探花精选

Malene Lindholm

Malene Lindholm

Affiliated to Research
Visiting address: Solnav盲gen 9, Biomedicum C5, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Molekyl盲r Arbetsfysiologi, 171 77 Stockholm
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About me

  • I am a translational scientist with a PhD in 探花精选 science working at the intersection of cardiometabolic disease, bioinformatics and molecular biology, currently serving as senior research engineer and Director of the Human Molecular Athlete Moonshot at Stanford University.

Research

  • My research is dedicated to deciphering the specific molecular mechanisms that mediate the health benefits of exercise, a crucial determinant in combating the global health crisis posed by sedentary lifestyles. Recognized as the fourth leading risk factor for mortality worldwide, physical inactivity is a modifiable behavior that, if addressed, has the potential to prevent numerous leading causes of premature mortality, including type II diabetes and cardiovascular diseases. By leveraging cutting-edge exercise interventions and multi-omic techniques alongside advanced cellular

    models, my work aims not only to delineate the molecular pathways that confer exercise鈥檚 protective effects but also to translate these findings into actionable strategies for the prevention and treatment of cardiometabolic conditions. This integrative approach stands to offer transformative insights into public health policies and therapeutic innovations, towards the goal of precision exercise health. 

Articles

  • Journal article: CIRCULATION RESEARCH. 2025;137(7):1045-1047
    Brochet P; Montalvo S; Lindholm ME; Jimenez-Morales D; Jin CA; Rasmussen BB; Kraus WE; Yan Z; Wheeler MT; Katz DH
  • Journal article: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2025;:S1043-2760(25)00151-1
    Plaza-Florido A; Lindholm ME; Carrera-Bastos P; Santos-Lozano A; Valenzuela PL; Fiuza-Luces C; Radom-Aizik S; Lucia A
  • Journal article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2025;12:1546493
    Lindholm ME; Abramowitz S; Waggott DM; Grove ME; Dewey FE; Pan C; Pavlovic A; Shang C; Huang Y; Bensabath L; Goldfeder RL; Cordero P; Erbilgin A; Priest JR; Chaib H; Puckelwartz MJ; Day SM; Mcnally EM; Cappola T; Dorn GW; Ashley EA; Wheeler MT
  • Journal article: CIRCULATION RESEARCH. 2025;136(11):1407-1432
    Shero JA; Lindholm ME; Sandri M; Stanford KI
  • Article: BMC MEDICAL ETHICS. 2025;26(1):22
    Ormond KE; Stanclift C; Reuter CM; Carter JN; Murphy KE; Lindholm ME; Wheeler MT
