探花精选

Division of Oral Health and Periodontology

The division is a very dynamic academic unit engaged in education and research, covering the clinical disciplines of periodontology and dental hygiene. Our primary education assignment is training dentists, dental hygienists and specialists in periodontology, whereas we also guide research education at the master's and doctoral levels. Several of our staff are associated with the University Dental Clinics or the ANA Futura Laboratory facilities.

Part of the:

Professor Georgios Belibasakis is head of the division that performs innovative research studies in the efficacy of prevention, improvement of diagnosis and enhancement of therapies for periodontal and peri-implant diseases. A branch of our research investigates the impact of oral heath on systemic diseases and conditions, as well as their bidirectional relationships, for the overall well being. We also carry out pedagogical research projects in the delivery of oral health and periodontology education. We have strong expertise in the microbial etiology and inflammatory pathogenesis of periodontal diseases, as well as the exploration of the oral microbiome and inflammatory burden in the connection between oral and general health.

Publications

All publications from group members

  • Article: JOURNAL OF ORAL MICROBIOLOGY. 2025;17(1):2479903
    Kaminska M; Dudzinska NAM; Yucel-Lindberg T; Soder B; Narayanan A; Potempa J; Mydel PM
  • Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2025
    Paz HES; Stolf CS; Bao K; Monteiro MF; Carvalho LM; Silbereisen A; Belibasakis GN; Casarin RCV; Bostanci N
  • Article: DENTOMAXILLOFACIAL RADIOLOGY. 2025;54(7):twaf042-539
    Park JH; Hamimi M; Choi JJE; Figueredo CMS; Cameron AB
  • Review: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY. 2025;140(3):300-311
    Joseph B; Mauramo M; Sorsa T; Anil S; Waltimo T
  • Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2025
    Bao K; Afacan B; Grossmann J; Silbereisen A; Ozturk V-O; Emingil G; Belibasakis GN; Bostanci N
  • Article: ACTA ODONTOLOGICA SCANDINAVICA. 2025;84:418-425
    Mikkola M; Kiukkonen A; Avellan N-L; Stoor P; Mattila V; Furuholm JO; Sorsa T; Nylund K
  • Article: JOURNAL OF PERIODONTOLOGY. 2025
    Modin C; Cederlund A; Gustafsson A; Yucel-Lindberg T; Jansson LE
  • Journal article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2025;52 Suppl 29:125-154
    Bostanci N; Manoil D; Van Holm W; Belibasakis GN; Teughels W
  • Letter: ORAL DISEASES. 2025;31(8):2663-2664
    Thomas JT; Joseph B; Anil S; Waltimo T; Sorsa T
  • Article: JOURNAL OF PERIODONTOLOGY. 2025;96(8):835-847
    Thomas JT; Joseph B; Varghese S; Vijayakumari BK; Sorsa T; Mauramo M; Anil S; Waltimo T
  • Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2025;52(Suppl 29):4-33
    Herrera D; Tonetti MS; Chapple I; Kebschull M; Papapanou PN; Sculean A; Abusleme L; Aimetti M; Belibasakis G; Blanco J; Bostanci N; Bouchard P; Buduneli N; Calciolari E; Carra MC; Chackartchi T; Dannewitz B; Danser M; Deng C; Derks J; Dietrich T; Discepoli N; Divaris K; Dommisch H; Donos N; Dutzan N; Eickholz P; Kuru BE; Almeida RF; Farina R; Feher B; Figuero E; Giannobile W; Gosset M; Graziani F; Gursoy UK; Hagenfeld D; Jepsen K; Jepsen S; Kumar P; Laine ML; Lambert F; Lang NP; Li Y; Loos B; Madianos P; Matesanz P; Mealey B; Molina A; Montero E; Nibali L; Preshaw P; Rakic M; Ramseier C; Salvi G; Sanchez N; Sanz-Sanchez I; Shapira L; Stavropoulos A; Tamimi F; Teughels W; Tomasi C; Trombelli L; Vassilopoulos S; Verket A; West N; Windisch P; Sanz M
  • Review: JOURNAL OF CLINICAL PERIODONTOLOGY. 2025;52(Suppl 29):125-154
    Bostanci N; Manoil D; Van Holm W; Belibasakis GN; Teughels W
  • Article: INTERNATIONAL JOURNAL OF DENTAL HYGIENE. 2025;23(3):625-631
    Malmqvist S; Strandberg P; Victorin I; Boberg E; Johannsen A
  • Article: EUROPEAN JOURNAL OF DENTISTRY. 2025
    Thomas JT; Joseph B; Sorsa T; Anil S; Waltimo T
  • Article: SCIENTIFIC REPORTS. 2025;15(1):24719
    Kesti E; Eurola A; Kaasinen M; Mustonen H; Hagstroem J; Sorsa T; Ristimaeki A; Seppaenen H; Haglund C; Sund M
  • Article: ORAL DISEASES. 2025;31(7):2084-2090
    Saraneva O; Furuholm J; Hagstrom J; Sorsa T; Rita V; Tervahartiala T; Valimaa H; Ruokonen H
  • Article: JOURNAL OF DENTAL RESEARCH. 2025;:220345251337745
    Bao K; Oscarsson J; Gehring P; Grossmann J; Belibasakis GN; Bostanci N
  • Book chapter: JOB HUNTING FOR THE 21ST CENTURY. 2025;p. 108-138
    Massela MCM; Belibasakis G; Wester G; Manzo M; Jaladurgam NR; Rittmann SK-MR
  • Article: DIAGNOSTICS. 2025;15(11):1411
    Penttala M; Sorsa T; Thomas JT; Grigoriadis A; Sakellari D; Sahni V; Gupta S; Parnanen P; Patila T; Raisanen IT
  • Article: EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY : OFFICIAL JOURNAL OF THE EUROPEAN ACADEMY OF PAEDIATRIC DENTISTRY. 2025;26(3):517-525
    Brannemo I; Norman J; Kvist T; Lindberg L; Tsilingaridis G
  • Show more

