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Pontus Plaven Sigray

Pontus Plaven Sigray

Postdoctoral Studies
Visiting address: Akademiska Stråket 1, Bioclinicum, J4-14, 17161 Solna
Postal address: K8 Klinisk neurovetenskap, K8 CPF Varrone, 171 77 Stockholm
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About me

  • My research is primarily focused on developing biomarkers and new treatments for neurodegenerative diseases by applying neuroimaging techniques, such as MRI and PET. Me, my group and my collaborators are currently running the ERAP phase IIa trial (clinicaltrial.gov ID: NCT06022068), where we evaluate the effect of the drug sirolimus/rapamycin on human neurodegeneration and aging.

     

    My work also involves creating and assessing biomarkers of aging that can be used as endpoints in clinical trials of geroprotective compounds. To this end, my group applies machine learning models to large batches of multi-modal imaging data to estimate the biological age of different organ-systems in the human body. 

     

    Team page:

Articles

  • Article: TRIALS. 2024;25(1):648
    Miskowiak KW; Damgaard V; Schandorff JM; Macoveanu J; Knudsen GM; Johansen A; Plaven-Sigray P; Svarer C; Fussing CB; Cramer K; Jørgensen MB; Kessing LV; Ehrenreich H
  • Article: GEROSCIENCE. 2024;46(5):4123-4133
    Doerfel RP; Arenas-Gomez JM; Svarer C; Ganz M; Knudsen GM; Svensson JE; Plaven-Sigray P
  • Article: JOURNAL OF NEUROSCIENCE. 2024;44(33):e1750232024
    Johansen A; Beliveau V; Colliander E; Raval NR; Dam VH; Gillings N; Aznar S; Svarer C; Plaven-Sigray P; Knudsen GM
  • Article: BMC NEUROLOGY. 2024;24(1):111
    Svensson JE; Bolin M; Thor D; Williams PA; Brautaset R; Carlsson M; Sorensson P; Marlevi D; Spin-Neto R; Probst M; Hagman G; Moren AF; Kivipelto M; Plaven-Sigray P
  • Article: HUMAN BRAIN MAPPING. 2023;44(17):6139-6148
    Dorfel RP; Arenas-Gomez JM; Fisher PM; Ganz M; Knudsen GM; Svensson JE; Plaven-Sigray P
  • Article: MOLECULAR PSYCHIATRY. 2023;28(10):4272-4279
    Johansen A; Armand S; Plaven-Sigray P; Nasser A; Ozenne B; Petersen IN; Keller SH; Madsen J; Beliveau V; Moller K; Vassilieva A; Langley C; Svarer C; Stenbaek DS; Sahakian BJ; Knudsen GM
  • Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2023;43(9):1544-1556
    Laurell GL; Plaven-Sigray P; Johansen A; Raval NR; Nasser A; Madsen CA; Madsen J; Hansen HD; Donovan LL; Knudsen GM; Lammertsma AA; Ogden RT; Svarer C; Schain M
  • Article: ADDICTION. 2023;118(6):1053-1061
    Jangard S; Jayaram-Lindstrom N; Isacsson NH; Matheson GJ; Plaven-Sigray P; Franck J; Borg J; Farde L; Cervenka S
  • Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2023;26(4):241-248
    Tangen A; Veldman ER; Svensson J; Tiger M; Nord M; Sorjonen K; Andersson M; Plaven-Sigray P; Varrone A; Halldin C; Varnas K; Borg J; Lundberg J
  • Article: NUCLEAR MEDICINE AND BIOLOGY. 2022;114-115:42-48
    Raval NR; Madsen CA; Shalgunov V; Nasser A; Battisti UM; Beaman EE; Juhl M; Jørgensen LM; Herth MM; Hansen HD; Plavén-Sigray P; Knudsen GM
  • Article: NEUROIMAGE. 2022;263:119620
    Laurell GL; Plaven-Sigray P; Svarer C; Ogden RT; Knudsen GM; Schain M
  • Article: NEUROPSYCHOPHARMACOLOGY. 2022;47(10):1863-1868
    Svensson JE; Tiger M; Plaven-Sigray P; Halldin C; Schain M; Lundberg J
  • Article: MOLECULAR PSYCHIATRY. 2022;27(2):1233-1240
    Plaven-Sigray P; Ikonen Victorsson P; Santillo A; Matheson GJ; Lee M; Collste K; Fatouros-Bergman H; Sellgren CM; Erhardt S; Agartz I; Halldin C; Farde L; Cervenka S
  • Article: FRONTIERS IN NEUROSCIENCE. 2022;16:847074
    Raval NR; Nasser A; Madsen CA; Beschorner N; Beaman EE; Juhl M; Lehel S; Palner M; Svarer C; Plaven-Sigray P; Jorgensen LM; Knudsen GM
  • Article: NPJ SCHIZOPHRENIA. 2021;7(1):46
    Lee M; Fatouros-Bergman H; Plaven-Sigray P; Victorsson PI; Sellgren CM; Erhardt S; Flyckt L; Farde L; Cervenka S
  • Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):264
    Svensson JE; Svanborg C; Plaven-Sigray P; Kaldo V; Halldin C; Schain M; Lundberg J
  • Article: JOURNAL OF NUCLEAR MEDICINE. 2021;62(3):412-417
    Laurell GL; Plaven-Sigray P; Jucaite A; Varrone A; Cosgrove KP; Svarer C; Knudsen GM; Ogden RT; Zanderigo F; Cervenka S; Hillmer AT; Schain M
  • Article: NEUROIMAGE. 2021;226:117523
    Freiburghaus T; Svensson JE; Matheson GJ; Plaven-Sigray P; Lundberg J; Farde L; Cervenka S
  • Article: FRONTIERS IN SYNAPTIC NEUROSCIENCE. 2021;13:715811
    Raval NR; Gudmundsen F; Juhl M; Andersen IV; Speth N; Videbaek A; Petersen IN; Mikkelsen JD; Fisher PM; Herth MM; Plaven-Sigray P; Knudsen GM; Palner M
  • Article: SCHIZOPHRENIA RESEARCH. 2020;222:175-184
    Matheson GJ; Plaven-Sigray P; Louzolo A; Borg J; Farde L; Petrovic P; Cervenka S
  • Show more

