探花精选

Simone Tambaro

Simone Tambaro

Senior Research Specialist | Docent
Visiting address: BioClinicum J10:30, Visionsgatan 4, 17164 Solna
Postal address: H1 Neurobiologi, v氓rdvetenskap och samh盲lle, H1 Neurogeriatrik Nilsson, 171 77 Stockholm

About me

  • I have several years of experience in neuroscience and pharmacological research. After completing my bachelor鈥檚 degree in 2001, I began my research career at Neuroscience Scarl, Cagliari University, Italy. I then pursued a Ph.D. in Neuroscience at the University of Cagliari (2007-2010), followed by a postdoctoral position at the University of Southern California, USA (2010-2012). In 2012, I was awarded a Marie Curie Postdoctoral Research Fellowship for the PET-BRAIN project, which I worked on until 2014. I have been working since 2014 and since 2022 in the position of Senior Research Specialist at the Division of Neurogeriatrics at 探花精选. I have established an independent research program focused on identifying new target proteins involved in the biological mechanisms of Alzheimer鈥檚 disease.  Throughout my career, I have secured several national grants (including those from Olle Engkvists Stiftelse, Alzheimerfonden, Demensfonden, and 脜hl茅n-Stiftelsen) as well as international grants from organizations such as the Alzheimer鈥檚 Association.

Research

  • My research is based on characterizing new target proteins involved in the biological bases of Alzheimer's disease. In particular, I am studying the AD
    pathophysiological role of the intramembrane signal peptide peptidase like 2b (SPPL2b). For this purpose, we use the new AD mouse model, the APP-knock-in mouse AppNL-G-F and the SPPL2b deficient mouse line. My research is also concerned with evaluating the role of the endocannabinoidergic system (ECS) in neurological-related disorders and the biological mechanisms by which ECS is involved in neurodegenerative diseases such as AD.


    Funding: 

    Alzheimer麓s Association, Olle Engkvists Stiftelse, Gun & Bertil Stohnes Stiftelse, Demensfonden, Lindh茅s Advokatbyr氓 Stiftelse, 脜hl茅n-stiftelsen, Stiftelsen fo虉r Gamla Tja虉narinnor

    Project team members:

