Christoph Ziegenhain
Biträdande Lektor
E-postadress: christoph.ziegenhain@ki.se
Telefon: +46852487120
µþ±ð²õö°ì²õ²¹»å°ù±ð²õ²õ: Solnavägen 9, 17165 Solna
Postadress: C2 Medicinsk biokemi och biofysik, C2 MSB Ziegenhain, 171 77 Stockholm
Artiklar
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2025Reconstitution of the uterine immune milieu after transplantationStrunz B; Ivarsson M; Sun D; Mayer C; Ziegenhain C; Guterstam Y; Solders M; Björklund A; Marquardt N; Kaipe H; Flöter-Rådestad A; Gidlöf S; Brannstrom M; Björkström N
- Article: NATURE COMMUNICATIONS. 2025;16(1):6629Hartmanis L; Ramskold D; Hendriks G-J; Johnsson P; Hallen G; Ma R; Larsson AJM; Hahne S; Ziegenhain C; Hartman J; Sandberg R
- Article: SCIENCE. 2025;389(6755):58-63Dumitru I; Paterlini M; Zamboni M; Ziegenhain C; Giatrellis S; Saghaleyni R; Bjoerklund A; Alkass K; Tata M; Druid H; Sandberg R; Frisen J
- Journal article: CELL REPORTS. 2025;44(6):115837Ward S; Crawford G; Norzawani B; Malactou C; Dutton E; Withnell I; Woollard KJ; Harwood C; Mcsorley HJ; Ziegenhain C; Larkeryd A; Sadanandam A; Strid J
- Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2025;233:s15-s16Scholzen KC; Zeisel L; Diekmann C; Thorn-Seshold O; Ziegenhain C; Arner ESJ
- Article: NATURE CELL BIOLOGY. 2024;26(10):1725-1733Ramskold D; Hendriks G-J; Larsson AJM; Mayr JV; Ziegenhain C; Hagemann-Jensen M; Hartmanis L; Sandberg R
- Article: NATURE IMMUNOLOGY. 2024;25(6):1007-1019Carrelha J; Mazzi S; Winroth A; Hagemann-Jensen M; Ziegenhain C; Hogstrand K; Seki M; Brennan MS; Lehander M; Wu B; Meng Y; Markljung E; Norfo R; Ishida H; Stralin KB; Grasso F; Karali CS; Aliouat A; Hillen A; Chari E; Siletti K; Thongjuea S; Mead AJ; Linnarsson S; Nerlov C; Sandberg R; Yoshizato T; Woll PS; Jacobsen SEW
- Article: CELL SYSTEMS. 2024;15(2):149-165.e10Mold JE; Weissman MH; Ratz M; Hagemann-Jensen M; Hard J; Eriksson C-J; Toosi H; Berghenstrahle J; Ziegenhain C; von Berlin L; Martin M; Blom K; Lagergren J; Lundeberg J; Sandberg R; Michaeeurolsson J; Frisen J
- Article: CANCER RESEARCH. 2024;84(2):211-225Moura PL; Mortera-Blanco T; Hofman IJ; Todisco G; Kretzschmar WW; Bjoerklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Cabrerizo Granados D; Barbosa I; Walldin G; Jansson M; Ashley N; Mead AJ; Lundin V; Dimitriou M; Yoshizato T; Woll PS; Ogawa S; Sandberg R; Jacobsen SEW; Hellstrom-Lindberg E
- Article: GENOME BIOLOGY. 2024;25(1):2Hunt G; Vaid R; Pirogov S; Pfab A; Ziegenhain C; Sandberg R; Reimegard J; Mannervik M
- Article: NATURE AGING. 2023;3(11):1430-1445Nikopoulou C; Kleinenkuhnen N; Parekh S; Sandoval T; Ziegenhain C; Schneider F; Giavalisco P; Donahue K-F; Vesting AJ; Kirchner M; Bozukova M; Vossen C; Altmueller J; Wunderlich T; Sandberg R; Kondylis V; Tresch A; Tessarz P
- Article: NATURE BIOTECHNOLOGY. 2022;40(10):1452-1457Hagemann-Jensen M; Ziegenhain C; Sandberg R
- Article: LEUKEMIA. 2022;36(9):2281-2292Mentz M; Keay W; Strobl CD; Antoniolli M; Adolph L; Heide M; Lechner A; Haebe S; Osterode E; Kridel R; Ziegenhain C; Wange LE; Hildebrand JA; Shree T; Silkenstedt E; Staiger AM; Ott G; Horn H; Szczepanowski M; Richter J; Levy R; Rosenwald A; Enard W; Zimber-Strobl U; Von Bergwelt-Baildon M; Hiddemann W; Klapper W; Schmidt-Supprian M; Rudelius M; Bararia D; Passerini V; Weigert O