Funding

Grants

  • Surveillance of the oral resistome for life-threatening oral infections
    Steering Group KI/Region Stockholm for Dental Resedarch
    1 January 2023 - 31 December 2025
    The advent of antibiotic therapy over the past century has brought along the global healthcare threat of antibiotic resistances. This biological complication can render pathogens unresponsive to treatment and permit the development of life-threatening infections. Oral infections are very common painful conditions, that impinge on the patient麓s well-being. However, on some occasions they may spread beyond the neighboring tissue even to distant vital organs via the blood stream, where they can become potentially lethal for the patients. These infections may also cause airway obstruction or cause damage to vital structures in the head and neck area. Effective antibiotic treatment can prove to be lifesaving in such cases. On the contrary, the presence of resistances among the involved microorganisms (鈥榬esistome鈥) may imperil the outcome. Important knowledge gaps exist in this healthcare domain, including lack of consensus on risk factors or standard treatment protocols, or insufficient estimation of antibiotic resistance levels within microbial communities and human populations. To contribute to bridging those gaps, this project aims to evaluate retrospectively the prevalence of oral infections, particularly of dental-origin, that required antibiotic treatment, while assessing the most common types of antibiotic resistances present. Patient registry data will be retrieved from Karolinska University Hospital, Huddinge in a complementary approach between clinical and laboratory hubs, as summarized in Workpackage-1. Workpackage-2 aims to prospectively evaluate antibiotic resistances in samples retrieved from oral infection referral patients at Karolinska University Laboratoty, by performing functional and molecular characterization of the isolates at the Department of Dental Medicine (ANA Futura Laboratories). Deeper molecular characterization of known and unknown resistance genes will be acquired by whole-genome sequencing (WGS) of the resistant bacterial isolates. This project will describe the current use of antibiotics in treating oral infections and initiate the mapping the 鈥榦ral resistome鈥, while paving the way for establishing a cross-Departmental regional Reference Centre for Antibiotic Resistances. Over time, the dynamic data collection will deliver much-needed scientific evidence for strategies and guidelines for antibiotic stewardship programs for treatment of oral infections and beyond.
  • Swedish Research Council
    1 December 2022 - 30 November 2025
    The Gram-positive anaerobic rod Filifactor alocis is an emerging聽oral pathogen聽associated with multiple oral infections. We聽discovered in聽 F. alocis a hitherto unknown RTX toxin, which we named FtxA. It is homologous to聽B. pertussis聽adenylate cyclase toxin (ACT) CyaA and to聽A. actinomycetemcomitans leukotoxin LtxA. FtxA is the 1st ACT and the 2nd RTX聽identified among the oral microbiome.The mechanisms by which it may act as a virulence factor of F. alocis to regulate the oral microbial ecology and immune response is an uncharted territory and the project麓s main aim. In the first segment of the project, clinical isolates and genetically manupulated F. alocis strains will be used to decipher the fucntional roles of FtxA in F. alocis microbe-microbe ecological competition and host-microbe immuno-pathogenic interactions of F. alocis.聽This approach will employ聽biofilms, immune cells and organotypic tissue in vitro models and metaproteomics. In the second segment, the virulence contribution of聽FtxA will be evaluated in a聽murine model of聽F. alocis聽infection, using single-cell proteomics. Moreover, the expression levels of FtxA will be evaluated in a聽cohort of periodontitis patients, where the oral levels of F. alocis have already been defined聽before and after treatment. By deciphering the fucntional properties of聽FtxA , the project will lay the foundation for novel prevention and therapeutic strategies against infections caused by聽F. alocis聽or other RTX-producing species.
  • FWF Austrian Science Fund
    1 March 2022 - 28 February 2026
    1) Project file. Modulation of dental plaque interactions with host cells by the periodontal pathogen Tannerella forsythia 2) Content of research project. The oral cavity, similarly to other human organs, is colonized by various microorganisms. Bacterial colonization is controlled by the host immune system and most oral bacteria are beneficial for humans. However, overgrow of some microorganisms might lead to the development of periodontitis, one of the most frequent infectious diseases of adults world-wide, which results in tooth loss, if untreated. In most cases, periodontitis is associated with increased numbers of the "red complex" bacteria - Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia - in the oral biofilm (dental plaque). These bacteria possess specific virulence factors, which facilitate invasion into the human body and cause tissue destruction. Studies in the last years provided evidence that the periodontal pathogen P. gingivalis is able to manipulate distinct components of the host immune system and, consequently, changes the interaction between the oral microbial community as a whole and the immune system. This ability of P. gingivalis is now considered as a key for the progression of periodontitis. 