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Karolina Kauppi

Karolina Kauppi

Principal Researcher
Visiting address: Nobels väg 12a, 17165 Solna
Postal address: C8 Medicinsk epidemiologi och biostatistik, C8 MEB Lichtenstein, 171 77 Stockholm
Part of:

About me

  • I am a senior researcher (docent in neuroscience) with interest in
    neurogenetics related to cognitive aging and dementia, but also cognitive
    symptoms in psychotic diseases.

    I am also affiliated with Umeå University


    Member of the Young Academy of Sweden
    www.sverigesungaakademi.se/ledamoter.html

    Training:
    PhD in physiology (on genetics, memory and brain functioning), Umeå
    University. 2013.
    MSc in Biomedicine, Umeå University 2009.
    *Postdoc: *
    Oslo University, 2013-2015
    University of California San Diego, 2015-2018

Research

  • I am currently working on a primary research project, funded by VR, UmeÃ¥
    University, and ̽»¨¾«Ñ¡, which focuses on the interplay between
    inherited risk factors and inflammatory factors in the development of
    cognitive impairment and dementia in aging.
    Normal aging is associated with changes in the brain that cause many
    cognitive abilities, such as memory, to decline in most people, but there is
    a large degree of individual variation! While some maintain very good
    cognitive ability in old age, others experience more severe declines. Both
    individual variations within the framework of normal aging and the risk of
    developing dementia, or pathological aging, have a significant genetic
    component with a complex inheritance pattern. The project aims to identify
    the mechanisms through which genes act and how they interact with other
    factors such as gender and environmental factors.
    In my research, I analyze data from the Betula project (Umeå University),
    where people's cognitive abilities, health, and brain structure have been
    followed for a long time, as well as from the Swedish Twin Registry at the
    ̽»¨¾«Ñ¡, and the international open database UK Biobank. In
    this project, I link genetic factors for Alzheimer's disease with results
    from cognitive tests, biomarkers for inflammation, and measures of brain
    structure and function that have been developed using functional magnetic
    resonance imaging.
    Increased understanding of the biological processes underlying how our brains
    age can be used to develop better drugs and treatments.
    I am also interested in psychiatric genetics and previous studies include
    work on the genetic relationship between schizophrenia and cognition.

