Jiangning Yang
Senior Research Specialist
E-mail: jiangning.yang@ki.se
Visiting address: Norrbacka S1:02, Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Kardio Pernow J, 171 77 Stockholm
Articles
- Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3099Yang JN; Sundqvist M; Zheng X; Jiao T; Collado A; Mahdi A; Tengbom J; Mergia E; Zhou Z; Carlstrom M; Akaike T; Cortese-Krott M; Weitzberg E; Lundberg JO; Pernow J
- Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3096Jiao T; Collado A; Mahdi A; Tengbom J; Tratsiakovich Y; Milne G; Alvarsson M; Lundberg J; Zhou Z; Yang J; Pernow J
- Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3066Collado A; Humoud R; Eldh M; Jiao T; Domingo E; Kontidou E; Yang J; Mahdi A; Gabrielsson S; Eriksson P; Zhou Z; Pernow J
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(17):e167693Yang J; Sundqvist ML; Zheng X; Jiao T; Collado A; Tratsiakovich Y; Mahdi A; Tengbom J; Mergia E; Catrina S-B; Zhou Z; Carlstroem M; Akaike T; Cortese-Krott MM; Weitzberg E; Lundberg JO; Pernow J
- Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2023;8(8):907-918Jiao T; Collado A; Mahdi A; Tengbom J; Tratsiakovich Y; Milne GT; Alvarsson M; Lundberg JO; Zhou Z; Yang J; Pernow J
- Article: JOURNAL OF INTERNAL MEDICINE. 2023;293(2):228-245Mahdi A; Wodaje T; Kovamees O; Tengbom J; Zhao A; Jiao T; Henricsson M; Yang J; Zhou Z; Nieminen AI; Levin M; Collado A; Brinck J; Pernow J
- Article: BASIC RESEARCH IN CARDIOLOGY. 2022;117(1):46Jiao T; Collado A; Mahdi A; Jurga J; Tengbom J; Saleh N; Verouhis D; Bohm F; Zhou Z; Yang J; Pernow J
- Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2022;7(3):193-204Mahdi A; Collado A; Tengbom J; Jiao T; Wodaje T; Johansson N; Farnebo F; Farnert A; Yang J; Lundberg JO; Zhou Z; Pernow J
- Article: DIABETES. 2022;71(2):285-297Zhou Z; Collado A; Sun C; Tratsiakovich Y; Mahdi A; Winter H; Chernogubova E; Seime T; Narayanan S; Jiao T; Jin H; Alvarsson M; Zheng X; Yang J; Hedin U; Catrina S-B; Maegdefessel L; Pernow J
- Article: PHARMACOLOGY. 2022;107(3-4):160-166Mahdi A; Jiao T; Tratsiakovich Y; Wernly B; Yang J; Ostenson C-G; Danser AHJ; Pernow J; Zhou Z
- Journal article: EUROPEAN HEART JOURNAL. 2021;42(Supplement_1):ehab724.3364Mahdi A; Collado A; Tengbom J; Jiao T; Wodaje T; Yang J; Lundberg JO; Zhou Z; Pernow J
- Article: ANTIOXIDANTS. 2021;10(7):1070Dallner G; Bentinger M; Hussain S; Sinha I; Yang J; Schwank-Xu C; Zheng X; Swiezewska E; Brismar K; Valladolid-Acebes I; Tekle M
- Article: MICROORGANISMS. 2021;9(6):1137Yaiw K-C; Mohammad A-A; Taher C; Cui HL; Costa H; Kostopoulou ON; Jung M; Assinger A; Wilhelmi V; Yang J; Straat K; Rahbar A; Pernow J; Soderberg-Naucler C
- Article: FRONTIERS IN PHARMACOLOGY. 2020;11:603226Mahdi A; Tratsiakovich Y; Tengbom J; Jiao T; Garib L; Alvarsson M; Yang J; Pernow J; Zhou Z
- Article: ATHEROSCLEROSIS. 2020;292:215-223Rafnsson A; Matic LP; Lengquist M; Mahdi A; Shemyakin A; Paulsson-Berne G; Hansson GK; Gabrielsen A; Hedin U; Yang J; Pernow J
- Journal article: EUROPEAN HEART JOURNAL. 2019;40(Supplement_1):ehz746.0897Yang JN; Jiao T; Tratsiakovich Y; Mahdi A; Zhou Z; Lundberg JO; Pernow J
- Journal article: EUROPEAN HEART JOURNAL. 2019;40(Supplement_1):ehz748.0351Jiao T; Yang JN; Sundqvist M; Tratsiakovich Y; Hellenius ML; Weitzberg E; Lundberg J; Pernow J
- Article: FRONTIERS IN PHARMACOLOGY. 2019;10:861Mahdi A; Jiao T; Yang J; Kovamees O; Alvarsson M; von Heijne M; Zhou Z; Pernow J