3) Hypothesis. It is currently unclear if other members of the red complex group possess a comparable ability to manipulate the host immune system. Based on own recent data we hypothesize that the periodontal pathogen T. forsythia is an emerging candidate for research into that direction. Thus, this project is designed to investigate T. forsythia for its host-manipulative ability. 4) Methods. To test our hypothesis, we have chosen a combined cell biology / microbiology approach. We will use a biofilm model consisting of five commensal oral microorganisms into which T. forsythia will be incorporated. To delineate effects caused by this pathogen, we will compare the reactions of different human cells involved in the immune response to the biofilm, once with and once without T. forsythia. We will set-up different biofilm-cell co-culture models and we will specifically investigate the biofilm-induced response in epithelial cells, neutrophils, macrophages, and gingival cells, which form the body`s first line of defense against bacterial infection. We will measure several functional parameters involved in the host response against infection and in the control of microbial growth. 5) Explanation indicating what is new/special about the project. The data obtained in this interdisciplinary project will unravel if and how T. forsythia is involved in manipulating the host immune response and disturbing the balance between the immune system and the oral microbial community. The results of this project might pinpoint novel therapeutic and prophylaxis approaches against periodontitis. Above that, learning about new facets of microbial-host interactions will contribute to increasing our general understanding of how bacteria thrive in our body.
  • FWF Austrian Science Fund
    1 December 2020 - 31 October 2025
    The globally occurring gum disease periodontitis critically involves the pathogenic bacterium Tannerella forsythia acting as a late colonizer of a polymicrobial biofilm, commonly known as dental plaque. We found that this bacterium has a unique cell surface protein glycosylation, which underpins its pathogenicity by influencing the relationship with other biofilm bacteria and the host through dedicated glycobiological and glycoimmunological interactions
    a specific sugar acid (nonulosonic acid) seems to be pivotal to these interactions. A comparison of all publicly available genome sequences of periodontitis-associated T. forsythia strains revealed the presence of a distinct gene cluster that underlays protein glycosylation. In contrast, the genome of the novel, putative periodontal health-associated Tannerella species BU063, which is the closest phylogenetic relative to T. forsythia, has a different glycosylation gene cluster lacking genes for sugar acid biosynthesis. We hypothesize that an altered glycome contributes to the difference of periodontal pathogenesis by Tannerella sp. BU063 and provides a new foundation to further understand the genome evolution and mechanisms of bacteria-host interaction in closely related oral microbes with different pathogenicity potential. Initial data indicate differences in surface-layer protein glycosylation and immunogenicity of Tannerella sp. BU063 compared to T. forsythia. Our novel procedures for cultivation and genetic manipulation of Tannerella sp. BU063 make detailed glycobiological investigations possible. We will investigate the glycoinfrastructure of the Tannerella sp. BU063 cell envelope and determine possible implications for the bacterium`s biofilm lifestyle and interaction with the host. Methods include anaerobic bacterial cultivation, mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR) for glycan structure elucidation, glycoproteomics, genetic manipulation, immune response profiling, biofilm techniques, and imaging. This project generates glycobiology information on a novel oral Tannerella species and aims at delineating glycobiology-mediated mechanisms that could support the association of this bacterium with periodontal health. In relation to the glycobiology knowledge of the pathogenic relative T. forsythia, this project might provide novel insight into the pathogenesis of periodontitis and pinpoint novel therapeutic and prophylaxis approaches against the disease. It also furthers our knowledge on the Bacteroidetes phylum, to which Tannerella species are affiliated, since this bacterial phylum is prominent not only in the oral but also in the gut microbiome. This project is a collaboration between Christina Sch盲ffer (principal investigator
    microbiology, glycobiology, biofilm, imaging), Friedrich Altmann (MS), Markus Blaukopf (NMR), all Universit盲t f眉r Bodenkultur, Vienna, Austria, Oleh Andrukhov (immunology
    Medical University, Vienna, Austria), and Georgios N. Belibasakis (interaction studies with selected host cells
    Karolinska Institutet, Huddinge, Sweden).
  • Chair-side molecular diagnostics for oral antibiotic resistances in dental practice
    Steering Group KI/Region Stockholm for Dental Research (SOF)
    1 January 2020 - 31 December 2022
  • Osseointegration in humans - A comprehensive approach from mouth to extremities
    CIMED Cooperation Grant
    15 April 2018 - 14 April 2019

