Activities for the Infection Biology Network
KI Infection Biology Network Seminars
Seminars & Events for 2025
MTC Infection and Immunity Seminar Monday September 22nd
Deciphering Modes of Action of Antimalarial Drugs by Thermal Protein Profiling.
Speaker: Zbynek Bozdech, School of Biological Sciences, Nanyang Technological University, Singapore
Date: Monday September 22nd
Time: 13h00
Place: Biomedicum room D1012
Host: Gerald McInerney
Selected Publications
1.鈥係amuel Pazicky, Seth Tjia, Guilherme B. Farias, Nisha Philip, Radoslaw M. Sobota, Andrew P. Waters, Tim-Wolf Gilberger, Zbynek Bozdech, Thermal profiling maps the dynamic interactome in malaria parasites. This is a preprint just accepted by Nature Microbiology for publication.
2 Go, K. D., Yan, X. F., Wirjanata, G., Ero, R., Pazicky, S., Dziekan, J., Tjia, S., Lescar, J., Bozdech, Z. & Gao, Y. G. Antimalarial drug artemisinin stabilizes PfRACK1 binding to the ribosome. Structure 33, 1386-1397 e1385, doi:10.1016/j.str.2025.05.008 (2025).
3 Wirjanata, G., Lin, J., Dziekan, J. M., El Sahili, A., Chung, Z., Tjia, S., Binte Zulkifli, N. E., Boentoro, J., Tham, R., Jia, L. S., Go, K. D., Yu, H., Partridge, A., Olsen, D., Prabhu, N., Sobota, R. M., Nordlund, P., Lescar, J. & Bozdech, Z. Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development. Cell Chem Biol 31, 743-759 e748, doi:10.1016/j.chembiol.2024.03.002 (2024).
4 Dziekan, J. M., Wirjanata, G., Dai, L., Go, K. D., Yu, H., Lim, Y. T., Chen, L., Wang, L. C., Puspita, B., Prabhu, N., Sobota, R. M., Nordlund, P. & Bozdech, Z. Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome. Nat Protoc 15, 1881-1921, doi:10.1038/s41596-020-0310-z (2020).
5 Dziekan, J. M., Yu, H., Chen, D., Dai, L., Wirjanata, G., Larsson, A., Prabhu, N., Sobota, R. M., Bozdech, Z. & Nordlund, P. Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay. Sci Transl Med 11, doi:10.1126/scitranslmed.aau3174 (2019).
KI Infection Retreat 2025 29-30th of September
Location: Yasuragi
Abstract submission information:
Abstracts are sent to Jens.karlsson@ki.se no later than 31st of May. Every student and postdoc are required to send in an abstract. The abstract should be submitted in the form of a structured abstract using the template below.
Download the abstract submission template (word file)
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Seminar Thursday, October 2nd, 13.00-14.00
Speaker: Prof Stefan P枚hlmann, Infection Biology Unit, German Primate Center, G枚ttingen, Germany
Title: 鈥淭he 3As of SARS-CoV-2 infection: Activators, Antibodies & ACE2鈥
Room: Nils Ringertz at Biomedicum, ground floor
Host: Gerald McInerney
Selected Recent Publications
Zhang L, Kempf A, Nehlmeier I, Cossmann A, Richter A, Bdeir N, Graichen L, Moldenhauer AS, Dopfer-Jablonka A, Stankov MV, Simon-Loriere E, Schulz SR, J盲ck HM, 膶i膷in-艩ain L, Behrens GMN, Drosten C, Hoffmann M, P枚hlmann S. . Cell. 2024 Feb 1;187(3):596-608
Hoffmann M, Kr眉ger N, Schulz S, Cossmann A, Rocha C, Kempf A, Nehlmeier I, Graichen L, Moldenhauer AS, Winkler MS, Lier M, Dopfer-Jablonka A, J盲ck HM, Behrens GMN, P枚hlmann S. . Cell. 2022 Feb 3;185(3):447-456
Hoffmann M, Arora P, Gro脽 R, Seidel A, H枚rnich BF, Hahn AS, Kr眉ger N, Graichen L, Hofmann-Winkler H, Kempf A, Winkler MS, Schulz S, J盲ck HM, Jahrsd枚rfer B, Schrezenmeier H, M眉ller M, Kleger A, M眉nch J, P枚hlmann S. . Cell. 2021 Apr 29;184(9):2384-2393
Hoffmann M, Kleine-Weber H, Schroeder S, Kr眉ger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, M眉ller MA, Drosten C, P枚hlmann S. . Cell. 2020 Apr 16;181(2):271-280
Hoffmann M, M枚sbauer K, Hofmann-Winkler H, Kaul A, Kleine-Weber H, Kr眉ger N, Gassen NC, M眉ller MA, Drosten C, P枚hlmann S (2020) . Nature 585: 588-590
Previous events
Symposium September 12, 2025, Georg and Eva Klein Hall, Biomedicum, KI
"Microbial pathogenesis, antimicrobial development, and RNA biology
symposium in honor of Staffan Normark鈥檚 Birthday"
Program
10:00-10:05 Opening remarks by the organizers
10.05-10.40 Scott Hultgren, Washington University, US "Molecular Blueprint for antibiotic-sparing therapeutics to transform treatment of infectious diseases"
