探花精选

Alexios Matikas

Alexios Matikas

Affiliated to Research | Associate Professor
Visiting address: BioClinicum, Bioclinicum J5:30, Akademiska str氓ket 1, 17164 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Foukakis Matikas, 171 77 Stockholm
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About me

  • I'm a senior consultant in 探花精选 oncology at Breast Center, Karolinska Comprehensive Cancer Center, research team leader and associate professor of oncology (docent) at 探花精选, appointed in May 2021. Since 2024 I also serve as deputy director of doctoral education (bitr盲dande studierektor) at the Oncology/Pathology department and as a member of Karolinska Institute's Dissertation Committee (Disputationskommitt茅n).

    Received my MD from Aristotle University Medical School, Greece with a scholarship for academic excellence, a MSc in cancer cell biology from Athens Medical School as the valedictorian and a Doctoral Degree (PhD) in circulating tumor cells from Crete Medical School. Following a 1-year research fellowship under the ESMO Georges Math茅 fellowship for immuno-oncology (2016-2017, 探花精选), 11/2017 I started working as postdoc on breast cancer immunology at 探花精选 and as a consultant physician at the breast cancer center, Karolinska University Hospital.

    Parallel to my clinical work, research and teaching I'm also heavily involved with the European Society for Medical Oncology (ESMO). I was previously a member of the Young Oncologists' committee (2020-2023) and currently serve as a member of the Leadership Development committee, the OncologyPRO working group and the Magnitude of Clinical Benefit Scale working group.

    In addition, I'm a member of the Swedish National Guidelines committee for breast cancer as responsible for the adjuvant therapy guidelines and a committee member for the regional Stockholm treatment guidelines.

Research

  • My clinical and research interest lies in breast cancer:

    -as a co-investigator and primary investigator of numerous clinical trials, including co-PI of the ongoing academic international ARIADNE trial (NCT05900206)
    -registry-based studies aiming to give answers to pertinent clinical questions in breast oncology
    -translational research focusing on the tumor-host relationship with both spatial and temporal interrogation of the underlying biology using multi-omics methods

    My research is supported by:

    - Cancerfonden
    - Radiumhemmets Forskningsfonder
    - Br枚stcancerf枚rbundet
    - 探花精选
    - Svenska L盲kares盲llskapet
    - Iris, Stig och Gerry Castenb盲cks
    - Percy Falk stipend for breast and prostate cancer
    - Region Stockholm
    - European Society for Medical Oncology

Teaching

  • I'm currently deputy director of doctoral education (bitr盲dande studierektor) at OnkPat, main supervisor of three PhD students at 探花精选 and co-supervisor of five students (four at KI, one at Sahlgrenska). I've also supervised a number of MSc and ERASMUS+ students. In addition:

    - 11 weeks of training in teaching in higher education, PhD supervision and pedagogy
    - Approximately 260 hours of teaching in accordance with criteria for docentur, 探花精选
    - Co-creator of 鈥淎cademy of Breast Oncology鈥, a series of webinars intended for young oncologists (12/2020 鈥 2/2025), total of 13 webinars with participation of international opinion leaders in the field
    - Head and co-creator of a course for doctoral students, 鈥淏asic principles of clinical and translational research鈥, 探花精选

