探花精选

Sara Garcia Ptacek

Sara Garcia Ptacek

Assistant Professor | Docent
Visiting address: Blickag氓ngen 16, 14152 Huddinge
Postal address: H1 Neurobiologi, v氓rdvetenskap och samh盲lle, H1 Klinisk geriatrik Eriksdotter, 171 77 Stockholm
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About me

  • I am an assistant professor with 50% research activity and work as a
    neurologist at the Cognitive Clinic, Karolinska University Hospital in Solna.
    I conduct registry research with the Swedish Dementia Registry, looking at
    factors to improve diagnosis, care, treatment and outcomes in dementia. I
    also study COVID, particularly in regards to geriatric populations and
    cognitive risks. I collaborate with the European Dementia with Lewy bodies
    (E-DLB) consortium.
    2023 Docent in Neurosciences at 探花精选, Sweden.
    2019 Fellow of the European Board of Neurology (FEBN)
    2017-2020: Postdoctoral fellowship funded by the Swedish Society of Medical
    Research.
    2017 Prize for Clinical Thesis from the Spanish National Royal Academy of
    Medicine
    2015 Excellence prize for PhD thesis from Universidad Complutense de Madrid
    *2015 PhD Thesis. "Dementia: preclinical stages and mortality in Swedish
    cohorts".* Universidad Complutense de Madrid, Spain. Supervisors: Maria Luz
    Cuadrado (Universidad Complutense de Madrid-tutor and thesis director) and
    Maria Eriksdotter (探花精选-thesis director). Cum Laude and
    European Mention.
    [1]
    [1]

Research

  • *Medication repurposing to slow cognitive decline in dementia:*
    Medication repurposing is a cost and time-effective way to discover new
    treatments. Swedish registers are a unique tool to detect medication
    candidates for repurposing. The Swedish Dementia Registry (SveDem) has
    >100000 patients and repeated measures of cognition over time (measured with
    the Mini-Mental State Examination鈥擬MSE), making it perfect to examine
    whether certain medications are associated with less cognitive decline in
    patients with dementia. We propose a study combining traditional cohort
    studies and newer artificial intelligence (machine learning) techniques to
    detect medications associated with slower cognitive decline in patients from
    SveDem. We will test pre-specified hypotheses since we suspect specific
    medications are better candidates to prevent cognitive decline, but we will
    also let the machine learning algorithms explore the data to find
    associations that we do not suspect in advance. Finally, the candidate
    medications will be tested in animal and cellular models to determine the
    mechanisms of their effects.
    *Influence of COVID-19 and the pandemic on care, treatment and cognition of
    persons with dementia in Sweden:*
    The Covid-19 pandemic has impacted the health and livelihood of most people
    worldwide but has disproportionately affected individuals in disadvantaged
    positions. We aim to examine the incidence and consequences of Covid-19 and
    the greater consequences of the pandemic in individuals with dementia. We
    identified individuals with Covid-19 from SmiNet and age, sex and region
    matched controls. Merged registries provided information on socioeconomic
    position in the years before and after Covid-19, social support and care,
    medications, dementia diagnosis and other comorbidities and mortality.
    Because Covid-19 disrupts care in patients with dementia, we use the Swedish
    Dementia Registry (SveDem), to determine how patients with dementia,
    specifically, fared during the pandemic. At present, we are have obtained
    this dataset and are actively seeking funding for this project.

