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Precisionsmedicin vid lungcancer – proteiner som nyckel till bättre behandling – Lukas Orres team

Målet med vår forskning är att hitta nya biomarkörer och mål för cancerbehandling för att förbättra precisionsmedicin vid lungcancer. För detta utvecklar och tillämpar vi avancerade metoder för att studera lungcancerproteomet i kliniska prover och effekterna av läkemedel på cancerceller. Genom att läsa av den molekylära fenotypen av cancer får vi unik information som kompletterar genomik för ökad diagnostisk precision, med förhoppningen om att förbättra överlevnaden hos lungcancerpatienter.

Publikationer

Alla gruppmedlemmars publikationer

  • Doctoral thesis: 2025
    Berkovska O
  • Journal article: CANCER RESEARCH. 2025;85(5_Supplement):b026
    Gudoityte G; Berkovska O; Orre L; Moussaud-Lemoderie E; Fernebro J; Joneborg U; Kallioniemi O; Seashore-Ludlow B
  • Article: ISCIENCE. 2025;28(2):111864
    Pan Y; Berkovska O; Marathe S; Mermelekas G; Gudoityte G; Wolide AD; Arslan T; Seashore-Ludlow B; Lehtio J; Orre LM
  • Article: LEUKEMIA. 2024;38(11):2382-2394
    Hagerstrand D; Oder B; Cortese D; Qu Y; Binzer-Panchal A; Osterholm C; Santos TDP; Rabbani L; Asl HF; Skaftason A; Ljungstrom V; Lundholm A; Koutroumani M; Haider Z; Jylha C; Mollstedt J; Mansouri L; Plevova K; Agathangelidis A; Scarfo L; Armand M; Muggen AF; Kay NE; Shanafelt T; Rossi D; Orre LM; Pospisilova S; Barylyuk K; Davi F; Vesterlund M; Langerak AW; Lehtio J; Ghia P; Stamatopoulos K; Sutton L-A; Rosenquist R
  • Article: CELL REPORTS MEDICINE. 2024;5(9):101699
    Long Jr D; Chan M; Han M; Kamdar Z; Ma RK; Tsai P-Y; Francisco AB; Barrow J; Shackelford DB; Yarchoan M; Mcbride MJ; Orre LM; Vacanti NM; Gujral TS; Sethupathy P
  • Article: NPJ PRECISION ONCOLOGY. 2024;8(1):38
    Struyf N; Osterroos A; Vesterlund M; Arnroth C; James T; Sunandar S; Mermelekas G; Bohlin A; Hamberg Levedahl K; Bengtzen S; Jafari R; Orre LM; Lehtio J; Lehmann S; Ostling P; Kallioniemi O; Seashore-Ludlow B; Erkers T
  • Article: ONCOIMMUNOLOGY. 2023;12(1):2233402
    Brownlie D; von Kries A; Valenzano G; Wild N; Yilmaz E; Safholm J; Al-Ameri M; Alici E; Ljunggren H-G; Schliemann I; Aricak O; de Flon FH; Michaelsson J; Marquardt N
  • Article: MOLECULAR CELL. 2023;83(20):3720-3739.e8
    Brunner A; Li Q; Fisicaro S; Kourtesakis A; Viiliainen J; Johansson HJ; Pandey V; Mayank AK; Lehtio J; Wohlschlegel JA; Spruck C; Rantala JK; Orre LM; Sangfelt O
  • Journal article: ANNALS OF ONCOLOGY. 2023;34:s1163-s1164
    Berkovska O; Mermelekas G; Orre L; Lehtio J
  • Preprint: RESEARCH SQUARE. 2023
    Erkers T; Struyf N; Arnroth C; Vesterlund M; James T; Sunandar S; Bohlin A; Hamberg-Levedahl K; Bengtzén S; Jafari R; Orre L; Lehtiö J; Lehmann S; Ostling P; Kallioniemi O; Seashore-Ludlow B
  • Article: DIAGNOSTIC CYTOPATHOLOGY. 2023;51(6):331-340
    Hysek M; Hellgren LS; Stenman A; Darai-Ramqvist E; Ljung E; Schliemann I; Condello V; Larsson C; Zedenius J; Jatta K; Juhlin CC
  • Journal article: CANCER RESEARCH. 2023;83(7):6612
    Erkers T; Struyf N; James T; Marabita F; Vesterlund M; Vu N; Arnroth C; Osterroos A; Bohlin A; Bengtzen S; Stahl M; Jafari R; Orre L; Pawitan Y; Seashore-Ludlow B; Lehtio J; Lehmann S; Ostling P; Kallioniemi O
  • Article: NPJ PRECISION ONCOLOGY. 2023;7(1):32