Articles

  • Journal article: LANCET REGIONAL HEALTH-EUROPE. 2025;59:101471
    Liu X; Binicy B; Acs B; Bergman LE; Loibl S; Gnant M; Untch M; Valachis A; Bergh J; Hartman J; Foukakis T; Matikas A
  • Article: LANCET REGIONAL HEALTH-EUROPE. 2025;58:101432
    Toli MA; Liu X; Massa D; Lando S; Boman C; Tsiknakis N; Tranchell C; Papakonstantinou A; Fotia G; Vernieri C; Guarneri V; Bergh J; Dieci MV; Bergman LE; Matikas A; Foukakis T
  • Journal article: ECLINICALMEDICINE. 2025;88:103493
    Bergman LE; Matikas A; Liu X; Foukakis T
  • Article: BMJ OPEN. 2025;15(8):e102626
    Matikas A; Naume B; Wildiers H; Sonke G; Dieci MV; Karakatsanis A; Andersson A; Barnekow E; Kessler LE; Einbeigi Z; Killander F; Linderholm B; Schiza A; Valachis A; Nearchou A; Engebraaten O; Porojnicu A; Soland MH; Mannsaker B; Raj SX; Blix ES; Nordstrand CS; Lambertini M; Vernieri C; Punie K; Sotiriou C; Bergh J; Villacampa G; Zouzos A; Hellstrom M; Hartman J; Foukakis T
  • Article: BREAST. 2025;82:104489
    Kjallquist U; Tsiknakis N; Acs B; Margolin S; Kessler LE; Levy S; Ekholm M; Lundgren C; Olsson E; Lindman H; Valachis A; Hartman J; Foukakis T; Matikas A
  • Journal article: CLINICAL CANCER RESEARCH. 2025;31(12):p1-02-28-p1-02-28
    Manikis G; Tzoras E; Tsiknakis N; Bernabe AM; Zhu Y; Wang K; Zerdes I; Bergh J; Hatschek T; Ostman A; Matikas A; Foukakis T
  • Journal article: CLINICAL CANCER RESEARCH. 2025;31(12):p2-05-30-p2-05-30-P20530
    Toli MA; Bergman LE; Liu X; Boman C; Tranchell C; Bergh J; Matikas A; Foukakis T
  • Journal article: CLINICAL CANCER RESEARCH. 2025;31(12):p2-01-30-p2-01-30-P20130
    Tzoras E; Sarafidis M; Sifakis EG; Salgkamis D; Acs B; Sun W; Zerdes I; Wang K; Bergh J; Hatschek T; Matikas A; Foukakis T
  • Journal article: ESMO REAL WORLD DATA AND DIGITAL ONCOLOGY. 2025;8:100128
    Valachis A; Matikas A
  • Article: LANCET ONCOLOGY. 2025;26(6):759-770
    Blondeaux E; Sonnenblick A; Agostinetto E; Bas R; Kim HJ; Franzoi MA; Bernstein-Molho R; Linn S; Kwong A; Pogoda K; Balmana J; Smeets A; Bajpai J; Moore HCF; Partridge AH; Phillips K-A; Toss A; Rousset-Jablonski C; Peccatori FA; Renaud T; Ferrari A; Paluch-Shimon S; Mando P; Lee JE; Fruscio R; Cui W; Wong SM; Vernieri C; Ruddy KJ; Dieci MV; Matikas A; Rozenblit M; Guven DC; Lee M; Villarreal-Garza C; Hwang SE; De Marchis L; Puglisi F; Kemp Z; Meireles PA; Parokonnaya A; Werutsky G; Okano M; Azim Jr HA; Mati K; Rosenberg S; Gelber R; Boni L; Lambertini M
  • Article: JOURNAL OF CLINICAL ONCOLOGY. 2025;43(14):1706-1719
    Lambertini M; Blondeaux E; Tomasello LM; Agostinetto E; Hamy A-S; Kim HJ; Franzoi MA; Bernstein-Molho R; Hilbers F; Pogoda K; Wildiers H; Bajpai J; Ignatiadis M; Moore HCF; Partridge AH; Phillips K-A; Toss A; Rousset-Jablonski C; Criscitiello C; Renaud T; Ferrari A; Paluch-Shimon S; Fruscio R; Cui W; Wong SM; Vernieri C; Ruddy KJ; Dieci MV; Matikas A; Rozenblit M; Villarreal-Garza C; De Marchis L; Puglisi F; Rodriguez-Wallberg KA; Duhoux FP; Livraghi L; Bruzzone M; Boni L; Balmana J
  • Article: INTERNATIONAL JOURNAL OF CANCER. 2025;156(8):1621-1633
    Kouvaraki M; Zerdes I; Sifakis EG; Sarafidis M; Matikas A; Tzoras E; Kjallquist U; Stathopoulou K; Lovrot J; Alkodsi A; Hartman J; Sotiriou C; Richard F; Hatschek T; Herold N; Bergh J; Rassidakis GZ; Foukakis T
  • Article: JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK. 2025;23(4):e247093
    Boman C; Tranchell C; Liu X; Bergman LE; Toli MA; Bergh J; Foukakis T; Matikas A
  • Article: NPJ BREAST CANCER. 2025;11(1):23
    Zerdes I; Matikas A; Mezheyeuski A; Manikis G; Acs B; Johansson H; Boyaci C; Boman C; Poncet C; Ignatiadis M; Bai Y; Rimm DL; Cameron D; Bonnefoi H; Bergh J; Macgrogan G; Foukakis T
  • Article: ECLINICALMEDICINE. 2025;81:103116
    Papakonstantinou A; Villacampa G; Navarro V; Oliveira M; Valachis A; Pascual T; Matikas A
  • Article: EJSO. 2025;51(3):109587
    Liu X; Bergman LE; Boman C; Foukakis T; Matikas A
  • Article: LANCET REGIONAL HEALTH-EUROPE. 2025;49:101162
    Matikas A; Papakonstantinou A; Loibl S; Steger GG; Untch M; Johansson H; Tsiknakis N; Hellstrom M; Greil R; Moebus V; Gnant M; Bergh J; Foukakis T
  • Article: JAMA ONCOLOGY. 2024;10(10):1331-1341
    Villacampa G; Navarro V; Matikas A; Ribeiro JM; Schettini F; Tolosa P; Martinez-Saez O; Sanchez-Bayona R; Ferrero-Cafiero JM; Salvador F; Papakonstantinou A; Prat A; Oliveira M; Pascual T
  • Article: ESMO OPEN. 2024;9(10):103714
    Agostinetto E; Bruzzone M; Hamy A-S; Kim HJ; Chiodi C; Bernstein-Molho R; Linn S; Pogoda K; Carrasco E; Derouane F; Bajpai J; Nader-Marta G; Lopetegui-Lia N; Partridge AH; Cortesi L; Rousset-Jablonski C; Giugliano F; Renaud T; Ferrari A; Paluch-Shimon S; Fruscio R; Cui W; Wong SM; Vernieri C; Ruddy KJ; Dieci MV; Matikas A; Rozenblit M; Aguilar Y Mendez D; De Marchis L; Borea R; Puglisi F; Pistelli M; Kufel-Grabowska J; Di Rocco R; Mariamidze E; Atzori F; Kourie HR; Popovic L; de Azambuja E; Blondeaux E; Lambertini M
  • Article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(26):3077-3082
    Matikas A; Moebus V; Greil R; Andersson A; Steger GG; Untch M; Fornander T; Malmstroem P; Schmatloch S; Johansson H; Hellstroem M; Brandberg Y; Gnant M; Loibl S; Foukakis T; Bergh J
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All other publications

