探花精选

Anna Falk

Anna Falk

Principal Researcher | Docent
Telephone: +46852482897
Visiting address: Solnav盲gen 9 - kvarter D7, 17165 Solna
Postal address: C4 Neurovetenskap, C4 Forskning Falk, 171 77 Stockholm
Part of:

About me

  • iPS cell models of human brain development in health and disease.
    I started the Falk lab in 2012 and have since educated four PhD students to
    finalize their PhD degrees with me as their main supervisor. The Falk lab has
    also had numerous amounts of postdocs and bachelor and master students
    through the years.
    I did my PhD at 探花精选 with Professor Jonas Fris茅n and
    continued with a postdoc in the lab of Professor Austin Smith at the
    University of Cambridge, UK.
    A couple of years ago I did a sabbatical in the lab of Professor Rusty Gage
    at the Salk Institute in San Diego, US.
    I really love my job and I do research since it is rewarding to go from
    ideas, hypothesis, project plan, experimental design, experiments, analysis,
    validating, summarizing, writing a story about novel findings to
    understanding disorders and with the potential to improve human health.
    Selected to the career development programme for young researcher as one of
    ten young research leaders in Sweden across all sciences. This grant (6 MSEK
    from the Swedish Foundation for Strategic Research SSF) provides support for
    successful young scientists to build up their own independent careers.
    Research grant from SciLifeLab/AZ to model human neurological disorders and
    to use the national core facilities at SciLifeLab (20 MSEK)
    I have a Master of Science in Molecular Biology from Ume氓 University
    PhD in Molecular Biology from 探花精选 about neural stem cells
    Docent (Associate Professor) in Stem cell Biology

Research

  • The Falk lab is deriving cellular models of neural stem cells, neurons and
    glia from iPS cells to study proliferation, differentiation, migration, fate
    choosing mechanisms using assays of transcriptome of bulk or single cells.
    Our studies concentrate mostly on early neurogenesis and modeling of
    neurodevelopment and neuropsychiatric disorders. We have revealed
    neurite outgrowth phenotypes in iPS cell models of Lissencephaly and other
    neurodevelopment disorders. We have on the single cells level investigated
    how iPS cell derived neural stem cells are choosing fate between neurons and
    glia and how that mechanisms is skewed in iPS cells from individuals
    diagnosed with autism and schizophrenia.
    The Falk lab is also driving translational projects investigating the
    regenerative potential of iPS cell derived neural cells in preclinical models
    with the aim to create ATMPs to take iPS derived cell to clinic. We have
    derived one of few clinical compliant GMP iPS cell lines that we have banked
    in a master bank and we are now investigating the route forward to clinic.
    The iPS Core facility at 探花精选 is providing services in the
    area of fibroblast establishment, reprogramming, iPS cell culture, neural
    induction, neural stem cells, neurons, astrocytes, neural crest and soon also
    whole brain organoids. The services are custom-tailored spanning from
    providing vials of frozen cells, to hand-on training, to customers monthly
    subscribing for mature human neurons. The iPS Core is the Swedish "Cell
    vending machine". Get your cell model of interest arrayed in the format you
    need. [1]
    *A few recent publications*
    Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR
    Axis that Promotes Malignancy. [2]
    膶an膷er M, Hutter S, Holmberg KO, Ros茅n G, Sundstr枚m A, Tailor J,
    Bergstr枚m T, Garancher A, Essand M, Wechsler-Reya RJ, Falk A, Weishaupt H,
    Swartling FJ
    /Cell Stem Cell 2019 Dec;25(6):855-870.e11/
    Single cell analysis of autism patient with bi-allelic NRXN1-alpha deletion
    reveals skewed fate choice in neural progenitors and impaired neuronal
    functionality. [3]
    Lam M, Moslem M, Bryois J, Pronk RJ, Uhlin E, Ellstr枚m ID, Laan L, Olive J,
    Morse R, R枚nnholm H, Louhivuori L, Korol SV, Dahl N, Uhl茅n P, Anderlid BM,
    Kele M, Sullivan PF, Falk A
    /Exp Cell Res 2019 10;383(1):111469/
    Human iPS-Derived Astroglia from a Stable Neural Precursor State Show
    Improved Functionality Compared with Conventional Astrocytic Models. [4]
    Lundin A, Delsing L, Clausen M, Ricchiuto P, Sanchez J, Sabirsh A, Ding M,
    Synnergren J, Zetterberg H, Brol茅n G, Hicks R, Herland A, Falk A
    /Stem Cell Reports 2018 03;10(3):1030-1045/
    An in vitro model of lissencephaly: expanding the role of DCX during
    neurogenesis. [5]
    Shahsavani M, Pronk RJ, Falk R, Lam M, Moslem M, Linker SB, Salma J, Day K,
    Schuster J, Anderlid BM, Dahl N, Gage FH, Falk A
    /Mol Psychiatry 2018 07;23(7):1674-1684/
    Derivation of human iPS cell lines from monozygotic twins in defined and xeno
    free conditions. [6]
    Uhlin E, R枚nnholm H, Day K, Kele M, Tammimies K, B枚lte S, Falk A
    /Stem Cell Res 2017 01;18():22-25/
    [1]
    [2]
    [3]
    [4]
    [5]
    [6]

