Research Division of Chemistry II- Jesper Z. Haeggström
The division employs a range of techniques in cellular, molecular, and structural biology together with animal models and LC-MS based lipid profiling with the goal to understand the role of eicosanoids and other lipid mediators in host defense and human diseases.
Research interests
Our division is focused on bioactive lipids, in particular the eicosanoids, a family of oxygenated metabolites of arachidonic acid encompassing prostaglandins, thromboxanes, leukotrienes, and lipoxins. These paracrine hormones play both physiological and pathogenic roles in man, in particular as signaling molecules in innate immune responses and inflammation within the respiratory and cardiovascular systems. We study all aspects of these mediators including chemical and structural identification of metabolites, cellular activation and regulation of eicosanoid biosynthesis, as well as biochemical and structural characterization of the enzymes and regulatory proteins of the biosynthetic pathways. In recent years, we have put special efforts into translation of our basic knowledge into clinical and applied projects, using collections of patient samples and animal models, in collaboration with clinical teams.
The eicosanoid cascade has generated a number of successful drugs such as NSAIDs, coxibs, latanoprost, and lukasts for treatment of pain, fever, arthritis, glaucoma, and asthma. As a consequence, part of our work is carried out in alliance with pharmaceutical industry.
Research group
Jesper Z. Haeggström Group
The eicosanoids, a family of lipid mediators in health and disease
Selected publications
Haeggström JZ, Newcomer ME
Annu Rev Pharmacol Toxicol 2023 Jan;63():407-428
Gabay G, Wang H, Zhang J, Moriconi JI, Burguener GF, Gualano LD, Howell T, Lukaszewski A, Staskawicz B, Cho MJ, Tanaka J, Fahima T, Ke H, Dehesh K, Zhang GL, Gou JY, Hamberg M, Santa-MarÃa GE, Dubcovsky J
Nat Commun 2023 Feb;14(1):539
Thulasingam M, Orellana L, Nji E, Ahmad S, Rinaldo-Matthis A, Haeggström JZ
Nat Commun 2021 Mar;12(1):1728
Shay AE, Nshimiyimana R, Samuelsson B, Petasis NA, Haeggström JZ, Serhan CN
Proc Natl Acad Sci U S A 2021 Dec;118(51):
Basavarajappa D, Uebbing S, Kreiss M, Lukic A, Suess B, Steinhilber D, Samuelsson B, RÃ¥dmark O
Proc Natl Acad Sci U S A 2020 Apr;117(15):8573-8583
Thulasingam M, Haeggström JZ
J Mol Biol 2020 Aug;432(18):4999-5022
Tang X, Fuchs D, Tan S, Trauelsen M, Schwartz TW, Wheelock CE, Li N, Haeggström JZ
J Thromb Haemost 2020 Apr;18(4):976-984
Di Gennaro A, Araújo AC, Busch A, Jin H, Wågsäter D, Vorkapic E, Caidahl K, Eriksson P, Samuelsson B, Maegdefessel L, Haeggström JZ
Proc Natl Acad Sci U S A 2018 Feb;115(8):1907-1912
Haeggström JZ
J Clin Invest 2018 Jul;128(7):2680-2690
Chini A, Monte I, Zamarreño AM, Hamberg M, Lassueur S, Reymond P, Weiss S, Stintzi A, Schaller A, Porzel A, GarcÃa-Mina JM, Solano R
Nat Chem Biol 2018 Feb;14(2):171-178
Contact
Jesper Z. Haeggström
Head of Division, ProfessorVisiting address
Division of Physiological Chemistry II
Biomedicum, 9A, floor 9
Solnavägen 9
171 65 Solna
Sweden