    Jack Badman

    Eileen Mac Sweeney

    Bjorn Bakker

    Wenjun Li

Articles

  • Journal article: ALZHEIMERS & DEMENTIA. 2024;20(Suppl 9):e093828
    Badman J; Chen G; Garcia SP; Nilsson P; Tambaro S
  • Journal article: ALZHEIMERS & DEMENTIA. 2024;20 Suppl 1:e089371
    Badman J; Chen G; Garcia SP; Nilsson P; Tambaro S
  • Journal article: ALZHEIMERS & DEMENTIA. 2024;20 Suppl 1:e089109
    Tambaro S; Solis AM; Tang B; De Oliveira TL; Qin C; Kavsek A; Sj枚lander A; Johnell K; Religa D; Riedel C; Nilsson P; H盲gg S
  • Article: PROGRESS IN NEUROBIOLOGY. 2024;235:102585
    Maccioni R; Travisan C; Badman J; Zerial S; Wagener A; Andrade-Talavera Y; Picciau F; Grassi C; Chen G; Lemoine L; Fisahn A; Jiang R; Fluhrer R; Mentrup T; Schroeder B; Nilsson P; Tambaro S
  • Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S13)
    Mitra S; Gera R; Tambaro S; Nilsson P; Linderoth B; Behbahani H; Darreh鈥怱hori T; Eriksdotter M
  • Journal article: IBRO REPORTS. 2023;15:s447
    Martins F; Chen G; Zhao H; Nilsson P; Tambaro S; Rebelo S
  • Article: ALZHEIMERS RESEARCH & THERAPY. 2023;15(1):137
    Tambaro S; Mitra S; Gera R; Linderoth B; Wahlberg LU; Darreh-Shori T; Behbahani H; Nilsson P; Eriksdotter M
  • Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S1)
    Gera R; Mitra S; Tambaro S; Nilsson P; Eriksdotter M
  • Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S1)
    Tambaro S; Mitra S; Gera R; Linderoth B; Wahlberg L; Behbahani H; Darreh鈥怱hori T; Nilsson P; Eriksdotter M
  • Article: BIOLOGY-BASEL. 2023;12(6):805
    Medina-Vera D; Zhao H; Bereczki E; Rosell-Valle C; Shimozawa M; Chen G; de Fonseca FR; Nilsson P; Tambaro S
  • Article: MOLECULAR THERAPY. 2023;31(2):487-502
    Manchanda S; Galan-Acosta L; Abelein A; Tambaro S; Chen G; Nilsson P; Johansson J
  • Article: BRAIN COMMUNICATIONS. 2022;5(1):fcad001
    Medina-Vera D; Enache D; Tambaro S; Abuhashish E; Rosell-Valle C; Winblad B; de Fonseca FR; Bereczki E; Nilsson P
  • Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:878303
    Jiang R; Shimozawa M; Mayer J; Tambaro S; Kumar R; Abelein A; Winblad B; Bogdanovic N; Nilsson P
  • Journal article: ALZHEIMERS & DEMENTIA. 2022;17
    Tambaro S; Riccardo M; Zerial S; Wagener A; Andrade鈥怲alavera Y; Fisahn A; Mentrup T; Schr枚der B; Nilsson P
  • Article: CELL RESEARCH. 2022;32(2):157-175
    Pang K; Jiang R; Zhang W; Yang Z; Li L-L; Shimozawa M; Tambaro S; Mayer J; Zhang B; Li M; Wang J; Liu H; Yang A; Chen X; Liu J; Winblad B; Han H; Jiang T; Wang W; Nilsson P; Guo W; Lu B
  • Article: MOLECULAR PSYCHIATRY. 2021;26(10):5557-5567
    Arroyo-Garcia LE; Isla AG; Andrade-Talavera Y; Balleza-Tapia H; Loera-Valencia R; Alvarez-Jimenez L; Pizzirusso G; Tambaro S; Nilsson P; Fisahn A
  • Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2020;105:103498
    Galan-Acosta L; Sierra C; Leppert A; Pouliopoulos AN; Kwon N; Noel RL; Tambaro S; Presto J; Nilsson P; Konofagou EE; Johansson J
  • Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32
    Chen G; Andrade-Talavera Y; Tambaro S; Leppert A; Nilsson HE; Zhong X; Landreh M; Nilsson P; Hebert H; Biverstal H; Fisahn A; Abelein A; Johansson J
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(8):2606-2615
    Tambaro S; Galan-Acosta L; Leppert A; Chen G; Biverstal H; Presto J; Nilsson P; Johansson J
  • Article: JOURNAL OF ALZHEIMER'S DISEASE REPORTS. 2018;2(1):27-39
    Dolfe L; Tambaro S; Tigro H; Del Campo M; Hoozemans JJM; Wiehager B; Graff C; Winblad B; Ankarcrona M; Kaldmae M; Teunissen CE; Ronnback A; Johansson J; Presto J
  • Article: NATURE COMMUNICATIONS. 2017;8(1):2081
    Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstal H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J
  • Article: BEHAVIOURAL PHARMACOLOGY. 2016;27(1):57-68
    Orru A; Casu MA; Tambaro S; Marchese G; Casu G; Ruiu S
  • Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2014;56:1-9
    Godar SC; Bortolato M; Castelli MP; Casti A; Casu A; Chen K; Ennas MG; Tambaro S; Shih JC
  • Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2014;729:67-74
    Tambaro S; Casu MA; Mastinu A; Lazzari P
  • Article: NEUROPHARMACOLOGY. 2013;75:223-232
    Bortolato M; Godar SC; Tambaro S; Li FG; Devoto P; Coba MP; Chen K; Shih JC
  • Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2013;110:137-144
    Tambaro S; Reali R; Volonterio A; Zanda M; Olimpieri F; Pinna GA; Lazzari P
  • Article: NEUROPHARMACOLOGY. 2013;70:268-277
    Tambaro S; Tomasi ML; Bortolato M
  • Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2013;62:256-269
    Manca I; Mastinu A; Olimpieri F; Falzoi M; Sani M; Ruiu S; Loriga G; Volonterio A; Tambaro S; Bottazzi MEH; Zanda M; Pinna GA; Lazzari P
  • Article: PSYCHONEUROENDOCRINOLOGY. 2013;38(4):542-551
    Frau R; Pillolla G; Bini V; Tambaro S; Devoto P; Bortolato M
  • Article: CENTRAL NERVOUS SYSTEM AGENTS IN MEDICINAL CHEMISTRY. 2012;12(4):254-276
    Lazzari P; Pau A; Tambaro S; Asproni B; Ruiu S; Pinna G; Mastinu A; Curzu MM; Reali R; Bottazzi MEH; Pinna GA; Murineddu G
  • Journal article: PHARMACEUTICALS. 2010;3(9):2799-2820
    Bortolato M; Bini V; Tambaro S
  • Journal article: CHEMINFORM. 2010;41(1):no
    Olimpieri F; Tambaro S; Fustero S; Lazzari P; Sanchez鈥怰osello M; Pani L; Volonterio A; Zanda M
  • Article: NEUROBIOLOGY OF DISEASE. 2010;37(1):177-185
    Luongo L; Palazzo E; Tambaro S; Giordano C; Gatta L; Scafuro MA; Rossi FS; Lazzari P; Pani L; de Novellis V; Malcangio M; Maione S
  • Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2009;19(16):4715-4719
    Olimpieri F; Tambaro S; Fustero S; Lazzari P; Sanchez-Rosello M; Pani L; Volonterio A; Zanda M
  • Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2005;525(1-3):150-153
    Tambaro S; Mongeau R; Dessi C; Pani L; Ruiu S
  • Article: BRAIN RESEARCH. 2005;1048(1-2):41-47
    Casu MA; Pisu C; Sanna A; Tambaro S; Spada GP; Mongeau R; Pani L
  • Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2005;312(2):710-717
    Tambaro S; Ruiu S; Dessi C; Mongeau R; Marchese G; Pani L
  • Article: BEHAVIOURAL BRAIN RESEARCH. 2004;149(1):9-16
    Marchese G; Bartholini F; Casu MA; Ruiu S; Casti P; Congeddu E; Tambaro S; Pani L
  • Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2003;306(1):363-370
    Ruiu S; Pinna GA; Marchese G; Mussinu JM; Saba P; Tambaro S; Casti P; Vargiu R; Pani L
  • Article: BIOLOGICAL RHYTHM RESEARCH. 2002;33(2):213-222
    Castagnola M; Cabras T; Denotti G; Fadda MB; Gambarini G; Lupi A; Manca I; Onnis G; Piras V; Soro V; Tambaro S; Messana I
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All other publications