- Article: NATURE COMMUNICATIONS. 2022;13(1):3456Lutz K; Musumeci A; Sie C; Dursun E; Winheim E; Bagnoli J; Ziegenhain C; Rausch L; Bergen V; Luecken MD; Oostendorp RAJ; Schraml BU; Theis FJ; Enard W; Korn T; Krug AB
- Article: NATURE METHODS. 2022;19(5):560-566Ziegenhain C; Hendriks G-J; Hagemann-Jensen M; Sandberg R
- Article: GENOME BIOLOGY. 2022;23(1):88Janjic A; Wange LE; Bagnoli JW; Geuder J; Nguyen P; Richter D; Vieth B; Vick B; Jeremias I; Ziegenhain C; Hellmann I; Enard W
- Article: NATURE GENETICS. 2022;54(3):306-317Johnsson P; Ziegenhain C; Hartmanis L; Hendriks G-J; Hagemann-Jensen M; Reinius B; Sandberg R
- Article: NATURE COMMUNICATIONS. 2021;12(1):6216Ziegenhain C; Sandberg R
- Article: PLOS COMPUTATIONAL BIOLOGY. 2021;17(3):e1008772Larsson AJM; Ziegenhain C; Hagemann-Jensen M; Reinius B; Jacob T; Dalessandri T; Hendriks G-J; Kasper M; Sandberg R
- Article: NATURE CELL BIOLOGY. 2021;23(1):23-31Boettcher A; Buettner M; Tritschler S; Sterr M; Aliluev A; Oppenlaender L; Burtscher I; Sass S; Irmler M; Beckers J; Ziegenhain C; Enard W; Schamberger AC; Verhamme FM; Eickelberg O; Theis FJ; Lickert H
- Article: NATURE COMMUNICATIONS. 2020;11(1):5972Mulholland CB; Nishiyama A; Ryan J; Nakamura R; Yigit M; Glueck IM; Trummer C; Qin W; Bartoschek MD; Traube FR; Parsa E; Ugur E; Modic M; Acharya A; Stolz P; Ziegenhain C; Wierer M; Enard W; Carell T; Lamb DC; Takeda H; Nakanashi M; Bultmann S; Leonhardt H
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(6):3270-3286Kober-Hasslacher M; Oh-Strauss H; Kumar D; Soberon V; Diehl C; Lech M; Engleitner T; Katab E; Fernandez-Saiz J; Piontek G; Li H; Menze B; Ziegenhain C; Enard W; Rad R; Boettcher JP; Anders H-J; Rudelius M; Schmidt-Supprian M
- Article: NATURE BIOTECHNOLOGY. 2020;38(6):708-714Hagemann-Jensen M; Ziegenhain C; Chen P; Ramskold D; Hendriks G-J; Larsson AJM; Faridani OR; Sandberg R
- Article: NATURE BIOTECHNOLOGY. 2020;38(6):747-755Mereu E; Lafzi A; Moutinho C; Ziegenhain C; McCarthy DJ; Alvarez-Varela A; Batlle E; Sagar; Gruen D; Lau JK; Boutet SC; Sanada C; Ooi A; Jones RC; Kaihara K; Brampton C; Talaga Y; Sasagawa Y; Tanaka K; Hayashi T; Braeuning C; Fischer C; Sauers S; Trefzer T; Conrad C; Adiconis X; Nguyen LT; Regev A; Levin JZ; Parekh S; Janjic A; Wange LE; Bagnoli JW; Enard W; Gut M; Sandberg R; Nikaido I; Gut I; Stegle O; Heyn H
- Article: NATURE COMMUNICATIONS. 2019;10(1):4667Vieth B; Parekh S; Ziegenhain C; Enard W; Hellmann I
- Article: JOURNAL OF NATURAL PRODUCTS. 2019;82(7):1961-1970Wang S; Gegenfurtner FA; Crevenna AH; Ziegenhain C; Kliesmete Z; Enard W; Mueller R; Vollmar AM; Schneider S; Zahler S
- Article: SCIENTIFIC REPORTS. 2019;9(1):9731Wang S; Crevenna AH; Ugur I; Marion A; Antes I; Kazmaier U; Hoyer M; Lamb DC; Gegenfurtner F; Kliesmetes Z; Ziegenhain C; Enard W; Vollmar A; Zahler S
- Article: HUMAN MOLECULAR GENETICS. 2019;28(5):701-717Medvedeva VP; Rieger MA; Vieth B; Mombereau C; Ziegenhain C; Ghosh T; Cressant A; Enard W; Granon S; Dougherty JD; Groszer M
