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Lalit Kumar Parameswaran Grace

Lalit Kumar Parameswaran Grace

Principal Researcher | Docent
Visiting address: BioMedicum A4, Solnavägen 9, 17165 Solna
Postal address: K6 Kvinnors och barns hälsa, K6 NOGRH Gemzell Danielsson, 171 77 Stockholm
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About me

Research

  • *Main areas of Research*
    * Endometrial regeneration and endometrial receptivity aiming at managing
    infertility
    * Identifying good quality embryos (GQE) for assisted reproductive
    treatment (ART) based on molecular profile of embryo spent media
    * Develop non-invasive, molecular based method to identify receptive
    endometrium and good quality of embryos for clinical use in ART
    * Endometriosis and endometriosis associated ovarian cancer (EAOC)
    * Effect of SARS-CoV-19 on placental gene expression
    We use 2D and 3D cell culture, single cell RNA sequencing, smartseq2 /
    smartseq3, spatial transcriptomics and bioinformatic tools to understand the
    molecular profile and mechanisms involved in different physiological and
    pathophysiological conditions in female fertility.
    *Few publications*
    1: von Grothusen C, Frisendahl C, Modhukur V, Lalitkumar PG, Peters M,
    Faridani
    OR, Salumets A, Boggavarapu NR, Gemzell-Danielsson K. Uterine fluid microRNAs
    are dysregulated in women with recurrent implantation failure. Hum Reprod.
    2022
    Apr 1;37(4):734-746. doi: 10.1093/humrep/deac019. PMID: 35147192; PMCID:
    PMC8971651.
    2: Ponandai-Srinivasan S, Saare M, Boggavarapu NR, Frisendahl C, Ehrström S,
    Riethmüller C, García-Uribe PA, Rettkowski J, Iyengar A, Salumets A,
    Lalitkumar
    PGL, Götte M, Gemzell-Danielsson K. Syndecan-1 modulates the invasive
    potential
    of endometrioma via TGF-β signalling in a subgroup of women with
    endometriosis.
    Hum Reprod. 2020 Oct 1;35(10):2280-2293. doi: 10.1093/humrep/deaa164. PMID:
    32897364.
    3: Sardana P, Banker J, Gupta R, Kotdawala A, Lalitkumar PGL, Banker M. The
    Influence of Delayed Blastocyst Development on the Outcome of Frozen-Thawed
    Transfer of Euploid and Untested Embryos. J Hum Reprod Sci. 2020 Apr-
    Jun;13(2):155-161. doi: 10.4103/jhrs.JHRS_115_19. Epub 2020 Jul 9. PMID:
    32792766; PMCID: PMC7394094.
    4: Kasvandik S, Saarma M, Kaart T, Rooda I, Velthut-Meikas A, Ehrenberg A,
    Gemzell K, Lalitkumar PG, Salumets A, Peters M. Uterine Fluid Proteins for
    Minimally Invasive Assessment of Endometrial Receptivity. J Clin Endocrinol
    Metab. 2020 Jan 1;105(1):dgz019. doi: 10.1210/clinem/dgz019. PMID: 31512719.
