Our research
Our research is focused at understanding how normal blood cell formation from stem cells in the bone marrow is organized and regulated to ensure replenishment of millions of blood cells per second, and on how normal stem cells upon acquisition of oncogenic mutations are transformed into malignant stem cells. The Jacobsen Group has demonstrated that the bone marrow contains different normal blood forming stem cells with different functions. We have also identified and characterized the cancer stem cells in different blood malignancies and demonstrated that these are resistant to different types of standard treatments and responsible for the relapse of the disease after otherwise successful therapy.
The goal of The Jacobsen Group’s research program is to identify new and more efficien