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The VOXEL group at ARC

We are specialised in neuroimaging techniques and methods pertaining to magnetic resonance imaging and positron emission tomography.

graphic illustration of a brain in cross-section
Image: Grégoria Kalpouzos

Focus

We have a strong focus on novel imaging techniques and methods, and multimodal imaging.

Aim

We want to contribute to the development of neuroimaging techniques and methods and create opportunities to establish new collaborations.

What we do

Here are some examples of what we currently do.

  • Brain iron imaging using quantitative susceptibility mapping and signal separation (paramagnetic/diamagnetic)
  • MR Elastography to assess stiffness and viscoelastic properties of the brain tissue and multidimentional diffusion, in collaboration with
  • PET imaging of the dopaminergic system, in collaboration with , University or Turku, Finland
  • Development of a high-resolution T2 sequence on 3T MRI for the assessment of the olfactory bulbs in collaboration with , Stockholm University
  • Development of a deep learning tool for the automated segmentation of midbrain nuclei (see section Available codes)
  • Contributions to the Stanford Multilayer Integration of Networks Toolbox (see section Available codes)
  • MR spectroscopy in collaboration with SUBIC and Örebro University

Current group members

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Farshad Falahati

Research Infrastructure Specialist, Engineer
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Grégoria Kalpouzos

Associate Professor, Senior Lecturer
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Martin Nilsson

Doctoral student
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Javier Oltra

Postdoctoral Researcher
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Goran Papenberg

Associate Professor, Principal Researcher
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Alireza Salami

Associate Professor, Principal Researcher
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Frida Smids

Doctoral student
What we do
MRISummary measures/assessment
T1-weightedMorphometrics, perivascular spaces
Diffusion Tensor Imaging (DTI)White-matter integrity, structural connectome
Functional MRI (task, rest)Activation, functional connectome
T2-FLAIRWhite-matter hyperintensities
Multi-echo Gradient Recalled Echo (meGRE)Relaxometry R2*, Quantitative Susceptibility Mapping (QSM) for iron quantification
Fast-Spin Echo, Magnetization TransferNeuromelanin (locus coeruleus, substantia nigra)
High-resolution T2Olfactory bulbs' anatomy
MR ElastographyCerebral stiffness, viscosity-elasticity
Multidimensional diffusion (MUDI)Subvoxel diffusion metrics (e.g., microanisotropy)
Pseudo-continuous Arterial Spin Labeling (pCASL)Quantitative cerebral blood flow (perfusion)
Susceptibility Weighted Imaging (SWI)Microbleeds
Neurite Orientation Dispersion and Density Imaging (NODDI)Neurite Density Index, Orientation Dispersion Index
1H MR Spectroscopy (MEGA-)PRESS, semi-LASERMetabolite concentrations (e.g., NAA, Cr, Cho, mI, Glx, GABA)
PET
PET
11C-RacloprideDopamine D2 receptors (at rest, and under reward)
11C-SCH23390Dopamine D1 receptors
18F-DOPADopamine synthesis
18F-PE2IDopamine transporter availability
11C-PBR28TSPO density, microglia

We also make use of publicly available data such as florbetapir (AV-45) and flortaucipir (AV-1451) PET for amyloid and tau, respectively.

Reference: Falahati F. Gustavsson J, Kalpouzos G (2024). . Imaging Neuroscience, 2: 1-20. Doi: 10.1162/imag_a_00304

Reference: Sarraf S, Avelar-Pereira B, Hosseini SMH; Alzheimer’s Disease Neuroimaging Initiative (2025). . Communications Biology 8(1):894. doi: 10.1038/s42003-025-08269-4.

Contact

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Grégoria Kalpouzos

Senior Lecturer
+46852485833

Contact us if you have any questions or would be interested in joining the group.

Content reviewer:
24-06-2025