Staff and contact

Head of Division

All members of the group

Activity and projects

Our goal is to perform cutting-edge research and education in oral health, to optimize prevention, diagnosis and treatment of common oral diseases, and contribute to the overall well-being.

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Georgios Belibasakis

Professor of Clinical Oral Infection Biology and Head of Oral Health and Periodontology

Oral microbiology and infection

Principal investigator: Georgios Belibasakis

Microbiome dynamics in oral health and disease

The aim of this research theme is to characterize the structural and functional composition of the oral microbiome. The specific aims include a) the identification of distinctive microbial patterns in oral health and oral infectious disease, such as dental caries, endodontic infections and periodontal and peri-implant disease, and b) the effect of the various treatment strategies on the dynamics changes of the site microbiome, towards the restoration of oral health. These studies involve analysis of biological samples obtained from clinical cohorts by conventional molecular and high-throughput technologies, such as next generation sequencing.

Oral biofilm ecology and interactions

This research theme aims at providing deeper insights to the ecology of oral biofilms and their intrinsic and extrinsic interactions. It is taken to understand the interaction between the individual microbial species with poly-microbial communities, the micro-environmental factors that drive their behavior, and their interaction with the oral cells/tissues in inducing a protective or destructive host response. These studies involve multi-species bacterial biofilm models grown in the laboratory. Among the scopes of this research is to test various antimicrobial modalities on the biofilms, as a preamble for validating candidate therapeutic interventions for future clinical application.

Chairside diagnostics for oral diseases

This research line has direct implication on patient diagnostics for oral infectious diseases. It aims at developing chair-side diagnostic tests for their implementation in clinical dental practice. It is based on developing saliva-based microfluidic assays for nucleic-acid detection of selected cariogenic and periodontopathogenic species, as well as protein bioassays for periodontal diseases. The back-bone of this research line is the Horizon2020 EU project DIAGORAS, in which 探花精选 is a partner.

Mapping of the oral resistome

This theme aims to investigate the presence of antibiotic resistances among microorganisms involved in oral infections that may imperil the outcome of antibiotic treatment. The project is founded on a cooperation with clinical and laboratory hubs at the Karolinska University Hospital and Karolinska University Laboratory, respectively. It is based on complementary retrospective and prospective approaches that screen for antibiotic resistances in the available registry data and in newly collected oral infection samples, respectively. In the latter approach, both conventional susceptibility testing and molecular detection of resistance genes are performed. Deeper molecular characterization of known and unknown resistance genes is acquired by whole genome sequencing. This continuous data collection will deliver a dynamic mapping of the 鈥oral resistome鈥 to assist in the development of strategies and guidelines for antibiotic stewardship programs.