  • Journal article: CIRCULATION. 2024;150:a4143199
    Katz D; Jin C; Smith G; Clark N; Iyer G; Keshishian HK; Hart P; Sanford J; Zhang Z; Ge Y; Robbins J; Barber J; Montalvo S; Jimenez-Morales D; Lindholm M; Zhen J; Jaeger B; Sparks L; Sagendorf T; Many G; Vetr N; Raja A; Amar D; Hsu F-C; Miller M; Xia A; Fleg J; Tracy R; Gerszten R; Adkins J; Walsh M; Sealfon S; Goodpaster B; Trappe S; Burant C; Carr S; Smith K; Snyder M; Montgomery S; Ashley E; Wheeler M
  • Article: JOURNAL OF APPLIED PHYSIOLOGY. 2024;137(3):473-493
    Jakicic JM; Kohrt WM; Houmard JA; Miller ME; Radom-Aizik S; Rasmussen BB; Ravussin E; Serra M; Stowe CL; Trappe S; Abouassi H; Adkins JN; Alekel DL; Ashley E; Bamman MM; Bergman BC; Bessesen DH; Broskey NT; Buford TW; Burant CF; Chen H; Christle JW; Clish CB; Coen PM; Collier D; Collins KA; Cooper DM; Cortes T; Cutter GR; Dubis G; Fernandez FM; Firnhaber J; Forman DE; Gaul DA; Gay N; Gerszten RE; Goodpaster BH; Gritsenko MA; Haddad F; Huffman KM; Ilkayeva O; Jankowski CM; Jin C; Johannsen NM; Johnson J; Kelly L; Kershaw E; Kraus WE; Laughlin M; Lester B; Lindholm ME; Lowe A; Lu C-J; McGowan J; Melanson EL; Montgomery S; Moore SG; Moreau KL; Muehlbauer M; Musi N; Nair VD; Newgard CB; Newman AB; Nicklas B; Nindl BC; Ormond K; Piehowski PD; Qian W-J; Rankinen T; Rejeski WJ; Robbins J; Rogers RJ; Rooney JL; Rushing S; Sanford JA; Schauer IE; Schwartz RS; Sealfon SC; Slentz C; Sloan R; Smith KS; Snyder M; Spahn J; Sparks LM; Stefanovic-Racic M; Tanner CJ; Thalacker-Mercer A; Tracy R; Trappe TA; Volpi E; Walsh MJ; Wheeler MT; Willis L
  • Article: FUNCTION. 2024;5(4):zqae014
    Schenk S; Sagendorf TJ; Many GM; Lira AK; de Sousa LGO; Bae D; Cicha M; Kramer KS; Muehlbauer M; Hevener AL; Rector RS; Thyfault JP; Williams JP; Goodyear LJ; Esser KA; Newgard CB; Bodine SC
  • Article: BMC BIOLOGY. 2024;22(1):147
    Geiger C; Needhamsen M; Emanuelsson EB; Norrbom J; Steindorf K; Sundberg CJ; Reitzner SM; Lindholm ME
  • Article: CELL GENOMICS. 2024;4(6):100421
    Nair VD; Pincas H; Smith GR; Zaslavsky E; Ge Y; Amper MAS; Vasoya M; Chikina M; Sun Y; Raja AN; Mao W; Gay NR; Esser KA; Smith KS; Zhao B; Wiel L; Singh A; Lindholm ME; Amar D; Montgomery S; Snyder MP; Walsh MJ; Sealfon SC
  • Article: CELL METABOLISM. 2024;36(6):1411-1429.e10
    Amar D; Gay NR; Jimenez-Morales D; Beltran PMJ; Ramaker ME; Raja AN; Zhao B; Sun Y; Marwaha S; Gaul DA; Hershman SG; Ferrasse A; Xia A; Lanza I; Fernandez FM; Montgomery SB; Hevener AL; Ashley EA; Walsh MJ; Sparks LM; Burant CF; Rector RS; Thyfault J; Wheeler MT; Goodpaster BH; Coen PM; Schenk S; Bodine SC; Lindholm ME
