̽»¨¾«Ñ¡

Rickard Sandberg

Rickard Sandberg

Professor
Telefon: +46852482941
µþ±ð²õö°ì²õ²¹»å°ù±ð²õ²õ: Solnavägen 9, 17165 Stockholm
Postadress: C5 Cell- och molekylärbiologi, C5 CMB Sandberg, 171 77 Stockholm
Del av:

Om mig

  • Utbildning
    - Doktorandstudier, institutionen för mikrobiologi, tumör- och cellbiologi (MTC), ̽»¨¾«Ñ¡, Stockholm, Sweden 2000-2004.
    - Postdoktorala studier, Massachusetts Institute of Technology (MIT), Cambridge, US 2005-2007.
    - Forskarassistent, institutionen för cell- och molekylärbiologi (CMB), ̽»¨¾«Ñ¡, Sweden 2008-2013.
    - Docent, institutionen för cell- och molekylärbiologi (CMB), ̽»¨¾«Ñ¡, Sweden 2013-

    Akademiska priser och utmärkelser
    - Torsten Söderbergs akademiprofessur i medicin 2022
    - Elected Member of EMBO 2019.
    - Elected Member of the Nobel Assembly at ̽»¨¾«Ñ¡ 2019.
    - Anders Jahre's ̽»¨¾«Ñ¡ prize for young ̽»¨¾«Ñ¡ researchers (Nordic prize) 2014
    - EMBO Young Investigator 2012
    - Sven and Ebba-Christina Hagbergs Prize 2012

Utvalda publikationer

  • Article: NATURE BIOTECHNOLOGY. 2020;38(6):708-714
    Hagemann-Jensen M; Ziegenhain C; Chen P; Ramskold D; Hendriks G-J; Larsson AJM; Faridani OR; Sandberg R
  • Article: NATURE COMMUNICATIONS. 2019;10(1):3138
    Hendriks G-J; Jung LA; Larsson AJM; Lidschreiber M; Forsman OA; Lidschreiber K; Cramer P; Sandberg R
  • Article: NATURE. 2019;565(7738):251-254
    Larsson AJM; Johnsson P; Hagemann-Jensen M; Hartmanis L; Faridani OR; Reinius B; Segerstolpe A; Rivera CM; Ren B; Sandberg R
  • Article: SCIENCE. 2014;343(6167):193-196
    Deng Q; Ramskold D; Reinius B; Sandberg R
  • Article: NATURE METHODS. 2013;10(11):1096-1098
    Picelli S; Bjorklund AK; Faridani OR; Sagasser S; Winberg G; Sandberg R

