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Gianluigi Pironti

Gianluigi Pironti

Senior Research Specialist | Assistant Professor
Visiting address: Karolinska Universitetssjh N3:05 ,enh för kardiologi, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Kardio Lund L, 171 77 Stockholm

About me

  • I lead the preclinical cardiovascular research activity aimed at uncovering how disturbances in excitation–contraction coupling, Ca²⁺ signaling, and inflammatory pathways contribute to impaired cardiac performance and remodeling. 

    I have established a unique and comprehensive platform that integrates a broad spectrum of experimental approaches, including in vivo and in vitro disease models, alongside advanced techniques for characterizing cardiovascular phenotypes through both non-invasive (echocardiography) and invasive (LV catheterization, PV-loop) assessments. These experimental approaches are complemented by cellular studies investigating contractility and Ca²⁺ signaling in cardiomyocytes. The research is carried out in close collaboration with national and international partners, promoting a multidisciplinary and translational environment that connects fundamental discoveries to potential clinical applications. 

Research

  • My research focuses on understanding the molecular and cellular mechanisms underlying heart failure (HF) and cardiovascular diseases (CVDs), with the goal of identifying new therapeutic targets and strategies to prevent and treat cardiac dysfunction. Our research focuses on elucidating the molecular mechanisms and pathophysiology underlying heart failure, ischemic heart disease, cardiometabolic syndrome, and inflammatory cardiomyopathies. The overarching goal is to identify novel therapeutic targets and develop interventions that modulate cardiac inotropy, fibrosis, and inflammation, ultimately improving outcomes for patients with cardiovascular disease.

Teaching

  • Lead teacher for the Cardiovascular module in the Master’s Programme in Translational Physiology and Pharmacology (MTPP) and for the Cardiovascular Pharmacology component of the Project Work course.

    I teach Physiology, Cardiovascular Pharmacology, and Local Anesthetics to ̽ѡ, bio̽ѡ, and undergraduate students, using interactive and problem-based approaches that link theory with experimental practice to enhance critical thinking and engagement.