  • Article: NATURE. 2024;629(8010):174-183
    Amar D; Gay NR; Jean-Beltran PM; Bae D; Dasari S; Dennis C; Evans CR; Gaul DA; Ilkayeva O; Ivanova AA; Kachman MT; Keshishian H; Lanza IR; Lira AC; Muehlbauer MJ; Nair VD; Piehowski PD; Rooney JL; Smith KS; Stowe CL; Zhao B; Clark NM; Jimenez-Morales D; Lindholm ME; Many GM; Sanford JA; Smith GR; Vetr NG; Zhang T; Armenteros JJA; Avila-Pacheco J; Bararpou N; Ge Y; Hou Z; Marwaha S; Presby DM; Raja AN; Savage EM; Steep A; Sun Y; Wu S; Zhen J; Bodine SC; Esser KA; Goodyear LJ; Schenk S; Montgomery SB; Fernandez FM; Sealfon SC; Snyder MP; Adkins JN; Ashley E; Burant CF; Carr SA; Clish CB; Cutter G; Gerszten RE; Kraus WE; Li JZ; Miller ME; Nair KS; Newgard C; Ortlund EA; Qian W-J; Tracy R; Wheeler MT; Dalton KP; Hastie T; Hershman SG; Samdarshi M; Teng C; Tibshirani R; Cornell E; Gagne N; May S; Bouverat B; Leeuwenburgh C; Lu C-J; Pahor M; Hsu F-C; Rushing S; Walkup MP; Nicklas B; Rejesk WJ; Williams JP; Xia A; Albertson BG; Barton ER; Booth FW; Caputo T; Cicha M; De Sousa LGO; Farrar R; Hevener AL; Hirshman MF; Jackson BE; Ke BG; Kramer KS; Lessard SJ; Makarewicz NS; Marshall AG; Nigro P; Powers S; Ramachandran K; Recto RS; Richards CZ-T; Thyfault J; Yan Z; Zang C; Amper MAS; Balci AT; Chavez C; Chikina M; Chiu R; Gritsenko MA; Guevara K; Hansen JR; Hennig KM; Hung C-J; Hutchinson-Bunch C; Jin CA; Liu X; Maner-Smith KM; Mani DR; Marjanovic N; Monroe ME; Moore RJ; Moore SG; Mundorff CC; Nachun D; Nestor MD; Nudelman G; Pearce C; Petyuk VA; Pincas H; Ramos I; Raskind AS; Rirak S; Robbins JM; Rubenstein AB; Ruf-Zamojski F; Sagendorf TJ; Seenarine N; Soni T; Uppal K; Vangeti S; Vasoya M; Vornholt A; Walsh MJ; Yu X; Zaslavsky E; Zebarjadi N; Bamman M; Bergman BC; Bessesen DH; Buford TW; Chambers TL; Coen PM; Cooper D; Haddad F; Gadde K; Goodpaste BH; Harris M; Huffman KM; Jankowsk CM; Johannsen NM; Kohr WM; Kraus WE; Lester B; Melanson EL; Moreau KL; Musi N; Newton RLJ; Radom-Aizik S; Ramaker ME; Rankinen T; Rasmussen BB; Ravussin E; Schauer IE; Schwartz RS; Sparks LM; Thalacker-Mercer A; Trappe S; Trappe TA; Volpi E
  • Journal article: PHYSIOLOGY. 2024;39:1914
    Lindholm ME; Zhen J; Amar D; Gay NR; Beltran PMJ
  • Journal article: NATURE COMMUNICATIONS. 2024;15(1):3346
    Vetr NG; Gay NR; Adkins JN; Montgomery SB
  • Article: NATURE METABOLISM. 2024;6(5):963-979