    5: Kotdawala AP, Mir P, Herrero J, Khajuria R, Lalitkumar PGL, Banker MR.
    Embryonic Aneuploidy after Preimplantation Genetic Screening: Age- and
    Indication-Matched Comparative Study between Indian and Spanish Population. J
    Hum Reprod Sci. 2019 Apr-Jun;12(2):141-149. doi: 10.4103/jhrs.JHRS_109_18.
    PMID:
    31293329; PMCID: PMC6594127.
    6: Banker M, Arora P, Banker J, Benani H, Shah S, Lalitkumar PGL. Prevalence
    of
    structural birth defects in IVF-ICSI pregnancies resulting from autologous
    and
    donor oocytes in Indian sub-continent: Results from 2444 births. Acta Obstet
    Gynecol Scand. 2019 Jun;98(6):715-721. doi: 10.1111/aogs.13541. Epub 2019 Feb
    20. PMID: 30663773.
    7: Ponandai-Srinivasan S, Lalitkumar PG, Garcia L, Varghese SJ, Carlson JW,
    Gemzell-Danielsson K, Floter Radestad A. Mifepristone mediates anti-
    proliferative effect on ovarian mesenchymal stem/stromal cells from female
    BRCA1-/2- carriers. Acta Obstet Gynecol Scand. 2019
    Feb;98(2):250-261. doi: 10.1111/aogs.13485. Epub 2018 Nov 15. PMID: 30325501.
    8: von Grothusen C, Lalitkumar PG, Ruiz-Alonso M, Boggavarapu NR, Navarro R,
    Miravet-Valenciano J, Gemzell-Danielsson K, Simon C. Effect of mifepristone
    on
    the transcriptomic signature of endometrial receptivity. Hum Reprod. 2018 Oct
    1;33(10):1889-1897. doi: 10.1093/humrep/dey272. PMID: 30137464.
    9: Ponandai-Srinivasan S, Andersson KL, Nister M, Saare M, Hassan HA,
    Varghese
    SJ, Peters M, Salumets A, Gemzell-Danielsson K, Lalitkumar PGL. Aberrant
    expression of genes associated with stemness and cancer in endometria and
    endometrioma in a subset of women with endometriosis. Hum Reprod. 2018 Oct
    1;33(10):1924-1938. doi: 10.1093/humrep/dey241. PMID: 30020448.
    10: Altmäe S, Koel M, Võsa U, Adler P, Suhorutšenko M, Laisk-Podar T,
    Kukushkina
    V, Saare M, Velthut-Meikas A, Krjutškov K, Aghajanova L, Lalitkumar PG,
    Gemzell-
    Danielsson K, Giudice L, Simón C, Salumets A. Meta-signature of human
    endometrial receptivity: a meta-analysis and validation study of
    transcriptomic
    biomarkers. Sci Rep. 2017 Aug 30;7(1):10077. doi: 10.1038/s41598-017-10098-3.
    PMID: 28855728; PMCID: PMC5577343.
    11: Boggavarapu NR, Lalitkumar S, Joshua V, Kasvandik S, Salumets A,
    Lalitkumar
    PG, Gemzell-Danielsson K. Compartmentalized gene expression profiling of
    receptive endometrium reveals progesterone regulated ENPP3 is differentially
    expressed and secreted in glycosylated form. Sci Rep. 2016 Sep 26;6:33811.
    doi:
    10.1038/srep33811. PMID: 27665743; PMCID: PMC5036034.