  • Review: SCIENCE SIGNALING. 2025;18(885):eadt2272
    Badman J; Parracino A; Kumar R; Tambaro S
  • Book chapter: ANANDAMIDE IN HEALTH AND DISEASE. 2025;p. 419-443
    Medina-Vera D; Tambaro S
  • Review: MOLECULAR NEUROBIOLOGY. 2025;62(1):46-76
    Vassal M; Martins F; Monteiro B; Tambaro S; Martinez-Murillo R; Rebelo S
  • Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2024;54:1406
    Gera R; Mitra S; Tambaro S; Nilsson P; Eriksdotter M
  • Preprint: BIORXIV. 2022
    Maccioni R; Travisan C; Zerial S; Wagener A; Andrade-Talavera Y; Picciau F; Grassi C; Chen G; Lemoine L; Fisahn A; Jiang R; Fluhrer R; Mentrup T; Schr枚der B; Nilsson P; Tambaro S
  • Review: FRONTIERS IN PSYCHIATRY. 2022;13:866052
    Morcuende A; Salud Garcia-Gutierrez M; Tambaro S; Nieto E; Manzanares J; Femenia T
  • Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2021;78(21-22):6807-6822
    Martins F; Santos I; Silva OAB; Tambaro S; Rebelo S
  • Review: BIOLOGY-BASEL. 2021;10(6):542
    Abate G; Uberti D; Tambaro S
  • Review: LIFE SCIENCES. 2019;224:120-127
    Premoli M; Aria F; Bonini SA; Maccarinelli G; Gianoncelli A; Della Pina S; Tambaro S; Memo M; Mastinu A
  • Review: JOURNAL OF ETHNOPHARMACOLOGY. 2018;227:300-315
    Bonini SA; Premoli M; Tambaro S; Kumar A; Maccarinelli G; Memo M; Mastinu A
  • Review: HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION. 2018;36(2):/j/hmbci.2018.36.issue-2/
    Mastinu A; Premoli M; Ferrari-Toninelli G; Tambaro S; Maccarinelli G; Memo M; Bonini SA
  • Conference publication: PROTEIN SCIENCE. 2017;26:31-32
    Chen G; Abelein A; Leppert A; Tambaro S; Biverstal H; Presto J; Johansson J
  • Meeting abstract: AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS. 2017;24(sup1):7-8
    Tambaro S; Galan-Acosta L; Leppert A; Presto J; Johansson J
  • Book chapter: CANNABINOID MODULATION OF EMOTION, MEMORY, AND MOTIVATION. 2015;p. 409-442
    Tambaro S; Bortolato M
  • Review: RECENT PATENTS ON CNS DRUG DISCOVERY. 2012;7(1):25-40
    Tambaro S; Bortolato M
  • Conference publication: JOURNAL OF DENTAL RESEARCH. 2002;81:B252
    Cassiano M; Lupi A; Giardina B; Patamia M; Cassiano L; Tambaro S; Cordaro M; Onnis G; Manca I; Gambarini G; Messana I
  • Conference publication: JOURNAL OF DENTAL RESEARCH. 2002;81:B252
    Fadda MB; Masana I; Sofn V; Tambaro S; Pirus V; Denotti G; Gamharmi G; Zuppi C; Patama M; Giardina B; Castagnola M; Lupi A