Inflammation and periodontal pathogenesis

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Nagihan Bostanci

Professor and Deputy Head of Department for International Affairs

Periodontology, periodontal Inflammation, periodontal microbiome, host-pathogen interactions, molecular microbial ecology, metaproteomics, systems biology, development of new antimicrobials, oral biofluid biomarkers.

Prof Bostanci麓s group focuses on in vitro and in vivo analysis of host-pathogen interactions in the context of periodontal diseases. This research line involves a range of complementary disciplines and approaches, including clinical periodontology, immunology, microbiology, bioengineering, proteomics, metaproteomics and systems biology. The group aims to better understand periodontal homeostasis and the underlying mechanisms of inflammatory periodontal pathogenesis. The ultimate goal is to improve the quality of periodontal care delivered through early and accurate diagnosis, and development of innovative targeted therapeutic approaches.

Her laboratory has three main research directions in periodontology including:

  • discovery of biomarkers of periodontal and systemic inflammation, in conjunction with multi- high-throughput 鈥渙mic鈥 technologies and systems biology approaches
  • understanding potential links between periodontal disease and women's health
  • understanding potential links between oral diseases and diabetes mellitus
  • deciphering how periodontal bacteria compete against each other by means of their specific virulence factors, and how the periodontal tissues 鈥嬧媋re affected during such complex interactions

Group members

, Postdoc

, Postdoc

Jeanette Norman, PhD student

Projects

  • Discovery of biomarkers of periodontal and systemic inflammation
  • Women鈥檚 health and periodontal disease
  • Development of novel in vitro model systems for studying periodontal infections

Research support

  • Swedish Research Council
  • 探花精选
  • SOF

Oral health in patients with memory disorders

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K氓re Buhlin

Senior Lecturer/Senior Dentist
+46852488276

Principal Investigator

K氓re Buhlin, Associate Professor, Division of Oral Diseases

The main objective is to investigate if periodontal disease and memory-related diseases, particularly Alzheimer麓s disease (AD), are associated. If a causal relation is found between dental infections and memory-related diseases it could have important clinical implications in the prevention of AD. The overall objective is to clarify whether oral inflammatory diseases can be related to the brain's memory capacity.

Methods: Three groups of patients with distinctive dementia diagnoses and matched controls will undergo a dental examination, including saliva and bacterial samples and radiological examination. Patients and controls will fill out a questionnaire that highlights their attitude to dental care, dental health, public health and socio-economic parameters. The controls will undergo Mini Mental State Examination. Analysis of plasma, saliva and cerebrospinal fluid (CSF) will be performed and the results will be correlated with dental status.

If a causal relationship between periodontal disease and memory-related diseases can be identified, it will open new possibilities for preventing disease in this vulnerable and frail patient group.

Project: Clinical, microbiological and immunological efficacy of antiseptics in the management of chronic periodontitis

To investigate polyhexamethylene guanidine phosphate antimicrobial activity and evaluate it in comparison to chlorhexidine and water. Evaluate it as a chair side rinse

Group members

  • Anton Vitt, PhD student, Division of Periodontology and Implant Dentistry
  • Jacob Holmer, PhD student, Division of Periodontology and Implant Dentistry

Collaborations

  • The Geriatric Clinic, Karolinska University Hospital, Huddinge, Sweden
  • Belarusian State Medical University, Minsk, Belarus

Financing

The Swedish Dental Society, CSTP grant, KI, SOF grant, Stockholm County Council, KIRT grant, KI

Systemic use of antibiotics in dentistry

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Margareta Hultin

Principal Investigator
+46852488248

Our research focuses mainly on questions on how systemic antibiotics is used in dentistry and its microbiological and clinical effect. (For example the effect of the use of antibiotics in implant dentistry). Our projects are also aimed at gaining knowledge on attitudes and prescription patterns of systemic antibiotics among dentists. Our general hypothesis is that there is a great potential for improvement of antibiotic utilization in odontology although there has been a reduction in antibiotic prescription in dentistry during the last decade. Our projects are designed to attain and develop antimicrobial stewardship in odontology. The project is driven by a large translational group collaborating to cover the identified knowledge gaps within antibiotic utilization in dentistry by combining epidemiological studies and methodology with clinical and basic science. Implementation of the results in the dental society will be aided by active participation in the strategic work to reduce antibiotic usage in dentistry by collaboration with Swedish Public Dental Service (Folktandv氓rden), Institution of dental medicine, 探花精选, Strama - the Swedish strategic program against antibiotic resistance, The Public Health Agency of Sweden, Swedish Medical Product Agency and other health authorities regarding guidelines and educational efforts.

