探花精选

Laura Fratiglioni

Laura Fratiglioni

Professor, Senior
Telephone: +46852485809
Visiting address: Tomtebodav盲gen 18 A, 17177 Solna
Postal address: H1 Neurobiologi, v氓rdvetenskap och samh盲lle, H1 ARC Medicin Rizzuto, 171 77 Stockholm
Part of:

About me

  • I am a 探花精选 doctor from Italy, specialized in both neurology and epidemiology. I moved to Sweden with my family 1996.

    I am currently employed as a professor at 探花精选. Since 2007, I have been the director of the Aging Research Center (ARC). In 2010, I was granted the Distinguished Professor Award by 探花精选. I have scientific, clinical, and pedagogical commitments.

    - My scientific production has led to 285 articles in peer-reviewed journals, 23 book chapters, and 12 reports. By October 2014 I had 18, 093 citations and an h-index of 70.
    - Under my supervision, 15 PhD students and nine postdocs have completed their studies since 1996. I am currently the main supervisor of 2 PhD students and co-supervisor of 5 students.
    - Since 1996, as principal investigator, I have regularly received grants from the major research councils in Sweden and from international agencies. Together with a multidisciplinary team of senior researchers, I was awarded a 10-year grant to build ARC by The Swedish Council for Working Life and Social Research (Forte; 11 million Swedish krona per year).
    - I have received several prizes, including the Lifetime Achievement Award from the American Alzheimer鈥檚 Association, Sohlberg鈥檚 Nordic Prize in Gerontology, and the 探花精选 Folksams prize in epidemiologic research.

    Relevant issues for the board of research
    1. To be able to implement KI鈥檚 鈥淪trategy 2018鈥 concerning research quality, research infrastructure, and support for younger researchers
    2. To strengthen clinical research
    3. To facilitate the integration of basic research within clinical and epidemiological research
    4. To reinforce the dialogue and the interaction between research and education

    Academic honours, awards and prizes

    PRIZES
    2013 Lifetime Achievement Award from the American Alzheimer鈥檚 Association
    2011 Wajlit och Eric Forsgrens prize for AD researcher - Ume氓 University
    2010 The Sohlberg's Nordic Prize in Gerontology
    2010 Sofiahemmet-Research and Education prize in dementia research
    2009 探花精选 Folksams prize in epidemiologic research
    2008 The Swedish Society of Medicine 鈥 鈥淚nga Sandeborg鈥檚 prize鈥
    2001 Italian Society of Neurology - Award 鈥淚n memory of Prof L Amaducci鈥

    AWARDS & HONORS
    2011 Forte- mid-term evaluation of ARC: 鈥榃e recommend support at a higher level鈥
    2011 KI - ERA evaluation (international independent panel): grading 鈥極ustanding鈥
    2010-2015 The 探花精选 - Distinguished Professor Award
    1996-1999 Medical Research Council, Sweden 鈥 4-year position as a Research Scientist
    1990-1993 Medical Research Council, Sweden 鈥 4-year position as a PhD student

Research

  • I am the principal investigator of the SNAC-Kungsholmen population study, the scientific coordinator for the Kungsholmen Project on Aging and Dementia, and co-investigator in several Swedish (Swedish Brian Power) and European consortia (NEW-AGE, HATICE, ESCAPE; MPI-age). My research group consists of 18 people, including two lecturers, two assistant professors, six post-docs, seven PhD students, one research assistant, and one research coordinator. We have four major lines of research: 1) Postponing dementia onset: Risk and protective factors for Alzheimer鈥檚 disease and other dementias, 2) Understanding the natural history of the dementias, 3) The body-mind connection, and 4) Health status and health trends in older people.