Articles

  • Journal article: ACTA PHYSIOLOGICA. 2025;241(11):e70115
    Shimari M; Picozzi G; Boeder A; Guimarães DD; Zhuge Z; Lundberg JO; Carlstrom M; Lund LH; Andersson DC; Pironti G
  • Journal article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(8):167377
    Rumyantseva A; Rosenberg F; Moedas M; Glasgow R; Pironti G; Bruton J; Wedell A; Hinze Y; Freyer C; Wredenberg A
  • Journal article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2024;327(5):H1257-H1271
    Jean-Charles P-Y; Roy B; Yu SM-W; Pironti G; Nagi K; Mao L; Kaur S; Abraham DM; Maudsley S; Rockman HA; Shenoy SK
  • Article: LAB ANIMAL. 2024;53(11):336-346
    Carvalho LRRA; Shimari M; Boeder AM; Zhuge Z; Cai M; Leijding C; Gastaldello S; Kleschyov AL; Schiffer TA; Guimaraes DD; Picozzi G; Lund LH; Fellstrom B; Weitzberg E; Lundberg JO; Hagberg CE; Pironti G; Andersson DC; Carlstrom M
  • Journal article: EUROPEAN HEART JOURNAL. 2024;45:ehae666.3757
    Pironti G; Hage C; Carlstrom M; Champeroux P; Stahlberg M; Stromberg P; Lovati E; Andersson DC; Lund LH
  • Journal article: EUROPEAN HEART JOURNAL. 2024;45:ehae666.1164
    Webb D; Hage C; Ljung-Faxen U; Pironti G; Thorvaldsen T; Andersson DC; Stahlberg M; Lund LH; Hellstrom PM
  • Article: ESC HEART FAILURE. 2024;11(1):601-605
    Erhardsson M; Faxen UL; Venkateshvaran A; Hage C; Pironti G; Thorvaldsen T; Webb D-L; Hellstroem PM; Andersson DC; Stahlberg M; Lund LH
  • Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.760
    Erhardsson M; Faxen UL; Venkateshvaran A; Hage C; Pironti G; Thorvaldsson T; Shahgaldi K; Webb DL; Hellstrom P; Andersson DC; Stalhberg M; Lund L
  • Article: EUROPEAN HEART JOURNAL. 2023;44(22):2009-2025
    Lund LH; Hage C; Pironti G; Thorvaldsen T; Ljung-Faxen U; Zabarovskaja S; Shahgaldi K; Webb D-L; Hellstrom PM; Andersson DC; Stahlberg M
  • Article: ACTA PHYSIOLOGICA. 2022;236(3):e13869
    Pironti G; Gastaldello S; Rassier DE; Lanner JT; Carlstrom M; Lund LH; Westerblad H; Yamada T; Andersson DC
  • Article: FASEB JOURNAL. 2021;35(12):e22010
    Liu Z; Chaillou T; Santos Alves E; Mader T; Jude B; Ferreira DMS; Hynynen H; Cheng AJ; Jonsson WO; Pironti G; Andersson DC; Kenne E; Ruas JL; Tavi P; Lanner JT
  • Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;9:640723
    Pironti G; Andersson DC; Lund LH
  • Article: CARDIOVASCULAR RESEARCH. 2020;116(3):619-632
    Manti M; Fornes R; Pironti G; Haworth SM; Zhengbing Z; Benrick A; Carlstrom M; Andersson D; Stener-Victorin E
  • Journal article: JOURNAL OF THE ENDOCRINE SOCIETY. 2019;3(Supplement_1):mon-217
    Manti M; Fornes R; Pironti G; Haworth SM; Zhuge Z; Hirschberg AL; De Castro Barbosa T; Benrick A; Carlström M; Andersson D; Stener-Victorin E
  • Article: HEART. 2018;104(24):2026-2034
    Pironti G; Bersellini-Farinotti A; Agalave NM; Sandor K; Fernandez-Zafra T; Jurczak A; Lund LH; Svensson CI; Andersson DC
  • Article: HYPERTENSION. 2018;71(3):507-517
    Schiattarella GG; Cattaneo F; Carrizzo A; Paolillo R; Boccella N; Ambrosio M; Damato A; Pironti G; Franzone A; Russo G; Magliulo F; Pirozzi M; Storto M; Madonna M; Gargiulo G; Trimarco V; Rinaldi L; De Lucia M; Garbi C; Feliciello A; Esposito G; Vecchione C; Perrino C
  • Article: PLOS ONE. 2016;11(5):e0154076
    Schiattarella GG; Cattaneo F; Pironti G; Magliulo F; Carotenuto G; Pirozzi M; Polishchuk R; Borzacchiello D; Paolillo R; Oliveti M; Boccella N; Avvedimento M; Sepe M; Lombardi A; Busiello RA; Trimarco B; Esposito G; Feliciello A; Perrino C
  • Article: BASIC RESEARCH IN CARDIOLOGY. 2016;111(3):34