Group Members

  • Dalia Khalil, assistant professor associated to 探花精选, Saudi Arabia
  • Caroline Grundstr枚m, PhD student, 探花精选, Uppsala l盲ns landsting - Folktandv氓rden

Collaborators

  • , professor, 探花精选 and University of Bergen
  • Aron Naimi-Akbar, 探花精选 - Stockholms l盲ns landsting and Karolinska University Hospital
  • , Senior professor 探花精选
  • Sofia Tranaeus, division head, SBU
  • , professor, 探花精选
  • , professor, 探花精选
  • Andreas Cederlund, assistant professor Stockholms l盲ns landsting - Folktandv氓rden,
  • Eastman
  • , PhD student, 探花精选 Stockholms l盲ns landsting/Folktandv氓rden
  • Frida Lundgren, Socialstyrelsen
  • Morten Enersen, Associate professor, University of Oslo
  • STRAMA
  • 贵辞濒办丑盲濒蝉辞尘测苍诲颈驳丑别迟别苍

Projects

Prescription of antibiotics in dentistry 鈥 a patient register study

Hypothesis: There is a potential for improvement of the utilization of antibiotics in dentistry supported by the unexplained large differences seen between different geographical areas, between private and public dentistry and gender.

Aim: Identify potential areas improvement potential regarding the prescription behavior of antibiotics in dentistry.

Material and methods: Data regarding provided dental care during the period 2009-2017 for adult patients (鈮20 years) of age will be collected from the Social Welfare Dental Health Register. Data regarding antibiotic prescriptions from dentistry retrieved at a pharmacy during the same study period will be extracted from the Swedish Drug Register. Prescriptions in close temporal connection to dental treatment will be regarded as associated with the treatment in question. Comparison between time-period before and after publication of recommendations, different geographical regions, gender, type of treatment, private or public care and remaining teeth will be done.

Peri-implantitis 鈥 Surgical treatment and risk factors

Dental implant therapy is used worldwide for the rehabilitation of partially and completely edentulous jaws and has shown successful results in a number of studies with survival rates of 90-95% for up to 20 years. However, complications do occur where peri-implantitis is shown to develop in approximately 20% of individuals and 10% of inserted implants. Considering the large number of patients receiving implants, the population developing peri-implantitis is significant.

The general aim of these studies is to assess the surgical treatment and risk factors for treatment of peri-implantitis and to determine clinical and microbiological changes in the oral and intestinal microflora after the use of adjunctive, systemic antibiotics. Within this PhD project, a series of studies are designed.

Prevalence of peri-implantitis in previously bone augmented partially or edentulous areas with special focus on the prevalence of peri-implantitis and the importance of implant maintenance treatment. The aim is also to investigate patients oral health-related quality of life after dental implant treatment with and without autogenous bone grafts.
To evaluate if the use of systemically, adjunctive antibiotics during peri-implant surgery will affect the clinical outcome. The use of two different combinations of antibiotic substances will be evaluated and compared to placebo (A= amoxicillin & metronidazole, B= penicillin V & metronidazole, C= placebo).
To determine the changes in antibiotic susceptibility of oral and intestinal microflora following a 7-day course of systemic antibiotics and to determine the long-term quantitative and qualitative changes in the oral and intestinal microflora following a 7-day course of systemic antibiotics.
To evaluate if the use of systemically, adjunctive antibiotics during peri-implant surgery will affect the long-term clinical outcome (2-3 years of follow up).

Antibiotic utilization in emergency dental care

The aim is to study the use of antibiotic in treatment of patients seeking for emergency dental care, and to determine the most common treatment measures during the emergency visit. A secondary aim is to investigate attitudes and routines towards antibiotic prescription among dentists providing emergency care. This observational questionnaire survey will be conducted at two emergency dental clinics (one public and one private), in Stockholm, Sweden.

