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Phillip Newton

Phillip Newton

Principal Researcher
Visiting address: BioMedicum A4, Solnav盲gen 9, 17165 Solna
Postal address: K6 Kvinnors och barns h盲lsa, K6 Barnonkologi och Barnkirurgi Blomgren Newton, 171 77 Stockholm
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About me

  • I read Biochemistry as an undergraduate at University College London, and
    have been studying long-bone growth since 2012 when I began my PhD at the
    University of Manchester and Roslin Institute (Edinburgh, UK). I then moved
    to Karolinska Institute and conducted postdoctoral research with Asst.
    Professor Andrei Chagin (Department of Physiology and Pharmacology), during
    which time I was also associated with Prof. Lars S盲vendahl's lab (Department
    of Women's and Children's Health). Since January 2020, I moved to the
    Department of Women's and Children's Health where I have started working as a
    principle investigator in the group of Prof. Klas Blomgren.
    Harold M. Frost Young Investigator Award (2019)
    American Society for Bone and Mineral Research Young Investigator Award
    (2016)

Research

  • Until we reach our adult height, our long-bones are being continuously
    lengthened because of the activity of narrow discs of cartilage in our
    long-bones, called growth plates. Growth plates are very interesting tissues.
    Each growth plate is made up of highly organised columns of cells
    (chondrocytes), in which the last cell in the column is continually removed
    and replaced by bone tissue. This process must be very tightly controlled so
    that our bones continue to grow in proportion to each other and so that we
    grow similarly to our peers. Long-bone growth is important as it ultimately
    determines how tall we become.
    My research aims to understand the fundamental aspects of long-bone growth at
    the cellular level and to unravel the signaling pathways controlling this
    process. By coupling clinical samples with basic research at the lab bench we
    endeavour to have a patient-oriented approach.
    *Selected publications:*
    *(1)* A radical switch in clonality reveals a stem cell niche in the
    epiphyseal growth plate.
    Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, Sun X, Sandhow
    L, Artemov AV, Ivashkin E, Suter S, Dyachuk V, El Shahawy M, Gritli-Linde A,
    Bouderlique T, Petersen J, Mollbrink A, Lundeberg J, Enikolopov G, Qian H,
    Fried K, Kasper M, Hedlund E, Adameyko I, S盲vendahl L, Chagin AS;
    /Nature/ 567(7747):234-238 (2019)* *
    *(2)* Superficial cells are self-renewing chondrocyte progenitors, which form
    the articular cartilage in juvenile mice.
    Li L*, Newton PT*, Bouderlique T, Sejnohova M, Zikmund T, Kozhemyakina E, Xie
    M, Krivanek J, Kaiser J, Qian H, Dyachuk V, Lassar AB, Warman ML, Barenius B,
    Adameyko I, Chagin AS;
    /FASEB// /31(3):1067-1084/ /(2016)
    *(3)* Pharmacological inhibition of lysosomes activates the mTORC1 signaling
    pathway in chondrocytes in an autophagy-independent manner.
    Newton PT*, Vuppalapati KK*, Bouderlique T, Chagin AS;
    /Autophagy/ 11(9):1594-607 (2015)
    *(4)* Clonal Genetic Tracing using the Confetti Mouse to Study Mineralized
    Tissues.
    Zhou B, Kaucka M, Chagin AS, Newton PT;
    /J. Vis. Exp./ (152), e60424, doi:10.3791/60424 (2019)
    *(5)* New insights into niclosamide action: autophagy activation in
    colorectal cancer (Commentary).
    Newton PT;
    /Biochem J/. 476(5):779-781 (2019)
    *(6)* Chondrogenic ATDC5 cells: an optimised model for rapid and
    physiological matrix mineralization.
    Newton PT*, Staines KA*, Spevak L, Boskey AL, Teixeira CC, Macrae VE,
    Canfield AE, Farquharson C;
    /Int J Mol Med/ 30(5):1187-93 (2012)
    *(7)* Novel KIAA0753 mutations extend the phenotype of skeletal ciliopathies.
    Hammarsj枚 A, Wang Z, Vaz R, Taylan F, Sedghi M, Girisha KM, Chitayat D,
    Neethukrishna K, Godoy R, Gowrishankar K, Lindstrand A, Nasiri J, Baktashian
    M, Newton PT, Guo L, Hofmeister W, Petterson M, Chagin AS, Nishimura G, Yan
    L, Matsumoto N, Shannon P, Nordgren A, Miyake N, Grigelioniene G, Ikegawa S;
    /Scientific Reports/ 7(1):15585 (2017)
    * denotes shared first authorship.