    Postponing dementia onset: Risk and protective factors for Alzheimer鈥檚 disease and other dementias. In the last two decades, significant progress has been made regarding the identification of risk and protective factors in dementia. Our group has contributed to the accumulating evidence that lifestyle and cardiovascular risk factors play important roles in the pathogenesis and development of dementia. In addition, we have proposed a life-course model for the development of dementia that is now commonly accepted. This model asserts that a) life-long cumulating lesions (of different kinds) lead to dementia when they no longer can be counteracted by compensatory mechanisms; b) most cases of dementia will occur in late life and most will be of the mixed type (i.e., neurodegenerative and vascular); c) there are specific time windows when some determinants may be active, although not during the whole life period; d) risk and protective factors may interact in both increasing and attenuating their effects on dementia development; e) not all old persons develop dementia, even at advanced ages, and learning from those who 鈥渆scape鈥 can shed new light on the pathogenesis of dementia; and f) delay of dementia onset seems to be the only realistic endpoint in prevention. Following this model, we are now examining old (vascular and psychosocial factors) and new hypotheses (psychological stress, nutrition, and pollution) with three major goals: a) to identify possible pathways through which protective factors may compensate for previous risk exposures, b) to detect underlying mechanisms, and c) to verify the extent to which established risk and protective factors may anticipate or delay dementia onset.

    Understanding the natural history of the dementias from mild cognitive impairment, early detection and progression to disability, institutionalization and death. ~~Cognitive deficits can be observed up to ten years before a dementia diagnosis is made; a sharp decline is more evident in the final three years. My colleagues and I have validated the use of such early cognitive deficits as a predictive tool for incipient dementia in the general population, but to date none of the proposed definitions has shown itself to be a sufficiently good predictor at the community level. This is mainly because cognitive impairment is common in the elderly population and has multiple causes. In our ongoing work on this topic, we are examining various individual-difference variables that might modulate both the onset of dementia and the decline once dementia has started. Of special interest here is whether certain favorable conditions (e.g., high educational level, an active lifestyle, advantageous genetic variants) would lead to a later change point and more rapid decline during the final years preceding dementia diagnosis, reflecting greater cognitive reserve. We are also integrating cognitive data with MRI findings to increase the ability to predict dementia onset, whereas social factors are taken into account when studying disability, institutionalization, and death in people affected by dementia.

    The body-mind connection. ~~Ongoing demographic changes are expected to lead not only to an increased number of people with chronic diseases, but also to the development of different patterns of diseases, such as multiple health and functional problems, referred to here as chronic multimorbidity (15). Multimorbidity is a very common syndrome in elderly people. It occurs in more than half of the 75+ old population, and the prevalence is higher in very old persons, women, and people from disadvantaged social classes. Almost nothing is known about risk factors for multimorbidity, but the consequences are well established: functional impairment, poor quality of life, and high health-care utilization and costs. We have recently started a new project to study the effect of multimorbidity on cognitive functions. Preliminary data show that multimorbidity affects both the progression from MCI to dementia and the progression of dementia toward functional dependence. Furthermore, specific chronic disorders such as heart failure, atrial fibrillation, and anemia are associated with an increased risk of dementia, which suggests that dementia may also develop in the absence of neurodegeneration. Finally, we have documented a deleterious effect of polypharmacy and of specific chronic disorders (depression, stroke, diabetes) in the development of cognitive impairment. On the basis of these findings, we hypothesize that chronic multimorbidity is a frail state that may anticipate onset of dementia by several years.

    Health status and health trends in old ages. Human health is a dynamic and multidimensional status, and this is especially evident in aging, when health changes occur more frequently and at an increased rate. Using data already collected in our cohort studies of middle-aged and elderly people, we are now addressing two research questions: 1) How can we measure the health status of older adults in a more comprehensive way? 2) What are the chains of events that culminate in the development of poor health in elderly people? Specifically, we aim to: 1) integrate multiple health dimensions in a score to better describe health and health trajectories among older adults and to relate health to work capability and societal engagement; 2) quantify the effect of the major social, environmental, psychological, and biological determinants and their life-long interactions on health and survival in older adults; 3) assess geographical variation in mental and physical health and their known determinants in Sweden; and 4) explore time trends in mortality and morbidity among the older population. This research line represents a timely initiative after two decades during which researchers in the aging field (including several from our group) have identified numerous factors that contribute to heath in aging. The challenge is now to understand the interplay among these many factors in a life course perspective, taking into account different components and their impact at the societal level.