- Article: CIRCULATION. 2019;139(23):2654-2663Sun C-W; Yang J; Kleschyov AL; Zhuge Z; Carlstrom M; Pernow J; Wajih N; Isbell TS; Oh J-Y; Cabrales P; Tsai AG; Townes T; Kim-Shapiro DB; Patel RP; Lundberg JO
- Journal article: FASEB JOURNAL. 2019;33:512.4Zhou Z; Mahdi A; Tratsiakovich Y; Jiao T; Yang J; Ostenson C-G; Danser AHJ; Pernow J
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018;19(12):E3942-3942Mahdi A; Jiao T; Tratsiakovich Y; Yang J; Ostenson C-G; Pernow J; Zhou Z
- Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2018;72(7):769-780Zhou Z; Mahdi A; Tratsiakovich Y; Zahoran S; Kovamees O; Nordin F; Gonzalez AEU; Alvarsson M; Ostenson C-G; Andersson DC; Hedin U; Hermesz E; Lundberg JO; Yang J; Pernow J
- Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2018;3(4):450-463Yang J; Zheng X; Mahdi A; Zhou Z; Tratsiakovich Y; Jiao T; Kiss A; Kovamees O; Alvarsson M; Catrina S-B; Lundberg JO; Brismar K; Pernow J
- Article: REDOX BIOLOGY. 2018;14:328-337Cortese-Krott MM; Mergia E; Kramer CM; Lueckstaedt W; Yang J; Wolff G; Panknin C; Bracht T; Sitek B; Pernow J; Stasch J-P; Feelisch M; Koesling D; Kelm M
- Article: ACTA PHYSIOLOGICA. 2017;221(3):174-181Kiss A; Tratsiakovich Y; Mahdi A; Yang J; Gonon AT; Podesser BK; Pernow J
- Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2017;37(suppl_1)Zhou Z; Mahdi A; Tratsiakovich Y; Kövamees O; Yang J; Pernow J
- Article: DIABETES & VASCULAR DISEASE RESEARCH. 2017;14(3):236-245Tratsiakovich Y; Kiss A; Gonon AT; Yang J; Sjoquist P-O; Pernow J
- Article: BASIC RESEARCH IN CARDIOLOGY. 2016;111(3):34Pironti G; Ivarsson N; Yang J; Farinotti AB; Jonsson W; Zhang S-J; Bas D; Svensson CI; Westerblad H; Weitzberg E; Lundberg JO; Pernow J; Lanner J; Andersson DC
- Article: PLOS ONE. 2014;9(8):e104731Kiss A; Tratsiakovich Y; Gonon AT; Fedotovskaya O; Lanner JT; Andersson DC; Yang J; Pernow J
- Article: ACTA PHYSIOLOGICA. 2014;210(3):590-599Yang J; Zheng X; Haugen F; Dare E; Lovdahl C; Schulte G; Fredholm BB; Valen G
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;720(1-3):121-123Tratsiakovich Y; Yang J; Gonon AT; Sjoquist P-O; Pernow J
- Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2013;169(1):83-88Tratsiakovich Y; Gonon AT; Kiss A; Yang J; Bohm F; Tornvall P; Settergren M; Channon KM; Sjoquist P-O; Pernow J
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(37):15049-15054Yang J; Gonon AT; Sjoquist P-O; Lundberg JO; Pernow J
- Journal article: EUROPEAN HEART JOURNAL. 2013;34(suppl_1):767Yang J; Gonon AT; Sjöquist P-O; Lundberg JO; Pernow J
- Journal article: EUROPEAN HEART JOURNAL. 2013;34(suppl_1):p5696Tratsiakovich Y; Gonon AT; Kiss A; Yang J; Bohm F; Tornvall P; Settergren M; Channon KM; Sjoquist PO; Pernow J
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;712(1-3):16-21Tratsiakovich Y; Gonon AT; Krook A; Yang J; Shemyakin A; Sjoquist P-O; Pernow J
- Article: ACTA PHYSIOLOGICA. 2011;201(2):219-226Gonon AT; Jung C; Yang J; Sjoquist P-O; Pernow J
- Article: ACTA PHYSIOLOGICA. 2010;199(2):211-220Wang Y; Yang JN; Arner A; Boels PJM; Fredholm BB
- Article: ACTA PHYSIOLOGICA. 2010;199(2):221-230Yang JN; Wang Y; Garcia-Roves PM; Bjornholm M; Fredholm BB
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2009;296(4):H1141-H1149Yang J-N; Chen J-F; Fredholm BB
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2009;106(2):631-639Yang J-N; Bjorklund O; Lindstrom-Tornqvist K; Lindgren E; Eriksson TM; Kahlstrom J; Chen J-F; Schwarzschild MA; Tobler I; Fredholm BB
- Article: PHYSIOLOGY & BEHAVIOR. 2008;95(5):668-676Bjorklund O; Halldner-Henriksson L; Yang J; Eriksson TM; Jacobson MA; Dare E; Fredholm BB
