SLE/APS/Vasculitis group
Main research focus is clinical studies, which are often performed as translational projects in collaboration with molecular immunologists, geneticists, epidemiologists, but also patients' perceptions of symptoms and educational needs are addressed. We also conduct research on pregnant patients with SLE and APS.
SLE
Since the mid-90s, we have characterized and collected samples from large cohorts of very well-characterized patients and matched controls that we follow longitudinally with careful cross-sectional studies approximately every 10 years.
- We have identified four autoantibody defined sub-groups among SLE patients. We are now performing further studies on how these sub-groups differ regarding symptoms, type of inflammation, and genetics.
- Studies on lupus nephritis including identification of biomarkers, histopathological studies and analysis of immune cell alterations following immunosuppressive and biologic therapy on renal SLE.
- Cardiac Magnetic Resonance studies (CMRI) to investigate microvascular function in the myocardium of SLE patients with and without chest symptoms.
- Autoantibody specificities in general and in circulating Immune complexes, collaboration with prof Johan Rönnelid.
- MS proteomic study to further characterize the four SLE subgroups.
- We collaborate internationally in studies of the genetics of SLE.
- Molecular inflammatory process in SLE target organs: skin and kidneys.
APS
We have collected samples from patients with APS since 2008. We investigate risk factors for recurring thromboses and pregnancy morbidities. We also focus on the coagulation and complement systems. In APS. Another focus is on the contribution of antiphospholipid antibodies to myocardial infarctions in the general population.
AAV
Since 2008, we have characterized and collected samples from large cohorts (n=350) of well-characterized patients with AAV from the rheumatology and nephrology departements. Longitudinal follow-up has been performed in patients with active disease for up to 10 years (n=100). We perform clinical studies, experimental studies and participate in national and international studies on AAV genetics. Additionally, we are studying patients' perception of educational needs and support using questionnaires and interviews.
Group members