Teaching

  • In 2008 in collaboration with other centers at KI and the universities of Lund and Ume氓, I started a National Graduate School for Aging Research, which supports an educational program with a biological, psychological, and socio-demographic profile. Preparations for a larger-scale multidisciplinary interaction at the national level are ongoing.

Articles

  • Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2025;80(9):glaf164
    Fabbri E; Candia J; Tanaka T; Moore AZ; Muratori P; Brugiavini A; Calderon-Larranaga A; Vetrano DL; Fratiglioni L; Crimmins E; Faul J; Langa KM; Weir D; Ferrucci L
  • Journal article: JOURNAL OF GLOBAL AGEING. 2025;:1-16
    Calder贸n-Larra帽aga A; von Saenger I; de la Fuente-N煤帽ez V; Ferrucci L; Semenza JC; Veenstra M; Sidorenko A; Kr枚ger T; Koivunen K; Iwarsson S; Fratiglioni L; Nilsen C; Religa D; Torg茅 CJ; Lennartsson C
  • Article: NATURE MEDICINE. 2025;31(6):2027-2035
    Grande G; Valletta M; Rizzuto D; Xia X; Qiu C; Orsini N; Dale M; Andersson S; Fredolini C; Winblad B; Laukka EJ; Fratiglioni L; Vetrano DL
  • Article: JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE. 2025;12(6):100124
    Mrhar A; Carballo-Caslaa A; Grande G; Vallettaa M; Fredolini C; Fratiglioni L; Kramberger MG; Kuharb A; Winblad B; Calderon-Larranaga A; Vetranoa DL
  • Article: AGE AND AGEING. 2025;54(1):afaf006
    Gentili S; Calderon-Larranaga A; Rizzuto D; Gordon AL; Agerholm J; Lennartsson C; Rundgren AH; Fratiglioni L; Vetrano DL
  • Journal article: INNOVATION IN AGING. 2024;8:355
    Triolo F; Vetrano DL; Trevisan C; Sjobrg L; Calderon-Larranaga A; Murri MB; Fratiglioni L; Dekhtyar S
  • Journal article: ALZHEIMERS & DEMENTIA. 2024;20(Suppl 3):e087382
    Laukka EJ; Ekstr枚m I; Grande G; Valletta M; Qiu C; Winblad B; Fredolini C; Fratiglioni L; Vetrano DL
  • Journal article: ALZHEIMERS & DEMENTIA. 2024;20 Suppl 2:e090454
    Ekstr枚m I; Vetrano DL; Ruane R; Grande G; Valletta M; Larsson M; Fredolini C; Winblad B; Fratiglioni L; Laukka EJ
  • Journal article: ALZHEIMERS & DEMENTIA. 2024;20(Suppl 4):e085931
    Sakakibara S; Dove A; Guo J; Grande G; Sj枚lund B; Agerholm J; Fratiglioni L; Xu W
  • Journal article: ALZHEIMERS & DEMENTIA. 2024;20 Suppl 3:e092262
    Ekstr枚m I; Avelar-Pereira B; Ruane R; Grande G; Fratiglioni L; Larsson M; Laukka EJ
  • Article: INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH. 2024;23(1):252
    Bacigalupe A; Martin U; Triolo F; Sjoberg L; Sterner TR; Dekhtyar S; Fratiglioni L; Calderon-Larranaga A
  • Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2024;25(11):105225
    Tazzeo C; Rizzuto D; Calderon-Larranaga A; Gentili S; Lennartsson C; Xia X; Fratiglioni L; Vetrano DL
  • Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2024;34:ckae144.980
    Gentili S; Locatelli G; Bellocco R; Calderon-Larranaga A; Rizzuto D; Lennartsson C; Hedberg Rundgren A; Fratiglioni L; Vetrano DL
  • Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2024;34:ckae144.648
    Gentili S; Calderon-Larranaga A; Rizzuto D; Agerholm J; Lennartsson C; Rundgren AH; Fratiglioni L; Vetrano D