Articles

  • Article: BIOMOLECULES. 2024;14(11):1400
    Frisendahl C; Tang Y; Boggavarapu NR; Peters M; Lalitkumar PG; Piltonen TT; Arffman RK; Salumets A; Goette M; Korsching E; Gemzell-Danielsson K
  • Article: COMMUNICATIONS BIOLOGY. 2024;7(1):1026
    Sarsenova M; Lawarde A; Pathare ADS; Saare M; Modhukur V; Soplepmann P; Terasmaa A; Kaambre T; Gemzell-Danielsson K; Lalitkumar PGL; Salumets A; Peters M
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(14):7590
    Utjes D; Boggavarapu NR; Rasul MF; Koberg I; Zulliger A; Ponandai-Srinivasan S; von Grothusen C; Lalitkumar PG; Papaikonomou K; Alkasalias T; Gemzell-Danielsson K
  • Journal article: HUMAN REPRODUCTION. 2024;39(Supplement_1):deae108.753
    Tang Y; Boggavarapu NR; Aronsson A; Gemzell-Danielsson K; Grace LKP
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(3):1608
    Tang Y; Boggavarapu NR; Aronsson A; Gemzell-Danielsson K; Lalitkumar PG
  • Article: FRONTIERS IN ENDOCRINOLOGY. 2024;15:1465393
    Sarsenova M; Boggavarapu NR; Kask K; Modhukur V; Samuel K; Karro H; Gemzell-Danielsson K; Lalitkumar PGL; Salumets A; Peters M; Lavogina D
  • Journal article: HUMAN REPRODUCTION. 2023;38(Supplement_1)
    Frisendahl C; Tang Y; Peters M; Ponandai-Srinivasan S; Parameswaran Grace LK; Rao Boggavarapu N; Salumets A; Götte M; Gemzell Danielsson K
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(4):4123
    Lalitkumar PGL; Lundstrom E; Bystrom B; Ujvari D; Murkes D; Tani E; Soderqvist G
  • Article: EVOLUTION MEDICINE AND PUBLIC HEALTH. 2023;11(1):8-17
    Anja Juran S; Tognetti A; Lundstrom JN; Kumar L; Stevenson RJ; Lekander M; Olsson MJ
  • Article: FRONTIERS IN ENDOCRINOLOGY. 2023;14:1026168
    Tang Y; Ponandai-srinivasan S; Frisendahl C; Andersson JK; Pavone D; Stewart EA; Lalitkumar PGL; Korsching E; Bogavarappu NR; Gemzell-Danielsson K
  • Article: HUMAN REPRODUCTION OPEN. 2022;2022(4):hoac043
    Koel M; Krjutskov K; Saare M; Samuel K; Lubenets D; Katayama S; Einarsdottir E; Vargas E; Sola-Leyva A; Lalitkumar PG; Gemzell-Danielsson K; Blesa D; Simon C; Lanner F; Kere J; Salumets A; Altmae S
  • Journal article: HUMAN REPRODUCTION. 2022;37(Supplement_1):deac107.397
    Von Grothusen C; Frisendahl C; Vijayachitra M; Grace LP; Peters M; Faridani O; Andres S; Boggavarapu NR; Gemzell-Danielsson K
  • Article: GENOME MEDICINE. 2022;14(1):64
    Bartlett TE; Evans I; Jones A; Barrett JE; Haran S; Reisel D; Papaikonomou K; Jones L; Herzog C; Pashayan N; Simoes BM; Clarke RB; Evans DG; Ghezelayagh TS; Ponandai-Srinivasan S; Boggavarapu NR; Lalitkumar PG; Howell SJ; Risques RA; Radestad AF; Dubeau L; Gemzell-Danielsson K; Widschwendter M
  • Article: HUMAN REPRODUCTION. 2022;37(4):734-746
    von Grothusen C; Frisendahl C; Modhukur V; Lalitkumar PG; Peters M; Faridani OR; Salumets A; Boggavarapu NR; Gemzell-Danielsson K
  • Article: HUMAN REPRODUCTION. 2020;35(10):2280-2293
    Ponandai-Srinivasan S; Saare M; Boggavarapu NR; Frisendahl C; Ehrstrom S; Riethmueller C; Garcia-Uribe PA; Rettkowski J; Iyengar A; Salumets A; Lalitkumar PGL; Goette M; Gemzell-Danielsson K
  • Article: JOURNAL OF HUMAN REPRODUCTIVE SCIENCES. 2020;13(2):155-161
    Sardana P; Banker J; Gupta R; Kotdawala A; Lalitkumar PGL; Banker M
  • Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2020;105(1):dgz019-230
    Kasvandik S; Saarma M; Kaart T; Rooda I; Velthut-Meikas A; Ehrenberg A; Gemzell K; Lalitkumar PG; Salumets A; Peters M
  • Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2019;98(6):715-721
    Banker M; Arora P; Banker J; Benani H; Shah S; Lalitkumar PGL
  • Article: JOURNAL OF HUMAN REPRODUCTIVE SCIENCES. 2019;12(2):141-149
    Kotdawala AP; Mir P; Herrero J; Khajuria R; Lalitkumar PGL; Banker MR
  • Article: DEVELOPMENTAL BIOLOGY. 2019;447(1):3-13
    Tguiko O; Jatsenko T; Grace LKP; Kurg A; Vermeesch JR; Lanner F; Altmae S; Salumets A
  • Show more