    Pironti G; Ivarsson N; Yang J; Farinotti AB; Jonsson W; Zhang S-J; Bas D; Svensson CI; Westerblad H; Weitzberg E; Lundberg JO; Pernow J; Lanner J; Andersson DC
  • Article: SCIENCE TRANSLATIONAL MEDICINE. 2015;7(319):319ra207
    Kirk JA; Chakir K; Lee KH; Karst E; Holewinski RJ; Pironti G; Tunin RS; Pozios I; Abraham TP; de Tombe P; Rockman HA; Van Eyk JE; Craig R; Farazi TG; Kass DA
  • Article: CARDIOVASCULAR RESEARCH. 2015;107(4):431-441
    Esposito G; Schiattarella GG; Perrino C; Cattaneo F; Pironti G; Franzone A; Gargiulo G; Magliulo F; Serino F; Carotenuto G; Sannino A; Ilardi F; Scudiero F; Brevetti L; Oliveti M; Giugliano G; Del Giudice C; Ciccarelli M; Renzone G; Scaloni A; Zambrano N; Trimarco B
  • Journal article: CIRCULATION RESEARCH. 2015;117(suppl_1)
    Kirk JA; Chakir K; Lee K; Pironti G; Ranek MJ; Tunin RS; de Tombe P; Shenoy SK; Rockman HA; Craig R; Kass DA
  • Article: CIRCULATION. 2015;131(24):2120-2130
    Pironti G; Strachan RT; Abraham D; Yu SM-W; Chen M; Chen W; Hanada K; Mao L; Watson LJ; Rockman HA
  • Article: PLOS ONE. 2014;9(9):e106024
    Angrisano T; Schiattarella GG; Keller S; Pironti G; Florio E; Magliulo F; Bottino R; Pero R; Lembo F; Avvedimento EV; Esposito G; Trimarco B; Chiariotti L; Perrino C
  • Journal article: CIRCULATION RESEARCH. 2014;115(suppl_1)
    Castaldi A; Zaglia T; Di Mauro V; Carullo P; Viggiani G; Borile G; Di Stefano B; Schiattarella GG; Gualazzi MG; Elia L; Stirparo GG; Pironti G; Kunderfranco P; Colorito ML; Esposito G; Bang M-L; Mongillo M; Condorelli G; Catalucci D
  • Article: CIRCULATION RESEARCH. 2014;115(2):273-283
    Castaldi A; Zaglia T; Di Mauro V; Carullo P; Viggiani G; Borile G; Di Stefano B; Schiattarella GG; Gualazzi MG; Elia L; Stirparo GG; Colorito ML; Pironti G; Kunderfranco P; Esposito G; Bang M-L; Mongillo M; Condorelli G; Catalucci D
  • Article: CIRCULATION RESEARCH. 2014;114(5):833-844
    Kim I-M; Wang Y; Park K-M; Tang Y; Teoh J-P; Vinson J; Traynham CJ; Pironti G; Mao L; Su H; Johnson JA; Koch WJ; Rockman HA
  • Article: APOPTOSIS. 2013;18(10):1252-1261
    Cannavo A; Rengo G; Liccardo D; Pironti G; Scimia MC; Scudiero L; De Lucia C; Ferrone M; Leosco D; Zambrano N; Koch WJ; Trimarco B; Esposito G
  • Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2013;2(3):e000086
    Perrino C; Schiattarella GG; Sannino A; Pironti G; Petretta MP; Cannavo A; Gargiulo G; Ilardi F; Magliulo F; Franzone A; Carotenuto G; Serino F; Altobelli GG; Cimini V; Cuocolo A; Lombardi A; Goglia F; Indolfi C; Trimarco B; Esposito G
  • Article: BIOINSPIRED BIOMIMETIC AND NANOBIOMATERIALS. 2013;2(1):20-27
    Sandri M; Rizzi R; Schiattarella GG; Ghiron JHL; Latronico MVG; Pironti G; Chiariello GA; Esposito G; Tampieri A; Condorelli G
  • Article: BASIC RESEARCH IN CARDIOLOGY. 2012;107(5):296
    Iaconetti C; Polimeni A; Sorrentino S; Sabatino J; Pironti G; Esposito G; Curcio A; Indolfi C
  • Article: BASIC RESEARCH IN CARDIOLOGY. 2011;106(4):577-589
    Esposito G; Perrino C; Cannavo A; Schiattarella GG; Borgia F; Sannino A; Pironti G; Gargiulo G; Di Serafino L; Franzone A; Scudiero L; Grieco P; Indolfi C; Chiariello M
  • Article: HYPERTENSION. 2010;55(1):137-143
    Esposito G; Perrino C; Schiattarella GG; Belardo L; di Pietro E; Franzone A; Capretti G; Gargiulo G; Pironti G; Cannavo A; Sannino A; Izzo R; Chiariello M
  • Article: JOURNAL OF CARDIOVASCULAR MEDICINE. 2009;10(11):861-865
    Esposito G; Franzone A; Cassese S; Schiattarella GG; Capretti G; Pironti G; Di Serafino L; Perrino C; Piscione F; Chiariello M
  • Show more

