Gosek K; Auld SC; Adelman MW; Nugent KL; Harris GH; Creel-Bulos C; Yang P; Detelich JF; Spainhour C; Cobb NK; Sonti R; Orr LA; Robinson PA; Sarafian F; Martinez E; Jones P; Nguyen J; Obermiller TF; Weiler-Lisowski B; Kufa L; Saba PL; Wyatt J; Youssef FA; Tanios M; Blevins D; Macias LR; Suarez AE; Reyes MB; Jung M; Melendrez M; Rosario-Remigio L; Su H; Friedman EB; Angelucci CM; Chaparro-Rojas F; Sternlieb MP; Sutter JB; Whealon S; Nair R; Lopez B; Amosu O; Tzehaie H; Wunderink RG; Patel C; Simonson A; Dodin J; Oliver T; Lupu RA; Meyers M; Albertson TE; Haczku A; Hardy E; Morrissey BM; Juarez MM; Pearson SJ; Lee RA; Amin AN; Jauregui A; Fields S; Ng D; Daniel BM; Yee K; Jones C; Burnham EL; McKeehan JD; Ittner CAG; Reilly JP; Mangalmurti NS; Rodrigues LG; Weisman AR; Khan KT; Wong SF; Yen AF; Peterfreund G; Kumar SI; Marshall PS; Huerta LE; Lindgren B; Lee JS; Barker AD; Lang JE; LaRose M; Landreth L; Parks L; Barot HV; Koff JL; Kazianis J; Boerger LL
  • Review: NPJ SCHIZOPHRENIA. 2021;7(1):43
    Sabe M; Zhao N; Crippa A; Kaiser S
  • Review: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2021;24(8):601-614
    Sabe M; Zhao N; Crippa A; Strauss GP; Kaiser S
  • Review: BRITISH JOURNAL OF SPORTS MEDICINE. 2020;54(20):1195-1201
    Blond K; Brinklov CF; Ried-Larsen M; Crippa A; Grontved A
  • Preprint: RESEARCH SQUARE. 2020
    Crippa A; De Laere B; Discacciati A; Larsson B; Connor JT; Gabriel EE; Thellenberg C; Jänes E; Enblad G; Ullen A; Hjälm-Eriksson M; Oldenburg J; Ost P; Lindberg J; Eklund M; Grönberg H
  • Preprint: RESEARCH SQUARE. 2020
    Crippa A; De Laere B; Discacciati A; Larsson B; Connor JT; Gabriel EE; Thellenberg C; Jänes E; Enblad G; Ullen A; Hjälm-Eriksson M; Oldenburg J; Ost P; Lindberg J; Eklund M; Grönberg H
  • Conference publication: ANNALS OF ONCOLOGY. 2019;30:354
    Lindberg J; De Laere B; Crippa A; Eklund M; Gronberg H
  • Conference publication: ANNALS OF ONCOLOGY. 2019;30
    De Laere B; Crippa A; Ghysel C; Ost P; Rajan P; Eklund M; Dirix L; Gronberg H; Lindberg J
  • Show more

Grants

  • Swedish Research Council
    1 January 2022 - 31 December 2025
    The lack of treatment-predictive biomarkers is an unmet clinical need in metastatic prostate cancer leading to inferior clinical outcomes, overtreatment and accelerating costs. The ProBio study (NCT03903835) is an ongoing randomized trial that builds on a novel adaptive study design and prospectively evaluates treatment predictive biomarker signatures in a large network of over 35 study centers in Europe. By using ProBio we will be able to rapidly evaluate both new and old drugs in subsets of patients with similar genomic biomarker. If successful, patients with prostate cancer will get individualized treatment based on treatment-predictive genomic biomarker signatures in the near future.To test this hypothesis, we will use a multiphase randomized study using an outcome-adaptive multi-arm biomarker-driven study design. We have the following main aims: To investigate if treatment decisions based on a biomarker signature identified by sequencing circulating tumor DNA improves progression free survival (primary endpoint)To ultimately show that the ProBio concept is a model for collaboration between academia and industry in the evaluation of new drugs in prostate cancer

Employments

  • Senior Research Specialist, Department of Medical Epidemiology and Biostatistics, ̽»¨¾«Ñ¡, 2022-

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Global Public Health, ̽»¨¾«Ñ¡, 2018

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