Artiklar

  • Article: SCIENCE. 2025;389(6755):58-63
    Dumitru I; Paterlini M; Zamboni M; Ziegenhain C; Giatrellis S; Saghaleyni R; Bjoerklund A; Alkass K; Tata M; Druid H; Sandberg R; Frisen J
  • Article: SCIENTIFIC REPORTS. 2025;15(1):3811
    Cougnoux A; Mahmoud L; Johnsson PA; Eroglu A; Gsell L; Rosenbauer J; Sandberg R; Hausser J
  • Article: DEVELOPMENTAL CELL. 2025;60(2):320-336.e9
    Grommisch D; Lund H; Eenjes E; Julien A; Goritz C; Harris RA; Sandberg R; Hagemann-Jensen M; Genander M
  • Article: NATURE CELL BIOLOGY. 2024;26(10):1725-1733
    Ramskold D; Hendriks G-J; Larsson AJM; Mayr JV; Ziegenhain C; Hagemann-Jensen M; Hartmanis L; Sandberg R
  • Article: NATURE COMMUNICATIONS. 2024;15(1):8373
    Noble JC; Lentini A; Hagemann-Jensen M; Sandberg R; Reinius B
  • Article: GENOME BIOLOGY. 2024;25(1):214
    Demirci I; Larsson AJM; Chen X; Hartman J; Sandberg R; Frisen J
  • Article: NATURE IMMUNOLOGY. 2024;25(6):1007-1019
    Carrelha J; Mazzi S; Winroth A; Hagemann-Jensen M; Ziegenhain C; Hogstrand K; Seki M; Brennan MS; Lehander M; Wu B; Meng Y; Markljung E; Norfo R; Ishida H; Stralin KB; Grasso F; Karali CS; Aliouat A; Hillen A; Chari E; Siletti K; Thongjuea S; Mead AJ; Linnarsson S; Nerlov C; Sandberg R; Yoshizato T; Woll PS; Jacobsen SEW
  • Article: ISCIENCE. 2024;27(4):109346
    Di Martino E; Ambikan A; Ramskold D; Umekawa T; Giatrellis S; Vacondio D; Romero AL; Galan MG; Sandberg R; Aden U; Lauschke VM; Neogi U; Blomgren K; Kele J
  • Article: CELL SYSTEMS. 2024;15(2):149-165.e10
    Mold JE; Weissman MH; Ratz M; Hagemann-Jensen M; Hard J; Eriksson C-J; Toosi H; Berghenstrahle J; Ziegenhain C; von Berlin L; Martin M; Blom K; Lagergren J; Lundeberg J; Sandberg R; Michaeeurolsson J; Frisen J
  • Article: CANCER RESEARCH. 2024;84(2):211-225
    Moura PL; Mortera-Blanco T; Hofman IJ; Todisco G; Kretzschmar WW; Bjoerklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Cabrerizo Granados D; Barbosa I; Walldin G; Jansson M; Ashley N; Mead AJ; Lundin V; Dimitriou M; Yoshizato T; Woll PS; Ogawa S; Sandberg R; Jacobsen SEW; Hellstrom-Lindberg E
  • Article: GENOME BIOLOGY. 2024;25(1):2
    Hunt G; Vaid R; Pirogov S; Pfab A; Ziegenhain C; Sandberg R; Reimegard J; Mannervik M
  • Article: NATURE AGING. 2023;3(11):1430-1445
    Nikopoulou C; Kleinenkuhnen N; Parekh S; Sandoval T; Ziegenhain C; Schneider F; Giavalisco P; Donahue K-F; Vesting AJ; Kirchner M; Bozukova M; Vossen C; Altmueller J; Wunderlich T; Sandberg R; Kondylis V; Tresch A; Tessarz P
  • Article: AGING-US. 2023;15(12):5240-5265
    Salignon J; Faridani OR; Miliotis T; Janssens GE; Chen P; Zarrouki B; Sandberg R; Davidsson P; Riedel CG
  • Journal article: LEUKEMIA RESEARCH. 2023;128:107135
    Moura P; Mortera-Blanco T; Hofman I; Todisco G; Kretzschmar W; Bjorklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Granados D; Barbosa I; Walldin G; Jansson M; Mead A; Lundin V; Dimitriou M; Yoshizato T; Woll P; Ogawa S; Sandberg R; Jacobsen SE; Hellstrom-Lindberg E
  • Article: DEVELOPMENTAL CELL. 2023;58(6):450-460.e6
    Subramanian E; Elewa A; Brito G; Kumar A; Segerstolpe A; Karampelias C; Bjorklund A; Sandberg R; Echeverri K; Lui W-O; Andersson O; Simon A
  • Article: NATURE COMMUNICATIONS. 2023;14(1):982
    Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O'Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
  • Article: NATURE BIOTECHNOLOGY. 2022;40(10):1452-1457
    Hagemann-Jensen M; Ziegenhain C; Sandberg R
  • Article: NATURE METHODS. 2022;19(5):560-566
    Ziegenhain C; Hendriks G-J; Hagemann-Jensen M; Sandberg R
  • Article: NATURE GENETICS. 2022;54(3):306-317
    Johnsson P; Ziegenhain C; Hartmanis L; Hendriks G-J; Hagemann-Jensen M; Reinius B; Sandberg R
  • Article: NATURE COMMUNICATIONS. 2021;12(1):6216
    Ziegenhain C; Sandberg R
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Alla övriga publikationer