    Many GM; Sanford JA; Sagendorf TJ; Hou Z; Nigro P; Whytock KL; Amar D; Caputo T; Gay NR; Gaul DA; Hirshman MF; Jimenez-Morales D; Lindholm ME; Muehlbauer MJ; Vamvini M; Bergman BC; Fernandez FM; Goodyear LJ; Hevener AL; Ortlund EA; Sparks LM; Xia A; Adkins JN; Bodine SC; Newgard CB; Schenk S; Adkins JN; Armenteros JJA; Amar D; Amper MAS; Ashley E; Asokan AK; Avila-Pacheco J; Bae D; Bamman MM; Bararpour N; Barnes J; Bergman BC; Bodine SC; Buford TW; Burant CF; Caputo T; Carbone NP; Carr SA; Chambers TL; Chavez C; Chiu R; Clish CB; Cutter GR; Dasari S; Dennis C; Evans CR; Fernandez FM; Gagne N; Gaul DA; Gay NR; Ge Y; Goodpaster BH; Goodyear LJ; Gritsenko MA; Hansen JR; Hennig KM; Hevener AL; Hirshman MF; Hou Z; Huffman KM; Hung C-J; Hutchinson-Bunch C; Ilkayeva O; Ivanova AA; Beltran PMJ; Jimenez-Morales D; Jin CA; Kachman MT; Keshishian H; Kraus WE; Lanza I; Lester B; Li JZ; Lindholm ME; Lira AK; Liu X; Maner-Smith KM; Many GM; May S; Monroe MR; Montgomery S; Moore RJ; Moore SG; Muehlbauer MJ; Nachun D; Nair KS; Nair V; Raja AN; Nestor MD; Newgard CB; Nigro P; Nudelman G; Ortlund EA; Petyuk VA; Piehowski PD; Pincas H; Qian W-J; Raskind A; Rasmussen BB; Rooney JL; Rushing S; Sagendorf TJ; Samdarshi M; Sanford JA; Schenk S; Sealfon SC; Smith KS; Smith GR; Snyder M; Sparks LM; Stowe CL; Talton JW; Teng C; Thalacker-Mercer A; Tracy R; Trappe TA; Vamvini M; Vasoya M; Vetr NG; Volpi E; Walkup MP; Walsh MJ; Wheeler MT; Whytock KL; Wu S; Xia A; Zaslavsky E; Zebarjadi N; Zhang T; Zhao B; Zhen J
  • Article: ISCIENCE. 2024;27(1):108638
    Emanuelsson EB; Arif M; Reitzner SM; Perez S; Lindholm ME; Mardinoglu A; Daub C; Sundberg CJ; Chapman MA
  • Article: AGING CELL. 2024;23(1):e13859
    Voisin S; Seale K; Jacques M; Landen S; Harvey NR; Haupt LM; Griffiths LR; Ashton KJ; Coffey VG; Thompson J-LM; Doering TM; Lindholm ME; Walsh C; Davison G; Irwin R; McBride C; Hansson O; Asplund O; Heikkinen AE; Piirila P; Pietilainen KH; Ollikainen M; Blocquiaux S; Thomis M; Dawn CK; Sharples AP; Eynon N
  • Article: ANTIOXIDANTS. 2023;12(12):2043
    Kjellberg A; Lindholm ME; Zheng X; Liwenborg L; Rodriguez-Wallberg KA; Catrina S-B; Lindholm P
  • Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2021;14(6):e003419
    Lindholm ME; Jimenez-Morales D; Zhu H; Seo K; Amar D; Zhao C; Raja A; Madhvani R; Abramowitz S; Espenel C; Sutton S; Caleshu C; Berry GJ; Motonaga KS; Dunn K; Platt J; Ashley EA; Wheeler MT
  • Article: NATURE COMMUNICATIONS. 2021;12(1):3471
    Amar D; Lindholm ME; Norrbom J; Wheeler MT; Rivas MA; Ashley EA
  • Show more

