Arun Selvam
About me
Arun Selvam is a researcher at 探花精选 with a focus on translational oncology and redox-based cancer therapy. His work bridges enzymology, molecular biology, and systems-level analyses to understand how selenium compounds, particularly Se-methylselenocysteine (MSC), can be harnessed for targeted therapy in hepatopancreatobiliary and pancreatic cancers. He has contributed to key publications on KYAT1 enzyme modulation, selenium metabolism, and omics-driven cancer research, and is actively engaged in developing innovative therapeutic strategies through enzyme engineering, transcriptomics, and ex vivo patient tissue models.
Research
My research focuses on selenium-based redox therapy in cancer, particularly the metabolism of Se-methylselenocysteine (MSC) and the role of KYAT1 in therapeutic modulation. I am interested in integrating enzymology, transcriptomics, and ex vivo patient models to uncover tumor-specific vulnerabilities in hepatopancreatobiliary and pancreatic cancers. In addition, I explore innovative approaches such as lipid nanoparticle (LNP) mediated mRNA delivery, affibody-based targeting, and cancer-specific microRNAs to develop new strategies for targeted therapy and personalized medicine.
Articles
- Journal article: BIOCHEMICAL PHARMACOLOGY. 2025;239:117038
- Article: TRANSLATIONAL ONCOLOGY. 2025;61:102512
- Journal article: BIOCHEMICAL JOURNAL. 2025;482(16):1163-1180
- Article: ANTIOXIDANTS. 2023;12(1):167
- Article: FRONTIERS IN ONCOLOGY. 2022;12:965182
- Article: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2022;662:25-62
- Article: ANTIOXIDANTS. 2021;10(7):1094
- Article: PATHOLOGY & ONCOLOGY RESEARCH. 2020;26(4):2669-2681
- Article: ANTIOXIDANTS. 2020;9(2):E139-139
- Article: ONCOTARGET. 2016;7(46):74686-74700
- Article: INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY. 2014;304(3-4):351-359
All other publications
- Preprint: MDPI AG. 2025
- Preprint: BIORXIV. 2025
- Preprint: ELSEVIER BV. 2025
- Preprint: ELSEVIER BV. 2025
- Doctoral thesis: 2021
- Preprint: BIORXIV. 2021
- Book chapter: SELENIUM: MOLECULAR AND INTEGRATIVE TOXICOLOGY. 2018;p. 251-269
- Review: NUTRIENTS. 2015;7(5):3536-3556
Employments
- Postdoctoral Researcher, Department of Laboratory Medicine, 探花精选, 2021-2025
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Laboratory Medicine, 探花精选, 2021