Articles

  • Article: NEUROLOGY. 2025;104(5):e213405
    Mo M; Eriksdotter M; Ajeganova S; Mitra S; Garcia-Ptacek S; Xu H
  • Article: NATURE COMMUNICATIONS. 2025;16(1):2748
    Mijalkov M; Storm L; Zufiria-Gerboles B; Vereb D; Xu Z; Canal-Garcia A; Sun J; Chang Y-W; Zhao H; Gomez-Ruiz E; Passaretti M; Garcia-Ptacek S; Kivipelto M; Svenningsson P; Zetterberg H; Jacobs H; Luedge K; Brunner D; Mehlig B; Volpe G; Pereira JB
  • Article: BMC MEDICINE. 2025;23(1):82
    Mo M; Abzhandadze T; Hoang MT; Sacuiu S; Jurado PG; Pereira JB; Naia L; Kele J; Maioli S; Xu H; Eriksdotter M; Garcia-Ptacek S
  • Article: JOURNAL OF ALZHEIMERS DISEASE. 2025;103(3):931-940
    Grau-Jurado P; Mostafaei S; Xu H; Mo M; Petek B; Kalar I; Naia L; Kele J; Maioli S; Pereira JB; Eriksdotter M; Chatterjee S; Garcia-Ptacek S
  • Article: NEUROLOGY. 2024;103(6):e209751
    Xu H; Eriksdotter M; Garcia-Ptacek S; Ferreira D; Ji D; Bruchfeld A; Xu Y; Carrero JJ
  • Article: BRAIN COMMUNICATIONS. 2024;6(5):fcae290
    Rennie A; Ekman U; Shams S; Ryden L; Samuelsson J; Zettergren A; Kern S; Oppedal K; Blanc F; Hort J; Garcia-Ptacek S; Antonini A; Lemstra AW; Padovani A; Kramberger MG; Rektorova I; Walker Z; Snaedal J; Pardini M; Taylor J-P; Bonanni L; Granberg T; Aarsland D; Skoog I; Wahlund L-O; Kivipelto M; Westman E; Ferreira D
  • Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2024;25(7):105011
    Abzhandadze T; Hoang MT; Mo M; Mostafaei S; Jurado PG; Xu H; Johnell K; Von Euler M; Eriksdotter M; Garcia-Ptacek S
  • Article: SSM-POPULATION HEALTH. 2024;25:101573
    Hoang MT; Kareholt I; Lindgren E; von Koch L; Xu H; Tan ECK; Johnell K; Nagga K; Eriksdotter M; Garcia-Ptacek S
  • Article: JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE. 2024;11(6):1703-1711
    Hoang MT; Jurado PG; Abzhandadze T; Mostafaei S; Mo M; Akerman M; Vestling K; Chen C; Xu H; Eriksdotter M; Garcia-Ptacek S
  • Article: ALZHEIMERS RESEARCH & THERAPY. 2023;15(1):220
    Petek B; Habel H; Xu H; Villa-Lopez M; Kalar I; Hoang MT; Maioli S; Pereira JB; Mostafaei S; Winblad B; Gregoric Kramberger M; Eriksdotter M; Garcia-Ptacek S
  • Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S22)
    Mo M; Xu H; Hoang MT; Jurado PG; Mostafaei S; K氓reholt I; Johnell K; Eriksdotter M; Garcia鈥怭tacek S
  • Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S24)
    Abzhandadze T; Hoang MT; Mostafaei S; von Euler M; Xu H; Eriksdotter M; Garcia鈥怭tacek S; Jurado PG
  • Article: JOURNAL OF ALZHEIMERS DISEASE. 2023;96(2):789-800
    Hoang MT; Kaareholt I; Schon P; von Koch L; Xu H; Tan ECK; Johnell K; Eriksdotter M; Garcia-Ptacek S
  • Article: JAMA NETWORK OPEN. 2023;6(10):e2338080
    Mo M; Zacarias-Pons L; Hoang MT; Mostafaei S; Jurado PG; Stark I; Johnell K; Eriksdotter M; Xu H; Garcia-Ptacek S
  • Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2023;24(9):1381-1388
    Mo M; Xu H; Hoang MT; Jurado PG; Mostafaei S; Kareholt I; Johnell K; Eriksdotter M; Garcia-Ptacek S
  • Article: SCIENTIFIC REPORTS. 2023;13(1):9480
    Mostafaei S; Hoang MT; Jurado PG; Xu H; Zacarias-Pons L; Eriksdotter M; Chatterjee S; Garcia-Ptacek S
  • Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S1)
    Xu H; Garcia鈥怭tacek S; Lindholm B; Eriksdotter M; Carrero JJ
  • Article: BMC NEUROLOGY. 2023;23(1):124
    Thurston C; Bezuidenhout L; Humphries S; Johansson S; von Koch L; Hager CK; Holmlund L; Sundberg CJ; Garcia-Ptacek S; Kwak L; Nilsson M; English C; Conradsson DM
  • Article: ALZHEIMER'S AND DEMENTIA: DIAGNOSIS, ASSESSMENT AND DISEASE MONITORING. 2023;15(1):e12422
    Aye S; Jonsson L; Gustavsson A; Tate A; Ptacek SG; Eriksdotter M
  • Article: KIDNEY INTERNATIONAL. 2023;103(1):166-176
    Xu H; Garcia-Ptacek S; Bruchfeld A; Fu EL; Shori TD; Lindholm B; Eriksdotter M; Carrero JJ
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All other publications