10.40-11.15 Fredrik Almqvist, Ume氓 University, Sweden "Disarming Fusobacterium nucleatum: Development of FadA Inhibitors to Enhance Immunotherapy and Reduce Tumor Burden in Colorectal Cancer"
11.15-11.50 Matthew Chapman, University of Michigan, US "Connecting the Fiber Between Neurodegenerative Disease and the Microbiome"
11.50-12.25 Kimberly Kline, University of Geneva, Switzerland "Pathogenesis of Enterococcal biofilm-associated infection"
12.25-13.00 BREAK
13.00-13.35 J枚rg Vogel, University of W眉rzburg, Germany "Asobiotics: Programmable antisense oligomers for selective targeting of microbes and phages"
13.35-14.10 Emmanuelle Charpentier, Max Planck Unit for the Science of Pathogens, Berlin, Germany "The journey towards the CRISPR-Cas genome editing revolution 鈥 The power of microbiology"
14.10-14.45 Elaine Tuomanen, St Jude麓s Children Research Hospital, Memphis, US "How the pneumococcus rewires prenatal brain development"
14.45-15.00 BREAK
15.00-15.45 Mathias Hornef, University of Aachen, Germany "Neonates are not small adults, postnatal establishment of intestinal host-microbial homeostasis"
15.45-16.20 Sebastian Suerbaum, Max von Pettenkofer Institute, LMU Munich, Germany "Genome and methylome variation in the gastric pathogen Helicobacter pylori"
Organizers:
Georgios Sotiriou, Edmund Loh and Birgitta Henriques-Normark KI Infection Biology Network
Monday June 9th 2025
"Bacterial meningitis: Mechanisms of neuronal damage and new therapeutic approaches to prevent it."
Speaker: Federico Iovino (Department of Neuroscience)
Team webpage: /en/research/research-areas-centres-and-networks/research-groups/neuro-infections-neuroinflammation-federico-iovino-group
When: Monday June 9th
Time: 13h00
Where: Biomedicum room D1012
Monday June 2nd at 13.00
"Multifaceted Proteomics for Deciphering Antibiotic Targets, Mechanism of Action, and Resistance"
Speaker: Amir Ata Saei (Department of Microbiology Tumor and Cell Biology)
Team webpage:
Where: Biomedicum room A0812
Date, time and venue: 5th May, 13.00, Christina Larsdotter seminar hall, Solna campus
Professor Mart Krupovic<, Institut Pasteur, France Mart Krupovic - Research - Institut Pasteur
Title: Viruses of archaea: the friendly side of the virosphere
Biosketch:
Mart Krupovic is the Head of the Archaeal Virology Unit in the Department of Microbiology at Institut Pasteur of Paris, France. He received his Ph.D. in 2010 in General Microbiology from the University of Helsinki, Finland. His current research focuses on the diversity, origin, and evolution of the virosphere, trying to decipher deep evolutionary connections between distantly related virus groups, with the goal of understanding the global organization of the virus world. As part of this effort, his group focuses on the archaeal virosphere, one of the least explored parts of the global virome. The research on archaeal viruses includes exploration of their diversity in different environments, characterization of structurally diverse virions, and study of molecular mechanisms of virus-host interactions. Dr. Krupovic serves as an editor or on the editorial boards of several peer-reviewed journals and is a member of the Executive Committee of the International Committee on Taxonomy of Viruses (ICTV). He is an elected Fellow of the American Academy of Microbiology, European Academy of Microbiology and Academia Europaea.
Publications:
Baquero DP, Medvedeva S, Martin-Gallausiaux C, Pende N, Sartori-Rupp A, Tachon S, Pedron T, Debarbieux L, Borrel G, Gribaldo S, Krupovic M. Stable coexistence between an archaeal virus and the dominant methanogen of the human gut. Nat Commun. 2024; 15(1):7702.
Krupovic M, Dolja VV, Koonin EV. Virome of the last eukaryotic common ancestor and eukaryogenesis. Nat Microbiol. 2023; 8(6):1008-1017.
Medvedeva S, Sun J, Yutin N, Koonin EV, Nunoura T, Rinke C, Krupovic M. Three families of Asgard archaeal viruses identified in metagenome-assembled genomes. Nat Microbiol. 2022; 7(7):962-973.
Contact:
Matti S盲llberg, matti.sallberg@ki.se
Contact for any questions about the infection network: Edmund Loh Edmund.loh@ki.se and Jens Karlsson jens.karlsson@ki.se