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Yana Ruchiy

Yana Ruchiy

Affiliated to Research
Visiting address: BioMedicum A4, Solnavägen 9, 17165 Solna
Postal address: K6 Kvinnors och barns hälsa, K6 Barnonkologi och Barnkirurgi Blomgren, 171 77 Stockholm
Part of:

About me

  • I am a former PhD student within the research group of Prof. Klas Blomgren, studying
    the effects of radiotherapy on tumour microenvironment in paediatric brain
    tumours.

Research

  • During my PhD studies, my research is mainly focused on two projects:
    1. The effects of lithium on tumour progression in a mouse model of Group 3
    medulloblastoma.
    In the course of this project, I have created an in vivo model of Group 3
    medulloblastoma through an orthotopic injection of medulloblastoma cells. I
    then used this model to study the effects of lithium and irradiation on
    tumour growth and analysed it through whole-brain immunostaining and volume
    imaging techniques.
    2. Studies of inter- and intra- tumoural heterogeneity and tumour
    microenvironment in medulloblastoma.
    In the course of this project, I analysed single-cell datasets from Swedish
    medulloblastoma patients, comprising all four medulloblastoma subtypes. The
    main goal of this study was to look into the individual genomic landscapes of
    these tumours and the interactions between the tumour cells and their
    microenvironment, to provide a more detailed characterisation of
    different medulloblastoma subtypes and try to identify potential therapeutic
    targets.

Articles

  • Article: NATURE COMMUNICATIONS. 2025;16(1):1577
    Perochon T; Krsnik Z; Massimo M; Ruchiy Y; Romero AL; Mohammadi E; Li X; Long KR; Parkkinen L; Blomgren K; Lagache T; Menassa DA; Holcman D
  • Journal article: NEURO-ONCOLOGY ADVANCES. 2024;6(1):vdae172
    Ruchiy Y; Tsea I; Preka E; Verhoeven BM; Olsen TK; Mei S; Sinha I; Blomgren K; Carlson L-M; Dyberg C; Johnsen JI; Baryawno N
  • Journal article: NEURO-ONCOLOGY. 2024;26:0
    Ruchiy Y; Nunes D; Salinas C; Kanatani S; Rosen G; Zhao M; Swartling FJ; Rodrigues CFD; Blomgren K; Carlson L-M
  • Article: NEURO-ONCOLOGY ADVANCES. 2024;6(1):vdae172
    Ruchiy Y; Tsea I; Preka E; Verhoeven BM; Olsen TK; Mei S; Sinha I; Blomgren K; Carlson L-M; Dyberg C; Johnsen JI; Baryawno N
  • Journal article: CANCER RESEARCH. 2022;82(12_Supplement):1677
    Tsea I; Ruchiy Y; Verhoeven M; Sinha I; Blomgren K; Carlson LM; Johnsen JI; Dyberg C; Baryawno N
  • Article: EMBO MOLECULAR MEDICINE. 2021;13(10):e14123
    Uhlitz F; Bischoff P; Peidli S; Sieber A; Trinks A; Luethen M; Obermayer B; Blanc E; Ruchiy Y; Sell T; Mamlouk S; Arsie R; Wei T-T; Klotz-Noack K; Schwarz RF; Sawitzki B; Kamphues C; Beule D; Landthaler M; Sers C; Horst D; Bluethgen N; Morkel M

All other publications

  • Doctoral thesis: 2025
    Ruchiy Y
  • Preprint: BIORXIV. 2025
    Romero AL; Preka E; Pizzirusso G; Arroyo-García LE; Zisiadis GA; Oliva-Vilarnau N; Ruchiy Y; Seitz T; Zhou K; Isla AG; Friess L; Sun Y; Canut MQ; Shamikh A; Xu Y; Zhu C; Rodrigues CFD; Fisahn A; Joseph B; Carlson L-M; Fragkopoulou A; Lauschke VM; Betsholtz C; Osman AM; Blomgren K
  • Preprint: BIORXIV. 2024
    Perochon T; Krsnik Z; Massimo M; Ruchiy Y; Romero AL; Mohammadi E; Li X; Long KR; Parkkinen L; Blomgren K; Lagache T; Menassa DA; Holcman D
  • Conference publication: NEURO-ONCOLOGY. 2023;25:i62
    Ruchiy Y; Tsea I; Verhoeven BM; Sinha I; Preka E; Olsen TK; Mei S; Blomgren K; Johnsen JI; Carlson L-M; Dyberg C; Baryawno N
  • Conference publication: CANCER RESEARCH. 2022;82(12)
    Tsea I; Ruchiy Y; Verhoeven M; Sinha I; Blomgren K; Carlson LM; Johnsen JI; Dyberg C; Baryawno N
  • Conference publication: BRAIN TUMOR RESEARCH AND TREATMENT. 2022;10(Suppl):s99
    Ruchiy Y; Zhao M; Rosen G; Swartling F; Blomgren K; Carlson L-M

Grants

  • Barncancerfonden
    1 January 2023 - 31 December 2023
  • Barncancerfonden
    1 January 2023 - 31 December 2023
  • Barncancerfonden
    1 January 2023 - 31 December 2023
  • Barncancerfonden
    1 January 2022 - 31 December 2022

Employments

  • Affiliated to Research, Department of Women's and Children's Health, ̽»¨¾«Ñ¡, 2025-2027

Degrees and Education

  • PhD, Medical Sciences, Novel therapeutic targets and treatment strategies in paediatric brain tumours, KBH, ̽»¨¾«Ñ¡, 2025
  • Molecular Medicine MSc, Charité - University Medicine Berlin, 2020
  • Biological Sciences BSc, Lancaster University, 2016

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