All other publications

  • Review: CELLS. 2024;13(17):1510
    Tang Y; Frisendahl C; Piltonen TT; Arffman RK; Lalitkumar PG; Gemzell-Danielsson K
  • Review: BIOLOGY OF REPRODUCTION. 2018;99(2):273-282
    Saare M; Krigul KL; Laisk-Podar T; Ponandai-Srinivasan S; Rahmioglu N; Kumar PGL; Zondervan K; Salumets A; Peters M
  • Conference publication: HUMAN REPRODUCTION. 2016;31:276
    Lalitkumar P; Vignesh-Srinivasan S; Andersson K; Green R; Gemzell-Danielsson K
  • Conference publication: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2016;26:171
    Srinivasan SV; Andersson K; Nister M; Danielsson KG; Lalitkumar P
  • Conference publication: HUMAN REPRODUCTION. 2016;31:11-12
    Srinivasan SV; Varghese SJ; Danielsson KG; Lalitkumar P
  • Conference publication: HUMAN REPRODUCTION. 2016;31:281-282
    von Grothusen C; Boggavarapu NR; Berger C; Menezes J; Gemzell-Danielsson K; Lalitkumar PG
  • Conference publication: HUMAN REPRODUCTION. 2016;31:277
    Boggavarapu NR; Lalitkumar S; Lalitkumar P; Gemzell-Danielsson K
  • Conference publication: REPRODUCTIVE SCIENCES. 2016;23:68A
    Li T; Lee KF; Lalitkumar PG; Danielsson KG; Yeung WSB; Ng EHY
  • Conference publication: HUMAN REPRODUCTION. 2015;30:275
    Lalitkumar PGL; Srinivasan PS; Varghese S; de-Cladio KA; Green R; Gemzell-Danielsson K
  • Review: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2014;72(2):148-157
    von Grothusen C; Lalitkumar S; Boggavarapu NR; Gemzell-Danielsson K; Lalitkumar PG
  • Conference publication: REPRODUCTIVE SCIENCES. 2014;21(3):227A
    Boggavarapu NR; Lalitkumar S; Srinivasan SP; Danielsson KG; Lalitkumar PGL
  • Conference publication: REPRODUCTIVE SCIENCES. 2014;21(3):224A-225A
    Lalitkumar PGL; Engman M; Varghese S; Gemzell-Danielsson K
  • Letter: CONTRACEPTION. 2013;88(4):581-582
    Gemzell-Danielsson K; Lalitkumar PGL; Berger C
  • Review: CONTRACEPTION. 2013;87(3):300-308
    Gemzell-Danielsson K; Berger C; Lalitkumar PGL
  • Conference publication: HUMAN REPRODUCTION. 2013;28:3
    Menezes J; Lalitkumar PGL; Borg P; Vaegter K; Wramsby M; Wramsby H
  • Conference publication: HUMAN REPRODUCTION. 2012;27
    Lalitkumar S; Menezes J; Evdokia D; Gemzell-Danielsson K; Lalitkumar PGL
  • Conference publication: HUMAN REPRODUCTION. 2012;27
    Menezes J; Lalitkumar PGL; Borg P; Ekwurtzel E; Nordqvist S; Vaegter K; Tristen C; Sjoeblom P
  • Meeting abstract: HUMAN REPRODUCTION. 2011;26:I226
    Engman M; Bystrom B; Varghese S; Lalitkumar PGL; Gemzell-Danielsson K
  • Conference publication: HUMAN REPRODUCTION. 2011;26:I209-I210
    Andersson KL; Sundqvist J; Scarselli G; Gemzell-Danielsson K; Lalitkumar PG
  • Conference publication: HUMAN REPRODUCTION. 2011;26:I70-I71
    Varghese SJ; Engman M; Brett G; Gemzell K; Lalitkumar PGL
  • Show more

Employments

  • Principal Researcher, Department of Women's and Children's Health, ̽»¨¾«Ñ¡, 2022-

Degrees and Education

  • Docent, ̽»¨¾«Ñ¡, 2021

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