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Jean Hausser

Jean Hausser

Principal Researcher
Visiting address: Solnavägen 9, 17165 Stockholm
Postal address: C5 Cell- och molekylärbiologi, C5 CMB Hausser, 171 77 Stockholm

About me

  • I am scientist interested in engineering effective cancer immunotherapies. I enjoy most working on important and challenging problems, where data are plentiful but where the amount of data makes it difficult to know where to start. I address this challenge by formulating hypotheses, turning these hypotheses into mathematical equations, and implementing these equations into new data science approaches that make best use of the data to solve the problem at hand.

    I initially trained in bioinformatics and data science for Masters and PhD, then as a mathematical theorist and finally as a cancer experimentalist during my postdoc, before starting my lab at Karolinska Institute.

    Main research achievements include finding mathematical order in the complexity of the fundamentals of gene regulation, and in the coordination of gene programs in tumors. I have attained these achievements by integrating bioinformatics and data science, mathematical modeling, and experimental approaches. I have published 30+ articles which have been cited more than 10000 times, and acquired 4 million euros in research funding.

Research

  • The lab researches mathematical rules in the molecular tricks that cancer cells use to escape destruction by immune cells. We seek to articulate the molecular chat between immune and cancer cells into equations, to serve as the foundation to engineer personalized cancer immunotherapy. We combine single-cell and spatial tumor profiling experiments, AI & data science, and physics-style mathematical modeling.

Teaching

    • Mathematical modeling in biomedicine. Karolinska Institute (2022-)
    • Systems biology. Teaching assistant in Uri Alon's class at Weizmann
      Institute (2014)
    • General biology. Teaching assistant in Michael Hall's class at Uni Basel
      (2010)

