̽ѡ

Päivi Östling

Päivi Östling

Senior Forskare
E-postadress: paivi.ostling@ki.se
Telefon: +46852482304
ö: SciLifeLab, Tomtebodavägen 23a, 17121 Solna
Postadress: K7 Onkologi-Patologi, K7 Forskning Kallioniemi Östling, 171 77 Stockholm
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Om mig

  • Jag specialiserar mig på precisionsmedicin för cancer vid SciLifeLab och institutionen för onkologi-patologi vid ̽ѡ (KI). Mitt arbete fokuserar på individualiserad läkemedelsprofilering och rumslig kartläggning av urinblåsecancer, i samarbete med Anders Ullén (K, KI OnkPat), Charlotte Stadler (KTH, Spatial Biology-enheten SciLifeLab) samt Olli Kallioniemis forskargrupp (KI OnkPat). Sedan pandemin har jag också varit involverad i att hitta nya användningsområden för redan godkända läkemedel för infektionssjukdomar med Remedi4All-konsortiet. Som medledare för PCM-programmet vid KI strävar jag efter att påskynda implementeringen av precisionsmedicin för cancer (PCM) och främja tvärvetenskapligt utbyte. Jag är med och organiserar en nationell PCM-kurs för kliniska doktorander, där SciLifeLab-teknologier, kliniska exempel och tidiga kliniska prövningskoncept presenteras. Denna kurs betonar vikten av multidisciplinära team i PCM-forskning.

    Som vetenskaplig ledare för precisionsmedicin vid SciLifeLab är min roll att främja nästa generations infrastruktur för precisionsmedicin. Jag har nyckelpositioner inom svensk life science, inklusive SWELife, Cancer Research KI, Karolinska Comprehensive Cancer Center Board, Genomic Medicine Sweden och PREDICT-biobanken. Min omfattande erfarenhet av forskning och strategiska roller är ovärderlig för att främja precisionsmedicin. Tillsammans med Precisionsmedicinteamet leder jag två stora infrastrukturprojekt: ett om att främja kliniska prövningar samt , som stödjer Health AI-leverantörer över hela Europa.