Articles

  • Article: JOURNAL OF ALZHEIMERS DISEASE. 2023;94(4):1443-1464
    Hackenhaar FS; Josefsson M; Adolfsson AN; Landfors M; Kauppi K; Porter T; Milicic L; Laws SM; Hultdin M; Adolfsson R; Degerman S; Pudas S
  • Article: NEUROBIOLOGY OF AGING. 2023;126:103-112
    Supiyev A; Karlsson R; Wang Y; Koch E; Hagg S; Kauppi K
  • Article: SCIENTIFIC REPORTS. 2023;13(1):8433
    Haglin S; Koch E; Hackenhaar FS; Nyberg L; Kauppi K
  • Article: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2023;32(4):446-454
    Koch E; Johnell K; Kauppi K
  • Article: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2023;120:110637
    Koch E; Kauppi K; Chen C-H
  • Article: GENES. 2022;13(3):412
    Koch E; Nyberg L; Lundquist A; Kauppi K
  • Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):520
    Koch E; Nyberg L; Lundquist A; Pudas S; Adolfsson R; Kauppi K
  • Article: ALZHEIMERS RESEARCH & THERAPY. 2021;13(1):130
    Hackenhaar FS; Josefsson M; Adolfsson AN; Landfors M; Kauppi K; Hultdin M; Adolfsson R; Degerman S; Pudas S
  • Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2021;76(6):955-963
    Pudas S; Josefsson M; Adolfsson AN; Landfors M; Kauppi K; Veng-Taasti LM; Hultdin M; Adolfsson R; Degerman S
  • Article: SCHIZOPHRENIA RESEARCH. 2020;222:167-174
    Koch E; Rosenthal B; Lundquist A; Chen C-H; Kauppi K
  • Article: TRANSLATIONAL PSYCHIATRY. 2020;10(1):250
    Kauppi K; Ronnlund M; Adolfsson AN; Pudas S; Adolfsson R
  • Article: NEUROBIOLOGY OF AGING. 2019;84:243.e1-243.e9
    Lo M-T; Kauppi K; Fan C-C; Sanyal N; Reas ET; Sundar VS; Lee W-C; Desikan RS; McEvoy LK; Chen C-H
  • Article: BRAIN. 2019;142(2):460-470
    Tan CH; Bonham LW; Fan CC; Mormino EC; Sugrue LP; Broce IJ; Hess CP; Yokoyama JS; Rabinovici GD; Miller BL; Yaffe K; Schellenberg GD; Kauppi K; Holland D; McEvoy LK; Kukull WA; Tosun D; Weiner MW; Sperling RA; Bennett DA; Hyman BT; Andreassen OA; Dale AM; Desikan RS
  • Article: BIOINFORMATICS. 2019;35(1):1-11
    Sanyal N; Lo M-T; Kauppi K; Djurovic S; Andreassen OA; Johnson VE; Chen C-H
  • Article: AMERICAN JOURNAL OF PSYCHIATRY. 2018;175(7):674-682
    Kauppi K; Rosenthal SB; Lo M-T; Sanyal N; Jiang M; Abagyan R; McEvoy LK; Andreassen OA; Chen C-H
  • Article: FRONTIERS IN NEUROSCIENCE. 2018;12:260
    Kauppi K; Fan CC; McEvoy LK; Holland D; Tan CH; Chen C-H; Andreassen OA; Desikan RS; Dale AM
  • Article: ACTA NEUROPATHOLOGICA. 2018;135(1):85-93
    Tan CH; Fan CC; Mormino EC; Sugrue LP; Broce IJ; Hess CP; Dillon WP; Bonham LW; Yokoyama JS; Karch CM; Brewer JB; Rabinovici GD; Miller BL; Schellenberg GD; Kauppi K; Feldman HA; Holland D; McEvoy LK; Hyman BT; Bennett DA; Andreassen OA; Dale AM; Desikan RS
  • Article: SCIENTIFIC REPORTS. 2017;7(1):15736
    Chen C-H; Wang Y; Lo M-T; Schork A; Fan C-C; Holland D; Kauppi K; Smeland OB; Djurovic S; Sanyal N; Hibar DP; Thompson PM; Thompson WK; Andreassen OA; Dale AM
  • Article: HUMAN MOLECULAR GENETICS. 2017;26(22):4530-4539
    Lo M-T; Wang Y; Kauppi K; Sanyal N; Fan C-C; Smeland OB; Schork A; Holland D; Hinds DA; Tung JY; Andreassen OA; Dale AM; Chen C-H
  • Article: JAMA PSYCHIATRY. 2017;74(10):1065-1075
    Smeland OB; Frei O; Kauppi K; Hill WD; Li W; Wang Y; Krull F; Bettella F; Eriksen JA; Witoelar A; Davies G; Fan CC; Thompson WK; Lam M; Lencz T; Chen C-H; Ueland T; Jonsson EG; Djurovic S; Deary IJ; Dale AM; Andreassen OA
  • Show more

All other publications

  • Corrigendum: ALZHEIMERS RESEARCH & THERAPY. 2024;16(1):39
    Hackenhaar FS; Josefsson M; Adolfsson AN; Landfors M; Kauppi K; Hultdin M; Adolfsson R; Degerman S; Pudas S
  • Review: AGEING RESEARCH REVIEWS. 2020;64:101184
    Nyberg L; Boraxbekk C-J; Sorman DE; Hansson P; Herlitz A; Kauppi K; Ljungberg JK; Lovheim H; Lundquist A; Adolfsson AN; Oudin A; Pudas S; Ronnlund M; Stiernstedt M; Sundstrom A; Adolfsson R

Grants

  • Swedish Research Council
    1 January 2023 - 31 December 2025
    The aim of this 4-year project is to map the genetic heterogeneities of Alzheimer’s Disease (AD), to accelerate the development of personalized treatments. A novel approach will be used to estimate an individual’s genetic risk load in key disease pathways, such as immune-system related pathways, by incorporating knowledge about gene expression, interactions among gene products etc. We will study how specific gene pathways influence AD risk and disease related endophenotypes, and their interplay with two major inherited risk factors: sex and the high-penetrance APOE ε4 allele. This will be possible by using data from two deeply phenotyped longitudinal cohorts on aging, Betula and SATSA, as well as large-scale data from the IGEMS consortia and the UK Biobank. We will focus on the following outcomes: AD risk, cognitive ability, brain atrophy, and plasma-based biomarkers of AD pathology (tau) and chronic inflammation. Finally, we will identify existing drugs with a genetic link to AD, as potential candidates for drug-repurposing, with focus on drugs where an epidemiological link to AD has been suggested (e.g. anti-inflammatories). Results from this project is expected to reveal differences in the pathophysiological mechanisms of AD among individuals with different inherited risk profiles. This will allow to perform clinical trials of drugs designed to target a specific pathway in a limited group of individuals where this pathway is most likely to be disrupted.
  • Swedish Research Council
    1 January 2018 - 31 December 2021
  • Swedish Research Council
    1 January 2015 - 31 December 2017

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