All other publications

  • Letter: EUROPEAN JOURNAL OF HEART FAILURE. 2023;25(11):2093-2095
    Hage C; Stahlberg M; Thorvaldsen T; Faxen UL; Pironti G; Webb D-L; Hellstrom PM; Andersson DC; Lund LH
  • Review: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2023;10:1228789
    Pironti G
  • Conference publication: EUROPEAN JOURNAL OF HEART FAILURE. 2021;23:31
    Pironti G; Gastaldello S; Rassier D; Carlstrom M; Lund LH; Westerblad H; Yamada T; Andersson D
  • Editorial comment: FRONTIERS IN PHYSIOLOGY. 2021;11:641771
    de Lucia C; Wallner M; Corradi D; Pironti G
  • Conference publication: EUROPEAN JOURNAL OF HEART FAILURE. 2020;22:4
    Pironti G; Gastaldello S; Rassier D; Lund L; Andersson DC
  • Conference publication: ACTA PHYSIOLOGICA. 2017;219:20-21
    Pironti G; Agalave A; Lanner J; Svensson C; Andersson D
  • Conference publication: ACTA PHYSIOLOGICA. 2017;219:16-17
    Chaillou T; Hynynen H; Ferreira D; Pironti G; Andersson D; Ruas J; Tavi P; Lanner J
  • Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S186
    Chaillou T; Hynynen H; Ferreira D; Pironti G; Kenne E; Andersson DC; Ruas JL; Tavi P; Lanner JT
  • Conference publication: EUROPEAN HEART JOURNAL. 2016;37:707
    Cattaneo F; Schiattarella G; Pironti GL; Magliulo F; Carotenuto G; Pirozzi M; Borzacchiello D; Paolillo R; Boccella N; Lombardi A; Sepe M; Feliciello A; Trimarco B; Esposito G; Perrino C
  • Corrigendum: PLOS ONE. 2016;11(7):e0158934
    Schiattarella GG; Cattaneo F; Pironti G; Magliulo F; Carotenuto G; Pirozzi M; Polishchuk R; Borzacchiello D; Paolillo R; Oliveti M; Boccella N; Avvedimento M; Sepe M; Gargiulo G; Lombardi A; Busiello RA; Trimarco B; Esposito G; Feliciello A; Perrino C
  • Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):598A-599A
    Ivarsson N; Pironti G; Yang J; Farinotti AB; Jonsson W; Svensson C; Westerblad H; Weitzberg E; Lundberg J; Pernow J; Lanner J; Andersson DC
  • Conference publication: CIRCULATION RESEARCH. 2015;117
    Kirk JA; Chakir K; Lee K; Pironti G; Ranek MJ; Tunin RS; de Tombe P; Shenoy SK; Rockman HA; Craig R; Kass DA
  • Conference publication: CIRCULATION RESEARCH. 2014;115
    Castaldi A; Zaglia T; Di Mauro V; Carullo P; Viggiani G; Borile G; Di Stefano B; Schiattarella GG; Gualazzi MG; Elia L; Stirparo GG; Pironti G; Kunderfranco P; Colorito ML; Esposito G; Bang M-L; Mongillo M; Condorelli G; Catalucci D
  • Conference publication: CIRCULATION. 2011;124(21)
    Perrino C; Gargiulo G; Schiattarella GG; Pironti G; Di Serafino L; Scudiero L; Serino F; Ilardi F; Petrillo G; Cirillo P; Esposito G
  • Conference publication: CIRCULATION. 2011;124(21)
    Perrino C; Schiattarella GG; Pironti G; Apicella M; Gargiulo G; Ilardi F; Magliulo F; Acquaviva AM; Esposito G
  • Conference publication: CIRCULATION. 2011;124(21)
    Schiattarella GG; Perrino C; Franzone A; Gargiulo G; Pironti G; Cannavo A; Sannino A; Serino F; Magliulo F; Ilardi F; Scaloni A; Zambrano N; Esposito G
  • Review: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2011;300(6):H1983-H1989
    Perrino C; Gargiulo G; Pironti G; Franzone A; Scudiero L; De Laurentis M; Magliulo F; Ilardi F; Carotenuto G; Schiattarella GG; Esposito G
  • Book chapter: ANTI-ANGIOGENESIS DRUG DISCOVERY AND DEVELOPMENT. 2011;p. 70-85
    Perrino C; Esposito G; Gargiulo G; Pironti G; G. Schiattarella G; Chiariello M
  • Conference publication: CIRCULATION. 2009;120(18):S814
    Esposito G; Petretta MP; Sannino A; Schiattarella GG; Capretti G; Pironti G; Gargiulo G; Di Pietro E; Perrino C; Chiariello M
  • Conference publication: CIRCULATION. 2009;120(18):S1167
    Esposito G; Schiattarella GG; Di Serafino L; Cannavo A; Borgia F; Pironti G; Franzone A; Sannino A; Perrino C; Chiariello M

Employments

  • Senior Research Specialist, Department of Medicine, ̽ѡ, 2022-
  • Senior Research Specialist, Department of Physiology and Pharmacology, ̽ѡ, 2023-2026
  • Researcher, Department of Medicine, ̽ѡ, 2019-2022
  • Assistant Professor, Department of Medicine, Huddinge, ̽ѡ, 2018-2019

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