Research support

探花精选 - SOF

Articles

  • Hultin M, Bostr枚m L, Gustafsson A. Neutrophil response and microbiological findings around teeth and dental implants. J Periodontol. 1998 Dec;69(12):1413-8.
  • Hultin M, Fischer J, Gustafsson A, Kallus T, Klinge B. Factors affecting late fixture loss and marginal bone loss around teeth and dental implants. Clin Implant Dent Relat Res. 2000;2(4):203-8.
  • Hultin M, Gustafsson A, Klinge B. Long-term evaluation of osseointegrated dental implants in the treatment of partly edentulous patients. J Clin Periodontol. 2000 Feb;27(2):128-33.
  • Hultin M, Gustafsson A, Hallstr枚m H, Johansson LA, Ekfeldt A, Klinge B. Microbiological findings and host response in patients with peri-implantitis. Clin Oral Implants Res. 2002 Aug;13(4):349-58.
  • Khalil D, Hultin M, Andersson Fred L, Parkbring Olsson N, Lund B. Antibiotic prescription patterns among Swedish dentists working with dental implant surgery:adherence to recommendations. Clin Oral Implants Res. 2014 Apr 15. 10.1111/clr.12402.
  • Khalil D, Hultin M, Fredriksson EH, Sj枚gren E, Lundholm P, Lund B, The use of intra oral radiographic sensors, a possible source of bacterial transmission in the dental office, Journal of Hospital Infection 2016, doi: 10.1016/j.jhin.2016.09.003.
  • Khalil D, Hultin M, Rashid MU, Lund B. Oral microflora and selection of resistance after a single dose of amoxicillin. Clin Microbiol Infect. 2016 Aug 26. pii: S1198-743X(16)30328-7. doi:10.1016/j.cmi.2016.08.008.
  • Klinge B, Flemming T, Cosyn J, De Bruyn H, Eisner BM, Hultin M, Isidor F, Lang NP, Lund B, Meyle J, Mombelli A, Navarro JM, Pjetursson B, Renvert S, Schliephake H. The patient undergoing implant therapy. Summary and consensus statements. The 4th EAO Consensus Conference 2015. Clin Oral Implants Res. 2015 Sep;26 Suppl 11:64-7. doi: 10.1111/clr.12675.
  • Lund B, Hultin M, Tranaeus S, Naimi-Akbar A, Klinge B. Complex systematic review - Perioperative antibiotics in conjunction with dental implant placement. Clin Oral Implants Res. 2015 Sep;26 Suppl 11:1-14. doi: 10.1111/clr.12637.
  • Naimi-Akbar A, Hultin M, Klinge A, Klinge B, Tran忙us S, Lund B. Antibiotic prophylaxis in orthognathic surgery: A complex systematic review. PLoS One. 2018 Jan 31;13(1):e0191161. doi: 10.1371/journal.pone.0191161.eCollection 2018.

Oral Health

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Annsofi Johannsen

Principle Investigator
+46852488265

My research comprise several areas in Oral health:

  • Stress and depression in relation to gingival inflammation/periodontitis
  • A new treatment method for peri-implantitis
  • Smoking and inflammation
  • Oral health among persons with Crohns disease
  • Toothbrush with incorporated blue LED light on gingival inflammation
  • Oral health among adolescents, adults, and elderly
  • Systematic reviews
  • Dental Hygienist profession

To achieve good oral health is one of the most significant tasks in order to maintain a good quality of life and well-being. My line of research emphasizes this goal and therefore it is very important.
My research include both quantitative, qualitative, and pedagogical studies.

Group members

, RDH, PhD- student, 探花精选 (KI), , DDS, Professor, Specialist Periodontology (KI), , DDS, PhD (KI), , DDS, Associate professor, Specialist Periodontology, KI, Dana Clinic, Stockholm, , Professor, Oral microbiology (KI), Talat Qadri, DDS, PhD, Kami Dental AB, Enk枚ping and RDH (KI)

Collaborations

Anders Liljeborg, Associate Professor, Royal Institute of Technology (KTA).