  • Conference publication: CURRENT DEVELOPMENTS IN NUTRITION. 2024;8:103625
    Norgren J; Matton A; Sindi S; Garcia-Ptacek S; Kivipelto M; K氓reholt I
  • Conference publication: ADVANCES IN ALZHEIMER'S DISEASE. 2024
    Secnik J; Xu H; Schwertner E; Hammar N; Alvarsson M; Winblad B; Eriksdotter M; Garcia-Ptacek S; Religa D
  • Conference publication: ALZHEIMERS & DEMENTIA. 2023;19(S22)
    Zhu N; Eriksdotter M; Garcia鈥怭tacek S; Mitra S; Ajeganova S; Carrero JJ; Chang Z; Xu H
  • Conference publication: ALZHEIMERS & DEMENTIA. 2023;19(S21)
    Mostafaei S; Garcia鈥怭tacek S; Zargarzadeh N; Habich A; Eriksdotter M
  • Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2023;38(Supplement_1):gfad063a_5352
    Xu H; Xu Y; Garcia-Ptacek S; Bruchfeld A; Eriksdotter M; Carrero JJ
  • Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2023;38:I99
    Xu H; Xu Y; Garcia-Ptacek S; Bruchfeld A; Eriksdotter M; Carrero JJ
  • Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2022;37(Supplement_3):gfac115.001
    Xu H; Garcia-Ptacek S; Bruchfeld A; Fu E; Shori TD; Lindholm B; Eriksdotter M; Carrero JJ
  • Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2022;37:I847
    Xu H; Garcia-Ptacek S; Bruchfeld A; Fu E; Shori TD; Lindholm B; Eriksdotter M; Carrero JJ
  • Preprint: MEDRXIV. 2021
    Garcia-Ptacek S; Xu H; Annetorp M; Jerlardtz VB; Cederholm T; Engstr枚m M; Kivipelto M; Lundberg LG; Metzner C; Olsson M; Nyvang JS; 脰berg CS; 脜kesson E; Religa D; Eriksdotter M
  • Conference publication: ALZHEIMERS & DEMENTIA. 2021;17(S10)
    Hoang MT; K氓reholt I; von Koch L; Xu H; Secnik J; Religa D; Tan EC; Johnell K; Garcia鈥怭tacek S
  • Conference publication: ALZHEIMERS & DEMENTIA. 2021;17(S10)
    Xu H; Garcia鈥怭tacek S; Eriksdotter M; Carrero JJ
  • Letter: NEUROLOGY. 2021;97(20):967
    Xu H; Garcia-Ptacek S; Lindholm B; Eriksdotter M; Carrero JJ
  • Letter: NEUROLOGY. 2021;97(20):965
    Xu H; Garcia-Ptacek S; Eriksdotter M
  • Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(18):10139
    Loera-Valencia R; Eroli F; Garcia-Ptacek S; Maioli S
  • Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2021;36(Supplement_1):gfab082.0012
    Xu H; Garcia-Ptacek S; Annetorp M; Bruchfeld A; Cederholm T; Johnson P; Kivipelto M; Metzner C; Religa D; Eriksdotter M
  • Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2021;36
    Xu H; Garcia-Ptacek S; Annetorp M; Bruchfeld A; Cederholm T; Johnson P; Kivipelto M; Metzner C; Religa D; Eriksdotter M
  • Conference publication: EPILEPSIA. 2021;62:168
    Hakansson S; Karlander M; Larsson D; Mahamud Z; Garcia-Ptacek S; Zelezniak A; Zelano J
  • Conference publication: ALZHEIMERS & DEMENTIA. 2020;16(S10)
    Secnik J; Xu H; Schwertner E; Hammar N; Alvarsson M; Winblad B; Eriksdotter M; Garcia鈥怭tacek S; Religa D
  • Conference publication: ALZHEIMERS & DEMENTIA. 2020;16(S6)
    Eriksdotter M; Xu H; J枚nsson L; Wimo A; Nordstr枚m P; Garcia鈥怭tacek S
  • Conference publication: ALZHEIMERS & DEMENTIA. 2020;16(S10)
    Xu H; Garcia鈥怭tacek S; Secnik J; Hoang MT; Tan EC; Religa D; Eriksdotter M
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Grants

  • Innovative ways to fight Alzheimer麓s disease: Fluid biomarkers and intracellular therapies
    Private donation from Leif Lundblad Family and others
    1 October 2023 - 30 September 2026
  • Causal inference using Dynamic Bayesian Networks to find medications related to slow cognitive decline in dementia: Studies from the Swedish Dementia Registry
    Loo and Hans Osterman Foundation 2022
    1 July 2022 - 1 July 2023

Employments

  • Assistant Professor, Department of Neurobiology, Care Sciences and Society, 探花精选, 2021-2027

Degrees and Education

  • Docent, 探花精选, 2023

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