  • Article: BRITISH JOURNAL OF PSYCHIATRY. 2024;225(2):321-327
    Triolo F; Vetrano DL; Trevisan C; Sjoberg L; Calderon-Larranaga A; Murri MB; Fratiglioni L; Dekhtyar S
  • Article: ALZHEIMERS & DEMENTIA. 2024;20(8):5662-5673
    Grande G; Li Y; Trevisan C; Rizzuto D; Kalpouzos G; Ding M; Laukka EJ; Bellander T; Fratiglioni L; Qiu C
  • Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2024;111(7):1316-1329
    Manzoni C; Kia DA; Ferrari R; Leonenko G; Costa B; Saba V; Jabbari E; Tan MMX; Albani D; Alvarez V; Alvarez I; Andreassen OA; Angiolillo A; Arighi A; Baker M; Benussi L; Bessi V; Binetti G; Blackburn DJ; Boada M; Boeve BF; Borrego-Ecija S; Borroni B; Brathen G; Brooks WS; Bruni AC; Caroppo P; Bandres-Ciga S; Clarimon J; Colao R; Cruchaga C; Danek A; de Boer SCM; de Rojas I; di Costanzo A; Dickson DW; Diehl-Schmid J; Dobson-Stone C; Dols-Icardo O; Donizetti A; Dopper E; Durante E; Ferrari C; Forloni G; Frangipane F; Fratiglioni L; Kramberger MG; Galimberti D; Gallucci M; Garcia-Gonzalez P; Ghidoni R; Giaccone G; Graff C; Graff-Radford NR; Grafman J; Halliday GM; Hernandez DG; Hjermind LE; Hodges JR; Holloway G; Huey ED; Illan-Gala I; Josephs KA; Knopman DS; Kristiansen M; Kwok JB; Leber I; Leonard HL; Libri I; Lleo A; Mackenzie IR; Madhan GK; Maletta R; Marquie M; Maver A; Menendez-Gonzalez M; Milan G; Miller BL; Morris CM; Morris HR; Nacmias B; Newton J; Nielsen JE; Nilsson C; Novelli V; Padovani A; Pal S; Pasquier F; Pastor P; Perneczky R; Peterlin B; Petersen RC; Piguet O; Pijnenburg YAL; Puca AA; Rademakers R; Rainero I; Reus LM; Richardson AMT; Riemenschneider M; Rogaeva E; Rogelj B; Rollinson S; Rosen H; Rossi G; Rowe JB; Rubino E; Ruiz A; Salvi E; Sanchez-Valle R; Sando SB; Santillo AF; Saxon JA; Schlachetzki JCM; Scholz SW; Seelaar H; Seeley WW; Serpente M; Sorbi S; Sordon S; St George-Hyslop P; Thompson JC; Van Broeckhoven C; Van Deerlin VM; Van der Lee SJ; Van Swieten J; Tagliavini F; van der Zee J; Veronesi A; Vitale E; Waldo ML; Yokoyama JS; Nalls MA; Momeni P; Singleton AB; Hardy J; Escott-Price V
  • Article: AGE AND AGEING. 2024;53(7):afae141
    Heikkila K; Pentti J; Dekhtyar S; Ervasti J; Fratiglioni L; Harkanen T; Kivimaki M; Koskinen S; Ngandu T; Stenlund S; Suominen S; Vahtera J; Rovio S; Stenholm S
  • Article: BMC MEDICINE. 2024;22(1):236
    Abbadi A; Kokoroskos E; Stamets M; Vetrano DL; Orsini N; Elmstahl S; Fagerstrom C; Wimo A; Skoldunger A; Berglund JS; Olsson CB; Wachtler C; Fratiglioni L; Calderon-Larranaga A
  • Article: JOURNAL OF INTERNAL MEDICINE. 2024;295(6):804-824
    Kirvalidze M; Bostrom A-M; Liljas A; Doheny M; Hendry A; Mccormack B; Fratiglioni L; Ali S; Ebrahimi Z; Elmstahl S; Eriksdotter M; Glaske P; Gustafsson L-K; Rundgren AH; Hvitfeldt H; Lennartsson C; Hammar LM; Nilsson GH; Nilsson P; Ohlen J; Sandgren A; Soderman A; Swedberg K; Vackerberg N; Vetrano DL; Wijk H; Agerholm J; Calderon-Larranaga A
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All other publications