Teaching

  • I have been the organizer of a master and PhD courses about cellular
    reprogramming in addition to hand-on course and train for culturing stem
    cells.
    I am continuously lecturing at 探花精选 and other Universities
    and supervising bachelor, master and PhD students.

Articles

  • Article: COMMUNICATIONS BIOLOGY. 2025;8(1):255
    Eidhof I; Ulfenborg B; Kele M; Shahsavani M; Winn D; Uhlen P; Falk A
  • Article: BRAIN BEHAVIOR AND IMMUNITY. 2025;123:28-42
    Bose R; Posada-Perez M; Karvela E; Skandik M; Keane L; Falk A; Spulber S; Joseph B; Ceccatelli S
  • Article: NEURO-ONCOLOGY. 2024;26(9):1685-1699
    Zhou L; van Bree N; Boutin L; Ryu J; Moussaud S; Liu M; Otrocka M; Olsson M; Falk A; Wilhelm M
  • Article: ADVANCED SCIENCE. 2024;11(25):e2401859
    Jain S; Voulgaris D; Thongkorn S; Hesen R; Hagg A; Moslem M; Falk A; Herland A
  • Article: FRONTIERS IN PHARMACOLOGY. 2024;15:1390058
    Winn D; Uhlin E; Kele M; Eidhof I; Falk A
  • Article: BIOLOGY OPEN. 2023;12(10):bio060113
    Mastropasqua F; Oksanen M; Soldini C; Alatar S; Arora A; Ballarino R; Molinari M; Agostini F; Poulet A; Watts M; Rabkina I; Becker M; Li D; Anderlid B-M; Isaksson J; Remnelius KL; Moslem M; Jacob Y; Falk A; Crosetto N; Bienko M; Santini E; Borgkvist A; Bo''lte S; Tammimies K
  • Article: SCIENTIFIC REPORTS. 2023;13(1):10519
    Arora A; Becker M; Marques C; Oksanen M; Li D; Mastropasqua F; Watts ME; Arora M; Falk A; Daub CO; Lanekoff I; Tammimies K
  • Journal article: NEUROSCIENCE APPLIED. 2023;2:101125
    Polit LD; Eidhof I; McNeill RV; Warre-Cornish KM; Ohki CMY; Walter NM; Sala C; Verpelli C; Radtke F; Galderisi S; Mucci A; Collo G; Edenhofer F; Castr茅n ML; R茅thelyi JM; Ejlersen M; Hohmann SS; Ilieva MS; Lukjanska R; Matuleviciute R; Michel TM; de Vrij FMS; Kushner SA; Lendemeijer B; Kittel-Schneider S; Ziegler GC; Gruber-Schoffnegger D; Pasterkamp RJ; Kasri A; Potier M-C; Knoblich JA; Br眉stle O; Peitz M; Pich EM; Harwood AJ; Abranches E; Falk A; Vernon AC; Gr眉nblatt E; Srivastava DP
  • Article: HUMAN MUTATION. 2022;43(11):1567-1575