Artiklar

  • Article: BIOMEDICINE & PHARMACOTHERAPY. 2025;191:118447
    Tampere M; H Le T; Asp E; Kalman A; Kaimal JM; Njenda D; Bäckström A; Axelsson U; Xu H; Ouyang W; Axelsson H; Marabita F; Moussaud-Lamodière E; Sepulveda CO; Seashore-Ludlow B; Vernersson C; Mirazimi A; Lundberg E; Östling P; Stadler C
  • Article: MOLECULAR ONCOLOGY. 2025;19(9):2574-2593
    Gudoityte G; Sharma O; Leuenberger L; Wallin E; Fernebro J; Ostling P; Bergstroem R; Lindberg J; Joneborg U; Kallioniemi O; Seashore-Ludlow B
  • Article: ESMO OPEN. 2025;10(8):105512
    Holmsten K; De Laere B; Sjodahl G; Lindberg J; Svedman FC; Ostling P; Eriksson P; Liedberg F; Ullen A
  • Journal article: ELIFE. 2025;13
    Trac QT; Huang Y; Erkers T; Östling P; Bohlin A; Osterroos A; Vesterlund M; Jafari R; Siavelis I; Backvall H; Kiviluoto S; Orre L; Rantalainen M; Lehtiö J; Lehmann S; Kallioniemi O; Pawitan Y; Vu TN
  • Journal article: BLOOD. 2024;144:1565
    Struyf N; Gezelius H; Lundmark A; Barizza C; Ploeger H; Pizarro LR; Uesterlund M; Mermelekas G; Osterroos A; Bohlin A; Bengtzen S; Levedahl KH; Jafari R; Orre LM; Lehtio J; Ostling P; Seashore-Ludlow B; Nordlund J; Lehmann S; Kallioniemi O; Erkers T
  • Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2024;43(1):107
    Fonseca P; Cui W; Struyf N; Tong L; Chaurasiya A; Casagrande F; Zhao H; Fernando D; Chen X; Tobin NP; Seashore-Ludlow B; Lundqvist A; Hartman J; Gondor A; Ostling P; Holmgren L
  • Journal article: CANCER RESEARCH. 2024;84(6_Supplement):4727
    Park SW; Liu E; Los A; Seashore-Ludlow B; Östling P; Molenaar J; Kallioniemi O; Stenman J; Karlsson K
  • Journal article: CANCER RESEARCH. 2024;84(6_Supplement):7517
    Ullman T; Krantz D; Elofsson H; Sepulveda CO; Zieba-Wicher A; Östling P; Ullén A; Basu S; Stadler C
  • Journal article: CANCER RESEARCH. 2024;84(6_Supplement):3100
    Potdar S; Ianevski F; Ianevski A; Tanoli Z; Wennerberg K; Seashore-Ludlow B; Kallioniemi O; Östling P; Aittokallio T; Saarela J
  • Journal article: CANCER RESEARCH. 2024;84(6):706
    Park SSW; Struyf N; Erkers T; Lehmann S; Meister MT; Drost J; Holstege FC; Herold N; Ostling P; Stenman J; Kallioniemi O; Henter J-I; Seashore-Ludlow B; Karlsson K
  • Article: NPJ PRECISION ONCOLOGY. 2024;8(1):38
    Struyf N; Osterroos A; Vesterlund M; Arnroth C; James T; Sunandar S; Mermelekas G; Bohlin A; Hamberg Levedahl K; Bengtzen S; Jafari R; Orre LM; Lehtio J; Lehmann S; Ostling P; Kallioniemi O; Seashore-Ludlow B; Erkers T
  • Article: MOLECULAR ONCOLOGY. 2024;18(2):317-335
    Zaghmi A; Aybay E; Jiang L; Shang M; Steinmetz-Spah J; Wermeling F; Kogner P; Korotkova M; Ostling P; Jakobsson P-J; Seashore-Ludlow B; Larsson K
  • Article: NPJ PRECISION ONCOLOGY. 2023;7(1):111
    Akerlund E; Gudoityte G; Moussaud-Lamodiere E; Lind O; Bwanika HC; Lehti K; Salehi S; Carlson J; Wallin E; Fernebro J; Ostling P; Kallioniemi O; Joneborg U; Seashore-Ludlow B
  • Article: NUCLEIC ACIDS RESEARCH. 2023;51(W1):W57-W61
    Potdar S; Ianevski F; Ianevski A; Tanoli Z; Wennerberg K; Seashore-Ludlow B; Kallioniemi O; Ostling P; Aittokallio T; Saarela J
  • Journal article: CANCER RESEARCH. 2023;83(7):6612
    Erkers T; Struyf N; James T; Marabita F; Vesterlund M; Vu N; Arnroth C; Osterroos A; Bohlin A; Bengtzen S; Stahl M; Jafari R; Orre L; Pawitan Y; Seashore-Ludlow B; Lehtio J; Lehmann S; Ostling P; Kallioniemi O
  • Article: NPJ PRECISION ONCOLOGY. 2023;7(1):32
    Trac QT; Pawitan Y; Mou T; Erkers T; Ostling P; Bohlin A; Osterroos A; Vesterlund M; Jafari R; Siavelis I; Backvall H; Kiviluoto S; Orre LM; Rantalainen M; Lehtio J; Lehmann S; Kallioniemi O; Vu TN
  • Journal article: IMMUNO-ONCOLOGY AND TECHNOLOGY. 2022;16:100328
    Flaberg E; Turkki R; Paavolainen L; Krantz D; Välimäki K; Schoonenberg A; Moussaud E; Holmsten K; Svedman FC; Kallioniemi O; Abrahamsson J; Liedberg F; Sjödahl G; Pellinen T; Ullén A; Östling P
  • Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(6):925-940
    Jadersten M; Lilienthal I; Tsesmetzis N; Lourda M; Bengtzen S; Bohlin A; Arnroth C; Erkers T; Seashore-Ludlow B; Giraud G; Barkhordar GS; Tao S; Fogelstrand L; Saft L; Ostling P; Schinazi RF; Kim B; Schaller T; Juliusson G; Deneberg S; Lehmann S; Rassidakis GZ; Hoglund M; Henter J-I; Herold N
  • Article: CELL REPORTS: METHODS. 2022;2(7):100256
    Sandstroem N; Carannante V; Olofsson K; Sandoz PA; Moussaud-Lamodiere EL; Seashore-Ludlow B; Van Ooijen H; Verron Q; Frisk T; Takai M; Wiklund M; Ostling P; Onfelt B
  • Journal article: HEMASPHERE. 2022;6:442-443
    Jädersten M; Lilienthal I; Tsesmetzis N; Lourda M; Bengtzén S; Bohlin A; Arnroth C; Erkers T; Seashore‐Ludlow B; Giraud G; Barkhordar GS; Tao S; Fogelstrand L; Saft L; Östling P; Schinazi R; Kim B; Schaller T; Juliusson G; Deneberg S; Lehmann S; Rassidakis G; Höglund M; Henter J; Herold N
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Alla övriga publikationer

