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Jakob conducted his PhD studies on human immunodeficiency syndromes affecting lymphocyte cytotoxicity in the Professor Yenan Bryceson research group from 2010 to 2017, in parallel with his clinical training. After obtaining his ̽»¨¾«Ñ¡ license and PhD in 2017, he became as a registrar in general adult psychiatry at Psychiatry Southwest, Stockholm. In 2018, he took up a postdoctoral researcher position in the Oxford Autoimmune Neurology Group led by Professor Sarosh Irani at the University of Oxford. There, he primarily studied lymphocyte function and clonality in the context of autoimmune neurological syndromes, specifically NMDA-R, LGI1 and CASPR2 autoantibody encephalitis as well as Neuromyelitis optica.

Jakob came back to Sweden in 2020 and took up his clinical duties at Psychiatry Southwest and a postdoctoral position in Professor Fredrik Piehl's group, where he focused on immune cell phenotyping in Myasthenia gravis.

In 2022, Jakob joined the Jenny Mjösberg research group at the Center for Infectious Medicine as a team leader, focusing on autoantibody-associated autoimmune encephalitis. He became a registrar in neurology at the Karolinska University Hospital in 2023. He is currently involved in building both national and Scandinavian networks for collaboration for the betterment of patient care and resarch around autoantibody-associated autoimmune encephalitis.