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2008;597(1-3):92-101JohanssonA SM; Lindgren E; Yang J-N; Herling AW; Fredholm BB
- Article: BURNS. 2007;33(5):606-612Labruto F; Pernow J; Yang J; Vaage J; Valen G
- Journal article: BURNS. 2007;33(1):s4Labruto F; Valen G; Vaage J; Yang J; Pernow J
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2006;290(4):H1469-H1473Lankford AR; Yang J-N; Rose'Meyer R; French BA; Matherne GP; Fredholm BB; Yang Z
- Article: BASIC RESEARCH IN CARDIOLOGY. 2005;100(3):198-207Labruto F; Yang JN; Vaage J; Valen G
- Article: ACTA PHYSIOLOGICA. 2004;182(2):133-143Schulte G; Sommerschild H; Yang J; Tokuno S; Goiny M; Lövdahl C; Johansson B; Fredholm BB; Valen G
- Journal article: EUROPEAN JOURNAL OF HEART FAILURE, SUPPLEMENT. 2003;2(1):135Labruto F; Yang J; Vaage J; Valen G
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All other publications
- Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2917Tengbom J; Collado A; Jiao T; Yang J; Zhou Z; Mahdi A; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2921Yang JN; Tratsiakovich YT; Jiao TJ; Mahdi AM; Tengbom JT; Zhou ZZ; Collado AC; Lundberg JL; Pernow JP
- Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2910Jiao T; Mahdi A; Tengbom J; Collado A; Jurga J; Saleh N; Verouhis D; Bohm F; Zhou Z; Yang J; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2022;43:3074Collado A; Jiao T; Zaccagnini G; Yang J; Carstrom M; Martelli F; Pernow J; Zhou Z
- Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S25Collado A; Jiao T; Zaccagnini G; Yang J; Carlstrom M; Martelli F; Pernow J; Zhou Z
- Conference publication: EUROPEAN HEART JOURNAL. 2021;42:3259Jiao T; Zhou Z; Mahdi A; Tengbom J; Tratsiakovich Y; Yang J; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2021;42:3364Mahdi A; Collado A; Tengbom J; Jiao T; Wodaje T; Yang J; Lundberg JO; Zhou Z; Pernow J
- Preprint: SSRN. 2021Mahdi A; Collado A; Tengbom J; Jiao T; Wodaje T; Johanssson N; Farnebo F; Färnert A; Yang J; Lundberg J; Zhou Z; Pernow J
- Preprint: SSRN ELECTRONIC JOURNAL. 2021Mahdi A; Collado A; Tengbom J; Jiao T; Wodaje T; Johanssson N; Farnebo F; Färnert A; Yang J; Lundberg JO; Zhou Z; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2019;40:3903Yang JN; Jiao T; Tratsiakovich Y; Mahdi A; Zhou Z; Lundberg JO; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2019;40:894Jiao T; Yang JN; Sundqvist M; Tratsiakovich Y; Hellenius ML; Weitzberg E; Lundberg J; Pernow J
- Review: CARDIOVASCULAR RESEARCH. 2019;115(11):1596-1605Pernow J; Mahdi A; Yang J; Zhou Z
- Editorial comment: AGING-US. 2018;10(12):3643-3644Zhou Z; Yang J; Pernow J
- Conference publication: CARDIOVASCULAR RESEARCH. 2018;114:S26-S27Yang JN; Tratsiakovich Y; Mahdi A; Zhou Z; Lundberg JO; Pernow J
- Conference publication: CARDIOVASCULAR RESEARCH. 2018;114:S42Zhou Z; Mahdi A; Tratsiakovich Y; Yang J; Pernow J
- Conference publication: CARDIOVASCULAR RESEARCH. 2018;114:S42Mahdi A; Tratsiakovich Y; Yang J; Ostenson C-G; Danser JAH; Pernow J; Zhou Z
- Conference publication: EUROPEAN HEART JOURNAL. 2017;38:1140Yang JN; Mahdi A; Zhou Z; Tratsiakovich Y; Kovamees O; Alvarsson M; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2017;38:51-52Zhou Z; Mahdi A; Tratsiakovich Y; Kovamees O; Alvarsson M; Yang J; Pernow J
- Review: MOLECULAR ASPECTS OF MEDICINE. 2017;55:20-25Fredholm BB; Yang J; Wang Y
- Conference publication: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2017;37Zhou Z; Mahdi A; Tratsiakovich Y; Kovamees O; Yang J; Pernow J
- Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):598A-599AIvarsson N; Pironti G; Yang J; Farinotti AB; Jonsson W; Svensson C; Westerblad H; Weitzberg E; Lundberg J; Pernow J; Lanner J; Andersson DC
- Conference publication: EUROPEAN HEART JOURNAL. 2015;36:526-527Tratsiakovich Y; Kiss A; Yang J; Gonon AT; Sjoquist PO; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2015;36:1208Yang JN; Zheng X; Tratsiakovich Y; Kiss A; Catarina S; Brismar K; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2013;34:1061Tratsiakovich Y; Gonon AT; Kiss A; Yang J; Bohm F; Tornvall P; Settergren M; Channon KM; Sjoquist PO; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2013;34:155-156Yang J; Gonon AT; Sjoquist P-O; Lundberg JO; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2011;32:331Tratsiakovich Y; Gonon AT; Krook A; Yang J; Sjoqvist P-O; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2010;31:44Gonon AT; Jung C; Yang J; Sjoquist P-O; Pernow J
- Doctoral thesis: 2008Yang J-N
- Published conference paper: ACTA PHYSIOLOGICA. 2007;190(1):87-96Johansson SM; Yang J-N; Lindgren E; Fredholm BB
- Published conference paper: ACTA PHYSIOLOGICA. 2007;190(1):63-75Yang J-N; Tiselius C; Dare E; Johansson B; Valen G; Fredholm BB
- Conference publication: ACTA PHARMACOLOGICA SINICA. 2006;27:182Yang J; Tiselius C; Bian Z; Lövdahl C; Daré E; Edström E; Johansson B; Thorén P; Valen G; Fredholm BB
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Grants
- Swedish Research Council1 December 2024 - 30 November 2028BackgroundThe risk of myocardial infarction is dependent on cardiovascular risk factors including type 2 diabetes (T2D) but underlying mechanisms are poorly understood. We identified that red blood cells (RBCs) mediate beneficial cardiovascular regulatory effects under hypoxic/ischemic conditions via signaling by nitric oxide (NO) and soluble guanylate cyclase (sGC) in the RBCs. By contrast, the RBCs become dyregulated in T2D and instead induce cardiovascular injury. This project investigates the signaling of RBCs in cardiovascular disease and explores novel therapeutic strategies that target RBC function in myocardial infarction and T2D.AimsTo determine themechanisms behind cardioprotective effect of RBCs in myocardial infarctionsignaling behind cardiovascular injury induced by RBCs in T2Drole of extracellular vesicles in signaling by RBCstherapeutic effects of treatments targeting RBC signalingWork planRBCs collected from patients with myocardial infarction, patients with T2D and healthy controls are investigated in bioassays including isolated hearts of ischemia/reperfusion, endothelial function and cell cultures.  Molecular mechanisms behind the effects of RBCs are identified with focus on the NO-sGC pathway in the RBCs. Therapeutic studies are performed ex vivo and in a randomized clinical study. SignificanceThis project unravels the RBC as a mediator of cardiovascular disease and has the potential to identify novel therapeutic strategies by targeting RBC signaling.
- Swedish Research Council1 January 2021 - 31 December 2024
- Swedish Heart-Lung Foundation1 January 2020 - 31 December 2022
- Swedish Research Council1 January 2017 - 31 December 2020
- Swedish Research Council1 January 2010 - 31 December 2011
Employments
- Senior Research Specialist, Department of Medicine, ̽»¨¾«Ñ¡, 2022-
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Molecular Medicine and Surgery, ̽»¨¾«Ñ¡, 2008