Articles

  • Article: BONE. 2024;188:117223
    Rathod B; Desai S; Samvelyan HJ; Bock L; Wu J; Ohlsson C; Palmquist A; Alm JJ; Newton PT; Andersson G; Windahl SH
  • Article: JOURNAL OF EXTRACELLULAR BIOLOGY. 2024;3(9):1-16
    Marchan-脕lvarez JG; Teeuwen L; Mamand D; Gabrielsson S; Blomgren K; Wiklander O; Newton P
  • Journal article: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2024;24:s181
    Sudupe L; Muinos-L贸pez E; L贸pez-P茅rez AR; Vilas-Zornoza A; Sarvide S; Ripalda-Cemborain P; Aguirre-Ruiz P; San Mart铆n-Uriz P; Larrayoz M; Alvarez-Gigli L; Abengozar M; Cenzano I; Cocera M; Ye J; Lagani V; Paiva B; Newton PT; Tegner J; Saez B; Martinez-Climent JA; Calvo IA; Gomez-Cabrero D; Pr贸sper F
  • Article: NATURE COMMUNICATIONS. 2024;15(1):2367
    Xie M; Kaiser M; Gershtein Y; Schnyder D; Deviatiiarov R; Gazizova G; Shagimardanova E; Zikmund T; Kerckhofs G; Ivashkin E; Batkovskyte D; Newton PT; Andersson O; Fried K; Gusev O; Zeberg H; Kaiser J; Adameyko I; Chagin AS
  • Journal article: BLOOD. 2023;142:4076
    Sudupe L; Muinos-Lopez E; Calvo IA; Rosa Lopez-Perez A; Vilas-Zornoza A; Sarvide S; Ripalda-Cemborain P; Bantan A; Ye J; Lagani V; Aguirre-Ruiz P; San-Martin P; Cenzano I; Larrayoz M; Alvarez-Gigli L; Abengozar-Muela M; Saez-Ochoa B; Newton PT; Tegner J; Paiva B; Martinez-Climent JAA; Gomez-Cabrero D; Prosper F
  • Article: NATURE COMMUNICATIONS. 2023;14(1):509
    Mirzazadeh R; Andrusivova Z; Larsson L; Newton PT; Galicia LA; Abalo XM; Avijgan M; Kvastad L; Denadai-Souza A; Stakenborg N; Firsova AB; Shamikh A; Jurek A; Schultz N; Nister M; Samakovlis C; Boeckxstaens G; Lundeberg J
  • Article: NATURE COMMUNICATIONS. 2022;13(1):6949
    Kaucka M; Araus AJ; Tesarova M; Currie JD; Bostrom J; Kavkova M; Petersen J; Yao Z; Bouchnita A; Hellander A; Zikmund T; Elewa A; Newton PT; Fei J-F; Chagin AS; Fried K; Tanaka EM; Kaiser J; Simon A; Adameyko I
  • Journal article: BONE REPORTS. 2022;16:101360
    Azar YM; S盲vendahl L; Blomgren K; Newton PT
  • Article: ELIFE. 2020;9:e55212
    Xie M; Gol'din P; Herdina AN; Estefa J; Medvedeva EV; Li L; Newton PT; Kotova S; Shavkuta B; Saxena A; Shumate LT; Metscher BD; Grossschmidt K; Nishimori S; Akovantseva A; Usanova AP; Kurenkova AD; Kumar A; Arregui IL; Tafforeau P; Fried K; Carlstrom M; Simon A; Gasser C; Kronenberg HM; Bastepe M; Cooper KL; Timashev P; Sanchez S; Adameyko I; Eriksson A; Chagin AS
  • Journal article: BONE REPORTS. 2020;13:100663
    Xie M; Li L; Newton P; Shumate L; Nishimori S; Kronenberg H; Bastepe M; Adameyko I; Chagin A
  • Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2020;217(3):e20191306
    Chen Y-H; Grigelioniene G; Newton PT; Gullander J; Elfving M; Hammarsjo A; Batkovskyte D; Alsaif HS; Kurdi WIY; Abdulwahab F; Shanmugasundaram V; Devey L; Bacrot S; Brodszki J; Huber C; Hamel B; Gisselsson D; Papadogiannakis N; Jedrycha K; Gurtl-Lackner B; Chagin AS; Nishimura G; Aschenbrenner D; Alkuraya FS; Laurence A; Cormier-Daire V; Uhlig HH
  • Article: REDOX BIOLOGY. 2020;28:101387
    Peleli M; Ferreira DMS; Tarnawski L; Haworth SM; Xuechen L; Zhuge Z; Newton PT; Massart J; Chagin AS; Olofsson PS; Ruas JL; Weitzberg E; Lundberg JO; Carlstrom M
  • Journal article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2019;(152)
    Zhou B; Kaucka M; Chagin AS; Newton PT
  • Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2019;(152)
    Zhou B; Kaucka M; Chagin AS; Newton PT
  • Article: NATURE. 2019;567(7747):234-238
    Newton PT; Li L; Zhou B; Schweingruber C; Hovorakova M; Xie M; Sun X; Sandhow L; Artemov AV; Ivashkin E; Suter S; Dyachuk V; El Shahawy M; Gritli-Linde A; Bouderlique T; Petersen J; Mollbrink A; Lundeberg J; Enikolopov G; Qian H; Fried K; Kasper M; Hedlund E; Adameyko I; Savendahl L; Chagin AS
  • Article: BRITISH JOURNAL OF ANAESTHESIA. 2019;122(3):350-360
    Yang T; Xu G; Newton PT; Chagin AS; Mkrtchian S; Carlstrom M; Zhang X-M; Harris RA; Cooter M; Berger M; Maddipati KR; Akassoglou K; Terrando N
  • Article: BONE REPORTS. 2018;8:64-71
    Newton PT; Xie M; Medvedeva EV; S盲vendahl L; Chagin AS
  • Article: SCIENTIFIC REPORTS. 2017;7(1):15585
    Hammarsjo A; Wang Z; Vaz R; Taylan F; Sedghi M; Girisha KM; Chitayat D; Neethukrishna K; Shannon P; Godoy R; Gowrishankar K; Lindstrand A; Nasiri J; Baktashian M; Newton PT; Guo L; Hofmeister W; Pettersson M; Chagin AS; Nishimura G; Yan L; Matsumoto N; Nordgren A; Miyake N; Grigelioniene G; Ikegawa S
  • Article: ELIFE. 2017;6:e25902
    Kaucka M; Zikmund T; Tesarova M; Gyllborg D; Hellander A; Jaros J; Kaiser J; Petersen J; Szarowska B; Newton PT; Dyachuk V; li L; Qian H; Johansson A-S; Mishina Y; Currie JD; Tanaka EM; Erickson A; Dudley A; Brismar H; Southam P; Coen E; Chen M; Weinstein LS; Hampl A; Arenas E; Chagin AS; Fried K; Adameyko I
  • Article: FASEB JOURNAL. 2017;31(3):1067-1084
    Li L; Newton PT; Bouderlique T; Sejnohova M; Zikmund T; Kozhemyakina E; Xie M; Krivanek J; Kaiser J; Qian H; Dyachuk V; Lassar AB; Warman ML; Barenius B; Adameyko I; Chagin AS
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