  • Preprint: BIORXIV. 2025
    Babatunde KA; Ngara M; Martinez Murillo P; Subramanian B; Hopke A; Lucchesi S; Novedrati M; Montesi G; Santoro F; Hagemann-Jensen M; Sandberg R; Filgueira L; Walch M; Irimia D; Mantel P-Y
  • Preprint: BIORXIV. 2025;BIORXIV
    Johnson BK; Majewski MF; Jang HJ; Siwicki RA; Wegener M; Semwal A; Morrison J; Gallik K; Hagemann-Jensen M; Foy K; Rossell LL; Siegwald EJ; Chesla DW; Teixeira JM; Adams M; Drapkin R; Esquibel C; Sheridan RTC; Wang T; Sandberg R; Triche TJ; Shen H
  • Preprint: BIORXIV. 2024
    Magnusson JP; Roohani Y; Stauber D; Situ Y; de Castroviejo Teba PR; Sandberg R; Leskovec J; Qi LS
  • Preprint: BIORXIV. 2024
    Contesse T; Bektash BY; Graziano M; Forastieri C; Contestabile A; Hahne S; Jung F; Nikolakopoulou I; Cao X; Skara V; Mantas I; Giatrellis S; Carlén M; Sandberg R; Calvigioni D; Meletis K
  • Preprint: BIORXIV. 2024
    Grommisch D; Lund H; Eenjes E; Julien A; Göritz C; Harris R; Sandberg R; Hagemann-Jensen M; Genander M
  • Preprint: BIORXIV. 2024
    Noble JC; Lentini A; Hageman-Jensen M; Sandberg R; Reinius B
  • Letter: CELL RESEARCH. 2023;33(11):883-886
    Stralin KB; Carrelha J; Winroth A; Ziegenhain C; Hagemann-Jensen M; Kettyle LM; Hillen A; Hogstrand K; Markljung E; Grasso F; Seki M; Mazzi S; Meng Y; Wu B; Chari E; Lehander M; Sandberg R; Woll PS; Jacobsen SEW
  • Preprint: BIORXIV. 2023
    Moura P; Mortera-Blanco T; Hofman IJF; Todisco G; Kretzschmar W; Björklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Granados D; Barbosa I; Walldin G; Jansson M; Ashley N; Mead A; Lundin V; Dimitriou M; Yoshizato T; Woll P; Ogawa S; Sandberg R; Jacobsen SE; Hellström-Lindberg E
  • Preprint: BIORXIV. 2023
    Martínez-López JA; Lindqvist A; Lopez-Pascual A; Chen P; Shcherbina L; Chriett S; Skene NG; Prasad RB; Lancien M; Johnson PF; Eliasson P; Louvet C; Muñoz-Manchado AB; Sandberg R; Hjerling-Leffler J; Wierup N
  • Preprint: BIORXIV. 2022
    Hunt G; Vaid R; Pirogov S; Pfab A; Ziegenhain C; Sandberg R; Reimegård J; Mannervik M
  • Editorial comment: NATURE METHODS. 2022;19(5):530-531
    Ziegenhain C; Sandberg R
  • Preprint: BIORXIV. 2022
    Mold J; Weissman M; Ratz M; Hagemann-Jensen M; Hård J; Eriksson C-J; Toosi H; Berghenstråhle J; von Berlin L; Martin M; Blom K; Lagergren J; Lundeberg J; Sandberg R; Michaëlsson J; Frisén J
  • Conference publication: SWISS MEDICAL WEEKLY. 2021;151:9S
    Babatunde K; Ngara M; Walch M; Subramanian B; Hagemann-Jensen M; Ghiran I; Sandberg R; Irimia D; Mantel PY
  • Preprint: BIORXIV. 2021
    Hagemann-Jensen M; Ziegenhain C; Sandberg R
  • Preprint: BIORXIV. 2021
    Ziegenhain C; Hendriks G-J; Hagemann-Jensen M; Sandberg R
  • Preprint: BIORXIV. 2021
    Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O’Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
  • Conference publication: BIOPHYSICAL JOURNAL. 2021;120(3):273A-274A
    Ambrosetti E; Bernardinelli G; Hoffecker IT; Hartmanis L; Kiriako G; de Marco A; Sandberg R; Hogberg B; Teixeira A