  • Conference publication: CLINICAL CANCER RESEARCH. 2025;31(12):gs1-08-gs1-08
    Lambertini M; Sonnenblick A; Agostinetto E; Bas R; Kim HJ; Franzoi MA; Molho RB; Linn S; Kwong A; Pogoda K; Balmana J; Smeets A; Bajpai J; Moore HCF; Partridge AH; Phillips K-A; Toss A; Rousset-Jablonski C; Peccatori FA; Renaud T; Ferrari A; Paluch-Shimon S; Mando P; Lee JE; Fruscio R; Cui W; Wong SM; Vernieri C; Ruddy KJ; Dieci MV; Matikas A; Rozenblit M; Guven DC; Lee M; Villarreal-Garza C; Hwang SE; De Marchis L; Puglisi F; Kemp Z; Meireles PA; Parokonnaya A; Werutsky G; Okano M; Azim Jr HA; Mati K; Rosenberg S; Gelber R; Boni L; Blondeaux E
  • Review: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. 2025;207:104602
    Filis P; Markozannes G; Chan DSM; Mauri D; Foukakis T; Matikas A; Droufakou S; Pentheroudakis G; Tsilidis K
  • Review: DRUG DISCOVERY TODAY. 2025;30(1):104250
    Filis P; Salgkamis D; Matikas A; Zerdes I
  • Editorial comment: OBSTETRICAL & GYNECOLOGICAL SURVEY. 2024;79(8):446-449
    Lambertini M; Blondeaux E; Agostinetto E; Hamy A-S; Kim HJ; Di Meglio A; Molho RB; Hilbers F; Pogoda K; Carrasco E; Punie K; Bajpai J; Ignatiadis M; Moore HCF; Phillips K-A; Toss A; Rousset-Jablonski C; Peccatori FA; Renaud T; Ferrari A; Paluch-Shimon S; Fruscio R; Cui W; Wong SM; Vernieri C; Ruddy KJ; Dieci MV; Matikas A; Rozenblit M; Villarreal-Garza C; de Marchis L; del Mastro L; Puglisi F; Estevez-Diz MDP; Rodriguez-Wallberg KA; Mrinakova B; Meister S; Livraghi L; Clatot F; Yerushalmi R; de Angelis C; Sanchez-Bayona R; Meattini I; Cichowska-Cwalinska N; Berliere M; Salama M; de Giorgi U; Sonnenblick A; Chiodi C; Lee Y-J; Maria C; Azim Jr HA; Boni L; Partridge AH
  • Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(16)
    Matikas A; Gnant M; Johansson H; Untch M; Tsiknakis N; Greil R; Loibl S; Foukakis T; Bergh JCS
  • Conference publication: ESMO OPEN. 2024;9:103031
    Zhu Y; Sifakis EG; Wang K; Zerdes I; Bergh J; Hatschek T; Matikas A; Foukakis T
  • Conference publication: ESMO OPEN. 2024;9:103110
    Matikas A; Bj枚hle J; Barnekow E; Isakssonfriman E; Zouzos A; Tzoras E; Johansson H; Margolin S; Acs B; Boyaci C; Sun W; Zerdes I; Kessler LE; Gryb盲ck P; Hellstr枚m M; Hartman J; Brandberg Y; Bergh J; Hatschek T; Foukakis T
  • Conference publication: ESMO OPEN. 2024;9:103075
    Tsiknakis N; Salgkamis D; Tzoras E; Wang K; Liu X; Manikis G; Sifakis EG; Bergh J; Marias K; Zerdes I; Matikas A; Foukakis T
  • Conference publication: ESMO OPEN. 2024;9:103063
    Zerdes I; Wang K; Salgkamis D; Zhu Y; Sifakis EG; Acs B; Hartman J; Hatschek T; Bergh J; Matikas A; Foukakis T
  • Meeting abstract: CANCER RESEARCH. 2024;84(9):po2-07-06-po2-07-06
    Wang K; Zhu Y; Zerdes I; Sifakis E; Manikis G; Salgkamis D; Tsiknakis N; Harbers L; Crosetto N; Bergh J; Matikas A; Hatschek T; Foukakis T
  • Editorial comment: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2024;103(4):775-778
    Matikas A; Bergh J
  • Preprint: RESEARCH SQUARE. 2024
    Kj盲llquist U; Tsiknakis N; Acs B; Margolin S; Kessler LE; Levy S; Ekholm M; Lundgren C; Olsson E; Lindman H; Valachis A; Hartman J; Foukakis T; Matikas A
  • Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2024;200:113830
    Foukakis T; Wang K; Zerdes I; Zhu Y; Sifakis E; Tsiknakis N; Manikis G; Salgkamis D; Harbers L; Bergh J; Johansson H; Crosetto N; Lehtio J; Matikas A; Hatschek T
  • Review: ONCOLOGIST. 2024;29(1):1-7
    Villacampa G; Papakonstantinou A; Fredriksson I; Matikas A
  • Review: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. 2023;192:104189
    Filis P; Zerdes I; Soumala T; Matikas A; Foukakis T
  • Meeting abstract: ANNALS OF ONCOLOGY. 2023;34:s307-s308
    Zerdes I; Matikas A; Mezheyeuski A; Acs B; Johansson H; Manikis G; Boyaci C; Boman CE; Poncet C; Ignatiadis M; Bai Y; Rimm D; MacGrogan G; Cameron DA; Bergh J; Bonnefoi H; Foukakis T
  • Editorial comment: ESMO OPEN. 2023;8(5):101625
    Lim KHJ; Westphalen CB; Berghoff AS; Cardone C; Connolly EA; Guven DC; Kfoury M; Kocakavuk E; Mando P; Mariamidze E; Matikas A; Moutafi M; Oing C; Pihlak R; Punie K; Sanchez-Bayona R; Sobczuk P; Starzer AM; Vuger AT; Zhu H; Cruz-Ordinario MVB; Altuna SC; Canario R; Vuylsteke P; Banerjee S; de Azambuja E; Cervantes A; Lambertini M; Mateo J; Amaral T
  • Review: EUROPEAN JOURNAL OF CANCER. 2023;190:112885
    Villacampa G; Matikas A; Oliveira M; Prat A; Pascual T; Papakonstantinou A
  • Preprint: RESEARCH SQUARE. 2023
    Digkas E; Smith D; Wennstig A-K; Matikas A; Tegnelius E; Valachis A
  • Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
    Matikas A; Johansson H; Gryb盲ck P; Bj枚hle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellstr枚m M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
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Grants