All other publications

  • Preprint: BIORXIV. 2025;BIORXIV
    Smith GR; Zhao B; Lindholm ME; Raja A; Viggars M; Pincas H; Gay NR; Sun Y; Ge Y; Nair VD; Sanford JA; Amper MAS; Vasoya M; Smith KS; Montgomery S; Zaslavsky E; Bodine SC; Esser KA; Walsh MJ; Snyder MP; Sealfon SC; MoTrPAC Study Group
  • Preprint: BIORXIV. 2025;BIORXIV
    Kelty TJ; Franczak E; Gay NR; Many GM; Sagendorf TJ; Sanford JA; Hou Z; Gaul DA; Fern谩ndez FM; Burant C; Hevener AL; Adkins JN; Bodine S; Lindholm ME; Ortlund EA; Schenk S; Thyfault JP; Rector RS
  • Preprint: BIORXIV. 2025
    Many G; Sagendorf T; Mitchell H; Sanford J; Cohen S; Misra R; Estevao I; Ludovico ID; Gaul D; Lindholm M; Ushakumary M; Pino J; Musi N; Nie J; Fern谩ndez F; Ortlund E; Esser K; Bodine S; Schenk S; Clair G; Adkins J; The MoTrPAC Study Group
  • Review: PHYSIOLOGY. 2025;40(2):0-202
    Katz DH; Lindholm ME; Ashley EA
  • Preprint: MEDRXIV. 2024
    Ormond K; Stanclift C; Reuter C; Carter J; Murphy K; Lindholm M; Wheeler M
  • Conference publication: PHYSIOLOGY. 2024;39:646
    Emanuelsson E; Arif M; Reitzner S; Perez S; Lindholm M
  • Preprint: BIORXIV. 2023;BIORXIV
    Many GM; Sanford JA; Sagendorf TJ; Hou Z; Nigro P; Whytock K; Amar D; Caputo T; Gay NR; Gaul DA; Hirshman M; Jimenez-Morales D; Lindholm ME; Muehlbauer MJ; Vamvini M; Bergman B; Fern Ndez FM; Goodyear LJ; Ortlund EA; Sparks LM; Xia A; Adkins JN; Bodine SC; Newgard CB; Schenk S; MoTrPAC Study Group
  • Preprint: BIORXIV. 2023;BIORXIV
    Amar D; Gay NR; Jimenez-Morales D; Beltran PMJ; Ramaker ME; Raja AN; Zhao B; Sun Y; Marwaha S; Gaul D; Hershman SG; Xia A; Lanza I; Fernandez FM; Montgomery SB; Hevener AL; Ashley EA; Walsh MJ; Sparks LM; Burant CF; Rector RS; Thyfault J; Wheeler MT; Goodpaster BH; Coen PM; Schenk S; Bodine SC; Lindholm ME; MoTrPAC Study Group
  • Preprint: BIORXIV. 2022
    Voisin S; Seale K; Jacques M; Landen S; Harvey NR; Haupt LM; Griffiths LR; Ashton KJ; Coffey VG; Thompson J-LM; Doering TM; Lindholm ME; Walsh C; Davison G; Irwin R; McBride C; Hansson O; Asplund O; Heikkinen AE; Piiril盲 P; Pietil盲inen KH; Ollikainen M; Blocquiaux S; Thomis M; Coletta DK; Sharples AP; Eynon N
  • Preprint: BIORXIV. 2022
    Group MS; Amar D; Gay NR; Beltran PMJ; Adkins JN; Armenteros JJA; Ashley E; Avila-Pacheco J; Bae D; Bararpour N; Burant C; Clish C; Cutter G; Dasari S; Dennis C; Evans CR; Fern谩ndez FM; Gaul D; Ge Y; Gerszten R; Goodyear LJ; Hou Z; Ilkayeva O; Ivanova AA; Jimenez-Morales D; Kachman MT; Keshishian H; Kraus WE; Lanza IR; Li J; Lindholm ME; Lira AC; Many GM; Marwaha S; Miller ME; Muehlbauer MJ; Nair KS; Nair VD; Raja AN; Newgard C; Ortlund EA; Piehowski PD; Presby DM; Qian W-J; Rooney JL; Sanford JA; Savage E; Sealfon SC; Smith GR; Smith KS; Steep A; Stowe CL; Sun Y; Tracy R; Vetr NG; Walsh MJ; Wu S; Zhang T; Zhao B; Zhen J; Albertson BG; Amper MAS; Balci AT; Bamman M; Barton ER; Bergman B; Bessesen D; Booth F; Bouverat B; Buford TW; Caputo T; Chambers TL; Chavez C; Chikina M; Chiu R; Cicha M; Coen PM; Cooper D; Cornell E; Dalton KP; De Sousa LO; Farrar R; Gadde K; Gagne