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Sophie Erhardt

Sophie Erhardt

Professor | Prefekt | Docent
E-postadress: sophie.erhardt@ki.se
Telefon: +46852486883
Mobiltelefon: +46706296706
µþ±ð²õö°ì²õ²¹»å°ù±ð²õ²õ: Solnavägen 9, Biomedicum C5, 17165 Solna
Postadress: C3 Fysiologi och farmakologi, C3 FyFa Neuropsykoimmunologi, 171 77 Stockholm
Del av:

Om mig

  • Professor i Experimentell Psykiatri samt forskargruppsledare för
    Neuropsykoimmunologi [1]på institutionen för fysiologi och farmakologi.
    [1]

Artiklar

  • Article: SCHIZOPHRENIA. 2025;11(1):88
    Malmqvist A; Eren F; Schwieler L; Orhan F; Fatouros-Bergman H; Flyckt L; Piehl F; Cervenka S; Baeck M; Sellgren CM; Engberg G; Erhardt S
  • Journal article: BIOLOGICAL PSYCHIATRY. 2025;97(9):s133
    Ercis M; Beaupre LMM; Fridh P; Weidenfors JA; Khan R; Coombes BJ; Cuellar-Barboza AB; Prieto ML; McElroy SL; Ozerdem A; Biernacka JM; Erhardt S; Frye MA
  • Article: AMERICAN JOURNAL OF PSYCHIATRY. 2025;182(4):389-400
    Orhan F; Malwade S; Khanlarkhani N; Gkogka A; Langeder A; Jungholm O; Koskuvi M; Lehtonen S; Schwieler L; Jardemark K; Tiihonen J; Koistinaho J; Erhardt S; Engberg G; Samudyata S; Sellgren CM
  • Article: BRAIN BEHAVIOR AND IMMUNITY. 2025;125:452-465
    Weidenfors JA; Griska V; Li X; Pranckeviciene A; Pakalniene J; Atlas A; Franzen-Rohl E; Piehl F; Lindquist L; Mickiene A; Engberg G; Schwieler L; Erhardt S
  • Article: BRAIN BEHAVIOR AND IMMUNITY. 2025;124:163-176
    Li X; Eden A; Malwade S; Cunningham JL; Bergquist J; Weidenfors JA; Sellgren CM; Engberg G; Piehl F; Gisslen M; Kumlien E; Virhammar J; Orhan F; Rostami E; Schwieler L; Erhardt S
  • Article: PLOS ONE. 2025;20(1):e0317201
    Wallin H; Jansson E; Erhardt S; Wallquist C; Hylander B; Jacobson SH; Caidahl K; Rickenlund A; Eriksson MJ
  • Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2024;56(10):2007-2015
    Kamandulis S; Lukonaitiene I; Snieckus A; Brazaitis M; Mickevicius M; Cernych M; Ruas J; Schwieler L; Louvrou V; Erhardt S; Westerblad H; Venckunas T
  • Article: EUROPEAN JOURNAL OF CLINICAL NUTRITION. 2024;78(8):677-683
    Louvrou V; Solianik R; Brazaitis M; Erhardt S
  • Article: JAMA PSYCHIATRY. 2024;81(5):468-476
    Lee M; Cernvall M; Borg J; Plaven-Sigray P; Larsson C; Erhardt S; Sellgren CM; Fatouros-Bergman H; Cervenka S
  • Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;117:313-319
    Koskuvi M; Malwade S; Lekander JG; Horbeck E; Bruno S; Larsson JH; Pelanis A; Isgren A; Goulding A; Fatouros-Bergman H; Samudyata; Schalling M; Piehl F; Erhardt S; Landen M; Cervenka S; Orhan F; Sellgren CM
  • Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2024;171:306-315
    Haroon H; Ho AM-C; Gupta VK; Dasari S; Sellgren CM; Cervenka S; Engberg G; Eren F; Erhardt S; Sung J; Choi D-S
  • Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2024;17:11786469241262876
    Sathyasaikumar KV; Blanco-Ayala T; Zheng Y; Schwieler L; Erhardt S; Tufvesson-Alm M; Poeggeler B; Schwarcz R
  • Article: PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2023;77(12):665-671
    Pils M; Rutsch J; Eren F; Engberg G; Piehl F; Cervenka S; Sellgren C; Trossbach S; Willbold D; Erhardt S; Bannach O; Korth C
  • Article: ACTA NEUROPSYCHIATRICA. 2023;37:e18
    Zheng Y-R; Tufvesson-Alm M; Trepci A; Imbeault S; Li X-Q; Schwieler L; Engberg G; Erhardt S
  • Article: PSYCHONEUROENDOCRINOLOGY. 2023;153:106110
    Balter LJT; Li X; Schwieler L; Erhardt S; Axelsson J; Olsson MJ; Lasselin J; Lekander M
  • Article: BRAIN BEHAVIOR AND IMMUNITY. 2023;111:376-385
    Eren F; Schwieler L; Orhan F; Malmqvist A; Piehl F; Cervenka S; Sellgren CM; Fatouros-Bergman H; Engberg G; Erhardt S
  • Article: SCHIZOPHRENIA RESEARCH. 2023;257:34-40
    Orhan F; Goiny M; Becklen M; Mathe L; Piehl F; Schwieler L; Fatouros-Bergman H; Farde L; Cervenka S; Sellgren CM; Engberg G; Erhardt S
  • Article: LEUKEMIA. 2023;37(4):888-900
    Boberg E; Kadri N; Hagey DWW; Schwieler L; El Andaloussi S; Erhardt S; Iacobaeus E; Le Blanc K
  • Journal article: NEUROSCIENCE APPLIED. 2023;2:103551
    Orhan F; Malwade S; Schwieler L; Tiihonen J; Koistinahu J; Erhardt S; Engberg G; Kent J; Samudyata S; Sellgren C
  • Article: NATURE COMMUNICATIONS. 2022;13(1):6427
    Gracias J; Orhan F; Horbeck E; Holmen-Larsson J; Khanlarkani N; Malwade S; Goparaju SK; Schwieler L; Demirel IS; Fu T; Fatourus-Bergman H; Pelanis A; Goold CP; Goulding A; Annerbrink K; Isgren A; Sparding T; Schalling M; Yanez VAC; Gopfert JC; Nilsson J; Brinkmalm A; Blennow K; Zetterberg H; Engberg G; Piehl F; Sheridan SD; Perlis RH; Cervenka S; Erhardt S; Landen M; Sellgren CM
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Alla övriga publikationer