  • Swedish Cancer Society
    1 January 2023
    Breast cancer is the most common form of cancer in women - one in 8 women will develop breast cancer in their lifetime. A large number of studies of tens of thousands of women with early breast cancer have shown that chemotherapy after surgical resection of the tumor improves survival in these patients. One such study was the Swedish PANTHER study. Chemotherapy can also be given before resection with equivalent effect, as in the Swedish PREDIX Lum B study and the international EORTC "p53" study. Lack of reliable markers sometimes leads to undertreatment and more often to overtreatment, which means more side effects and increased costs. The project concerns the analysis of tumor material already taken from patients who participated in the PANTHER, PREDIX Lum B and EORTC studies and focuses on hormone-sensitive breast cancer, which is considered a less aggressive variant. However, these patients have a long-standing and increasing risk of cancer recurrence and benefit greatly from chemotherapy, while some are exposed to unnecessary side effects. Gene expression, clinical factors and the immune microenvironment will be analyzed and the factors with the greatest predictive/prognostic value will then be integrated into a model expected to have a much higher predictive capacity compared to models from single sources. With this project, we intend to create a new prognostic and predictive tool that can help us select the right treatment for the right patient with hormone-sensitive early breast cancer - 70% of all breast cancer cases. In other words, we will create a tool that can help us limit chemotherapy to only those breast cancer patients who need it most. In the long term, this project is expected to lead to clinically useful markers to be able to select, on an individual level, suitable candidates who are treated with optimized treatments: better effect, fewer side effects and reduced costs are the project's goals.
  • Swedish Research Council
    1 December 2020 - 31 December 2024

Employments

  • Associate Professor, Department of Oncology-Pathology, 探花精选, 2023-2026
  • Affiliated to Research, Department of Oncology-Pathology, 探花精选, 2023-2026

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