    Eisfeldt J; Rezayee F; Pettersson M; Lagerstedt K; Malmgren H; Falk A; Grigelioniene G; Lindstrand A
  • Article: STEM CELL REPORTS. 2022;17(10):2203-2219
    Drouin-Ouellet J; Legault EM; Nilsson F; Pircs K; Bouquety J; Petit F; Shrigley S; Birtele M; Pereira M; Storm P; Sharma Y; Bruzelius A; Vuono R; Kele M; Stoker TB; Ottosson DR; Falk A; Jakobsson J; Barker RA; Parmar M
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(16):9392
    Eisfeldt J; Schuy J; Stattin E-L; Kvarnung M; Falk A; Feuk L; Lindstrand A
  • Article: ENVIRONMENTAL TOXICOLOGY. 2022;37(8):2044-2057
    Reis L; Raciti M; Rodriguez PG; Joseph B; Al Rayyes I; Uhlen P; Falk A; Lima STDC; Ceccatelli S
  • Article: EBIOMEDICINE. 2022;77:103882
    Xu T; Li X; Guo Y; Uhlin E; Holmberg L; Mitra S; Winn D; Falk A; Sundstrom E
  • Article: STAR PROTOCOLS. 2021;2(2):100528
    Calvo-Garrido J; Winn D; Maffezzini C; Wedell A; Freyer C; Falk A; Wredenberg A
  • Article: JOURNAL OF NEUROINFLAMMATION. 2021;18(1):124
    Rostami J; Mothes T; Kolahdouzan M; Eriksson O; Moslem M; Bergstrom J; Ingelsson M; O'Callaghan P; Healy LM; Falk A; Erlandsson A
  • Article: NEUROTHERAPEUTICS. 2021;18(2):1257-1272
    Xu N; Xu T; Mirasol R; Holmberg L; Vincent PH; Li X; Falk A; Benedikz E; Rotstein E; Seiger A; Akesson E; Falci S; Sundstrom E
  • Article: FRONTIERS IN GENETICS. 2021;12:803683
    Schuy J; Eisfeldt J; Pettersson M; Shahrokhshahi N; Moslem M; Nilsson D; Dahl N; Shahsavani M; Falk A; Lindstrand A
  • Article: VIRUSES-BASEL. 2020;13(1):E37-37
    Pettke A; Tampere M; Pronk R; Wallner O; Falk A; Warpman Berglund U; Helleday T; Mirazimi A; Puumalainen M-R
  • Article: BIOMEDICINE & PHARMACOTHERAPY. 2020;131:110788
    Rostami J; Jantti M; Cui H; Rinne MK; Kukkonen JP; Falk A; Erlandsson A; Myohanen T
  • Article: TRANSLATIONAL PSYCHIATRY. 2020;10(1):312
    Becker M; Mastropasqua F; Reising JP; Maier S; Ho M-L; Rabkina I; Li D; Neufeld J; Ballenberger L; Myers L; Moritz V; Kele M; Wincent J; Willfors C; Sitnikov R; Herlenius E; Anderlid B-M; Falk A; Bolte S; Tammimies K
  • Show more