  • Preprint: BIORXIV. 2025
    Asp E; Rietdijk J; Tampere M; Axelsson H; Njenda D; Potdar S; Kalman A; Georgieva P; Lapins M; Ballante F; Soler A; de Kort M; Aittokallio T; Zaliani A; Kuzikov M; Gribbon P; Lo D; Carreras-Puigvert J; Seashore-Ludlow B; Spjuth O; Östling P
  • Preprint: BIORXIV. 2025
    Kuzikov M; Kalman A; Reinshagen J; Huchting J; Qian K; Axelsson H; Tampere M; Östling P; Seashore-Ludlow B; Gadiya Y; Gribbon P; Zaliani A
  • Review: NATURE REVIEWS DRUG DISCOVERY. 2025;24(7):521-542
    Tanoli Z; Fernandez-Torras A; Ozcan UO; Kushnir A; Nader KM; Gadiya Y; Fiorenza L; Ianevski A; Vaha-Koskela M; Miihkinen M; Seemab U; Leinonen H; Seashore-Ludlow B; Tampere M; Kalman A; Ballante F; Benfenati E; Saunders G; Potdar S; Garcia IG; Garcia-Serna R; Talarico C; Beccari AR; Schaal W; Polo A; Costantini S; Cabri E; Jacobs M; Saarela J; Budillon A; Spjuth O; Ostling P; Xhaard H; Quintana J; Mestres J; Gribbon P; Ussi AE; Lo DC; de Kort M; Wennerberg K; Fratelli M; Carreras-Puigvert J; Aittokallio T
  • Preprint: ELIFE. 2025
    Trac QT; Huang Y; Erkers T; Ostling P; Bohlin A; Osterroos A; Vesterlund M; Jafari R; Siavelis I; Backvall H; Kiviluoto S; Orre L; Rantalainen M; Lehtio J; Lehmann S; Kallioniemi O; Pawitan Y; Vu TN
  • Letter: NATURE MEDICINE. 2025;31(6):1730-1732
    Kampe A; Gudmundsson S; Walsh CP; Lindblad-Toh K; Johansson A; Clareborn A; Ameur A; Edsjo A; Fioretos T; Ehrencrona H; Eriksson D; Fall T; Franks PW; Gyllensten U; Haag M; Hagwall A; Johansson Soller M; Lehtio J; Lu Y; Magnusson PKE; Melen E; Melin B; Michaelsson K; Nordgren A; Nordlund J; Saal LH; Schwenk JM; Sikora P; Sundstrom J; Taylan F; Van Guelpen B; Wadelius M; Wedell A; Wirta V; Ostling P; Jacobsson B; Sjoblom T; Persson B; Rosenquist R; Lindstrand A; Lappalainen T
  • Preprint: BIORXIV. 2024
    Trac QT; Huang Y; Erkers T; Östling P; Bohlin A; Österroos A; Vesterlund M; Jafari R; Siavelis I; Bäckvall H; Kiviluoto S; Orre L; Rantalainen M; Lehtiö J; Lehmann S; Kallioniemi O; Pawitan Y; Vu TN
  • Preprint: BIORXIV. 2024
    Coelho R; Seashore-Ludlow B; Schütz S; Lombardo FC; Moussaud-Lamodière E; Casanova R; Ficek-Pascual J; Labrosse KB; Hensler M; Lopez-Nunez M; Rimmer N; Fedier A; Lima R; Sartorius CM; Kurzeder C; Singer F; Bertolini A; Consortium TP; Fucikova J; Rätsch G; Bodenmiller B; Kallioniemi O; Östling P; David L; Heinzelmann-Schwarz V; Jacob F
  • Review: JOURNAL OF INTERNAL MEDICINE. 2023;294(4):413-436
    Rosenquist R; Bernard E; Erkers T; Scott DW; Itzykson R; Rousselot P; Soulier J; Hutchings M; Ostling P; Cavelier L; Fioretos T; Smedby KE
  • Conference publication: 2023
    Tampere M; Kalman A; Rietdijk J; Axelsson H; Njenda D; Kaimal JM; Lapins M; Ballante F; Le TH; Bäckström A; Seashore-Ludlow B; Lundberg E; Spjuth O; Carreras-Puigvert J; Stadler C; Östling P