  • Preprint: BIORXIV. 2025
    Mäki-Marttunen V; Nerland S; Jørgensen K; Høgestøl E; Rokicki J; Alnæs D; Borgwardt S; Boye B; Buitelaar J; Bøen E; Cervenka S; Conzelmann A; Erhardt S; Franke B; Celius EG; Harbo H; Hilland E; Hoekstra P; Hartman CA; Jonassen R; Jönsson EG; Landrø N; Lesch K-P; Maglanoc L; Pauli P; Sellgren CM; Nygaard G; Oosterlaan J; Schmidt A; Schwarz E; Ziegler GC; Agartz I; Westlye LT; Andreassen O; Kaufmann T; Elvsåshagen T
  • Preprint: MEDRXIV. 2024
    Lee M; Cullen A; Matheson G; Lu Z-A; Bergen S; Sellgren C; Erhardt S; Fatouros-Bergman H; Cervenka S
  • Conference publication: NEUROPSYCHOPHARMACOLOGY. 2024;49:400-401
    Erhardt S; Schrey D; Ebberyd A; Eriksson LI; Gomez M
  • Review: PHARMACOLOGICAL REVIEWS. 2024;76(6):978-1008
    Pocivavsek A; Schwarcz R; Erhardt S
  • Editorial comment: NEUROPSYCHOPHARMACOLOGY. 2024;49(1):307-308
    Pocivavsek A; Erhardt S
  • Conference publication: NEUROPSYCHOPHARMACOLOGY. 2023;48:356-357
    Erhardt S; Gravenfors Y; Schwieler L
  • Letter: BRAIN BEHAVIOR AND IMMUNITY. 2023;114:163-164
    Eren F; Schwieler L; Orhan F; Malmqvist A; Piehl F; Cervenka S; Sellgren CM; Fatouros-Bergman H; Engberg G; Erhardt S
  • Preprint: BIORXIV. 2023
    Orhan F; Malwade S; Khanlarkhani N; Gkoga A; Jungholm O; Koskuvi M; Lehtonen Å ; Schwieler L; Jardemark K; Tiihonen J; Koistinaho J; Erhardt S; Engberg G; Samudyata S; Sellgren C
  • Conference publication: BIOLOGICAL PSYCHIATRY. 2023;93(9):S24
    Tye S; Price J; Walker A; Sutor S; Erhardt S; Schwieler L; Cullen K; Voort JV; Frye M; Bobo W; Shiroma P
  • Conference publication: BIOLOGICAL PSYCHIATRY. 2023;93(9):S24
    Voort JV; Singh B; Riva-Posse P; Erhardt S; Schwieler L; Pazdernik V; Frye M; Tye S
  • Preprint: MEDRXIV. 2023
    Pils M; Rutsch J; Eren F; Engberg G; Piehl F; Cervenka S; Sellgren C; Troßbach S; Willbold D; Erhardt S; Bannach O; Korth C
  • Review: BRAIN SCIENCES. 2023;13(3):505
    Chahla MAN; Khalil MI; Comai S; Brundin L; Erhardt S; Guillemin GJ
  • Conference publication: NEUROPSYCHOPHARMACOLOGY. 2022;47:378-379
    Erhardt S; Schwieler L; Sellgren CM; Eren F; Cervenka S; Piehl F; Bergman HF; Orhan F; Engberg G
  • Conference publication: NEUROPSYCHOPHARMACOLOGY. 2022;47:277
    Tye S; Price JB; Walker A; Kruse J; Cullen K; Frye M; Schwieler L; Erhardt S
  • Conference publication: NEUROPSYCHOPHARMACOLOGY. 2022;47:290-291
    Schwieler L; Weidenfors JA; Griska V; Li X; Piehl F; Mickiene A; Erhardt S
  • Corrigendum: MOLECULAR PSYCHIATRY. 2022;27(3):1855
    Sellgren CM; Imbeault S; Larsson MK; Oliveros A; Nilsson IAK; Codeluppi S; Orhan F; Bhat M; Tufvesson-Alm M; Gracias J; Kegel ME; Zheng Y; Faka A; Svedberg M; Powell SB; Caldwell S; Kamenski ME; Vawter MP; Schulmann A; Goiny M; Svensson CI; Hokfelt T; Schalling M; Schwieler L; Cervenka S; Choi D-S; Landen M; Engberg G; Erhardt S
  • Preprint: MEDRXIV. 2021
    Gracias J; Orhan F; Hörbeck E; Holmén-Larsson J; Khanlarkani N; Malwade S; Goparaju S; Schwieler L; Fatourus-Bergman H; Pelanis A; Goold C; Goulding A; Annerbrink K; Isgren A; Sparding T; Schalling M; Yañez VC; Göpfert J; Nilsson J; Brinkmalm A; Blennow K; Zetterberg H; Engberg G; Piehl F; Sheridan S; Perlis R; Cervenka S; Erhardt S; Landen M; Sellgren C
  • Conference publication: NEUROPSYCHOPHARMACOLOGY. 2019;44(SUPPL 1):490-491
    Erhardt S; Sellgren CM; Schwieler L; Imbeault S; Engberg G
  • Conference publication: NEUROPSYCHOPHARMACOLOGY. 2019;44(SUPPL 1):169-170
    Engberg G; Xu C; Sellgren C; Fatouros-Bergman H; Blennow K; Zetterberg H; Brinkmalm A; Erhardt S
  • Letter: SCHIZOPHRENIA RESEARCH. 2019;208:490-492
    Santillo AF; Lundgren S; Xu C; Orhan F; Fatouros-Bergman H; Blennow K; Zetterberg H; Portelius E; Cervenka S; Jonsson EG; Erhardt S; Engberg G
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Forskningsbidrag