  • Preprint: MEDRXIV. 2025;MEDRXIV
    Thomassen JQ; Hampton L; Ulms B; Grenier-Boley B; Heikkinen S; Garcia P; Castillo-Morales A; Kikuchi M; Gim J; Cao H; K眉莽眉kali F; Amin N; Yoon D; de Rojas I; Jerez PA; Alvarez V; Arosio B; Bellenguez C; Bergh S; Billingsley K; Blauwendraat C; Boada M; Borroni B; Boss霉 P; Bullido MJ; Daniele A; Carracedo 脕; de Mendon莽a A; Cookson M; Deckert J; Dichgans M; Djurovic S; Dols-Icardo O; Dufouil C; D眉zel E; Escott-Price V; Fladby T; Fratiglioni L; Fu AKY; Galimberti D; Garc铆a-Alberca JM; Giedraitis V; Garcia-Ribas G; Graff C; Grimmer T; Gr眉nblatt E; Hanon O; Hausner L; Heilmann-Hemibach S; Hort J; Jessen F; Jensen K; Jonson C; Kim Y; Kuznetsov N; Leinonen V; Lipponen A; Luo J; Makarious M; Martiskainen H; Masullo C; Mecocci P; Mehrabian S; Mir P; Miyashita A; Moebus S; Mok KY; Porcel LM; Moreno F; Nacmias B; Parnetti L; Pastor P; P茅rez-Tur J; Peters O; Pijnenburg YAL; Pi帽ol-Ripoll G; Popp J; Rainero I; Real LM; Riedel-Heller S; Rodriguez-Rodriguez E; Rongve A; Rossi G; Royo JL; Rujescu D; Saltvedt I; S谩ez ME; S谩nchez-Valle R; Sanchez-Garcia F; Sandau N; Scarmeas N; Scheffler K; Scherbaum N; Schneider A; Selb忙k G; Seripa D; Solfrizzi V; Spallazzi M; Squassina A; Stordal E; Tesi N; Tremolizzo L; Tripathi KP; van der Flier WM; Williams J; Wiltfang J; Aarsland D; Singleton AB; Amouyel P; Debette S; Nicolas G; van der Lee S; Holstege H; Fernandez MV; Kehoe PG; Sleegers K; Ingelsson M; Ghidoni R; Andreassen OA; Holmans PA; S谩nchez-Juan P; Sims R; Ip NY; Lee KH; Ikeuchi T; Ramirez A; Ruiz A; Hiltunen M; Lambert J-C; van Duijn C; Nalls M; Frikke-Schmidt R
  • Editorial comment: GERONTOLOGIST. 2024;64(4):gnae001
    Ungar A; Cherubini A; Fratiglioni L; de la Fuente-nunez V; Fried LP; Krasovitsky MS; Tinetti M; Officer A; Vellas B; Ferrucci L
  • Editorial comment: EUROPEAN GERIATRIC MEDICINE. 2024;15(2):285-290
    Ungar A; Cherubini A; Fratiglioni L; de la Fuente-N煤帽ez V; Fried L; Krasovitsky MS; Tinetti M; Officer A; Vellas B; Ferrucci L
  • Editorial comment: JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES. 2024;79(3):gbad176
    Ungar A; Cherubini A; Fratiglioni L; de la Fuente-Nunez V; Fried LP; Sally Krasovitsky M; Tinetti M; Officer A; Vellas B; Ferrucci L
  • Editorial comment: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2024;79(3):glad264
    Ungar A; Cherubini A; Fratiglioni L; de la Fuente-Nunez V; Fried LP; Krasovitsky MS; Tinetti ME; Officer A; Vellas B; Ferrucci L