  • Preprint: RESEARCH SQUARE. 2023
    Erkers T; Struyf N; Arnroth C; Vesterlund M; James T; Sunandar S; Bohlin A; Hamberg-Levedahl K; Bengtzén S; Jafari R; Orre L; Lehtiö J; Lehmann S; Ostling P; Kallioniemi O; Seashore-Ludlow B
  • Preprint: RESEARCH SQUARE. 2023
    Seashore-Ludlow B; Åkerlund E; Gudoityte G; Moussaud-Lamodière E; Lind O; Bwanika HC; Lehti K; Saheli S; Carlson J; Wallin E; Fernebro J; Ostling P; Kallioniemi O; Joneborg U
  • Meeting abstract: CANCER RESEARCH. 2023;83(7):4578
    Carannante V; Sandstrom N; Olofsson K; Neo SY; Sandoz PA; Van Ooijen H; Verron Q; Fontana J; Toullec D; Moussaud-Lamodiere E; Seashore-Ludlow B; Frisk T; Takai M; Ostling P; Haglund F; Lundqvist A; Wiklund M; Onfelt B
  • Conference publication: BLOOD. 2022;140:6299
    Erkers T; Marabita F; Struyf N; Vesterlund M; James T; Arnroth C; Bohlin A; Bengtzen S; Osterroos A; Stahl M; Jafari R; Orre L; Pawitan Y; Seashore-Ludlow B; Lehtio J; Lehmann S; Ostling P; Kallioniemi O
  • Conference publication: BLOOD. 2022;140:6290
    Struyf N; Arnroth C; Sunandar S; Bohlin A; Bengtzen S; Lehmann S; Kallioniemi O; Ostling P; Seashore-Ludlow B; Erkers T
  • Review: JOURNAL OF INTERNAL MEDICINE. 2022;292(2):243-261
    Wasterlid T; Cavelier L; Haferlach C; Konopleva M; Froehling S; Ostling P; Bullinger L; Fioretos T; Smedby KE
  • Conference publication: CANCER RESEARCH. 2022;82(12)
    Akerlund E; Gudoityte G; Lamodiere EM; Carlson J; Wallin E; Fernebro J; Kallioniemi O; Ostling P; Joneborg U; Seashore-Ludlow B
  • Corrigendum: NATURE CANCER. 2022;3(5):649
    Tamborero D; Dienstmann R; Rachid MH; Boekel J; Lopez-Fernandez A; Jonsson M; Razzak A; Brana I; De Petris L; Yachnin J; Baird RD; Loriot Y; Massard C; Martin-Romano P; Opdam F; Schlenk RF; Vernieri C; Masucci M; Villalobos X; Chavarria E; Balmana J; Apolone G; Caldas C; Bergh J; Ernberg I; Frohling S; Garralda E; Karlsson C; Tabernero J; Voest E; Rodon J; Lehtio J
  • Preprint: BIORXIV. 2022
    Kaimal JM; Tampere M; Le T; Axelsson U; Xu H; Axelsson H; Bäckström A; Marabita F; Moussaud-Lamodière E; Njenda D; Sepulveda CO; Oyuang W; Seashore-Ludlow B; Vernersson C; Mirazimi A; Lundberg E; Östling P; Stadler C
  • Preprint: RESEARCH SQUARE. 2021
    Stahl M; Aswad L; Leo I; Kunold E; Post F; Erkers T; Struyf N; Mermelekas G; Joshi R; Gracia-Villacampa E; Östling P; Kalloniemi O; Tamm KP; Siavelis I; Lehtiö J; Vesterlund M; Jafari R
  • Letter: NATURE MEDICINE. 2020;26(7):992-994
    Tamborero D; Dienstmann R; Rachid MH; Boekel J; Baird R; Brana I; De Petris L; Yachnin J; Massard C; Opdam FL; Schlenk R; Vernieri C; Garralda E; Masucci M; Villalobos X; Chavarria E; Calvo F; Frohling S; Eggermont A; Apolone G; Voest EE; Caldas C; Tabernero J; Ernberg I; Rodon J; Lehtio J
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Forskningsbidrag