  • Preprint: BIORXIV. 2021
    Ziegenhain C; Sandberg R
  • Preprint: BIORXIV. 2020
    Network BICC; Adkins RS; Aldridge AI; Allen S; Ament SA; An X; Armand E; Ascoli GA; Bakken TE; Bandrowski A; Banerjee S; Barkas N; Bartlett A; Bateup HS; Behrens MM; Berens P; Berg J; Bernabucci M; Bernaerts Y; Bertagnolli D; Biancalani T; Boggeman L; Booeshaghi AS; Bowman I; Bravo HC; Cadwell CR; Callaway EM; Carlin B; O'Connor C; Carter R; Casper T; Castanon RG; Castro JR; Chance RK; Chatterjee A; Chen H; Chun J; Colantuoni C; Crabtree J; Creasy H; Crichton K; Crow M; D'Orazi FD; Daigle TL; Dalley R; Dee N; Degatano K; Dichter B; Diep D; Ding L; Ding S-L; Dominguez B; Dong H-W; Dong W; Dougherty EL; Dudoit S; Ecker JR; Eichhorn SW; Fang R; Felix V; Feng G; Feng Z; Fischer S; Fitzpatrick C; Fong O; Foster NN; Galbavy W; Gee JC; Ghosh SS; Giglio M; Gillespie TH; Gillis J; Goldman M; Goldy J; Gong H; Gou L; Grauer M; Halchenko YO; Harris JA; Hartmanis L; Hatfield JT; Hawrylycz M; Helba B; Herb BR; Hertzano R; Hintiryan H; Hirokawa KE; Hockemeyer D; Hodge RD; Hood G; Horwitz GD; Hou X; Hu L; Hu Q; Huang ZJ; Huo B; Ito-Cole T; Jacobs M; Jia X; Jiang S; Jiang T; Jiang X; Jin X; Jorstad NL; Kalmbach BE; Kancherla J; Keene CD; Kelly K; Khajouei F; Kharchenko PV; Kim G; Ko AL; Kobak D; Konwar K; Kramer DJ; Krienen FM; Kroll M; Kuang X; Kuo H-C; Lake BB; Larsen R; Lathia K; Laturnus S; Lee AY; Lee C-T; Lee K-F; Lein ES; Lesnar P; Li A; Li X; Li X; Li YE; Li Y; Li Y; Lim B; Linnarsson S; Liu CS; Liu H; Liu L; Lucero JD; Luo C; Luo Q; Macosko EZ; Mahurkar A; Martone ME; Matho KS; McCarroll SA; McCracken C; McMillen D; Miranda E; Mitra PP; Miyazaki PA; Mizrachi J; Mok S; Mukamel EA; Mulherkar S; Nadaf NM; Naeemi M; Narasimhan A; Nery JR; Ng L; Ngai J; Nguyen TN; Nickel L; Nicovich PR; Niu S-Y; Ntranos V; Nunn M; Olley D; Orvis J; Osteen JK; Osten P; Owen SF; Pachter L; Palaniswamy R; Palmer CR; Pang Y; Peng H; Pham T; Pinto-Duarte A; Plongthongkum N; Poirion O; Preissl S; Purdom E; Qu L; Rashid M; Reed NM; Regev A; Ren B; Ren M; Rimorin C; Risso D; Rivkin AC; Muñoz-Castañeda R; Romanow WJ; Ropelewski AJ; de Bézieux HR; Ruan Z; Sandberg R; Savoia S; Scala F; Schor M; Shen E; Siletti K; Smith JB; Smith K; Somasundaram S; Song Y; Sorensen SA; Stafford DA; Street K; Sulc J; Sunkin S; Svensson V; Tan P; Tan ZH; Tasic B; Thompson C; Tian W; Tickle TL; Tieu M; Ting JT; Tolias AS; Torkelson A; Tung H; Vaishnav ED; Van den Berge K; van Velthoven CTJ; Vanderburg CR; Veldman MB; Vu M; Wakeman W; Wang P; Wang Q; Wang X; Wang Y; Wang Y; Welch JD; White O; Williams E; Xie F; Xie P; Xiong F; Yang XW; Yanny AM; Yao Z; Yin L; Yu Y; Yuan J; Zeng H; Zhang K; Zhang M; Zhang Z; Zhao S; Zhao X; Zhou J; Zhuang X; Zingg B
  • Preprint: BIORXIV. 2020
    Johnsson P; Ziegenhain C; Hartmanis L; Hendriks G-J; Hagemann-Jensen M; Reinius B; Sandberg R
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Forskningsbidrag