  • Editorial comment: INNOVATION IN AGING. 2024;8(2):igad133
    Ungar A; Cherubini A; Fratiglioni L; de la Fuente-Nunez V; Fried LP; Krasovitsky MS; Tinetti M; Officer A; Vellas B; Ferrucci L
  • Conference publication: ALZHEIMERS & DEMENTIA. 2022;18(S11)
    Imahori Y; Wu J; Ljungman P; Vetrano DL; Laukka EJ; Grande G; Fratiglioni L; Qiu C
  • Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29:147
    Speh A; Payton N; Kramberger MG; Grande G; Qiu C; Winblad B; Fratiglioni L; Backman L; Laukka EJ
  • Conference publication: INNOVATION IN AGING. 2021;5:184
    Shang Y; Wu W; Dove A; Guo J; Welmer A-K; Rizzuto D; Fratiglioni L; Xu W
  • Conference publication: INNOVATION IN AGING. 2021;5:531
    Vetrano D; Zucchelli A; Onder G; Bernabei R; Fratiglioni L; Marengoni A; Lapi F
  • Conference publication: INNOVATION IN AGING. 2021;5:71-72
    Saadeh M; Prinelli F; Vetrano D; Xu W; Welmer A-K; Dekhtyar S; Fratiglioni L; Calderon-Larranaga A
  • Conference publication: INNOVATION IN AGING. 2021;5:15
    Zucchelli A; Marengoni A; Vetrano D; Ferrucci L; Fratiglioni L; Bernabei R; Onder G; Romanelli G
  • Conference publication: INNOVATION IN AGING. 2021;5:607
    Calderon-Larranaga A; Hu X; Haaksma M; Rizzuto D; Fratiglioni L; Vetrano D
  • Conference publication: INNOVATION IN AGING. 2021;5:642-643
    Guo J; Marseglia A; Shang Y; Dove A; Grande G; Fratiglioni L; Xu W
  • Conference publication: ALZHEIMERS & DEMENTIA. 2021;17(S10)
    Imahori Y; Vetrano DL; Xia X; Grande G; Ljungman P; Fratiglioni L; Qiu C
  • Review: AGEING RESEARCH REVIEWS. 2021;69:101351
    Vetrano DL; Triolo F; Maggi S; Malley R; Jackson TA; Poscia A; Bernabei R; Ferrucci L; Fratiglioni L
  • Conference publication: INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE. 2021;28(SUPPL 1):S200
    Sindi S; Perez LM; Vetrano D; Kareholt I; Sjoberg L; Darin-Mattsson A; Kivipelto M; Fratiglioni L; Inzitari M; Calderon-Larranaga A
  • Preprint: MEDRXIV. 2021
    Beridze G; Triolo F; Grande G; Fratiglioni L; Calder贸n-Larra帽aga A
  • Conference publication: ALZHEIMERS & DEMENTIA. 2020;16(S10)
    Hooshmand B; Refsum H; Smith AD; Grande G; Marseglia A; Laukka EJ; B盲ckman L; Fratiglioni L
  • Review: AGEING RESEARCH REVIEWS. 2020;64:101045
    Grande G; Qiu C; Fratiglioni L
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Grants