  • Swedish Research Council
    1 January 2025 - 31 December 2028
    Drug combinations constitute an important therapeutic strategy, but the huge combinatorial space makes screening infeasible using conventional methods. The purpose of this project is to develop a novel phenotypic screening platform (ADONIS) that can autonomously explore and identify efficient drug combinations.We will develop iterative screening for drug combinations that shift cells towards a desired state. We use multiplexed microscopy imaging (Cell Painting) as profiling technology, which constitutes an excellent tradeoff between cost, speed, and information content. In our previous VR-funded project we developed a robotized lab and implemented fully automated Cell Painting, and in this project we will expand it to perform: i) autonomous screening for drug combinations towards soft-tissue sarcoma and colorectal cancer
    ii) genetic knock-out experiments to illuminate drug resistance
    and iii) generative AI to design novel drug leads.Our approach stands out by using image-based cell profiling data that allows for using the latest deep learning methods, and an AI model that selects the next batch of experiments to be carried out in an automated lab. This makes it possible to convert brute-force approaches, such as drug screening, into search problems that can be approached systematically with machine intelligence. With our project we will contribute to realizing this transition to more efficient scientific discoveries where AI iteratively interacts with the physical world.
  • Swedish Research Council
    1 January 2023 - 31 December 2026
    The rapid development of technologies for molecular profiling paves the way for precision medicine approaches to match patients with effective treatment. Through the development of a coordinating support unit, we aim to provide access to SciLifeLab’s technology platforms to support academic and industry-initiated clinical trials. We will establish customized diagnostic packages jointly with clinical trials units across the country to strengthen our attractiveness as a clinical trial site and to ensure early access of patients to both innovative technologies and emerging treatments.Our goal is to identify mature technologies to be evaluated in observational studies and adopted in interventional biomarker-driven clinical trials. To build this capacity, connecting SciLifeLab national infrastructure to clinical practice, key developments supporting cross-platform data, sample and analysis flows with timelines and quality complying with the needs of clinical trials are needed. Our unit will unite services from current and emerging sequencing technologies, to proteome, metabolome, spatial biology techniques, and drug efficacy testing. Our competitive edge is the repertoire of technologies at SciLifeLab, which once combined provide a unique opportunity for clinical trials. With the ‘service packages’ we aim to make Sweden competitive as a trial site, catalyze academy-industry ecosystems and provide opportunities for early access to the latest diagnostic technologies and treatments.
  • High-throughput siRNA and miRNA functional screening to identify key regulators of androgen signalling in prostate cancer
    Academy of Finland
    9 January 2011 - 31 December 2012
  • High-throughput siRNA and miRNA functional screening to identify key regulators of androgen signalling in prostate cancer
    Academy of Finland
    1 January 2010 - 31 August 2011

ԲäԾԲ

  • Senior Forskare, Onkologi-Patologi, ̽ѡ, 2022-
  • Senior Forskare, Klinisk neurovetenskap, ̽ѡ, 2025-2028

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