    Trac QT; Pawitan Y; Mou T; Erkers T; Ostling P; Bohlin A; Osterroos A; Vesterlund M; Jafari R; Siavelis I; Backvall H; Kiviluoto S; Orre LM; Rantalainen M; Lehtio J; Lehmann S; Kallioniemi O; Vu TN
  • Conference publication: BLOOD. 2022;140:6299
    Erkers T; Marabita F; Struyf N; Vesterlund M; James T; Arnroth C; Bohlin A; Bengtzen S; Osterroos A; Stahl M; Jafari R; Orre L; Pawitan Y; Seashore-Ludlow B; Lehtio J; Lehmann S; Ostling P; Kallioniemi O
  • Article: NATURE PROTOCOLS. 2022;17(8):1832-1867
    Arslan T; Pan Y; Mermelekas G; Vesterlund M; Orre LM; Lehtio J
  • Article: LAB ON A CHIP. 2022;22(11):2192-2199
    Marques F; Hauser J; Iseri E; Schliemann I; van der Wijngaart W; Roxhed N
  • Preprint: RESEARCH SQUARE. 2021
    Lehtiö J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer H; Mermelekas G; Pirmoradian M; Jönsson M; Brunnström H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevska M; Hanson CG; Haakensen VD; Helland Å; Tamborero D; Johansson H; Branca R; Planck M; Staaf J; Orre L
  • Preprint: RESEARCH SQUARE. 2021
    Lehtiö J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer H; Mermelekas G; Pirmoradian M; Jönsson M; Brunnström H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevska M; Hanson CG; Haakensen VD; Helland Å; Tamborero D; Johansson H; Branca R; Staaf J; Orre L
  • Preprint: RESEARCH SQUARE. 2021
    Lehtiö J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer H; Mermelekas G; Pirmoradian M; Jönsson M; Brunnström H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevska M; Hanson CG; Haakensen VD; Helland Å; Tamborero D; Johansson H; Branca R; Planck M; Staaf J; Orre L
  • Preprint: RESEARCH SQUARE. 2021
    Lehtiö J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer H; Mermelekas G; Pirmoradian M; Jönsson M; Brunnström H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevska M; Hanson CG; Haakensen VD; Helland Å; Tamborero D; Johansson H; Branca R; Planck M; Staaf J; Orre L
  • Article: NATURE CANCER. 2021;2(11):1224-1242
    Lehtio J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer HM; Mermelekas G; Pirmoradian M; Jonsson M; Brunnstrom H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevskaz M; Hansen CG; Haakensen VD; Helland A; Tamborero D; Johansson HJ; Branca RM; Planckz M; Staaf J; Orre LM
  • Article: JOURNAL OF EXTRACELLULAR VESICLES. 2021;10(9):e12128
    Veerman RE; Teeuwen L; Czarnewski P; Gucluler Akpinar G; Sandberg A; Cao X; Pernemalm M; Orre LM; Gabrielsson S; Eldh M
  • Article: AMERICAN JOURNAL OF HEMATOLOGY. 2021;96(5):580-588
    Mou T; Pawitan Y; Stahl M; Vesterlund M; Deng W; Jafari R; Bohlin A; Osterroos A; Siavelis L; Backvall H; Erkers T; Kiviluoto S; Seashore-Ludlow B; Ostling P; Orre LM; Kallioniemi O; Lehmann S; Lehtio J; Trung NV
  • Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(6):928-943
    Tran YZ; Minozada R; Cao X; Johansson HJ; Branca RM; Seashore-Ludlow B; Orre LM
  • Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(6):1047-1057
    Zhu Y; Orre LM; Tran YZ; Mermelekas G; Johansson HJ; Malyutina A; Anders S; Lehtio J
  • Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2020;318(4):L831-L843
    Gouveia L; Kraut S; Hadzic S; Vazquez-Liebanas E; Kojonazarov B; Wu C-Y; Veith C; He L; Mermekkas G; Schermuly RT; Weissmann N; Betsholtz C; Andrae J
  • Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419
    Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CBJ; Sandhow L; Kutzner J; Myrberg IH; Bunten SS; Axelsson H; Zhang SM; Rasti A; Makela P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtio J; Rassidakis GZ; Tamm KP; Warpman-Berglund U; Heyman M; Grander D; Lehmann S; Lundback T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
  • Article: SCIENTIFIC REPORTS. 2020;10(1):3651
    de Sousa IP; Gourmel C; Berkovska O; Burger M; Leroux J-C
  • Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(1):128-141
    Haytural H; Mermelekas G; Emre C; Nigam SM; Carroll SL; Winblad B; Bogdanovic N; Barthet G; Granholm A-C; Orre LM; Tjernberg LO; Frykman S
  • Article: ONCOGENE. 2019;38(43):6881-6897
    Fotouhi O; Kjellin H; Juhlin CC; Pan Y; Vesterlund M; Ghaderi M; Yousef A; Andersson-Sand H; Kharaziha P; Caramuta S; Kjellman M; Zedenius J; Larsson C; Orre LM
  • Article: NATURE COMMUNICATIONS. 2019;10(1):1600
    Johansson HJ; Socciarelli F; Vacanti NM; Haugen MH; Zhu Y; Siavelis I; Fernandez-Woodbridge A; Aure MR; Sennblad B; Vesterlund M; Branca RM; Orre LM; Huss M; Fredlund E; Beraki E; Garred O; Boekel J; Sauer T; Zhao W; Nord S; Hoglander EK; Jans DC; Brismar H; Haukaas TH; Bathen TF; Schlichting E; Naume B; Geisler J; Hofvind S; Engebraten O; Geitvik GA; Langerod A; Karesen R; Maelandsmo GM; Sorlie T; Skjerven HK; Park D; Hartman-Johnsen O-J; Luders T; Borgen E; Kristensen VN; Russnes HG; Lingjaerde OC; Mills GB; Sahlberg KK; Borresen-Dale A-L; Lehtio J
  • Article: MOLECULAR CELL. 2019;73(1):166-182.e7
    Orre LM; Vesterlund M; Pan Y; Arslan T; Zhu Y; Woodbridge AF; Frings O; Fredlund E; Lehtio J
  • Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2019;18(8):S40
    Johansson HJ; Socciarelli F; Vacanti NM; Haugen MH; Zhu Y; Siavelis I; Fernandez-Woodbridge A; Aure MR; Sennblad B; Vesterlund M; Branca RM; Orre LM; Huss M; Fredlund E; Beraki E; Garred O; Boeke J; Sauer T; Zhao W; Nord S; Hoglander EK; Jans DC; Brismar H; Haukaas TH; Bathen TF; Schlichting E; Naume B; Luders T; Borgen E; Kristensen VN; Russnes HG; Lingjaerde OC; Mills GB; Sahlberg KK; Borresen-Dale A-L; Lehtio J
  • Article: NATURE BIOTECHNOLOGY. 2018;36(6):521-529
    Wei B; Jolma A; Sahu B; Orre LM; Zhong F; Zhu F; Kivioja T; Sur I; Lehtio J; Taipale M; Taipale J
  • Corrigendum: NATURE COMMUNICATIONS. 2018;9(1):1852
    Zhu Y; Orre LM; Johansson HJ; Huss M; Boekel J; Vesterlund M; Fernandez-Woodbridge A; Branca RMM; Lehtio J
  • Article: NATURE COMMUNICATIONS. 2018;9(1):903
    Zhu Y; Orre LM; Johansson HJ; Huss M; Boekel J; Vesterlund M; Fernandez-Woodbridge A; Branca RMM; Lehtio J
  • Preprint: BIORXIV. 2017
    Wei B; Jolma A; Sahu B; Orre LM; Zhong F; Zhu F; Kivioja T; Sur IK; Lehtiö J; Taipale M; Taipale J
  • Article: BMC CANCER. 2017;17(1):650
    Reithmeier A; Panizza E; Krumpel M; Orre LM; Branca RMM; Lehtio J; Ek-Rylander B; Andersson G
  • Article: SCIENTIFIC REPORTS. 2017;7(1):4513
    Panizza E; Branca RMM; Oliviusson P; Orre LM; Lehtio J
  • Article: ONCOGENE. 2017;36(6):731-745
    Zhou Y; Frings O; Branca RM; Boekel J; le Sage C; Fredlund E; Agami R; Orre LM
  • Letter: LEUKEMIA & LYMPHOMA. 2016;57(11):2672-2676
    Schliemann I; Oschlies I; Nagel I; Penas EMM; Siebert R; Sander B
  • Journal article: CANCER RESEARCH. 2016;76(14_Supplement):1109
    Zhou Y; Frings O; Fredlund E; Boekel J; Branca RM; Orre LM
  • Conference publication: CANCER RESEARCH. 2016;76:3881
