Britta Wahren Project
We have designed small DNA constructs to be used for immunotherapy and propylaxis in human immunodeficiency virus disease and in colorectal carcinoma.
Research project
The resulting vaccines have been used in human trials in four different countries in Europe and Africa. They appear to be very effective in priming for immune responses against a variety of HIV strains because they stimulate both innate, humoral and cell-mediated immunities. Genetic vaccines have several advantages: they make the person produce the vaccine protein in his own cells, and the vaccine thus becomes tailor-made for the immune responses of the vaccinated individual. The HIV DNA vaccine will be studied for decrease of viral reservoir in children born to HIV-infected mothers in South Africa. In a consortium involving European countries we hold a PhD school for learning on HIV and now also Covid-19 immunology and vaccines.
Research networks
Collaborators
- Merlin Robb, for clinical HIV studies internationally, Military HIV research program and National Institutes of Health, USA.
- Paolo Rossi and Paolo Palma for pediatric HIV vaccine studies, Tor Vergata University and Bambino Gesu Hospital, Italy. &
- Margaret A. Liu, honorary doctor and foreign adjunct professor, Protherimmune and ̽»¨¾«Ñ¡, USA and SE.
- Joan Joseph Munne, for PhD education in EU project EAVI2020, University Hospital Vall d´Hebron, Spain.
- Athina Kilpeläinen, PhD examination Barcelona 2020, IrsiCaixa, Barcelona, .
- Jorma Hinkula, for animal research.
- At the ̽»¨¾«Ñ¡ primarily Pontus Blomberg, Maria Isaguliants, Stefan Petkov, Karl Ljungberg, Gunnel Biberfeld, Eric Sandström, and the Francesca Chiodi group.
Publications
Wahren B.
Hum Vaccin Immunother. 2022 Feb 25:1-4.
Latanova AA, Petkov S, Kilpelainen A, Jansons J, Latyshev OE, Kuzmenko YV, Hinkula J, Abakumov MA, Valuev-Elliston VT, Gomelsky M, Karpov VL, Chiodi F, Wahren B, Logunov DY, Starodubova ES, Isaguliants MG
Sci Rep 2018 May;8(1):8078
Hinkula J, Petkov S, Ljungberg K, Hallengärd D, Bråve A, Isaguliants M, et al
Heliyon 2017 Jun;3(6):e00339
Bauer A, Podola L, Mann P, Missanga M, Haule A, Sudi L, Nilsson C, Kaluwa B, Lueer C, Mwakatima M, Munseri PJ, Maboko L, Robb ML, Tovanabutra S, Kijak G, Marovich M, McCormack S, Joseph S, Lyamuya E, Wahren B, Sandström E, Biberfeld G, Hoelscher M, Bakari M, Kroidl A, Geldmacher C
J Virol 2017 Sep;91(18):
Klein N, Palma P, Luzuriaga K, Pahwa S, Nastouli E, Gibb DM, et al
Lancet Infect Dis 2015 Sep;15(9):1108-1114
Nilsson C, Hejdeman B, Godoy-Ramirez K, Tecleab T, Scarlatti G, Bråve A, et al
PLoS One 2015 ;10(6):e0131748
Palma P, Gudmundsdotter L, Finocchi A, Eriksson LE, Mora N, Santilli V, et al
Vaccines (Basel) 2014 Jul;2(3):563-80
Sandström E, Nilsson C, Hejdeman B, Bråve A, Bratt G, Robb M, Cox J, Vancott T, Marovich M, Stout R, Aboud S, Bakari M, Pallangyo K, Ljungberg K, Moss B, Earl P, Michael N, Birx D, Mhalu F, Wahren B, Biberfeld G,
J Infect Dis 2008 Nov;198(10):1482-90
Calarota S, Bratt G, Nordlund S, Hinkula J, Leandersson AC, Sandström E, Wahren B
Lancet 1998 May;351(9112):1320-5
WAHREN B
Nature 1965 Jan;205():409-10
Other references
- Professor Britta Wahren has been interviewed by Swedish National Radio (SverigesRadio P4) to mark World Aids Day on December 1st, 2016 .The interview looks at how far research has progressed with the development of an HIV vaccine. .
- After receiving the KI Silver medal 2015 for outstanding achievement in the field of ̽»¨¾«Ñ¡ research, Britta Wahren talks about her research past and present.
- Wahren B & Wahren P. Framtidens farliga smitta – hur kan vi skydda oss. Britta Wahren, Patrik Wahren, KI University Press 2007.
- In 2015 Britta Wahren received the Grand Silver Medal Award of ̽»¨¾«Ñ¡ for outstanding ̽»¨¾«Ñ¡ research.
- Britta Wahren participates in a interview with the Swedish Radio (SR) called "".
- Contributing to KI essay pages and documentation project on the history of ̽»¨¾«Ñ¡ and /om-ki/essasamling.