  • Swedish Cancer Society
    1 January 2022
    Cancer research has resulted in thousands of active substances that have been tested or used in the clinical treatment of cancer. These affect various cellular processes in the cell such as cell division, repair of the genetic material, regulation of the genetic material, activation of cell responses or immune cells. Methodology to identify the initial response in the cancer cell after treatment with these substances has unfortunately been lacking, and most of the effects of treatments have been studied at a later stage in the cancer cells. We have developed a methodology that enables the identification of the initial cell responses to treatment in cancer cells. We will study how blood cancer (forms of leukemia) and breast cancer cells respond to treatment with hundreds to thousands of different active substances. This will provide important insights into the exact mechanisms of action of these substances, which we hope can explain why different substances have a better effect on different types of leukemia and breast cancer types. We will also investigate how cancer cells, but also the nearby immune cells and cancer-associated fibroblasts, are affected by the same panel of substances. We hope that the insights into the initial response of cancer cells to treatments can form the basis for more rational development of specific and potent substances, and that it can demonstrate effective combinations of existing substances. In the longer term, we want to investigate whether this method can also show which treatment options are best suited for each individual cancer patient. For example, panels of relevant treatments can be tested on a primary tumor and initial responses read immediately and examined to see if these responses can predict how the tumor will respond to the various treatments in an improved form of precision medicine.
  • Swedish Research Council
    1 January 2018 - 31 December 2027
    Recent technological advances have enabled global gene expression analyses in single cells, allowing transcriptional programs to be investigated in terms of cellular frequencies and magnitudes. Moving away from population-level experiments depicting cellular averages, to analyses of large numbers of individual cells, promises to dramatically improve our understanding of gene regulation. Indeed, initial analyses revealed stochastic allelic transcription that had been masked in previous population-level experiments. The overarching goal of this proposal is to develop single-cell sequencing technologies that will allow for unprecedented detailed studies of gene regulation. In particular, we will develop massively parallel single-cell transcriptome methods that maintain full-length transcriptome coverage, and genetically engineered mouse models for allele-resolution gene expression and lineage-reconstructions in single cells. These methods will be used to (i) infer transcriptional burst frequencies and magnitudes, and relate those to genomic sequences, (ii) investigate the temporal dynamics of random monoallelic expression at different resolutions in the reconstructed lineage tree, (iii) explore the phenotypic consequences of stochastic allelic expression in the context of variable penetrance and expressivity, common in human genetic disease. Taken together, in this research program we will develop an experimental foundation for gene regulatory studies at single-cell resolution.
  • National Institute of Mental Health
    1 September 2017 - 30 June 2024
  • Exploring the temporal dynamics of autosomal random monoallelic expression
    International Human Frontier Science Program Organization
    1 May 2017 - 30 April 2020
  • Knut and Alice Wallenberg Foundation
    1 January 2017 - 1 January 2022
  • JPND utlysning 2013. Cross-Disease analysis of pathways.
    Swedish Research Council
    1 December 2014 - 31 December 2016
  • EMBO Young Investigators Award 2012
    Swedish Research Council
    1 January 2013 - 31 December 2015
  • Swedish Research Council
    1 January 2013 - 31 December 2017
  • Knut and Alice Wallenberg Foundation
    1 January 2013 - 1 January 2018
  • The anatomy of a gene expression program
    Swedish Foundation for Strategic Research
    1 January 2011 - 31 December 2016
  • Swedish Research Council
    1 January 2009 - 31 December 2012
  • Swedish Research Council
    1 January 2009 - 31 December 2012

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  • Professor, Cell- och molekylärbiologi, ̽»¨¾«Ñ¡, 2015-

Examina och utbildning

  • Docent, Bioinformatik, ̽»¨¾«Ñ¡, 2013
  • MEDICINE DOKTORSEXAMEN, Institutionen för mikrobiologi, tumör- och cellbiologi, ̽»¨¾«Ñ¡, 2004
  • LICENTIATEXAMEN, Institutionen för mikrobiologi, tumör- och cellbiologi, ̽»¨¾«Ñ¡, 2002
  • Medicine Magisterexamen, ̽»¨¾«Ñ¡, 2000

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