- Article: ISME JOURNAL. 2018;12(12):2907-2918Granato ET; Ziegenhain C; Marvig RL; Kummerli R
- Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2018;75(24):4539-4555Gegenfurtner FA; Zisis T; Al Danaf N; Schrimpf W; Kliesmete Z; Ziegenhain C; Enard W; Kazmaier U; Lamb DC; Vollmar AM; Zahler S
- Article: NATURE COMMUNICATIONS. 2018;9(1):2937Bagnoli JW; Ziegenhain C; Janjic A; Wange LE; Vieth B; Parekh S; Geuder J; Hellmann I; Enard W
- Article: BRIEFINGS IN FUNCTIONAL GENOMICS. 2018;17(4):220-232Ziegenhain C; Vieth B; Parekh S; Hellmann I; Enard W
- Article: GIGASCIENCE. 2018;7(6):giy059Parekh S; Ziegenhain C; Vieth B; Enard W; Hellmann I
- Article: JOURNAL OF CELL SCIENCE. 2018;131(10):jcs212886Gegenfurtner FA; Jahn B; Wagner H; Ziegenhain C; Enard W; Geistlinger L; Raedler JO; Vollmar AM; Zahler S
- Article: NATURE. 2018;554(7690):62-68Mueller S; Engleitner T; Maresch R; Zukowska M; Lange S; Kaltenbacher T; Konukiewitz B; Oellinger R; Zwiebel M; Strong A; Yen H-Y; Banerjee R; Louzada S; Fu B; Seidler B; Goetzfried J; Schuck K; Hassan Z; Arbeiter A; Schoenhuber N; Klein S; Veltkamp C; Friedrich M; Rad L; Barenboim M; Ziegenhain C; Hess J; Dovey OM; Eser S; Parekh S; Constantino-Casas F; de la Rosa J; Sierra MI; Fraga M; Mayerle J; Kloeppel G; Cadinanos J; Liu P; Vassiliou G; Weichert W; Steiger K; Enard W; Schmid RM; Yang F; Unger K; Schneider G; Varela I; Bradley A; Saur D; Rad R
- Article: ONCOTARGET. 2017;8(65):108738-108759Garz A-K; Wolf S; Grath S; Gaidzik V; Habringer S; Vick B; Rudelius M; Ziegenhain C; Herold S; Weickert M-T; Smets M; Peschel C; Oostendorp RAJ; Bultmann S; Jeremias I; Thiede C; Doehner K; Keller U; Goetze KS
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(45):E9579-E9588Krendl C; Shaposhnikov D; Rishko V; Ori C; Ziegenhain C; Sass S; Simon L; Mueller NS; Straub T; Brooks KE; Chavez SL; Enard W; Theis FJ; Drukker M
- Article: BIOINFORMATICS. 2017;33(21):3486-3488Vieth B; Ziegenhain C; Parekh S; Enard W; Hellmann I
- Journal article: EXPERIMENTAL HEMATOLOGY. 2017;53:s73Oezdemir EZ; Ebinger S; Ziegenhain C; Enard W; Jeremias I
- Article: NATURE GENETICS. 2017;49(5):742-752Witzel M; Petersheim D; Fan Y; Bahrami E; Racek T; Rohlfs M; Puchalka J; Mertes C; Gagneur J; Ziegenhain C; Enard W; Stray-Pedersen A; Arkwright PD; Abboud MR; Pazhakh V; Lieschke GJ; Krawitz PM; Dahlhoff M; Schneider MR; Wolf E; Horny H-P; Schmidt H; Schaffer AA; Klein C
- Article: MOLECULAR CELL. 2017;65(4):631-643.e4Ziegenhain C; Vieth B; Parekh S; Reinius B; Guillaumet-Adkins A; Smets M; Leonhardt H; Heyn H; Hellmann I; Enard W
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(1):165-181Schreck C; Istvanffy R; Ziegenhain C; Sippenauer T; Ruf F; Henkel L; Gaertner F; Vieth B; Florian MC; Mende N; Taubenberger A; Prendergast A; Wagner A; Pagel C; Grziwok S; Goetze KS; Guck J; Dean DC; Massberg S; Essers M; Waskow C; Geiger H; Schiemann M; Peschel C; Enard W; Oostendorp RAJ