Projects

Peri-implantits

The project compare treatment of peri-implantitis with either 970 nm laser or conventional mucosal flap surgery, to measure clinical parameters, inflammatory and microbial response. The project includes an in-vitro study with the aim to investigate the effects of laser on e.g., the surface structure of dental implants. Deep interviews will clarify the patients' experiences about these different treatment methods. We will also compare the immune cell profile in peri-implantitis with the immune cell profile in periodontitis and health lesions.

Theory-based behavioural interventions 鈥 A pedagogic and patient centered project

Comprehensive dental care should include effective, evidence-based behavioural methods (such as qualified counselling and/or theory-based counselling) for the patient education, intended to achieve long-term lifestyle changes and behaviours or importance to oral health. The overall aim is to explore the existing teaching regarding the use of behavioural intervention methods, identify and obstacles and design a separate syllabus within this topic, to achieve better oral health and quality of life among the patients. To identify prerequisites and limitations for using theory-based behavioural interventions among the dental hygienist by questionnaires and in-depth interviews. And explore the patients鈥 perspectives regarding these methods to see if it can affect oral health and quality of life.

Collaborations

, DDS, Associate professor, Division of Oral Rehabilitation, 探花精选,, Professor, Department of Learning, Informatics, Management and Ethics, 探花精选, Henrique Luis, Professor, University of Lisbon.

Systematic reviews

In another ongoing systematic literature dental erosions is studied based on different issues such as diagnosis, treatment, and prevention. Collaboration with SBU and Eastman Institute.

 

Dental Hygienist profession today and a future perspective

The purpose is to identify the stakeholders view of the dental hygienist profession regarding tasks and skills today and from a future perspective. The project will identify important aspects regarding the dental hygienist's competence and the content of dental hygiene education and also the continuing education to be able to meet the future social need. Both a web-based survey and depth interviews with stakeholders will be carried out. Collaboration with co-workers at KI.

Research support

  • SOF/SLL
  • EU/Erasmus+ Project
  • The Swedish Research Council

Articles

Effects of Adjunctive Daily Blue Light Toothbrushing on Dental Plaque and Gingival Inflammation - A Randomized Controlled Study. (2018)
Bjurshammar, N, Malmqvist, S, Johannsen, G, Bostrom, E, Fyrestam, J, Ostman, C. and Johannsen, A. 
Open Journal of Stomatology, 8, 287-303 DOI: 10.4236/ojst.2018.810027.

 DOI: 10.4236/ojst.2018.810027.
Andersson P, Johannsen A
Acta Odontol. Scand. 2016 ;74(4):285-90


Johannsen A, Fored MC, H氓kansson J, Ekbom A, Gustafsson A
PLoS ONE 2015 ;10(8):e0134001


Johannsen A, Susin C, Gustafsson A
Periodontol. 2000 2014 Feb;64(1):111-26


Johannsen G, Tellefsen G, Johannsen A, Liljeborg A
Acta Odontol. Scand. ;71(3-4):508-17

Dental hygienist students麓learning about motivational interviewing. Dental hygienist students麓 learning about motivational interviewing
Johansson A, Johannsen, G, Uhlin, K. Johannsen A
Dental. Journal 2014, 2(2), 65-77. DOI: 10.3390/dj2020065


Johannsen A, Westergren A, Johannsen G
J. Clin. Periodontol. 2012 Jul;39(7):681-7


Johannsen A, Rydmark I, S枚der B, Asberg M
J. Periodont. Res. 2007 Dec;42(6):546-52


Erdenborg J, Malmqvist S, Bjurshammar N, Johannsen G, Hultin M, Johannsen A. Stakeholder J
Int Soc Prev Community Dent. 2020 Jan 24;10(1):54-61.


Johannsen A, Malmqvist S, Gra莽a S, Assun莽茫o V, Albuquerque T, Luis H.J
Int Soc Prev Community Dent. 2019 May-Jun;9(3):296-302.


Johannsen A, Emilson CG, Johannsen G, Konradsson K, Lingstr枚m P, Ramberg P.
Heliyon. 2019 Dec 9;5(12):e02850.


Sfeatcu R, Dumitrache MA, C膬r膬mid膬 M, Johannsen A, Perlea P.
Int J Dent Hyg. 2019 Aug;17(3):221-228.

 

 

 

 

 

 

 

 

Keywords:
Aggressive Periodontitis Infectious Medicine Microbiology in the Medical Area Odontology Oral Health Show all
Content reviewer:
Georgios Belibasakis
Kicki Carlsson
04-09-2025