    Johansson H; Zhu Y; Haugland M; Sahlberg K; Fredlund E; Huss M; Vacanti N; Aure MR; Sennblad B; Kjellqvist S; Orre L; Lingjaerde OC; Borresen-Dale A-L; Lehtio J
  • Meeting abstract: CANCER RESEARCH. 2016;76:2385
    Guo M; Heller S; Thorslund J; Orre L; Lehtio J; Nister M; Hagerstrand D
  • Article: EXPERIMENTAL CELL RESEARCH. 2015;336(1):158-170
    Berglund E; Dare E; Branca RMM; Akcakaya P; Frobom R; Berggren P-O; Lui W-O; Larsson C; Zedenius J; Orre L; Lehtio J; Kim J; Branstrom R
  • Article: MOLECULAR & CELLULAR PROTEOMICS. 2014;13(6):1552-1562
    Zhu Y; Hultin-Rosenberg L; Forshed J; Branca RMM; Orre LM; Lehtio J
  • Article: NATURE METHODS. 2014;11(1):59-62
    Branca RMM; Orre LM; Johansson HJ; Granholm V; Huss M; Perez-Bercoff A; Forshed J; Kall L; Lehtio J
  • Article: ONCOGENE. 2013;32(49):5531-5540
    Orre LM; Panizza E; Kaminskyy VO; Vernet E; Graslund T; Zhivotovsky B; Lehtio J
  • Conference publication: CANCER RESEARCH. 2013;73(8):833
    Orre L; Panizza E; Kaminskyy V; Graslund T; Zhivotovsky B; Lehtio J
  • Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2011;47:S78
    Lehtio J; De Petris L; Pernemalm M; Forshed J; Branca R; Orre LM
  • Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2011;6(6):S304
    Orre LM; Le Sage C; Agami R; Lehtio J
  • Article: THYROID. 2010;20(10):1067-1076
    Sofiadis A; Dinets A; Orre LM; Branca RM; Juhlin CC; Foukakis T; Wallin G; Hoog A; Hulchiy M; Zedenius J; Larsson C; Lehtio J
  • Article: PROTEOME SCIENCE. 2010;8:9
    De Petris L; Pernemalm M; Elmberger G; Bergman P; Orre L; Lewensohn R; Lehtio J
  • Article: PROTEOME SCIENCE. 2009;7:43
    Stranneheim H; Orre LM; Lehtio J; Flygare J
  • Article: LUNG CANCER. 2009;63(3):410-417
    De Petris L; Orre LM; Kanter L; Pernemalm M; Koyi H; Lewensohn R; Lehtio J
  • Conference publication: CANCER RESEARCH. 2009;69
    Sofiadis A; Zedenius J; Wallin G; Foukakis T; Hoog A; Orre L; Lehtio J; Larsson C
  • Article: PROTEOMICS. 2008;8(15):3008-3018
    Eriksson H; Lengqvist J; Hedlund J; Uhlen K; Orre LM; Bjellqvist B; Persson B; Lehtio J; Jakobsson P-J
  • Article: JOURNAL OF PROTEOME RESEARCH. 2008;7(7):2712-2722
    Pernemalm M; Orre LM; Lengqvist J; Wikstrom P; Lewensohn R; Lehtio J
  • Doctoral thesis: 2008
    Orre L
  • Conference publication: ANTICANCER RESEARCH. 2008;28(5C):3275-3276
    Eriksson H; Lengqvist J; Hedlund J; Uhlen K; Orre LM; Bjellqvist B; Persson B; Lehtio J; Jakobsson P-J
  • Conference publication: ANTICANCER RESEARCH. 2008;28(5C):3430-3431
    Orre LM; Vernet E; Lengvist J; Graslund T; Lewensohn R; Lehtio J
  • Article: MOLECULAR & CELLULAR PROTEOMICS. 2007;6(12):2122-2131
    Orre LM; Pernemalm M; Lengqvist J; Lewensohn R; Lehtio J
  • Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;342(4):1211-1217
    Orre LM; Stenerlöw B; Dhar S; Larsson R; Lewensohn R; Lehtiö J
  • Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;341(2):334-342
    Orre LM; Fält S; Szeles A; Lewensohn R; Wennborg A; Flygare J
  • Journal article: BLOOD. 2005;106(11):2367
    Stenke L; Orre L; Dhar S; Larsson R; Lewensohn R; Lehtiö J
  • Conference publication: BLOOD. 2005;106(11):666A
    Stenke L; Orre L; Dhar S; Larsson R; Lewensohn R; Lehtiö J
  • Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2004;3(10):S35
    Orre L; Dhar S; Lewensohn R; Stenke L; Larsson R; Lehtioe J
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Erika Rindsjö
2025-05-26