Grants

  • Unraveling the Therapeutic Potential of SPPL2b in Alzheimer's Disease
    Alzhimer麓s Association
    1 July 2024 - 30 June 2027
    The main question that we want to answer in this project is, how does the brain-specific intramembrane enzyme SPPL2b affect Alzheimer's disease (AD), and may it be used as a target for the creation of novel therapies? AD is characterized by an abnormal accumulation of toxic proteins (amyloid peptides) in the brain, inflammation, and progressive memory loss that affect a person鈥檚 ability to carry out daily activities. Recently, immunotherapy showed positive results in reducing plaque and slowing down cognitive decline. Still, this therapeutic approach cannot block the progression of AD and reverse memory impairment highlighting the important need in finding novel approaches to treat this disease. Our study focuses on the SPPL2b enzyme, which is involved in processing proteins involved in amyloid peptide production, inflammation, and memory process. We think that the modulation or inhibition of SPPL2b activity may help prevent the synthesis of dangerous proteins and lessen brain inflammation. We will investigate this theory by looking at the SPPL2b gene deletion results in a mouse model of AD. Additionally, we will look for SPPL2b and associated proteins in samples of human brains from various disease stages. This will enable us to comprehend the relationship between SPPL2b and AD. Additionally, we will conduct lab tests and computer simulations to look for potential SPPL2b-specific inhibitors. Our goals are to understand how SPPL2b contributes to Alzheimer's, find potential new ways to detect the disease early, and identify compounds that can block the enzyme's harmful actions. If successful, this research could lead to new drugs that slow down or halt the progression of Alzheimer's disease.
  • BRI2 role in neuronal differentiation and the underlying molecular mechanisms: towards an innovative regenerative therapy for Alzheimer鈥檚 Disease
    Funda莽茫o para a Ci锚ncia e Tecnologia
    1 January 2022 - 31 December 2025

Employments

  • Senior Research Specialist, Department of Neurobiology, Care Sciences and Society, 探花精选, 2022-

Degrees and Education

  • Docent, 探花精选, 2025

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