  • Swedish Research Council for Health Working Life and Welfare
    1 January 2025 - 31 December 2027
    Research problem and questions. Even if dementia cannot be cured, older persons with this condition and their relatives can still have a long-lasting good quality of life if offered appropriate 探花精选 and social care. As recently discussed in a FORTE-funded national symposium organized by the main applicant, the integrated person-centered model is recognized as a promising approach for improved health and service utilization outcomes, but questions remain about how to organize, provide, and assess such care. This project intends to answer the following questions concerning older adults with dementia: 1) How can we ensure a person-centered and holistic assessment and follow up? 2) What are the predictors and clinical/care consequences of major acute events? and 3) How can we facilitate their seamless transfer across care settings?Data and methods. Three studies will be implemented. Study 1 will leverage on data from an existing, multi-center, population-based cohort (Swedish National Study on Aging and Care, SNAC) to examine the predictive capacity of the Health Assessment Tool (HAT) for detecting progression from cognitive impairment to dementia. Study 2 will explore, based on data from the Swedish Dementia Registry, the predictors of common major acute events (i.e. falls, pneumonia, myocardial infarction) and how the latter impact dementia progression and health/social care use, including unplanned hospitalizations. Finally, Study 3 will identify and map care transitions within and between 探花精选 and social care settings using an integrated national register dataset, with special emphasis on the rehabilitation and hospital discharge phases of care trajectories.Relevance and utilization. The present project is a contribution to the long-awaited need for integrated person-centered care throughout the dementia continuum, which will add quality to the many years older persons may live with cognitive impairment and dementia by slowing down their progression.Plan for project realization. We will draw on our team鈥檚 longstanding multidisciplinary expertise on aging and dementia research, already established collaborations, the involvement of key partners representing the councils of Elderly Research and Cognitive Disorders at the National Board of Health and Welfare, and the ease of access to the proposed longitudinal databases and register data. This will facilitate, not only the feasibility of the project, but also the timely implementation of its findings.
  • Swedish Research Council
    1 January 2023 - 31 December 2028
    With this application, we seek support to consolidate and expand the National E-infrastructure for Aging Research (NEAR) after the building phase, supported by the VR-grant for national infrastructures (2018-22). NEAR鈥檚 purpose is to empower aging research in Sweden by providing substantial added value to the field: a broad, multidisciplinary research perspective that cannot be achieved with the individual databases
    increased sample size and variation, which enhance representativeness and generalizability
    and a critical mass of data that opens new research avenues and supports innovation. The ultimate goal is to contribute to identifying sustainable intervention strategies for better health and care for older people. During the first 3 years, we have followed the original plan with only marginal deviations: the Consortium of 8 Swedish universities, where the 15 local databases are located, has been established, NEAR fundaments are in place and initial use of NEAR was started with 8 ongoing projects (www.near-aging.se). NEAR-Phase 2 (2023-28) will be implemented by means of 9 modules: 1) organizing and governing, 2) completing the technical platform, 3) updating the documentation, 4) continuing data harmonization, 5) increasing visibility and user numbers, 6) enriching the local databases, 7) including new databases and registries, 8) supporting users & knowledge advancement, and 9) fulfilling knowledge gaps and developing new methods. The availability of such a large collection of social, biological and 探花精选 data, and the scientific excellence of the NEAR founders, will reinforce the international profile of Swedish aging research, promote new collaborations and support the development of a new generation of well-qualified researchers. Ultimately, NEAR will contribute to societal development by providing a platform for researchers, companies and non-profit organizations to improve public health and health care in a field that requires urgent innovation.
  • Swedish Research Council
    1 January 2022 - 31 December 2024
  • Swedish Research Council
    1 December 2021 - 30 November 2024
  • Swedish Research Council for Health Working Life and Welfare
    1 November 2021 - 31 October 2025