  • Swedish Research Council
    1 January 2025 - 31 December 2027
    The kynurenine pathway, generating neuroactive metabolites, plays a crucial role in mental processes. Excess of kynurenic acid (KYNA), driven by immune activation, triggers psychosis and cognitive dysfunction. This project aims to reduce brain KYNA by developing kynurenine aminotransferase (KAT) III inhibitors. Traditionally, KAT II dominates KYNA production
    however, our research reveals that immune activation induces KAT III. Together with SciLifeLab DDD, we have developed potent, brain-penetrant, and patentable KAT III-selective molecules. Our research encompasses five work packages where we will a) perform in vivo proof-of-concept studies of our developed KAT III inhibitors and assess KAT II and KAT III inhibition´s comparative efficacy in curbing KYNA production in immune-induced states. b) Investigate KAT III inhibition´s impact on dopamine neurotransmission and cognition. c) Develop antisense oligonucleotids (ASOs) for KAT III. d) Utilize brain-specific cellular models to investigate the efficacy of ASOs to prevent KYNA production, and to elucidate KAT II and KAT III localization and their specific roles in KYNA production. e) Develop biomarkers for patient selection for KAT III inhibitor treatment and to verify treatment response. This project may revolutionize psychiatric care with tailored treatments for immune-induced cognitive impairment or psychosis. Through interdisciplinary collaboration, we aim to advance psychiatry into modern precision medicine´s forefront.
  • Swedish Research Council
    1 January 2022 - 31 December 2024
  • Swedish Research Council
    1 January 2022 - 31 December 2024
  • Generation of enzyme inhibitors for the treatment of immune-induced psychosis and cognitive deficits
    Novo Nordisk Foundation
    1 August 2021 - 31 July 2022
  • Swedish Research Council
    1 January 2020 - 31 December 2023
  • Swedish Research Council
    1 November 2019 - 30 November 2019
  • Swedish Research Council
    1 January 2018 - 31 December 2021
  • Swedish Research Council
    1 January 2018 - 31 December 2020
  • Swedish Research Council
    1 January 2017 - 31 December 2019
  • Swedish Research Council
    1 January 2014 - 31 December 2017
  • Swedish Research Council
    1 January 2012 - 31 December 2013
  • Swedish Research Council
    1 January 2012 - 31 December 2013
  • Swedish Research Council
    1 September 2010 - 31 August 2016
  • Swedish Research Council
    1 September 2010 - 31 August 2016
  • Swedish Research Council
    1 January 2010 - 31 December 2011
  • Swedish Research Council
    1 January 2009 - 31 December 2012

´¡²Ô²õ³Ùä±ô±ô²Ô¾±²Ô²µ²¹°ù

  • Professor, Fysiologi och farmakologi, ̽»¨¾«Ñ¡, 2016-

Examina och utbildning

  • Docent, Farmakologi, ̽»¨¾«Ñ¡, 2006
  • MEDICINE DOKTORSEXAMEN, Institutionen för fysiologi och farmakologi, ̽»¨¾«Ñ¡, 2001

Uppdrag

  • Prefekt, Fysiologi och farmakologi, ̽»¨¾«Ñ¡, 2022-

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