- Article: CANCER CELL. 2016;30(6):849-862Ebinger S; Oezdemir EZ; Ziegenhain C; Tiedt S; Alves CC; Grunert M; Dworzak M; Lutz C; Turati VA; Enver T; Horny H-P; Sotlar K; Parekh S; Spiekermann K; Hiddemann W; Schepers A; Polzer B; Kirsch S; Hoffmann M; Knapp B; Hasenauer J; Pfeifer H; Panzer-Gruemayer R; Enard W; Gires O; Jeremias I
- Article: SCIENTIFIC REPORTS. 2016;6:25533Parekh S; Ziegenhain C; Vieth B; Enard W; Hellmann I
- Article: AIDS. 2015;29(10):1147-1159Schneider M; Tigges B; Meggendorfer M; Helfer M; Ziegenhain C; Brack-Werner R
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Alla övriga publikationer
- Preprint: BIORXIV. 2024;BIORXIVLause J; Ziegenhain C; Hartmanis L; Berens P; Kobak D
- Preprint: BIORXIV. 2024Strunz B; Ivarsson MA; Sun D; Ziegenhain C; Crona-Guterstam Y; Solders M; Björklund A; Marquardt N; Kaipe H; Flöter-Rådestad A; Gidlöf S; Brännström M; Björkström NK
- Letter: CELL RESEARCH. 2023;33(11):883-886Stralin KB; Carrelha J; Winroth A; Ziegenhain C; Hagemann-Jensen M; Kettyle LM; Hillen A; Hogstrand K; Markljung E; Grasso F; Seki M; Mazzi S; Meng Y; Wu B; Chari E; Lehander M; Sandberg R; Woll PS; Jacobsen SEW
- Editorial comment: NATURE METHODS. 2022;19(5):530-531Ziegenhain C; Sandberg R
- Corrigendum: NATURE CELL BIOLOGY. 2021;23(5):566-576Bottcher A; Buttner M; Tritschler S; Sterr M; Aliluev A; Oppenlander L; Burtscher I; Sass S; Irmler M; Beckers J; Ziegenhain C; Enard W; Schamberger AC; Verhamme FM; Eickelberg O; Theis FJ; Lickert H
- Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):6443Mulholland CB; Nishiyama A; Ryan J; Nakamura R; Yigit M; Gluck IM; Trummer C; Qin W; Bartoschek MD; Traube FR; Parsa E; Ugur E; Modic M; Acharya A; Stolz P; Ziegenhain C; Wierer M; Enard W; Carell T; Lamb DC; Takeda H; Nakanishi M; Bultmann S; Leonhardt H
Forskningsbidrag
- Swedish Research Council1 January 2023 - 31 December 2026Alternative splicing of pre-mRNA is a crucial regulator of cellular identities and gives rise to additional diversity in the human proteome. In this project, I will study the interplay of stochastic effects and deterministic regulation on outcomes of alternative splicing in human cells. Revealing novel insights into this poorly understood relationship will allow us to better comprehend the molecular mechanisms of this ubiquitous cellular process.Here, I will describe cell-to-cell variation in isoform choice at genome-wide resolution and resolve splicing patterns in single transcriptional bursts. In addition, I will shed light on the role of epigenetic cues governing alternative splicing control through new multimodal single-cell sequencing assays and complementary functional experiments. Lastly, using CRISPR/Cas9 screens I will generate a detailed splicing-regulatory network for RNA binding proteins in neuroprogenitors and in-vitro differentiated neurons at unprecedented resolution.This innovative research program is set at the intersection of cutting-edge experimental methodology and computational biology and will elucidate regulation of alternative splicing in an exciting and new direction. With new insights into splicing heterogeneity and its regulatory mechanisms, it may become possible to engineer more stable and effective regenerative medicine tools.