探花精选

Cecilia Williams

Cecilia Williams

Principal Researcher
Visiting address: Blickag氓ngen 16, 14152 Flemingsberg
Postal address: H7 Medicin, Huddinge, H7 GUT Williams, 171 77 Stockholm
Part of:

About me

  • Hormone signalling and non-coding RNAs in cancer

    Cecilia Williams leads a group at KI that is shared with her lab at KTH and SciLifeLab. She received her PhD training in DNA sequencing technologies and the p53 tumor suppressor gene at KTH, postdoc training in gene expression profiling techniques and stem cells, and was later a researcher at 探花精选 where she studied the role of estrogen receptor beta. In 2009, she joined the Center of Nuclear Receptors and Cell Signaling at University of Houston as Assistant Professor and received a tenured Associate Professorship in 2015. Her main activities at BioNut are focused at understanding hormonal signalling and the role of non-coding RNAs in cancer, and include supervision of doctoral students.


    Education
    1994 M.S. (Civ. Ing.) in Chemical Engineering with specialization in Biotechnology, KTH Royal Institute of Technology, Stockholm
    2002 Ph.D. Biotechnology, KTH Royal Institute of Technology. /Molecular Archaeology of Cancer - Analysis of the Human p53 Tumor Suppressor Gene.

Research

  • Hormone signalling and non-coding RNAs in cancer

    The Williams鈥 group focuses on understanding key molecular mechanisms in cancer, applying a combination of large-scale genomic approaches, focused mechanistic experiments and animal studies. The goal is to understand critical pathways so that we can define biomarkers of their activity and suggest better cancer treatments and preventive approaches. The hormone estrogen increases the risk of breast cancer, but can simultaneously protect against colorectal cancer. It is not understood exactly how, but if we can achieve a detailed knowledge of this mechanism, we could design approaches that can protect against colon cancer while not promoting breast cancer.

    Estrogenic signaling is mediated by the estrogen receptors, ERalpha, ERbeta and GPER1. ERalpha and ERbeta are ligand-activated nuclear receptors and as such excellent therapeutic targets. Our research focuses on understanding estrogen-induced pathways in breast and colon cancer, and the impact that environmental or dietary estrogenic exposure may have. Related to this, is the identification of molecular mechanisms involving microRNAs and long non-coding RNAs, molecules with great potential as novel biomarkers and therapeutic targets. These molecules are likely to contribute to the estrogenic effects, but this area remains to be explored. Our previous work include identification of the estrogen-regulated transcriptome, the roles of specific microRNAs in cell migration, and expression and regulations of lncRNAs, with a focus on cancer.

Teaching

  • Course responsible, teacher, and examiner for Clinical Applications of Biotechnology (6.0 credits, 2019-2023), Master's programme in Molecular Techniques in 
    Life Science (SciLifeLab)

Articles

  • Article: CANCER LETTERS. 2025;622:217661
    Birgersson M; Holm M; Gallardo-Dodd CJ; Chen B; Stepanauskaite L; Hases L; Kutter C; Archer A; Williams C
  • Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2024;242:106526
    Monteiro FL; Stepanauskaite L; Archer A; Williams C
  • Article: ENVIRONMENT INTERNATIONAL. 2024;190:108937
    Perez-Zabaleta M; Williams C; Cetecioglu Z
  • Article: MOLECULAR SYSTEMS BIOLOGY. 2024;20(4):374-402
    Sommerauer C; Gallardo-Dodd CJ; Savva C; Hases L; Birgersson M; Indukuri R; Shen JX; Carravilla P; Geng K; Sondergaard JN; Ferrer-Aumatell C; Mercier G; Sezgin E; Korach-Andre M; Petersson C; Hagstrom H; Lauschke VM; Archer A; Williams C; Kutter C
  • Article: TOXICOLOGICAL SCIENCES. 2023;193(2):119-130
    Thrikawala S; Mesmar F; Bhattacharya B; Muhsen M; Mukhopadhyay S; Flores S; Upadhyay S; Vergara L; Gustafsson J-A; Williams C; Bondesson M
  • Article: PROTEIN & CELL. 2023;14(2):123-136
    Cheng Y; Lu X; Li F; Chen Z; Zhang Y; Han Q; Zeng Q; Wu T; Li Z; Lu S; Williams C; Xia W
  • Article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2023;20(5):4181
    Chekkala A; Atasoy M; Williams C; Cetecioglu Z
  • Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2023;858(Pt 3):160023
    Perez-Zabaleta M; Archer A; Khatami K; Jafferali MH; Nandy P; Atasoy M; Birgersson M; Williams C; Cetecioglu Z
  • Article: CANCERS. 2022;14(24):6029
    Monteiro FL; Stepanauskaite L; Williams C; Helguero LAA
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(18):10408
    Hases L; Birgersson M; Indukuri R; Archer A; Williams C
  • Journal article: ANNALS OF ONCOLOGY. 2022;33:s640
    Schagerholm C; Robertson S; Sifakis EG; Hases L; Williams C; Hartman J
  • Article: CANCERS. 2022;14(13):3098
    Huang D; Huang Z; Indukuri R; Revanna CB; Berglund M; Guan J; Yakimchuk K; Damdimopoulos A; Williams C; Okret S
  • Article: CANCERS. 2022;14(6):1414
    Monteiro FL; Williams C; Helguero LA
  • Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:313-343
    Archer A; Kutter C; Williams C
  • Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:203-221
    Indukuri R; Damdimopoulos A; Williams C
  • Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:1-23
    Birgersson M; Katona B; Lindskog C; Pont茅n F; Williams C
  • Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2022;1390:213-225
    Hases L; Archer A; Williams C
  • Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:930227
    Song D; He H; Indukuri R; Huang Z; Stepanauskaite L; Sinha I; Haldosen L-A; Zhao C; Williams C
  • Article: ACTA ONCOLOGICA. 2021;60(7):881-887
    Simin J; Liu Q; Wang X; Fall K; Williams C; Callens S; Engstrand L; Brusselaers N
  • Article: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2021;53(11):1216-1225
    Liu Q; Simin J; Debelius J; Fall K; Sadr-Azodi O; Engstrand L; Williams C; Brusselaers N
  • Show more

News from KI

Events from KI