Articles

  • Article: SCIENTIFIC REPORTS. 2025;15(1):3811
    Cougnoux A; Mahmoud L; Johnsson PA; Eroglu A; Gsell L; Rosenbauer J; Sandberg R; Hausser J
  • Article: NATURE COMMUNICATIONS. 2024;15(1):3226
    Watson SS; Duc B; Kang Z; de Tonnac A; Eling N; Font L; Whitmarsh T; Massara M; Hausser J; Bodenmiller B; Joyce JA
  • Article: NATURE COMMUNICATIONS. 2023;14(1):7182
    El Marrahi A; Lipreri F; Kang Z; Gsell L; Eroglu A; Alber D; Hausser J
  • Article: EXPERIMENTAL CELL RESEARCH. 2023;425(2):113527
    Mahmoud L; Cougnoux A; Bekiari C; Teba PARDC; El Marrahi A; Panneau G; Gsell L; Hausser J
  • Article: NATURE COMMUNICATIONS. 2019;10(1):5423
    Hausser J; Szekely P; Bar N; Zimmer A; Sheftel H; Caldas C; Alon U
  • Article: CELL. 2019;179(5):1207-1221.e22
    Laks E; McPherson A; Zahn H; Lai D; Steif A; Brimhall J; Biele J; Wang B; Masud T; Ting J; Grewal D; Nielsen C; Leung S; Bojilova V; Smith M; Golovko O; Poon S; Eirew P; Kabeer F; de Algara TR; Lee SR; Taghiyar MJ; Huebner C; Ngo J; Chan T; Vatrt-Watts S; Walters P; Abrar N; Chan S; Wiens M; Martin L; Scott RW; Underhill TM; Chavez E; Steidl C; Da Costa D; Ma Y; Coope RJN; Corbett R; Pleasance S; Moore R; Mungall AJ; Mar C; Cafferty F; Gelmon K; Chia S; Marra MA; Hansen C; Shah SP; Aparicio S
  • Article: ENVIRONMENTAL MICROBIOLOGY. 2019;21(3):1068-1085
    Bucher T; Keren-Paz A; Hausser J; Olender T; Cytryn E; Kolodkin-Gal I
  • Article: NATURE COMMUNICATIONS. 2019;10(1):68
    Hausser J; Mayo A; Keren L; Alon U
  • Article: CELL. 2016;166(5):1282-1294.e18
    Keren L; Hausser J; Lotan-Pompan M; Slutskin IV; Alisar H; Kaminski S; Weinberger A; Alon U; Milo R; Segal E
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2015;290(33):20284-20294
    Tattikota SG; Rathjen T; Hausser J; Khedkar A; Kabra UD; Pandey V; Sury M; Wessels H-H; Mollet IG; Eliasson L; Selbach M; Zinzen RP; Zavolan M; Kadener S; Tschoep MH; Jastroch M; Friedlaender MR; Poy MN
  • Article: PLOS COMPUTATIONAL BIOLOGY. 2015;11(7):e1004224
    Korem Y; Szekely P; Hart Y; Sheftel H; Hausser J; Mayo A; Rothenberg ME; Kalisky T; Alon U
  • Article: NATURE METHODS. 2015;12(3):233-235
    Hart Y; Sheftel H; Hausser J; Szekely P; Ben-Moshe NB; Korem Y; Tendler A; Mayo AE; Alon U
  • Journal article: NATURE REVIEWS GENETICS. 2014;15(10):702
    Hausser J; Zavolan M
  • Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(6):2722-2735
    Latreille M; Hausser J; Stuetzer I; Zhang Q; Hastoy B; Gargani S; Kerr-Conte J; Pattou F; Zavolan M; Esguerra JLS; Eliasson L; Ruelicke T; Rorsman P; Stoffel M
  • Article: BIOESSAYS. 2014;36(6):617-626
    Bruemmer A; Hausser J
  • Article: PLOS COMPUTATIONAL BIOLOGY. 2014;10(5):e1003602
    Rothschild D; Dekel E; Hausser J; Bren A; Aidelberg G; Szekely P; Alon U
  • Article: CELL METABOLISM. 2014;19(1):122-134
    Tattikota SG; Rathjen T; McAnulty SJ; Wessels H-H; Akerman I; van de Bunt M; Hausser J; Esguerra JLS; Musahl A; Pandey AK; You X; Chen W; Herrera PL; Johnson PR; O'Carroll D; Eliasson L; Zavolan M; Gloyn AL; Ferrer J; Shalom-Feuerstein R; Aberdam D; Poy MN
  • Article: MOLECULAR SYSTEMS BIOLOGY. 2013;9:711
    Hausser J; Syed AP; Selevsek N; van Nimwegen E; Jaskiewicz L; Aebersold R; Zavolan M
  • Article: GENOME RESEARCH. 2013;23(4):604-615
    Hausser J; Syed AP; Bilen B; Zayolanl M
  • Article: NATURE METHODS. 2013;10(3):253-255
    Khorshid M; Hausser J; Zavolan M; van Nimwegen E
  • Article: METHODS. 2012;58(2):106-112
    Jaskiewicz L; Bilen B; Hausser J; Zavolan M
  • Article: HEPATOLOGY. 2012;55(1):98-107
    Kruetzfeldt J; Roesch N; Hausser J; Manoharan M; Zavolan M; Stoffel M
  • Article: PLOS PATHOGENS. 2011;7(12):e1002405
    Suffert G; Malterer G; Hausser J; Viiliainen J; Fender A; Contrant M; Ivacevic T; Benes V; Gros F; Voinnet O; Zavolan M; Ojala PM; Haas JG; Pfeffer S
  • Article: NATURE. 2011;474(7353):649-653
    Trajkovski M; Hausser J; Soutschek J; Bhat B; Akin A; Zavolan M; Heim MH; Stoffel M
  • Article: NATURE METHODS. 2011;8(7):559-564
    Kishore S; Jaskiewicz L; Burger L; Hausser J; Khorshid M; Zavolan M
  • Journal article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2010;(41)
    Hafner M; Landthaler M; Burger L; Khorshid M; Hausser J; Berninger P; Rothballer A; Ascano M; Jungkamp A-C; Munschauer M; Ulrich A; Wardle GS; Dewell S; Zavolan M; Tuschl T
  • Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2010;(41):2034
    Hafner M; Landthaler M; Burger L; Khorshid M; Hausser J; Berninger P; Rothballer A; Ascano M; Jungkamp A-C; Munschauer M; Ulrich A; Wardle GS; Dewell S; Zavolan M; Tuschl T
  • Article: CELL. 2010;141(1):129-141
    Hafner M; Landthaler M; Burger L; Khorshid M; Hausser J; Berninger P; Rothballer A; Ascano MJ; Jungkamp A-C; Munschauer M; Ulrich A; Wardle GS; Dewell S; Zavolan M; Tuschl T
  • Article: GENOME RESEARCH. 2009;19(11):2009-2020
    Hausser J; Landthaler M; Jaskiewicz L; Gaidatzis D; Zavolan M
  • Article: JOURNAL OF MACHINE LEARNING RESEARCH. 2009;10:1469-1484
    Hausser J; Strimmer K
  • Article: NUCLEIC ACIDS RESEARCH. 2009;37(Web Server issue):W266-W272
    Hausser J; Berninger P; Rodak C; Jantscher Y; Wirth S; Zavolan M
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(14):5813-5818
    Poy MN; Hausser J; Trajkovski M; Braun M; Collins S; Rorsman P; Zavolan M; Stoffel M
  • Journal article: BMC BIOINFORMATICS. 2007;8:248
    Gaidatzis D; van Nimwegen E; Hausser J; Zavolan M
  • Article: BMC BIOINFORMATICS. 2007;8:69
    Gaidatzis D; van Nimwegen E; Hausser J; Zavolan M
  • Show more

All other publications

  • Preprint: BIORXIV. 2025
    Hermet L; Laoubi L; Scavino M; Doffin A-C; Gazeu A; Berthet J; Pillat B; Tissot S; Rusakiewicz S; Michallet M-C; Bendriss-Vermare N; Valladeau-Guilemond J; Hausser J; Caux C; Hubert M
  • Letter: MOLECULAR BIOLOGY AND EVOLUTION. 2022;39(1):msab297
    Adler M; Tendler A; Hausser J; Korem Y; Szekely P; Bossel N; Hart Y; Karin O; Mayo A; Alon U
  • Review: NATURE REVIEWS CANCER. 2020;20(4):247-257
    Hausser J; Alon U
  • Preprint: BIORXIV. 2018
    Matalon O; Steinberg A; Sass E; Hausser J; Levy ED
  • Review: NATURE REVIEWS GENETICS. 2014;15(9):599-612
    Hausser J; Zavolan M
  • Book chapter: HANDBOOK OF RNA BIOCHEMISTRY. 2014;p. 833-860
    Hausser J; Zavolan M

Grants

  • Swedish Research Council
    1 January 2025 - 31 December 2027
  • Swedish Cancer Society
    1 January 2022
  • Swedish Research Council
    1 January 2019 - 31 December 2022
  • Swiss National Science Foundation
    1 June 2018 - 28 February 2019
  • Prediction of cancer cell adaptations to drugs
    Swedish Cancer Society
    1 January 2018
  • Swiss National Science Foundation
    1 August 2015 - 31 July 2017
  • Swiss National Science Foundation
    1 April 2013 - 31 August 2013

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