All other publications

  • Preprint: BIORXIV. 2025
    Kang W; Yip H; Verron Q; Bouwman BAM; Li-Wang X; Yaghi AA; Murata M; Stout M; Salviati L; Shu X; Yasuzawa K; Gaviraghi M; Pracana R; Lord J; Ballarino R; Falk A; Shin JW; Kasukawa T; Yip CW; Kato M; Takahashi H; Crosetto N; Carninci P; Bienko M
  • Preprint: BIORXIV. 2025
    Martinez-Curiel R; Rinc贸n-Cerrada P; Al Khani A-M; Tsupykov O; Mart铆n-Hern谩ndez D; Monni E; Savchenko E; Rodr铆guez LR; Kidnapillai S; Bruzelius A; Hidalgo I; Canals I; Bengzon J; Skibo G; Ottosson DR; Falk A; Ahlenius H; Lindvall O; Kokaia Z; Palma-Tortosa S
  • Editorial comment: CELL STEM CELL. 2025;32(3):341-342
    Parmar M; Falk A
  • Preprint: BIORXIV. 2024
    Zhou L; van Bree N; Boutin L; Moussaud S; Otrocka M; Falk A; Wilhelm M
  • Editorial comment: CELL STEM CELL. 2024;31(2):152-154
    Eidhof I; Twohig D; Falk A
  • Preprint: BIORXIV. 2022
    Mastropasqua F; Oksanen M; Soldini C; Alatar S; Arora A; Ballarino R; Molinari M; Agostini F; Poulet A; Watts M; Rabkina I; Becker M; Li D; Anderlid B-M; Isaksson J; Remnelius KL; Moslem M; Jacob Y; Falk A; Crosetto N; Bienko M; Santini E; Borgkvist A; B枚lte S; Tammimies K
  • Preprint: BIORXIV. 2022
    Arora A; Becker M; Marques C; Oksanen M; Li D; Mastropasqua F; Watts ME; Arora M; Falk A; Daub CO; Lanekoff I; Tammimies K
  • Corrigendum: BIOMEDICINE & PHARMACOTHERAPY. 2021;133:111019
    Rostami J; Jantti M; Cui H; Rinne MK; Kukkonen JP; Falk A; Erlandsson A; Myohanen T
  • Conference publication: GLIA. 2021;69:E186
    Konstantinidis E; Beretta C; Falk A; Erlandsson A
  • Review: MOLECULAR AND CELLULAR NEUROSCIENCE. 2020;107:103533
    Delsing L; Herland A; Falk A; Hicks R; Synnergren J; Zetterberg H
  • Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):3504
    Reyes AP; Petrus-Reurer S; Sanchez SP; Kumar P; Douagi I; Bartuma H; Aronsson M; Westman S; Lardner E; Andre H; Falk A; Nandrot EF; Kvanta A; Lanner F
  • Review: MOLECULAR AUTISM. 2020;11(1):42
    Drakulic D; Djurovic S; Syed YA; Trattaro S; Caporale N; Falk A; Ofir R; Heine VM; Chawner SJRA; Rodriguez-Moreno A; van den Bree MBM; Testa G; Petrakis S; Harwood AJ
  • Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):2346
    Reyes AP; Petrus-Reurer S; Sanchez SP; Kumar P; Douagi I; Bartuma H; Aronsson M; Westman S; Lardner E; Andre H; Falk A; Nandrot EF; Kvanta A; Lanner F
  • Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(SUPPL 1):588
    Schuy J; Eisfeldt J; Pettersson M; Shahrokhshahi N; Shahsavani M; Nilsson D; Falk A; Lindstrand A
  • Review: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2019;2019:2149812-10
    Kiero艅 M; 呕ekanowski C; Falk A; W臋偶yk M
  • Review: SCHIZOPHRENIA RESEARCH. 2019;210:3-12
    Moslem M; Olive J; Falk A
  • Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1143
    Kvarnung M; Shahsavani M; Taylan F; Breeuwsma N; Laan L; Schuster J; Jin Z; Nilsson D; Lieden A; Anderlid B; Nordenskjold M; Lundberg ES; Birnir B; Dahl N; Nordgren A; Lindstrand A; Falk A
  • Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1437
    Mastropasqua F; Rabkina I; Becker M; Anderlid B; Bolte S; Falk A; Tammimies K
  • Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1501-1502
    Laan L; Klar J; Sobol M; Hoeber J; Zakaria M; Anneren G; Falk A; Schuster J; Dahl N
  • Review: CELL DEATH DISCOVERY. 2018;4:7
    Navarro AM; Susanto E; Falk A; Wilhelm M
  • Show more

Grants

  • VINNOVA
    1 October 2021 - 30 September 2026
  • Swedish Cancer Society
    1 January 2021
  • Swedish Research Council
    1 January 2020 - 31 December 2022
  • Swedish Research Council
    1 December 2017 - 31 December 2019
  • Knut and Alice Wallenberg Foundation
    1 January 2013 - 1 January 2018
  • Swedish Research Council
    1 August 2010 - 31 July 2011

Employments

  • Principal Researcher, Department of Neuroscience, 探花精选, 2022-

Degrees and Education

  • Docent, 探花精选, 2014
  • Doctor Of Philosophy, Department of Cell and Molecular Biology, 探花精选, 2006

Supervision

  • Jakob Schuy, Studies of structural chromosome rearrangments to identify genes involved in congenital brain disorders
  • Robin Pronk, Brain development in a dish
  • Elias Uhlin, Human Induced Pluripotent Stem Cells in Regenerative Medicine
  • Matti Lam, SINGLE CELL ANALYSIS OF IPS DERIVED NEURAL STEM CELLS AND NEURONS
  • Anders Lundin, Human iPSC derived neural cells as models of brain development and as tools in pharmaceutical drug discovery
  • Mansoureh Shahsavani, Cellular models of human brain disorders, from skin to brain

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