̽»¨¾«Ñ¡

Onur Dagliyan

Onur Dagliyan

Assistant Professor
Visiting address: Solnavägen 9, 17177 Stockholm
Postal address: C2 Medicinsk biokemi och biofysik, C2 Molekylär neurobiologi Dagliyan, 171 77 Stockholm
Part of:

About me

  • Title: Assistant Professor

    Education & Training
    Research fellow in the laboratory of Michael Greenberg, Harvard Medical School, Boston, USA. Specialization: Molecular neurobiology
    Ph.D. in Biochemistry and Biophysics, UNC School of Medicine, Chapel Hill, USA. Specialization: Protein signaling and engineering
    B.S, and M.S. in Chemical and Biological Engineering, Koç University, Istanbul. Specialization: Machine learning, drug screening, molecular clock


    Grants&Awards:
    European Research Council (ERC) Starting Grant
    Swedish Research Council (Vetenskapsrådet) Svenska Sällskapet för Medicinsk Forskning (SSMF)
    The Swedish Brain Foundation (Hjärnfonden)
    The Strategic Research Area Neuroscience (StratNeuro)
    ̽»¨¾«Ñ¡ Allocation GrantGoldenson Fellow 2020
    William Randolph Hearst Fund 2019-2020
    Alice and Joseph Brooks Postdoctoral Fellowship 2017-2018
    Advanced imaging certificate from Max Planck Institute of Neuroscience 2017
    UNC Lineberger Graduate Fellow of the Year 2014
    Howard Hughes Medical Institute Predoctoral Fellowship 2012-2015
    National Science Foundation- Materials Computation Center Travel Award 2012
    Director’s Award from the Biological and Bio̽»¨¾«Ñ¡ Sciences Program, UNC 2010

Research

  • Current Interest: Molecular neurobiology, neural circuits, neuronal plasticity, protein engineering, biosensors, molecular optogenetics, extrinsic order and disorder

    Lab website: /en/research/groups/dagliyan-lab
    Twitter:
    Google Scholar: ;hl=en

Teaching

  • Lecturer, “Neuronal circuits for appetite, food intake and satiety“, Karolinska  Institutet, 2022-
    Lecturer, “Protein Structure“, ̽»¨¾«Ñ¡, 2022-
    Lecturer, “DNA and RNA Structure“, ̽»¨¾«Ñ¡, 2022-
    Lecturer, “Introduction to biochemistry: Metabolism“, Karolinska
    Institutet, 2022-
    Teaching assistant, Macromolecular Equilibria course, 2012
    Teaching assistant, Chemical and Biological Engineering Senior Project
    course, 2009
    Teaching assistant, Process Design course, 2008