N; Goodpaster BH; Gritsenko MA; Guevara K; Haddad F; Hansen JR; Harris M; Hastie T; Hennig KM; Hershman SG; Hevener A; Hirshman MF; Hsu F-C; Huffman KM; Hung C-J; Hutchinson-Bunch C; Jackson BE; Jankowski C; Jin CA; Johannsen NM; Ke BG; Kohrt WM; Kramer KS; Leeuwenburgh C; Lessard SJ; Lester B; Liu X; Lu C-J; Makarewicz NS; Maner-Smith KM; Mani; Marjanovic N; Marshall A; May S; Melanson E; Monroe ME; Moore RJ; Moore S; Moreau KL; Mundorff CC; Musi N; Nachun D; Nestor MD; Newton RL; Nicklas B; Nigro P; Nudelman G; Pahor M; Pearce C; Petyuk VA; Pincas H; Powers S; Radom-Aizik S; Ramachandran K; Ramaker ME; Ramos I; Rankinen T; Raskind A; Rasmussen BB; Ravussin E; Rector RS; Rejeski WJ; Richards C; Rirak S; Robbins JM; Rubenstein AB; Ruf-Zamojski F; Rushing S; Sagendorf TJ; Samdarshi M; Schauer IE; Schwartz R; Seenarine N; Soni T; Sparks LM; Teng C; Thalacker-Mercer A; Thyfault J; Tibshirani R; Trappe S; Trappe TA; Uppal K; Vangeti S; Vasoya M; Volpi E; Vornholt A; Walkup MP; Williams J; Xia A; Yan Z; Yu X; Zang C; Zaslavsky E; Zebarjadi N; Bodine SC; Carr S; Esser K; Montgomery SB; Schenk S; Snyder MP; Wheeler MT
  • Conference publication: ACTA PHYSIOLOGICA. 2022;236:57
    Lindholm ME
  • Preprint: BIORXIV. 2020
    Lindholm M; Jimenez-Morales D; Zhu H; Seo K; Amar D; Zhao C; Raja A; Madhvani R; Espenel C; Sutton S; Caleshu C; Berry G; Motonaga K; Dunn K; Platt J; Ashley E; Wheeler M
  • Conference publication: CIRCULATION. 2020;142(Suppl_3)
    Lindholm ME; Zhu H; Seo K; Jimenez-Morales D; Zhao C; Ashley EA; Wheeler MT
  • Conference publication: CIRCULATION. 2020;142
    Lindholm ME; Zhu H; Seo K; Jimenez-Morales D; Zhao C; Ashley EA; Wheeler MT
  • Review: CELL. 2020;181(7):1464-1474
    Sanford JA; Nogiec CD; Lindholm ME; Adkins JN; Amar D; Dasari S; Drugan JK; Fernandez FM; Radom-Aizik S; Schenk S; Snyder MP; Tracy RP; Vanderboom P; Trappe S; Walsh MJ
  • Preprint: BIORXIV. 2019
    Amar D; Lindholm M; Norrbom J; Wheeler M; Rivas M; Ashley E
  • Preprint: BIORXIV. 2019
    Voisin S; Harvey NR; Haupt LM; Griffiths LR; Ashton KJ; Coffey VG; Doering TM; Thompson JM; Benedict C; Cedernaes J; Lindholm ME; Craig JM; Rowlands DS; Sharples AP; Horvath S; Eynon N
  • Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1310
    Lindholm ME; Zhu H; Huang Y; Ashley EA; Wheeler M
  • Conference publication: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2019;73(9):1027
    Lindholm M; Zhu H; Huang Y; Ashley EA; Wheeler M
  • Preprint: SSRN ELECTRONIC JOURNAL. 2019
    Amar D; Lindholm ME; Norrbom J; Wheeler MT; Rivas M; Ashley EA
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Grants

  • National Heart Lung and Blood Institute
    1 July 2022 - 31 August 2024
  • Swedish Research Council
    1 January 2019 - 31 December 2021

Employments

  • Affiliated to Research, Department of Physiology and Pharmacology, 探花精选, 2023-2026

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Physiology and Pharmacology, 探花精选, 2015
  • Master Of Medical Science, 探花精选, 2009

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