    Dementia is one of the major causes of disability and dependence and its impact on healthcare systems leads to an enormous burden on our current and future society. The goal of this project is to provide evidence supporting timely and personalized care for people with cognitive disorders (mild cognitive impairment [MCI] and dementia). Specifically, we aim to 1) Explore care needs and care utilization in people with MCI and dementia and capture their changes depending on disease progression, comorbidities, and social context, 2) Compare dementia cases diagnosed at specialized settings with undiagnosed cases (identified in population-based cohort studies) to detect potentially different care trajectories, 3) Map the 30-year secular trend of care use and institutionalization in people with dementia from the 1990s to 2020s in Sweden (urban and rural areas), and 4) Develop a predictive model to provide an updated estimate of the number of people with MCI and dementia given decreasing dementia incidence and increasing survival, and to identify who will need home assistance or institutionalization and when. To address these aims, we rely on the expertise of a multidisciplinary team, and high-quality data from three population-based cohorts studies and a national quality registry: the Kungsholmen Project (KP, n=1810 aged 鈮75, 1987-2000), the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K, n=3363 aged 鈮60, 2001-2021) and Nordanstig (SNAC-N, n=766 aged 鈮60, 2001-2021), and the Swedish Dementia Registry (SveDem, n=100133, 2007-2021). In these datasets, MCI and dementia were diagnosed using standard criteria, and data on the quantity and quality of formal (home and institution) and informal care were collected. Information on contextual factors and 探花精选 conditions is available. Findings from this project will provide practical information for healthcare managers to plan and deliver tailored and stage-specific care to people with cognitive disorders.
  • Swedish Research Council for Health Working Life and Welfare
    1 November 2021 - 31 October 2025
    This project aims at increasing our knowledge concerning care needs and patterns of care utilization of frail and clinically complex older adults, to identify timely actions towards a more proactive and integrated healthcare. An increased rate of transition of frail individuals between healthcare (primary care, hospital) and social care providers (home care services, institutions) has been observed but not well characterized. At the same time, fragmented and idiosyncratic care transitions are arguably responsible for a quicker functional decline, which accelerates frailty development. Finally, patients鈥 perspective and experiences have been rarely taken into consideration when designing care paths, especially when frailty is at play. Taking advantage of three well-characterized Swedish population-based studies part of the Swedish National Study on Aging and Care (SNAC), and of the National E-Infrastructure on Aging Research (NEAR) we will analyze data of over 7,000 individuals 60+, living in both urbanized and rural areas of four different Regions. We plan to develop three interconnected subprojects having the following aims: 1) To characterize seniors鈥 care transition patterns while considering their underlying clinical conditions, frailty, and the availability of formal and informal social care
    2) To quantify the impact of unplanned and avoidable healthcare episodes, and the fast transition through different care settings, on the clinical trajectories and frailty
    and 3) To better understand patients鈥 experiences and preferences in relation to their history of healthcare utilization and care transition episodes, while considering their clinical and frailty trajectories. Through this project, we expect to identify relevant risk profiles and harmful care utilization patterns as a basis for more integrated and person-centered care, which hopefully will delay or postpone frailty, reduce morbidity burden, and improve patients鈥 experiences and quality of life.
  • Swedish Research Council
    1 January 2021 - 31 December 2024
  • Swedish Research Council
    1 January 2021 - 31 December 2024
  • Swedish Research Council
    1 August 2020 - 31 December 2020
  • Swedish Research Council for Health Working Life and Welfare
    1 July 2019 - 30 June 2022
  • Swedish Research Council
    1 January 2019 - 31 December 2021
  • Swedish Research Council
    1 January 2018 - 31 December 2022
  • Swedish Research Council
    1 December 2017 - 31 December 2022
  • Swedish Research Council for Health Working Life and Welfare
    1 October 2017 - 30 September 2020
  • Swedish Research Council for Health Working Life and Welfare
    1 October 2017 - 30 September 2020
  • Swedish Research Council
    1 January 2017 - 31 December 2020
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2017 - 31 December 2022
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2016 - 31 December 2018
  • Swedish Research Council
    1 January 2016 - 31 December 2017
  • Swedish Research Council
    1 January 2016 - 31 December 2018
  • Show more

Employments

  • Professor, Senior, Department of Neurobiology, Care Sciences and Society, 探花精选, 2025-2025
  • Professor, Department of Neurobiology, Care Sciences and Society, 探花精选, 2023-2024

Degrees and Education

  • Docent, 探花精选, 1997

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