Articles

  • Journal article: NATURE NEUROSCIENCE. 2024;27(12):2267-2268
    Ernfors P; Castelo-Branco G; Uhlen P; Linnarsson S; Marklund U; Hjerling-Leffler J; Dagliyan O
  • Article: SCIENCE ADVANCES. 2023;9(46):eadh1110
    Ripoli C; Dagliyan O; Renna P; Pastore F; Paciello F; Sollazzo R; Rinaudo M; Battistoni M; Martini S; Tramutola A; Sattin A; Barone E; Saneyoshi T; Fellin T; Hayashi Y; Grassi C
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(2):917
    Pastore F; Battistoni M; Sollazzo R; Renna P; Paciello F; Li Puma DD; Barone E; Dagliyan O; Ripoli C; Grassi C
  • Journal article: BIOENGINEERING & TRANSLATIONAL MEDICINE. 2022;7(2):e10292
    Renna P; Ripoli C; Dagliyan O; Pastore F; Rinaudo M; Re A; Paciello F; Grassi C
  • Article: NATURE COMMUNICATIONS. 2022;13(1):430
    Cakir B; Tanaka Y; Kiral FR; Xiang Y; Dagliyan O; Wang J; Lee M; Greaney AM; Yang WS; DuBoulay C; Kural MH; Patterson B; Zhong M; Kim J; Bai Y; Min W; Niklason LE; Patra P; Park I-H
  • Article: CELL. 2021;184(22):5670-5685.e23
    Liu B; Stone OJ; Pablo M; Herron JC; Nogueira AT; Dagliyan O; Grimm JB; Lavis LD; Elston TC; Hahn KM
  • Article: NATURE. 2021;590(7844):115-121
    Yap E-L; Pettit NL; Davis CP; Nagy MA; Harmin DA; Golden E; Dagliyan O; Lin C; Rudolph S; Sharma N; Griffith EC; Harvey CD; Greenberg ME
  • Article: NATURE METHODS. 2020;17(9):928-936
    Wu HD; Kikuchi M; Dagliyan O; Aragaki AK; Nakamura H; Dokholyan NV; Umehara T; Inoue T
  • Article: CELL REPORTS. 2020;31(11):107764
    Ozkan-Dagliyan I; Diehl JN; George SD; Schaefer A; Papke B; Klotz-Noack K; Waters AM; Goodwin CM; Gautam P; Pierobon M; Peng S; Gilbert TSK; Lin KH; Dagliyan O; Wennerberg K; Petricoin EF; Tran NL; Bhagwat SV; Tiu RV; Peng S-B; Herring LE; Graves LM; Sers C; Wood KC; Cox AD; Der CJ
  • Article: CURRENT OPINION IN STRUCTURAL BIOLOGY. 2019;57:17-22
    Dagliyan O; Hahne KM
  • Article: NATURE PROTOCOLS. 2019;14(6):1863-1883
    Dagliyan O; Dokholyan NV; Hahn KM
  • Article: NATURE COMMUNICATIONS. 2018;9(1):4042
    Dagliyan O; Krokhotin A; Ozkan-Dagliyan I; Deiters A; Der CJ; Hahn KM; Dokholyan NV
  • Article: PLOS COMPUTATIONAL BIOLOGY. 2018;14(8):e1006321
    Ma X; Dagliyan O; Hahn KM; Danuser G
  • Article: ACS SYNTHETIC BIOLOGY. 2017;6(7):1257-1262
    Dagliyan O; Karginov AV; Yagishita S; Gale ME; Wang H; DerMardirossian C; Wells CM; Dokholyan NV; Kasai H; Hahn KM
  • Article: SCIENCE. 2016;354(6318):1441-1444
    Dagliyan O; Tarnawski M; Chu P-H; Shirvanyants D; Schlichting I; Dokholyan NV; Hahn KM
  • Article: NATURE CHEMICAL BIOLOGY. 2016;12(10):802-809
    Hodgson L; Spiering D; Sabouri-Ghomi M; Dagliyan O; DerMardirossian C; Danuser G; Hahn KM
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(8):3682-3692
    Shobair M; Dagliyan O; Kota P; Dang YL; He H; Stutts MJ; Dokholyan NV
  • Article: JOURNAL OF MOLECULAR BIOLOGY. 2014;426(10):2082-2097
    Furukawa Y; Teraguchi S; Ikegami T; Dagliyan O; Jin L; Hall D; Dokholyan NV; Namba K; Akira S; Kurosaki T; Baba Y; Standley DM
  • Article: BIOCHEMISTRY. 2013;52(40):7082-7090
    Freeman TCJ; Black JL; Bray HG; Dagliyan O; Wu YI; Tripathy A; Dokholyan NV; Leisner TM; Parise LV
  • Article: CHEMISTRY AND BIOLOGY. 2013;20(6):847-856
    Kummer L; Hsu C-W; Dagliyan O; MacNevin C; Kaufholz M; Zimmermann B; Dokholyan NV; Hahn KM; Plueckthun A
  • Show more

All other publications

  • Preprint: BIORXIV. 2025
    Lyu G; Garcia-Swinburn R; Kreutzmann J; Xiong A; Kojima R; Abaurre C; Tremolanti C; Gellhaar S; Uhlén P; Svenningsonn P; Castelo-Branco G; Dagliyan O; Salto C; Arenas E
  • Dataset: 2016
    Dokholyan N; Dagliyan O
  • Dataset: 2014
    Dokholyan N; Dagliyan O
  • Dataset: 2014
    Dokholyan N; Dagliyan O
  • Review: JOURNAL OF MOLECULAR CELL BIOLOGY. 2014;6(2):104-115
    Redler RL; Shirvanyants D; Dagliyan O; Ding F; Kim DN; Kota P; Proctor EA; Ramachandran S; Tandon A; Dokholyan NV

Grants

  • Swedish Research Council
    1 January 2022 - 31 December 2025
    Upon the arrival of stimuli with new experiences, neuronal circuits regulate a large set of molecular adaptation programs at the DNA, RNA, and protein levels to store the necessary information and to perform computations. Many of these molecular events have been shown to be involved in the excitation of neuronal circuits responsible for a particular behavior, learning ability, and memory. However an activated neuronal circuit has to be balanced with inhibitory events, and the molecular mechanisms of such inhibition are mostly unknown. This excitatory-inhibitory balance is particularly important to develop innovative therapeutic approaches for brain disorders including epilepsy, depression, schizophrenia, autism, and learning disorders. The two-third of my research program here will unravel two molecular mechanisms by which the inhibitory arm of the excitatory-inhibitory balance is established. The last part of the research program will focus on the development of technologies that enable the building of causal links between the spatiotemporal role of a protein and neuronal circuits. Overall this research program will allow us to better understand sensory-experience dependent circuit modulations at the molecular level and will pave the way to develop new therapeutic approaches for brain disorders.

Employments

  • Research Fellow, Neurobiology, Department of Neurobiology, Harvard Medical School, 2016-
  • Assistant Professor, Department of Medical Biochemistry and Biophysics, ̽»¨¾«Ñ¡, 2022-2028

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