All other publications

  • Review: GEROSCIENCE. 2025;:1-17
    Svensson JE; Schain M; Plaven-Sigray P
  • Review: JAMA PSYCHIATRY. 2024;81(5):468-476
    Lee M; Cernvall M; Borg J; Plaven-Sigray P; Larsson C; Erhardt S; Sellgren CM; Fatouros-Bergman H; Cervenka S
  • Review: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(11):2805-2819
    Svensson JE; Schain M; Knudsen GM; Ogden RT; Plaven-Sigray P
  • Letter: BIOLOGICAL PSYCHIATRY. 2021;89(3):e5-e8
    Plaven-Sigray P; Matheson GJ; Coughlin JM; Hafizi S; Laurikainen H; Ottoy J; De Picker L; Rusjan P; Hietala J; Howes OD; Mizrahi R; Morrens M; Pomper MG; Cervenka S
  • Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(1_SUPPL):228-229
    Plaven-Sigray P; Matheson GJ; Coughlin JM; Hafizi S; Laurikainen H; Ottoy J; de'Picker L; Rusjan PM; Hietala J; Howes OD; Mizrahi R; Morrens M; Pomper MG; Cervenka S
  • Letter: NEUROIMAGE. 2020;207:116371
    Svensson JE; Schain M; Plaven-Sigray P; Cervenka S; Tiger M; Nord M; Halldin C; Farde L; Lundberg J
  • Letter: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(2):502-504
    Matheson GJ; Plaven-Sigray P; Tuisku J; Rinne J; Matuskey D; Cervenka S
  • Editorial comment: PSYCHOLOGICAL MEDICINE. 2019;49(10):1624-1628
    Plaven-Sigray P; Cervenka S
  • Corrigendum: PSYCHOLOGICAL MEDICINE. 2019;49(9):1583-1584
    Plaven-Sigray P; Cervenka S
  • Doctoral thesis: 2018
    Sigray PP
  • Review: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 2018;373(1744):20170156
    Farde L; Plaven-Sigray P; Borg J; Cervenka S

Selected grants

  • The search for an aging biomarker: in vivo quantification of age-related proteins using Positron Emission Tomography in humans
    Impetus Longevity Grant

Grants

  • Swedish Research Council - International post-doc grant
    Swedish Research Council
  • Lundbeck Foundation post-doc grant
    Lundbeck Foundation
  • Evaluating the effects of rapamycin treatment in Alzheimer’s disease using positron emission tomography
    Demensförbundet - Demensfonden
  • Evaluating rapamycin treatment in Alzheimer’s disease using positron emission tomography
    Åhlénstiftelsen Medical Research grant
  • Fonden för psykisk hälsa research grant
    Fonden för psykisk hälsa
  • Swedish Society for Medical Research - postdoc stipend
    Swedish Society for Medical Research
  • Evaluating the effects of rapamycin treatment in Alzheimer’s disease using positron emission tomography: a pilot study
    Loo and Hans Osterman Foundation for Medical Research
  • mTOR inhibition as a neuroprotective treatment in Alzheimer’s Disease
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  • mTOR inhibition as a neuroprotective treatment
    Ã…ke Wibergs Stiftelse

Employments

  • Postdoctoral Studies, Department of Clinical Neuroscience, ̽»¨¾«Ñ¡, 2025-2028
  • Postdoctoral Researcher, Department of Clinical Neuroscience, ̽»¨¾«Ñ¡, 2022-2025
  • Postdoc, Neurobiology Research Unit, Copenhagen University Hospital, 2019-2025

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, ̽»¨¾«Ñ¡, 2019
  • Degree Of Master Of Science In Psychology, ̽»¨¾«Ñ¡, 2013

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